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  1. Article ; Online: Prevalence and Impact of Coagulation Dysfunction in COVID-19 in China: A Meta-Analysis.

    Jin, Shanen / Jin, Yiyang / Xu, Bai / Hong, Jun / Yang, Xianghong

    Thrombosis and haemostasis

    2020  Volume 120, Issue 11, Page(s) 1524–1535

    Abstract: Background:  The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19.: Methods:  A meta-analysis of ...

    Abstract Background:  The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19.
    Methods:  A meta-analysis of the prevalence of different abnormal coagulation indicators in COVID-19 patients in China was performed. The difference of coagulation indicators and the incidence of DIC were compared between severe cases and nonsevere cases as well as nonsurvivors and survivors, respectively.
    Results:  A total of 22 Chinese studies involving 4,889 confirmed COVID-19 inpatients were included. The average D-dimer value of COVID-19 patients is 0.67 µg/mL (95% confidence interval [CI]: 0.56-0.78), and 29.3% (95% CI: 20.1-38.5%) of patients showed elevated D-dimer values. Severe patients had significantly higher D-dimer levels and prolonged prothrombin time (PT) compared with nonsevere patients. Nonsurvivors had significantly higher D-dimer levels, prolonged PT, and decreased platelet count compared with survivors. In total, 6.2% (95% CI: 2.6-9.9%) COVID-19 patients were complicated by disseminated intravascular coagulation (DIC), in which the log risk ratio in nonsurvivors was 3.267 (95% CI: 2.191-4.342,
    Conclusion:  The prevalence of coagulopathy in Chinese COVID-19 inpatients is high, and both the abnormal coagulation indicators and DIC are closely associated with the severity and poor prognosis of these COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Closely monitoring of coagulation indicators and application of appropriate anticoagulation may improve the prognosis of COVID-19 inpatients in China.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/epidemiology ; Blood Coagulation Disorders/mortality ; COVID-19 ; China/epidemiology ; Coronavirus Infections/blood ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors ; Severity of Illness Index
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1714369
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  2. Article: Prevalence and Impact of Coagulation Dysfunction in COVID-19 in China: A Meta-Analysis

    Jin, Shanen / Jin, Yiyang / Xu, Bai / Hong, Jun / Yang, Xianghong

    Thromb Haemost

    Abstract: BACKGROUND: The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19. METHODS: A meta-analysis of the ... ...

    Abstract BACKGROUND: The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19. METHODS: A meta-analysis of the prevalence of different abnormal coagulation indicators in COVID-19 patients in China was performed. The difference of coagulation indicators and the incidence of DIC were compared between severe cases and nonsevere cases as well as nonsurvivors and survivors, respectively. RESULTS: A total of 22 Chinese studies involving 4,889 confirmed COVID-19 inpatients were included. The average D-dimer value of COVID-19 patients is 0.67 µg/mL (95% confidence interval [CI]: 0.56-0.78), and 29.3% (95% CI: 20.1-38.5%) of patients showed elevated D-dimer values. Severe patients had significantly higher D-dimer levels and prolonged prothrombin time (PT) compared with nonsevere patients. Nonsurvivors had significantly higher D-dimer levels, prolonged PT, and decreased platelet count compared with survivors. In total, 6.2% (95% CI: 2.6-9.9%) COVID-19 patients were complicated by disseminated intravascular coagulation (DIC), in which the log risk ratio in nonsurvivors was 3.267 (95% CI: 2.191-4.342, Z = 5.95, p < 0.05) compared with that in survivors. CONCLUSION: The prevalence of coagulopathy in Chinese COVID-19 inpatients is high, and both the abnormal coagulation indicators and DIC are closely associated with the severity and poor prognosis of these COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Closely monitoring of coagulation indicators and application of appropriate anticoagulation may improve the prognosis of COVID-19 inpatients in China.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #653691
    Database COVID19

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  3. Article ; Online: Prevalence and Impact of Coagulation Dysfunction in COVID-19 in China

    Jin, Shanen / Jin, Yiyang / Xu, Bai / Hong, Jun / Yang, Xianghong

    Thrombosis and Haemostasis ; ISSN 0340-6245 2567-689X

    A Meta-Analysis

    2020  

    Abstract: Abstract Background The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19. Methods A meta-analysis of ...

    Abstract Abstract Background The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19. Methods A meta-analysis of the prevalence of different abnormal coagulation indicators in COVID-19 patients in China was performed. The difference of coagulation indicators and the incidence of DIC were compared between severe cases and nonsevere cases as well as nonsurvivors and survivors, respectively. Results A total of 22 Chinese studies involving 4,889 confirmed COVID-19 inpatients were included. The average D-dimer value of COVID-19 patients is 0.67 µg/mL (95% confidence interval [CI]: 0.56–0.78), and 29.3% (95% CI: 20.1–38.5%) of patients showed elevated D-dimer values. Severe patients had significantly higher D-dimer levels and prolonged prothrombin time (PT) compared with nonsevere patients. Nonsurvivors had significantly higher D-dimer levels, prolonged PT, and decreased platelet count compared with survivors. In total, 6.2% (95% CI: 2.6–9.9%) COVID-19 patients were complicated by disseminated intravascular coagulation (DIC), in which the log risk ratio in nonsurvivors was 3.267 (95% CI: 2.191–4.342, Z = 5.95, p < 0.05) compared with that in survivors. Conclusion The prevalence of coagulopathy in Chinese COVID-19 inpatients is high, and both the abnormal coagulation indicators and DIC are closely associated with the severity and poor prognosis of these COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Closely monitoring of coagulation indicators and application of appropriate anticoagulation may improve the prognosis of COVID-19 inpatients in China.
    Keywords Hematology ; covid19
    Language English
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    DOI 10.1055/s-0040-1714369
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Prevalence and Impact of Coagulation Dysfunction in COVID-19 in China: A Meta-Analysis

    Jin, Shanen / Jin, Yiyang / Xu, Bai / Hong, Jun / Yang, Xianghong

    Thrombosis and Haemostasis

    2020  Volume 120, Issue 11, Page(s) 1524–1535

    Abstract: Background: The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19.: Methods: A meta-analysis of ... ...

    Abstract Background: The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19.
    Methods: A meta-analysis of the prevalence of different abnormal coagulation indicators in COVID-19 patients in China was performed. The difference of coagulation indicators and the incidence of DIC were compared between severe cases and nonsevere cases as well as nonsurvivors and survivors, respectively.
    Results: A total of 22 Chinese studies involving 4,889 confirmed COVID-19 inpatients were included. The average D-dimer value of COVID-19 patients is 0.67 µg/mL (95% confidence interval [CI]: 0.56–0.78), and 29.3% (95% CI: 20.1–38.5%) of patients showed elevated D-dimer values. Severe patients had significantly higher D-dimer levels and prolonged prothrombin time (PT) compared with nonsevere patients. Nonsurvivors had significantly higher D-dimer levels, prolonged PT, and decreased platelet count compared with survivors. In total, 6.2% (95% CI: 2.6–9.9%) COVID-19 patients were complicated by disseminated intravascular coagulation (DIC), in which the log risk ratio in nonsurvivors was 3.267 (95% CI: 2.191–4.342, Z  = 5.95, p  < 0.05) compared with that in survivors.
    Conclusion: The prevalence of coagulopathy in Chinese COVID-19 inpatients is high, and both the abnormal coagulation indicators and DIC are closely associated with the severity and poor prognosis of these COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Closely monitoring of coagulation indicators and application of appropriate anticoagulation may improve the prognosis of COVID-19 inpatients in China.
    Keywords COVID-19 ; coagulopathy ; disseminated intravascular coagulation ; venous thromboembolism ; anticoagulation
    Language English
    Publishing date 2020-07-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1714369
    Database Thieme publisher's database

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  5. Article ; Online: Past climate cooling promoted global dispersal of amphipods from Tian Shan montane lakes to circumboreal lakes.

    Hou, Zhonge / Jin, Pengyu / Liu, Hongguang / Qiao, Huijie / Sket, Boris / Cannizzaro, Andrew G / Berg, David J / Li, Shuqiang

    Global change biology

    2022  Volume 28, Issue 12, Page(s) 3830–3845

    Abstract: ... records. We found that the species arose in Tian Shan in Central Asia and dispersed into montane lakes ... with accelerated diversification rates outside Tian Shan. Climatically suitable regions for geographic lineages ... Tibet and North America are predicted to expand, whereas ranges in East Asia, Europe and Tian Shan ...

    Abstract Climate changes have substantial impacts on the geographic distribution of montane lakes and evolutionary dynamics of cold-adapted species. Past climate cooling is hypothesized to have promoted the dispersal of cold-adapted species via montane lakes, while future climate warming is thought to constrain their distributions. We test this hypothesis by using phylogeographic analysis and niche modeling of the Holarctic crustacean Gammarus lacustris with global sampling comprised of 567 sequenced individuals and 3180 occurrence records. We found that the species arose in Tian Shan in Central Asia and dispersed into montane lakes along the Alps, Himalayas, Tibet, East Asia, and the North American Rocky Mountain ranges, with accelerated diversification rates outside Tian Shan. Climatically suitable regions for geographic lineages of G. lacustris were larger during cooling periods (LGM), but smaller during warming periods (Mid-Holocene). In the future (2070) scenario, potential distributions in the Himalayas, North Tibet, South Tibet and North America are predicted to expand, whereas ranges in East Asia, Europe and Tian Shan will decline. Our results suggest that Mid-Miocene-to-Pleistocene continuous cooling promoted multiple independent dispersal events out of Tian Shan due to increased availability of montane lakes via "budding" of lineages. Montane lakes are conduits through which cold-adapted amphipods globally dispersed, dominating circumboreal lakes. However, future climate warming is likely to force organisms to shift upward in altitude and northward in latitude, leading to a future change in local populations. These findings highlight the importance of conservation of montane lakes, especially in the context of climate change.
    MeSH term(s) Amphipoda ; Animals ; Climate Change ; Ecosystem ; Humans ; Lakes ; Phylogeny ; Phylogeography
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1281439-8
    ISSN 1365-2486 ; 1354-1013
    ISSN (online) 1365-2486
    ISSN 1354-1013
    DOI 10.1111/gcb.16160
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  6. Article ; Online: Synthesis of Benzofuran-Fused Oxepines through Cs

    Jin, Hai-Shan / Zhu, Tong

    The Journal of organic chemistry

    2024  Volume 89, Issue 5, Page(s) 3271–3278

    Abstract: Benzofuran-fused derivatives display important and reliable therapeutic properties. Herein, we describe the synthesis of benzofuran-fused oxepines using aurones and crotonate-derived sulfonium salts via a [4 + 3] annulation reaction in the presence of ... ...

    Abstract Benzofuran-fused derivatives display important and reliable therapeutic properties. Herein, we describe the synthesis of benzofuran-fused oxepines using aurones and crotonate-derived sulfonium salts via a [4 + 3] annulation reaction in the presence of Cs
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02715
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  7. Article ; Online: A The complete chloroplast genome and phylogenetic analysis of Bupleurum yinchowense Shan & Yin Li.

    Zhang, Gaixia / Kong, Weijun / Wang, Qiuling / Lu, Fuhua / Jin, Yue / Jiang, Jiemei / Shi, Linchun

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 3, Page(s) 1233–1235

    Abstract: Bupleurum ... ...

    Abstract Bupleurum yinchowense
    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2020.1866465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Letter by Jin-shan and Xue-bin Regarding Article, "Chronic Myocardial Infarction: Where Is It Located?"

    Jin-Shan, He / Xue-Bin, Li

    Circulation

    2018  Volume 137, Issue 18, Page(s) 1976

    MeSH term(s) Humans ; Myocardial Infarction
    Language English
    Publishing date 2018-04-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.032293
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  9. Article ; Online: Letter by Jin-shan and Xue-bin Regarding Article, "Platelets Express Activated P2Y

    Jin-Shan, He / Xue-Bin, Li

    Circulation

    2018  Volume 137, Issue 17, Page(s) 1874

    MeSH term(s) Blood Platelets ; Diabetes Mellitus ; Humans ; Signal Transduction
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.032074
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  10. Article ; Online: Letter by Jin-shan and Xue-bin Regarding Article, "Idiopathic Ventricular Fibrillation in a 29-Year-Old Man".

    Jin-Shan, He / Xue-Bin, Li

    Circulation

    2018  Volume 137, Issue 6, Page(s) 643–644

    MeSH term(s) Adult ; Humans ; Male ; Ventricular Fibrillation
    Language English
    Publishing date 2018-02-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.031068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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