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Article ; Online: PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8

Liu, Shan-Shan / Bai, Tong-Tong / Que, Tao-Lin / Luo, An / Liang, Yu-Xin / Song, Yu-Xin / Liu, Tian-Yi / Chen, Jin-Wei / Li, Jing / Li, Nan / Zhang, Ze-Chen / Chen, Nan-Nan / Liu, Yu / Zhang, Ze-Cai / Zhou, Yu-Long / Wang, Xue / Zhu, Zhan-Bo

Veterinary microbiology

2024 Volume 291, Page(s) 110034

Abstract: Bovine viral diarrhea virus (BVDV) has caused massive economic losses in the cattle business worldwide. Fatty acid synthase (FASN), a key enzyme of the fatty acid synthesis (FAS) pathway, has been shown to support virus replication. To investigate the ... ...

Abstract	Bovine viral diarrhea virus (BVDV) has caused massive economic losses in the cattle business worldwide. Fatty acid synthase (FASN), a key enzyme of the fatty acid synthesis (FAS) pathway, has been shown to support virus replication. To investigate the role of fatty acids (FAs) in BVDV infection, we infected CD8
MeSH term(s)	Cattle ; Animals ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Diarrhea Viruses, Bovine Viral/physiology ; Diarrhea Virus 1, Bovine Viral ; CD8-Positive T-Lymphocytes ; Fatty Acids ; Lipids
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Fatty Acids ; Lipids
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2024.110034
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Article ; Online: Bronchogenic cyst located between abdominal aorta and the lesser curvature of stomach.

Ma, Yu Qi / Bi, Xin Ran / Zhan, Wei Peng / Ma, Yun Tao

Asian journal of surgery

2024 Volume 47, Issue 4, Page(s) 1965–1967

MeSH term(s)	Humans ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/surgery ; Bronchogenic Cyst/diagnostic imaging ; Bronchogenic Cyst/surgery ; Stomach/surgery ; Abdomen
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.12.126
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Article: Exploring the Diagnostic Value of High-Frequency Ultrasound Technology for Subcutaneous Lipohypertrophy in Diabetes Patients Receiving Insulin Injections.

Sun, Zhan-He / Yu, Cheng-Hong / Wang, Xin

Diabetes, metabolic syndrome and obesity : targets and therapy

2024 Volume 17, Page(s) 1359–1366

Abstract: Objective: This study aims to investigate the clinical application value of high-frequency ultrasound technology in diagnosing subcutaneous lipohypertrophy at insulin injection sites in diabetes patients.: Methods: All diabetes patients treated in ... ...

Abstract	Objective: This study aims to investigate the clinical application value of high-frequency ultrasound technology in diagnosing subcutaneous lipohypertrophy at insulin injection sites in diabetes patients. Methods: All diabetes patients treated in our hospital from January 2022 to January 2023 were selected as the study subjects. The incidence of subcutaneous lipohypertrophy was calculated at the end of the study period. All patients were screened, and those meeting the inclusion criteria were registered, and basic data were collected. Patients were screened for subcutaneous lipohypertrophy using conventional clinical examination (control group) and high-frequency ultrasound technology (study group). Results: The study found that the incidence of subcutaneous lipohypertrophy in diabetes patients receiving insulin injections in our hospital from January 2022 to January 2023 was 80.99%. The average longitudinal diameter of subcutaneous lipohypertrophy in these patients was 11.66 (7.56, 21.44) mm, the transverse diameter was 12.04 (8.96, 18.29) mm, depth was (5.62±2.17) mm, and the area was 188.79 (76.85, 331.78) mm². The clinical detection rate in the study group was higher than that in the control group (P<0.05). The quantity of detected sites was greater in the study group compared to the control group (P<0.05). Conclusion: The incidence of subcutaneous lipohypertrophy in diabetes patients receiving insulin injections is relatively high clinically, and high-frequency ultrasound technology demonstrates significant potential in diagnosis. By providing high-resolution imaging and quantitative data, it effectively improves the clinical detection rate and clarifies symptoms. This technology is likely to become an important auxiliary tool in future diabetes treatment, providing more precise treatment plans for patients.
Language	English
Publishing date	2024-03-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S443737
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Article: 广东省汕头市生态修复关键点识别与差异化规划.

Jian, Yu-Qing / Dai, Yu-Xin / Huang, Zhi-Bin / Zhan, Ang-Shuo / Li, He-Cheng / Wang, Zhi-Fang

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 10, Page(s) 2730–2738

Abstract: Territorial ecological restoration planning is a carrier process for carrying out territorial space regulation and ecological restoration. However, current urban planning efforts only focus on ecological processes, and fail to coordinate the development ... ...

Title translation	Identification of key points and differentiation planning strategies of Shantou, Guangdong, China.
Abstract	Territorial ecological restoration planning is a carrier process for carrying out territorial space regulation and ecological restoration. However, current urban planning efforts only focus on ecological processes, and fail to coordinate the development of both ecology and society. Taking Shantou, a city in Guangdong Province, as an example, we focused on the identification of ecological restoration nodes and the development of differentiated planning strategies from a comprehensive ecological-social perspective. By considering ecosystem integrity, we extracted the ecological corridors and key points by identifying ecological sources and constructing resistance surfaces, constructed an ecological recreation service evaluation system from the social perspective in terms of recreational allocation and recreational value to identify key areas for recreation services, and obtained different types of ecological restoration strategies by synthesizing the results of ecology and recreation. The results showed that there were 136 ecological corridors and 77 ecological nodes in Shantou, with a total length of 380.58 km. The most important recreation areas were the coastline, several inland bays, and wetland tidal flats, with an area of 33.78 km
MeSH term(s)	Ecosystem ; Conservation of Natural Resources/methods ; Wetlands ; Cities ; China ; Ecology
Language	Chinese
Publishing date	2023-10-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202310.024
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Article ; Online: Performance of the 2019 ACR/EULAR Classification Criteria for IgG4-Related Disease in a Large Chinese Cohort.

An, Zhuo-Yu / Fu, Jiang-Nan / Zeng, Qiao-Zhu / Zhufeng, Yun-Zhi / Ning, Xiao-Ran / Li, Hui-Juan / Ma, Xiang-Bo / Wang, Kun-Kun / Bian, Wen-Jie / Zhang, Yu-Xin / Li, Zhan-Guo / Liu, Yan-Ying

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2024 Volume 30, Issue 2, Page(s) 73–78

Abstract: Objective: The purpose of this research was to ascertain the effectiveness of the newly established criteria for classifying IgG4-related disease (IgG4-RD), as applied to a large Chinese cohort in real-world clinical settings.: Methods: Patient data ... ...

Abstract	Objective: The purpose of this research was to ascertain the effectiveness of the newly established criteria for classifying IgG4-related disease (IgG4-RD), as applied to a large Chinese cohort in real-world clinical settings. Methods: Patient data were procured from the digital health records of 4 prominent academic hospitals. The criterion standard for identifying IgG4-RD patients was from a seasoned rheumatologist. The control group consisted of individuals with other ailments such as cancer, other forms of pancreatitis, infectious diseases, and illnesses that mimic IgG4-RD. Results: A total of 605 IgG4-RD patients and 760 mimickers were available for analysis. The 2019 EULAR/ACR criteria have a sensitivity of 69.1% and a specificity of 90.9% in this large Chinese cohort. IgG4-RD had a greater proportion of males (55.89% vs 36.25%, p < 0.001), an older average age at diagnosis (54.91 ± 13.44 vs 48.91 ± 15.71, p < 0.001), more pancreatic (29.59% vs 6.12%, p < 0.001) and salivary gland (63.30% vs 27.50%, p < 0.001) involvement, and a larger number of organ involvement (3.431 ± 2.054 vs 2.062 ± 1.748, p < 0.001) compared with mimickers. Conclusions: The 2019 EULAR/ACR criteria are effective in classifying IgG4-RD in Chinese patients, demonstrating high specificity and moderate sensitivity.
MeSH term(s)	Humans ; Male ; Asian People ; China ; Immunoglobulin G4-Related Disease/diagnosis ; Pancreatitis/diagnosis ; Salivary Glands ; Female
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000002057
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Article ; Online: Water-Soluble Porphyrin-Based Nanoparticles Derived from Electrostatic Interaction for Enhanced Photodynamic Therapy.

Li, Yu-Xin / Liu, Yamin / Wang, Hui / Li, Zhan-Ting / Zhang, Dan-Wei

ACS applied bio materials

2022 Volume 5, Issue 2, Page(s) 881–888

Abstract: Pyrrole and porphyrin-derived nanoparticles have great potential use in bioimaging and therapy because of their unique magnetic, optical, and other photophysical properties, whereas the poor solubility in aqueous solution is one of the drawbacks of ... ...

Abstract	Pyrrole and porphyrin-derived nanoparticles have great potential use in bioimaging and therapy because of their unique magnetic, optical, and other photophysical properties, whereas the poor solubility in aqueous solution is one of the drawbacks of current photosensitizers for their photodynamic therapy (PDT) applications. Here, we developed a kind of water-soluble porphyrin-based nanoparticles that are coassembled mainly by the electrostatic interaction of anionic porphyrins and cationic tetraphenylmethane derivative. No aggregation-caused quenching (ACQ) was detected for these nanoparticles. In addition, the simple porphyrin transformation into nanoparticles improved their ability to generate reactive oxygen species singlet oxygen (
MeSH term(s)	Nanoparticles ; Photochemotherapy/methods ; Porphyrins ; Static Electricity ; Water
Chemical Substances	Porphyrins ; Water (059QF0KO0R)
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.1c01262
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Article: [Application of artificial intelligence in the diagnosis of prostate cancer].

Zhang, Ke-Xin / Yu, Zhan-Peng / Shen, Tian-Yi / Tang, Hao

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 12, Page(s) 1043–1047

Abstract: With the rise of precision medicine, the continuous expansionWith the rise of precision medicine, the continuous expansion the collective push from many other the application of Artificial Intelligence (AI) in prostate cancer diagnosis is increasingly ... ...

Abstract	With the rise of precision medicine, the continuous expansionWith the rise of precision medicine, the continuous expansion the collective push from many other the application of Artificial Intelligence (AI) in prostate cancer diagnosis is increasingly becoming a focal point. AI technology can effectively utilize diverse detection methods such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and whole pathology slide imaging to efficiently identify and differentiate between benign and malignant lesions. The encouraging results from numerous studies herald the enormous potential of this field. This article aims to provide a comprehensive summary and analysis of the research progress made in AI for prostate cancer diagnosis, in order to better grasp the trends in this area of development.
MeSH term(s)	Male ; Humans ; Artificial Intelligence ; Prostatic Neoplasms/diagnostic imaging ; Prostate ; Pelvis ; Magnetic Resonance Imaging
Language	Chinese
Publishing date	2024-04-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article: [Action mechanisms of Xiaoluowan (II) in the treatment of epididymitis: A network pharmacology-based study].

Zhan, Ming-Wei / Lou, Qiang / Liu, Peng-Fei / Wang, Lei / Zhan, Xu-Xin / Lai, Yu-Qi / Yu, Yi / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 4, Page(s) 298–305

Abstract: Objective: To explore the potential action mechanisms of Xiaoluowan (II) (XLW-II) in the treatment of epididymitis through a network pharmacology approach.: Methods: We searched various databases for relevant targets associated with epididymitis and ... ...

Abstract	Objective: To explore the potential action mechanisms of Xiaoluowan (II) (XLW-II) in the treatment of epididymitis through a network pharmacology approach. Methods: We searched various databases for relevant targets associated with epididymitis and XLW-II and obtained the common targets of epididymitis and XLW-II on the Venny platform. We acquired the protein-protein interactions (PPI) using the STRING data and had them visualized with the Cytoscape software. After topological analysis, we retrieved the key targets, followed by gene ontology (GO) and KEGG pathway enrichment analyses using the DAVID database. Results: A total of 2 38 drug targets, 2 150 disease targets and 85 common targets were identified. The core targets for the treatment of epididymitis with XLW-II identified by PPI network analysis included TNF, IL6, IL1B, MMP9, AKT1, PTGS2 and TP53. GO function analysis revealed the involvement of the common targets in such biological processes as response to hypoxia, regulation of apoptotic processes, inflammatory response, and positive regulation of the MAPK cascade. KEGG pathway analysis suggested that the signaling pathways such as the cancer pathway, PI3K-Akt pathway, protein glycosylation pathway in cancer, Ras pathway and chemokine pathway might be related to the action mechanisms of XLW-II in the treatment of epididymitis. Conclusion: The potential targets and signaling pathways of Xiaoluowan (II) in the treatment of epididymitis were identified on the basis of network pharmacology, which has provided a novel insight into its action mechanisms and offered a new direction for further relevant studies.
MeSH term(s)	Male ; Humans ; Epididymitis/drug therapy ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Neoplasms ; Drugs, Chinese Herbal
Chemical Substances	xiaoluowan ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Drugs, Chinese Herbal
Language	Chinese
Publishing date	2024-04-10
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article: [Exploring the mechanism of levocarnitine in the treatment of epididymitis based on network pharmacology and molecular docking technology].

Zhan, Ming-Wei / Wang, Lei / Zhan, Xu-Xin / Liu, Peng-Fei / Lou, Qiang / Lai, Yu-Qi / Yu, Yi / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 8, Page(s) 698–704

Abstract: Objective: To explore the potential mechanism of action of levocarnitine in the treatment of epididymitis based on network pharmacology and experimental research.: Methods: The target proteins related to epididymitis and levocarnitine were retrieved ... ...

Abstract	Objective: To explore the potential mechanism of action of levocarnitine in the treatment of epididymitis based on network pharmacology and experimental research. Methods: The target proteins related to epididymitis and levocarnitine were retrieved through multiple databases, and the common targets were obtained using Venny software. The protein-protein interactions were obtained using the STRING database. Cytoscape software was used for visualization, and key targets were selected after topological analysis. GO and KEGG pathway enrichment analysis was performed using the DAVID database. Molecular docking was performed using Autodock Vina. Results: A total of 130 drug targets and 2 151 disease targets were obtained, with 47 common targets. Protein-protein interaction network analysis identified core targets of levocarnitine in the treatment of epididymitis, including AKT1, HSP90AA1, ALB, CASP3, GSK3B, and GSR. KEGG pathway analysis suggested that metabolic pathways, lipid metabolism and atherosclerosis, cancer pathways, fluid shear stress and atherosclerosis, measles, chemical carcinogens-reactive oxygen species, purine metabolism, PI3K-Akt, and other signaling pathways may be associated with the mechanism of levocarnitine in the treatment of epididymitis. Conclusion: This study revealed through network pharmacology that levocarnitine may act on multiple signaling pathways by targeting AKT1, HSP90AA1, ALB, CASP3, GSK3B, GSR, etc., thereby potentially exerting therapeutic effects on epididymitis.
MeSH term(s)	Male ; Humans ; Molecular Docking Simulation ; Carnitine ; Network Pharmacology ; Caspase 3 ; Epididymitis ; Phosphatidylinositol 3-Kinases ; Atherosclerosis
Chemical Substances	Carnitine (S7UI8SM58A) ; Caspase 3 (EC 3.4.22.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	Chinese
Publishing date	2024-04-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article: [Mechanism of regulation of CNP rat model by oxalis decoction via cGAS-STING signaling pathway].

Lou, Qiang / Zhan, Ming-Wei / Lai, Yu-Qi / Zhan, Xu-Xin / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 12, Page(s) 973–979

Abstract: Objective: To investigate the therapeutic mechanism of oxalis decoction on CNP rats by regulating cGAS-STING signaling pathway.: Methods: Thirty specific pathogen-free SD male rats were randomly divided into normal control group (NC), model control ... ...

Abstract	Objective: To investigate the therapeutic mechanism of oxalis decoction on CNP rats by regulating cGAS-STING signaling pathway. Methods: Thirty specific pathogen-free SD male rats were randomly divided into normal control group (NC), model control group (MC), and oxalis decoction group (OD),with 10 rats in each group.The left and right anterior abdominal lobes of each group were surgically exposed.The normal control group was injected by the same volume of normal saline.After the model was successfully established,the OD group was given ［9.37g/(kg·d)］ by gavage once a day, and the NC and MC groups were given ［0.01/(mｌ/g)］ normal saline by gavage. From the 7th day of administration, the body weight of the rats in each group was recorded every 7 days for dynamic comparison. After 50 days of administration, the prostate index of the rats in each group was calculated, the morphological and pathological changes of the prostate tissue were observed by HE staining,and the expression levels of tumor necrosis factorα(TNF-α), interleukin-1β(IL-1β)and IL-6 in serum were detected by ELISA. RT-qPCR was used to detect the mRNA expression of cGAS, STING, TRAF6 and HSP70 in prostate tissue of rats in each group. Results: Versus the NC group and OD group, the prostate organ index in MC group was significantly higher than that in other groups (P<0.01). Versus the NC group, the HE staining results of the MC group showed that the prostate gland structure was disordered, and the interstitial and acinar epithelium were extensively edema, accompanied by a large number of lymphocyte infiltration, cell swelling, loose cytoplasm, and a small number of foam cells. Versus the MC group, HE staining showed that the edema of interstitial and acinar epithelial cells in the rat prostate tissue was reduced after the OD group intervention, and the inflammatory cell infiltration in the interstitium was significantly reduced.Versus to NC group, the expression levels of TNF-α,IL-1βandIL-6 in MC group were significantly increased（P<0.01 ).Versus to MC group,the expression levels of TNF-α, IL-1β and IL-6 in OD group were decreased (P<0.05). Versus the NC group, the mRNA expression of cGAS, STING and TRAF6 in the MC group was significantly up-regulated,and HSP70mRNA was significantly down-regulated(P<0.01).Versus the MC group,the OD group had significantly decreased mRNA expression of cGAS, STING and TRAF6 and significantly increased mrna expression of HSP70(P<0.05). Conclusions: CNP has autoimmune disorders that cause inflammatory responses.The key target for CNP treatment is to regulate innate immunity.The treatment with oxalis decoction can significantly improve the prostate organ index and pathological changes in CNP rats, which may be related to the down-regulation of cGAS-STING innate immune signaling pathway and the inhibition of inflammatory mediators secretion.
MeSH term(s)	Rats ; Male ; Animals ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/metabolism ; Saline Solution ; TNF Receptor-Associated Factor 6/metabolism ; Interleukin-1beta/metabolism ; Signal Transduction ; Edema ; RNA, Messenger
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-6 ; Saline Solution ; TNF Receptor-Associated Factor 6 ; Interleukin-1beta ; RNA, Messenger
Language	Chinese
Publishing date	2024-04-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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