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Article ; Online: Medical Students' Intention to Change After Receiving Formative Feedback: Employing Social Cognitive Theories of Behavior.

Johnson, Natasha R / Dzara, Kristina / Pelletier, Andrea / Goldfarb, Ilona Telefus

Medical science educator

2022 Volume 32, Issue 6, Page(s) 1447–1454

Abstract: Introduction: We applied Azjen's theory of planned behavior (TPB) and Triandis' theory of interpersonal behavior (TIB) to understand medical students' intention to change behavior based on feedback received during an obstetrics and gynecology clerkship. ...

Abstract	Introduction: We applied Azjen's theory of planned behavior (TPB) and Triandis' theory of interpersonal behavior (TIB) to understand medical students' intention to change behavior based on feedback received during an obstetrics and gynecology clerkship. Both models presume that behavioral intention is strongly related to actual behavior. Materials and methods: We collected free-text responses from students during a year-long Results: We reviewed 1,443 feedback entries from 122 students between July 2, 2018, and May 31, 2019. Conclusions: While
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article
ISSN	2156-8650
ISSN (online)	2156-8650
DOI	10.1007/s40670-022-01668-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Costs of Contradictory Messages About Live Vaccines in Pregnancy.

Jaffe, Elana / Goldfarb, Ilona Telefus / Lyerly, Anne Drapkin

American journal of public health

2021 Volume 111, Issue 3, Page(s) 498–503

Abstract: The increased risk of harm from COVID-19 infection in pregnancy highlights the importance of including pregnant people in COVID-19 vaccine development and deployment. Promising vaccines being developed include replication-competent platforms, which are ... ...

Abstract	The increased risk of harm from COVID-19 infection in pregnancy highlights the importance of including pregnant people in COVID-19 vaccine development and deployment. Promising vaccines being developed include replication-competent platforms, which are typically contraindicated during pregnancy because of theoretical risk. However, replicating vaccines are administered in and around pregnancy, either inadvertently because of unknown pregnancy status or when recommended.The historical cases of Ebola virus, yellow fever, and rubella demonstrate that contradictory messages around the safety of live vaccines in pregnancy have critical public health costs. First, restricting study or use of replicating vaccines in pregnancy may delay or deny access to the only available protection against deadly diseases. Additionally, not vaccinating pregnant people may slow epidemic control. Finally, uncertainty and worry around the safety of live vaccines may lead to terminations of otherwise desired pregnancies after inadvertent vaccination in pregnancy.If one of the vaccines deployed to combat the current global COVID-19 pandemic is replication competent, historical cases offer important lessons for ethical and effective protection for pregnant populations.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Drug Development/organization & administration ; Drug Development/standards ; Female ; Humans ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; Pregnant Women/psychology ; SARS-CoV-2 ; Vaccines, Live, Unattenuated/adverse effects
Chemical Substances	COVID-19 Vaccines ; Vaccines, Live, Unattenuated
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2020.306045
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Article ; Online: Pregnant women's perceptions of risks and benefits when considering participation in vaccine trials.

Jaffe, Elana / Lyerly, Anne Drapkin / Goldfarb, Ilona Telefus

Vaccine

2020 Volume 38, Issue 44, Page(s) 6922–6929

Abstract: Introduction: Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women's views and decision-making processes about ... ...

Abstract	Introduction: Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women's views and decision-making processes about vaccine research participation during infectious disease outbreaks remain underexplored. This study aims to examine women's decision-making processes around vaccine research participation during infectious disease outbreaks. Methods: We conducted qualitative semi-structured in-depth interviews with pregnant and recently pregnant women (n = 13), eliciting their views on four hypothetical Zika Virus vaccine research scenarios and probing their decision-making processes around participation. After recorded interviews were transcribed, thematic analysis was conducted based on a priori and emergent themes. Results: Most women interviewed were accepting of vaccine research scenarios. Three broad themes-evidence, risk, and trust-characterized women's decision-making processes. Women varied in how different types and levels of evidence impacted their considerations, which risks were most salient to their decision-making processes, and from whom they trusted recommendations about vaccine research participation. Exemplary quotes from each theme are presented, and lessons for vaccine development during the current COVID-19 pandemic and future outbreaks are discussed. Conclusion: Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population.
MeSH term(s)	Adult ; Clinical Trials as Topic ; Decision Making ; Female ; Humans ; Interviews as Topic ; Patient Acceptance of Health Care/psychology ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; Pregnant Women/psychology ; Risk Assessment ; Vaccination ; Vaccines ; Viral Vaccines ; Zika Virus Infection/prevention & control
Chemical Substances	Vaccines ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-09-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.08.059
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Article ; Online: SARS-CoV-2 Placentitis and Intraparenchymal Thrombohematomas Among COVID-19 Infections in Pregnancy.

Huynh, Anh / Sehn, Jennifer K / Goldfarb, Ilona Telefus / Watkins, Jaclyn / Torous, Vanda / Heerema-McKenney, Amy / Roberts, Drucilla J

JAMA network open

2022 Volume 5, Issue 3, Page(s) e225345

MeSH term(s)	COVID-19/complications ; COVID-19/virology ; Female ; Hematoma/pathology ; Hematoma/virology ; Humans ; Male ; Placenta Diseases/pathology ; Placenta Diseases/virology ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; Retrospective Studies ; SARS-CoV-2 ; Stillbirth ; Thrombosis/pathology ; Thrombosis/virology
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.5345
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pregnant women's perceptions of risks and benefits when considering participation in vaccine trials

Jaffe, Elana / Lyerly, Anne Drapkin / Goldfarb, Ilona Telefus

Vaccine. 2020 Oct. 14, v. 38, no. 44

2020

Abstract: Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women’s views and decision-making processes about vaccine research ... ...

Abstract	Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women’s views and decision-making processes about vaccine research participation during infectious disease outbreaks remain underexplored. This study aims to examine women’s decision-making processes around vaccine research participation during infectious disease outbreaks.We conducted qualitative semi-structured in-depth interviews with pregnant and recently pregnant women (n = 13), eliciting their views on four hypothetical Zika Virus vaccine research scenarios and probing their decision-making processes around participation. After recorded interviews were transcribed, thematic analysis was conducted based on a priori and emergent themes.Most women interviewed were accepting of vaccine research scenarios. Three broad themes—evidence, risk, and trust—characterized women’s decision-making processes. Women varied in how different types and levels of evidence impacted their considerations, which risks were most salient to their decision-making processes, and from whom they trusted recommendations about vaccine research participation. Exemplary quotes from each theme are presented, and lessons for vaccine development during the current COVID-19 pandemic and future outbreaks are discussed.Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population.
Keywords	COVID-19 infection ; Zika virus ; decision making ; risk ; vaccine development ; vaccines
Language	English
Dates of publication	2020-1014
Size	p. 6922-6929.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.08.059
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Effects of COVID-19 Hospital Practices on Breastfeeding Initiation and Duration Postdischarge.

Rostomian, Lara / Angelidou, Asimenia / Sullivan, Katherine / Melvin, Patrice R / Shui, Jessica E / Telefus Goldfarb, Ilona / Bartolome, Ruby / Chaudhary, Neha / Singh, Rachana / Vaidya, Ruben / Steele, Tina / Yanni, Diana / Patrizi, Silvia / Culic, Ivana / Parker, Margaret G / Belfort, Mandy B

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

2022 Volume 17, Issue 9, Page(s) 736–744

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Aftercare ; Breast Feeding/methods ; COVID-19/epidemiology ; Female ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Pandemics/prevention & control ; Patient Discharge ; Pregnancy ; SARS-CoV-2
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2234680-6
ISSN	1556-8342 ; 1556-8253
ISSN (online)	1556-8342
ISSN	1556-8253
DOI	10.1089/bfm.2022.0039
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Article ; Online: Responsible Care in the Face of Shifting Recommendations and Imperfect Diagnostics for Zika Virus.

Goldfarb, Ilona Telefus / Jaffe, Elana / Lyerly, Anne Drapkin

JAMA

2017 Volume 318, Issue 21, Page(s) 2075–2076

MeSH term(s)	Centers for Disease Control and Prevention, U.S. ; Decision Making ; Epidemics ; Female ; Health Services Accessibility ; Humans ; Infant, Newborn ; Mass Screening/standards ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; United States/epidemiology ; Zika Virus ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology
Language	English
Publishing date	2017-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2017.15680
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Article: Pregnant women's perceptions of risks and benefits when considering participation in vaccine trials

Jaffe, Elana / Lyerly, Anne Drapkin / Goldfarb, Ilona Telefus

Vaccine

Abstract: INTRODUCTION: Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women's views and decision-making processes about ... ...

Abstract	INTRODUCTION: Despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women's views and decision-making processes about vaccine research participation during infectious disease outbreaks remain underexplored. This study aims to examine women's decision-making processes around vaccine research participation during infectious disease outbreaks. METHODS: We conducted qualitative semi-structured in-depth interviews with pregnant and recently pregnant women (n = 13), eliciting their views on four hypothetical Zika Virus vaccine research scenarios and probing their decision-making processes around participation. After recorded interviews were transcribed, thematic analysis was conducted based on a priori and emergent themes. RESULTS: Most women interviewed were accepting of vaccine research scenarios. Three broad themes-evidence, risk, and trust-characterized women's decision-making processes. Women varied in how different types and levels of evidence impacted their considerations, which risks were most salient to their decision-making processes, and from whom they trusted recommendations about vaccine research participation. Exemplary quotes from each theme are presented, and lessons for vaccine development during the current COVID-19 pandemic and future outbreaks are discussed. CONCLUSION: Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #745908
Database	COVID19

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Article ; Online: Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.

Liff, Ingrid / Adeli, Sharareh / Goldfarb, Ilona Telefus / Sawyer, Michala R / Phillippe, Mark

Reproductive sciences (Thousand Oaks, Calif.)

2020 Volume 27, Issue 2, Page(s) 555–560

Abstract: These experiments aimed to understand the relationship between interleukin 10 (IL10), the IL10 receptor subunits, and progesterone (P4) at the time of parturition. We hypothesized that there is a biologic connection between IL10 and P4, supporting an ... ...

Abstract	These experiments aimed to understand the relationship between interleukin 10 (IL10), the IL10 receptor subunits, and progesterone (P4) at the time of parturition. We hypothesized that there is a biologic connection between IL10 and P4, supporting an immunomodulatory mechanism for the onset of labor. Using samples from control and P4-treated pregnant mice, we assessed the production of IL10 and its receptor subunits (IL10Rα and IL10Rβ) in gestational tissues. After preliminary studies, P4-treated pregnant mice were compared with controls to assess for differences in IL10 and IL10 receptor subunit expression throughout gestation. To investigate the contribution of the P4 receptor at the onset of labor, we performed timed studies on pregnant mice after treatment with RU486. Samples collected included placentas, placentation sites, and maternal livers. IL10, IL10Rα, and IL10Rβ levels were measured in homogenized tissue using ELISA assays; the cytokine results were normalized for homogenate protein concentration. Control mice delivered on gd 18-19, and P4 treatment prevented parturition to beyond gd 20, as expected. In treated mice, P4 not only prevented the anticipated nadir of IL10 at term, but maintained elevated levels of IL10 through gd 20 (p < 0.05). P4 also reversed the anticipated decrease of the IL10Rα, which was increased in P4-treated mice (p < 0.05). Treatment with RU486 did not modulate the expression of IL10 or IL10Rα, but showed a significant decrease in the level of IL10Rβ (p < 0.05). Progesterone functions at least in part through the IL10 signaling pathway to prolong gestation.
MeSH term(s)	Animals ; Female ; Interleukin-10/metabolism ; Interleukin-10 Receptor alpha Subunit/metabolism ; Interleukin-10 Receptor beta Subunit/metabolism ; Mice, Inbred C57BL ; Parturition/drug effects ; Parturition/metabolism ; Placenta/drug effects ; Placenta/metabolism ; Pregnancy ; Progesterone/administration & dosage ; Progesterone/metabolism ; Uterus/drug effects ; Uterus/metabolism
Chemical Substances	IL10 protein, mouse ; Interleukin-10 Receptor alpha Subunit ; Interleukin-10 Receptor beta Subunit ; Interleukin-10 (130068-27-8) ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-019-00022-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pregnant women's attitudes toward Zika virus vaccine trial participation.

Goldfarb, Ilona Telefus / Jaffe, Elana / James, Kaitlyn / Lyerly, Anne Drapkin

Vaccine

2018 Volume 36, Issue 45, Page(s) 6711–6717

Abstract: Introduction: As Zika virus infection during pregnancy can cause a range of congenital anomalies, pregnant women may be a target population for vaccination in future outbreaks. Their inclusion in vaccine trials is critical to ensure safe and effective ... ...

Abstract	Introduction: As Zika virus infection during pregnancy can cause a range of congenital anomalies, pregnant women may be a target population for vaccination in future outbreaks. Their inclusion in vaccine trials is critical to ensure safe and effective vaccines in pregnancy. Though many vaccine candidates are in development, pregnant women's willingness to participate in Zika virus vaccine research is unknown. This study aims to describe pregnant women's attitudes toward Zika virus vaccine research participation, as well as perceived barriers to and facilitators of enrollment. Methods: Pregnant and recently postpartum women (n = 128) attending prenatal care at Massachusetts General Hospital completed surveys querying their willingness to participate in four hypothetical Zika virus vaccine trials and their motivations for participation. Demographics, information on prior Zika virus exposure, and vaccine acceptance were collected. Results: Most women (77%) accepted participation in at least one hypothetical Zika virus vaccine trial, and women were significantly more likely to accept prospective enrollment in an inactivated vaccine trial compared to a live-attenuated vaccine trial (p-value <0.0001) or a nucleic acid-based vaccine trial (p-value <0.0444). Important motivators for participation included evidence from research with pregnant and non-pregnant people, a desire to protect the baby from Zika, perceptions of vaccine safety, and provider recommendation. Conclusions: A majority of women in this cohort were willing to participate in a Zika virus vaccine trial while pregnant, however, differences in acceptance exist between vaccine platforms. The high value placed on evidence by participants highlights the importance of gathering and communicating pregnancy-specific data to potential research participants and their providers. Women's motivations for accepting research participation during pregnancy are important to inform the Zika virus vaccine research agenda, candidate prioritization, and trial design.
MeSH term(s)	Adult ; Female ; Humans ; Patient Acceptance of Health Care ; Postpartum Period/psychology ; Pregnancy ; Pregnant Women ; Prenatal Care/methods ; Surveys and Questionnaires ; Vaccination/psychology ; Zika Virus/immunology ; Zika Virus/pathogenicity ; Zika Virus Infection/immunology ; Zika Virus Infection/prevention & control
Language	English
Publishing date	2018-09-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.09.042
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