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  1. Article ; Online: Corrigendum to "The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7" [Bioorganic Chem., 141 (2023) 106864].

    Li, Hecheng / Li, Jianping / Ma, Yubo / Wang, Ziming / Peng, Zihe / Xu, Hang / Bi, Hang / Althaf Hussain, Shaik / Li, Zhaolun

    Bioorganic chemistry

    2023  Volume 143, Page(s) 106956

    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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  2. Article: MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1.

    Wei, Zhicheng / Xu, Bowen / Yin, Yanjiang / Chang, Jianping / Li, Zhiyu / Zhang, Yefan / Che, Xu / Bi, Xinyu

    Cancer cell international

    2024  Volume 24, Issue 1, Page(s) 129

    Abstract: Background: The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma.: Methods: The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target ... ...

    Abstract Background: The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma.
    Methods: The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of miR-380. The Cell Counting Kit 8 assay, flow cytometry, and Transwell assay were used to detect the effects of miR-380 and LIS1 on the proliferation, S-phase ratio, and invasiveness of HCCC-9810/HuCCT1/QBC939 cells. Western blotting was used to determine the effect of miR-380 on MMP-2/p-AKT. Immunohistochemistry detected the regulatory effect of miR-380 on the expression of MMP-2/p-AKT/LIS1.
    Results: Expression of miR-380 in cholangiocarcinoma was decreased but expression of LIS1 was increased. LIS1 was confirmed to be a target gene of miR-380. Transfection with miR-380 mimics inhibited the proliferation, S-phase arrest, and invasion of HCCC-9810/HuCCT1/QBC939 cells, and LIS1 reversed these inhibitory effects. miR-380 inhibitor promoted proliferation, S-phase ratio, and invasiveness of HCCC-9810/HuCCT1/QBC939 cells. si-LIS1 salvaged the promotive effect of miR-380 inhibitor. Overexpression of miR-380 inhibited expression of MMP-2/p-AKT/LIS1, but miR-380 inhibitor promoted their expression.
    Conclusion: An imbalance of miR-380 expression is closely related to cholangiocarcinoma, and overexpression of miR-380 inhibits the expression of MMP-2/p-AKT by directly targeting LIS1.
    Language English
    Publishing date 2024-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-024-03241-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exploration of prognostic biomarkers in head and neck squamous cell carcinoma microenvironment from TCGA database.

    Li, Ying / Bi, Jianping / Pi, Guoliang / He, Hanping / Li, Yanping / Han, Guang

    Annals of translational medicine

    2023  Volume 11, Issue 4, Page(s) 163

    Abstract: Background: Immune checkpoint blockade (ICB) therapies have redefined human cancer treatment, including for head and neck squamous cell carcinoma (HNSCC). However, clinical responses to various immune checkpoint inhibitors are often accompanied by ... ...

    Abstract Background: Immune checkpoint blockade (ICB) therapies have redefined human cancer treatment, including for head and neck squamous cell carcinoma (HNSCC). However, clinical responses to various immune checkpoint inhibitors are often accompanied by immune-related adverse events (irAEs). Therefore, it is crucial to obtain a comprehensive understanding of the association between different immune tumor microenvironments (TMEs) and the immunotherapeutic response.
    Methods: The research data were obtained from The Cancer Genome Atlas (TCGA) database. We applied RNA-seq genomic data from tumor biopsies to assess the immune TME in HNSCC. As the TME is a heterogeneous system that is highly associated with HNSCC progression and clinical outcome, we relied on the Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithm to calculate immune and stromal scores that were evaluated based on the immune or stromal components in the TME. Then, the Tumor Immune Dysfunction and Exclusion algorithm (TIDE) was used to predict the benefits of ICB to each patient. Finally, we identified specific prognostic tumor-infiltrating immune cells (TIICs) by quantifying the cellular composition of the immune response in HNSCC and its association to survival outcome, using the CIBERSORT algorithm.
    Results: Utilizing the HNSCC cohort of the TCGA database and TIDE and ESTIMATE algorithm-derived immune scores, we obtained a list of microenvironment-associated lncRNAs that predicted different clinical outcomes in HNSCC patients. We validated these correlations in a different HNSCC cohort available from the TCGA database and provided insight into the prediction of response to ICB therapies in HNSCC.
    Conclusions: This study confirmed that CD8
    Language English
    Publishing date 2023-02-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-6481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Microenvironment Created by SnSe

    Guo, Jiajia / Mao, Yang / Ao, Jianping / Han, Yanchen / Cao, Chun / Liu, Fangfang / Bi, Jinlian / Wang, Shenghao / Zhang, Yi

    Small (Weinheim an der Bergstrasse, Germany)

    2022  Volume 18, Issue 47, Page(s) e2203354

    Abstract: The ambient air-processed preparation of kesterite ... ...

    Abstract The ambient air-processed preparation of kesterite Cu
    Language English
    Publishing date 2022-09-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202203354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Correction: Liu et al. The EFP Formation and Penetration Capability of Double-Layer Shaped Charge with Wave Shaper.

    Liu, Yakun / Yin, Jianping / Wang, Zhijun / Zhang, Xuepeng / Bi, Guangjian

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 9

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2021-04-25
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14092210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bone collision detection method for robot assisted fracture reduction based on vibration excitation.

    Cai, Chenxu / Zheng, Xuran / Shi, Mingyang / Bi, Jianping / Zhang, Qinhe

    Computer methods and programs in biomedicine

    2022  Volume 229, Page(s) 107317

    Abstract: Background and objective: In the process of robotic fracture reduction, there is a risk of unintended collision of broken bones, which is not conducive to ensuring the safety of the reduction system. In order to solve this problem, this paper proposed a ...

    Abstract Background and objective: In the process of robotic fracture reduction, there is a risk of unintended collision of broken bones, which is not conducive to ensuring the safety of the reduction system. In order to solve this problem, this paper proposed a vibration-based collision detection method for fracture reduction process.
    Methods: Based on the two degree-of-freedom vibration response model, the factors affecting the respond of the vibration, including the excitation voltage, the clamping length at the proximal and distal ends, the mass and tensile force of the soft tissue, were obtained. The effects of these factors on the vibration transfer performance of broken bones and soft tissue were investigated by single factor experiments.
    Results: The results showed that, in terms of peak value, the increase of excitation voltage would make the vibration amplitude increase linearly, and the increase of soft tissue mass and tension increased the vibration transmission capacity of soft tissue in the frequency range of 500-1000 Hz. In terms of peak frequency, the clamping length at the distal end had the greatest influence, which reached 74 Hz, followed by 45 Hz at the proximal end. While the influence of other factors was little. According to single factor experiments, the excitation frequency in the verification experiments was determined as 677 Hz. Under the vibration interference with the acceleration amplitude of 1.2 G, this method achieved correct detection.
    Conclusion: This research developed a broken bone collision detection method based on vibration excitation. The method can correctly detect the collision of broken bones with strong anti-interference ability. It is of great significance to improve the safety of fracture reduction process.
    MeSH term(s) Humans ; Vibration ; Robotics ; Bone and Bones ; Fractures, Bone ; Fracture Fixation
    Language English
    Publishing date 2022-12-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.107317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 521: Show issues Location:
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  7. Article ; Online: Response letter: Letter to the editor regarding Wei W et al.: ''Experience of the Hubei cancer hospital in Wuhan, China".

    Bi, Jianping / Wei, Wei / Hu, Desheng / Han, Guang

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2020  Volume 155, Page(s) e8–e9

    MeSH term(s) COVID-19 ; Cancer Care Facilities ; China/epidemiology ; Disease Outbreaks ; Humans ; Neoplasms/epidemiology ; SARS-CoV-2 ; Workflow
    Keywords covid19
    Language English
    Publishing date 2020-09-06
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2020.08.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7.

    Li, Hecheng / Li, Jianping / Ma, Yubo / Wang, Ziming / Peng, Zihe / Xu, Hang / Bi, Hang / Althaf Hussain, Shaik / Li, Zhaolun

    Bioorganic chemistry

    2023  Volume 141, Page(s) 106864

    Abstract: Phthalates such as DHEP are among the widely used compounds in industry. It has been shown that DHEP can convey various biological consequences in mammalian cells, among them, the carcinogenic effects of DHEP are emphasized. The present study aimed to ... ...

    Abstract Phthalates such as DHEP are among the widely used compounds in industry. It has been shown that DHEP can convey various biological consequences in mammalian cells, among them, the carcinogenic effects of DHEP are emphasized. The present study aimed to assess the impact of DHEP exposure on the proliferation and invasiveness of DU145 prostate cancer cells through in vitro and in vivo models. The DU145 cells were treated with increasing concentrations of DHEP and the tumorigenic parameters were analyzed. KLF7 as a probable mediator of the effect of DHEP was either overexpressed or knocked down in DU145 to evaluate the probable impact of KLF7 on the biological effects of DHEP. The effect of DHEP was also studied in a DU145 xenograft tumor model. The moderate doses of DHEP increased the proliferation and migration of DU145 cells. In the case of gene expression patterns, DHEP reduced the levels of p53 and KLF7 while elevated the expression of β-catenin. The knock-down of KLF7 conveyed comparable effects to that of DHEP to some degree and increased the proliferation of DU145 cells, while the transduction of KLF7 increased the expressions of p53 and p21 along with controlling the tumor size. The present study demonstrated the potential of DHEP in increasing the tumorigenic properties of DU145 cells along with a focus on the underlying mechanisms. Sustained exposure to DHEP can cause a dysregulation in balance between oncogenes and tumor suppressor genes which is the hallmark of malignant transformation. Thus, special considerations seem necessary for the safe exploitation of phthalates.
    MeSH term(s) Male ; Animals ; Humans ; beta Catenin/metabolism ; Up-Regulation ; Down-Regulation ; Tumor Suppressor Protein p53/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Mammals/metabolism ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Kruppel-Like Transcription Factors/pharmacology
    Chemical Substances phthalic acid (6O7F7IX66E) ; beta Catenin ; Tumor Suppressor Protein p53 ; diclofenac hydroxyethylpyrrolidine (119623-66-4) ; KLF7 protein, human ; Kruppel-Like Transcription Factors
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Micro Fracture Behavior of Composite Honeycomb Sandwich Structure.

    Bi, Guangjian / Yin, Jianping / Wang, Zhijun / Jia, Zijian

    Materials (Basel, Switzerland)

    2020  Volume 14, Issue 1

    Abstract: To study the influence of structure size and composite forms on the mechanical properties of the composite double honeycomb sandwich structure, a composite double honeycomb sandwich structure was initially designed. The dynamic response of a composite ... ...

    Abstract To study the influence of structure size and composite forms on the mechanical properties of the composite double honeycomb sandwich structure, a composite double honeycomb sandwich structure was initially designed. The dynamic response of a composite double-layer honeycomb sandwich structure under high-speed impact was studied through theoretical analysis and numerical simulation. Ls-dyna software was used to simulate the initially designed composite structure. According to the numerical simulation results and the proposed method for calculating the fracture energy of the composite double honeycomb sandwich structure, the effects of different composite forms on the mechanical properties were analyzed. The results show that the proposed fracture energy calculation method can effectively describe the variation trend of the honeycomb structure and the micro-element fracture situation in the valid time. The fracture energy curve has a high sensitivity to cell density and material, and the strength of the top core has a great influence on the overall energy absorption. Compared with the traditional honeycomb protection structure, the energy absorption of the initially designed composite honeycomb sandwich structure was improved effectively.
    Language English
    Publishing date 2020-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14010135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Long-Term Outcomes of Nasopharyngeal Carcinoma by Epstein-Barr Virus Status in the Chinese Population: A Multicenter Investigation.

    Xiong, Yudi / Yuan, Mengting / Liu, Zhigang / Huang, Jing / Bi, Jianping / Pi, Guoliang / Li, Ying / Li, Yanping / He, Hanping / Verma, Vivek / Tian, Suqing / Han, Guang

    Journal of clinical medicine

    2023  Volume 12, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12083005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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