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  1. Article: A Novel Control Method of

    Abe, Yu / Honda, Michiyo

    Pharmaceutics

    2023  Volume 15, Issue 6

    Abstract: Enterococcus ... ...

    Abstract Enterococcus faecalis
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061629
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  2. Article ; Online: Nano-particle motion in a monolithic silica column using the single-particle tracking method.

    Abe, Yusaku / Tomioka, Naoki / Matsuda, Yu

    Nanoscale advances

    2024  Volume 6, Issue 7, Page(s) 1874–1879

    Abstract: Porous materials are used in a variety of industrial applications owing to their large surface areas, large pore volumes, hierarchical porosities, and low densities. The motion of particles inside the pores of porous materials has attracted considerable ... ...

    Abstract Porous materials are used in a variety of industrial applications owing to their large surface areas, large pore volumes, hierarchical porosities, and low densities. The motion of particles inside the pores of porous materials has attracted considerable attention. We investigated nano-particle motion in a porous material using the single-particle tracking method. Particle motion such as absorption and desorption at the wall was observed. The displacement probability distribution deviated from the Gaussian distribution at the tail, indicating non-Gaussian motion of the particles. Moreover, an analysis of the relative angle between three consecutive particle positions revealed that the probability of the particle moving backward was approximately twice that of the particle moving forward. These results indicate that particle motion inside porous materials is highly complex and that a single-particle study is essential for fabricating a structure that is suitable for applications.
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d3na01028g
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  3. Article ; Online: Impact of preoperative haemoglobin, albumin, lymphocyte, and platelet score on oral cancer prognosis.

    Ito, Yu / Abe, Atsushi / Hayashi, Hiroki

    Oral diseases

    2024  

    Abstract: Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.: Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) ...

    Abstract Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.
    Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) who underwent radical surgery between 2012 and 2022 were included. Factors affecting overall survival and disease-free survival according to the haemoglobin, albumin, lymphocyte, and platelet score were examined. Patients were categorised into low- and high-score groups using optimal cut-off values obtained from receiver operating characteristic curve analysis.
    Results: The low-score group had poorer overall and disease-free survival (p < 0.001 each). Multivariate analysis identified alcohol consumption (hazard ratio [HR], 3.83; 95% confidence interval [CI]: 1.56-9.41, p = 0.003); vascular invasion (HR, 3.97; 95% CI: 1.60-9.85, p = 0.003); and the haemoglobin, albumin, lymphocyte, and platelet score (HR, 0.39; 95% CI: 0.20-0.78, p = 0.007) as independent prognostic factors for overall survival and vascular (HR, 3.66; 95% CI: 1.79-7.50, p < 0.001) and lymphovascular (HR, 2.44; 95% CI: 1.36-4.41, p = 0.003) invasion as independent prognostic factors for disease-free survival.
    Conclusion: The preoperative haemoglobin, albumin, lymphocyte, and platelet score may be a significant prognostic factor for patients with oral squamous cell carcinoma undergoing radical surgery.
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14950
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
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  4. Article ; Online: Relationship between dietary patterns and physical performance in the very old population: a cross-sectional study from the Kawasaki Aging and Wellbeing Project.

    Yu, Tao / Oguma, Yuko / Asakura, Keiko / Abe, Yukiko / Arai, Yasumichi

    Public health nutrition

    2023  Volume 26, Issue 6, Page(s) 1163–1171

    Abstract: Objectives: As the world's population is ageing, improving the physical performance (PP) of the older population is becoming important. Although diets are fundamental to maintaining and improving PP, few studies have addressed the role of these factors ... ...

    Abstract Objectives: As the world's population is ageing, improving the physical performance (PP) of the older population is becoming important. Although diets are fundamental to maintaining and improving PP, few studies have addressed the role of these factors in adults aged ≥ 85 years, and none have been conducted in Asia. This study aimed to determine the dietary patterns (DP) and examine their relationship with PP in this population.
    Design: This cross-sectional study (Kawasaki Aging and Wellbeing Project) estimated food consumption using a brief-type self-administered diet history questionnaire. The results were adjusted for energy after aggregating into thirty-three groups, excluding possible over- or underestimation. Principal component analysis was used to identify DP, and outcomes included hand grip strength (HGS), timed up-and-go test, and usual walking speed.
    Setting: This study was set throughout several hospitals in Kawasaki city.
    Participants: In total, 1026 community-dwelling older adults (85-89 years) were enrolled.
    Results: Data of 1000 participants (median age: 86·9 years, men: 49·9 %) were included in the analysis. Three major DP (DP1: various foods, DP2: red meats and coffee, DP3: bread and processed meats) were identified. The results of multiple regression analysis showed that the trend of DP2 was negatively associated with HGS (B, 95 % CI -0·35, -0·64, -0·06).
    Conclusions: This study suggests a negative association between HGS and DP characterised by red meats and coffee in older adults aged ≥ 85 years in Japan.
    MeSH term(s) Male ; Humans ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Hand Strength ; Coffee ; Aging ; Physical Functional Performance
    Chemical Substances Coffee
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980023000113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 6998: Show issues

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  5. Article ; Online: Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF.

    Mori, Takahiro / Yu, Ziheng / Tao, Hui / Abe, Ikuro

    Organic letters

    2022  Volume 24, Issue 8, Page(s) 1737–1741

    Abstract: The Fe- and 2-oxoglutarate-dependent oxygenase SptF is a promising powerful biocatalys with unusual catalytic versatility and promiscuity. The site-specific random substitution of N150, I63, and N65, which are involved in substrate interactions, ... ...

    Abstract The Fe- and 2-oxoglutarate-dependent oxygenase SptF is a promising powerful biocatalys with unusual catalytic versatility and promiscuity. The site-specific random substitution of N150, I63, and N65, which are involved in substrate interactions, generated three compounds that were not produced by the SptF wild type. The substrate binding mode was dramatically altered by the introduction of only one or two substitutions. These results provide insights into the engineering of Fe- and 2-oxoglutarate-dependent oxygenases for chemoenzymatic syntheses of bioactive compounds.
    MeSH term(s) Oxygenases
    Chemical Substances Oxygenases (EC 1.13.-)
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00409
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  6. Article ; Online: Development of a new treatment for preterm birth complications using amniotic fluid stem cell therapy.

    Abe, Yushi / Sato, Yu / Tanaka, Mamoru / Ochiai, Daigo

    Histology and histopathology

    2023  Volume 38, Issue 9, Page(s) 965–974

    Abstract: This paper describes the current status of studies and clinical trials on the use of mesenchymal stem cells (MSCs) and amniotic fluid stem cells (AFSCs) for complications of preterm birth (PTB), an urgent issue in the perinatal field. PTB is a serious ... ...

    Abstract This paper describes the current status of studies and clinical trials on the use of mesenchymal stem cells (MSCs) and amniotic fluid stem cells (AFSCs) for complications of preterm birth (PTB), an urgent issue in the perinatal field. PTB is a serious challenge in clinical medicine that is increasing globally, and effective control of its complications is necessary for newborns' subsequent long life. Classical treatments are inadequate, and many patients have PTB complications. A growing body of evidence provided by translational medicine and others indicates that MSCs, and among them, the readily available AFSCs, may be useful in treating PTB complications. AFSCs are the only MSCs available prenatally and are known to be highly anti-inflammatory and tissue-protective and do not form tumors when transplanted. Furthermore, because they are derived from the amniotic fluid, a medical waste product, no ethical issues are involved. AFSCs are an ideal cell resource for MSC therapy in neonates. This paper targets the brain, lungs, and intestines, which are the vital organs most likely to be damaged by PTB complications. The evidence to date and future prospects with MSCs and AFSCs for these organs are described.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Amniotic Fluid ; Premature Birth ; Mesenchymal Stem Cells ; Stem Cell Transplantation/adverse effects ; Cell Differentiation
    Language English
    Publishing date 2023-03-15
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-607
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3013: Show issues Location:
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  7. Article ; Online: Interconversion of Highly Entangled Polyhedra into Concave Polyhedra by Nitrate-Induced Ternary Coordination.

    Domoto, Yuya / Abe, Masahiro / Genov, Georgi R / Yu, Zhengsu / Fujita, Makoto

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 33, Page(s) e202303714

    Abstract: Entangled ( ... ...

    Abstract Entangled (M
    Language English
    Publishing date 2023-05-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202303714
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  8. Article ; Online: Temporal-Focusing Multiphoton Excitation Single-Molecule Localization Microscopy Using Spontaneously Blinking Fluorophores.

    Lai, Jian-Zong / Lin, Chun-Yu / Chen, Shean-Jen / Cheng, Yu-Min / Abe, Manabu / Lin, Tzu-Chau / Chien, Fan-Ching

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202404942

    Abstract: Single-molecule localization microscopy (SMLM) based on temporal-focusing multiphoton excitation (TFMPE) and single-wavelength excitation is used to visualize the three-dimensional (3D) distribution of spontaneously blinking fluorophore-labeled ... ...

    Abstract Single-molecule localization microscopy (SMLM) based on temporal-focusing multiphoton excitation (TFMPE) and single-wavelength excitation is used to visualize the three-dimensional (3D) distribution of spontaneously blinking fluorophore-labeled subcellular structures in a thick specimen with a nanoscale-level spatial resolution. To eliminate the photobleaching effect of unlocalized molecules in out-of-focus regions for improving the utilization rate of the photon budget in 3D SMLM imaging, SMLM with single-wavelength TFMPE achieves wide-field and axially confined two-photon excitation (TPE) of spontaneously blinking fluorophores. TPE spectral measurement of blinking fluorophores is then conducted through TFMPE imaging at a tunable excitation wavelength, yielding the optimal TPE wavelength for increasing the number of detected photons from a single blinking event during SMLM. Subsequently, the TPE fluorescence of blinking fluorophores is recorded to obtain a two-dimensional TFMPE-SMLM image of the microtubules in cancer cells with a localization precision of 18 ± 6 nm and an overall imaging resolution of approximately 51 nm, which is estimated based on the contribution of Nyquist resolution and localization precision. Combined with astigmatic imaging, the system is capable of 3D TFMPE-SMLM imaging of brain tissue section of a 5XFAD transgenic mouse with the pathological features of Alzheimer's disease, revealing the distribution of neurotoxic amyloid-beta peptide deposits.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202404942
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  9. Article ; Online: High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry.

    Yumoto, Yu / Endo, Takuro / Harada, Hiroshi / Kobayashi, Kaoru / Nakabayashi, Takeshi / Abe, Yoshikazu

    Xenobiotica; the fate of foreign compounds in biological systems

    2024  Volume 54, Issue 2, Page(s) 45–56

    Abstract: In the early stages of drug discovery, adequate evaluation of the potential drug-drug interactions (DDIs) of drug candidates is important. Several CYP3A activators are known to lead to underestimation of DDIs. These compounds affect midazolam 1'- ... ...

    Abstract In the early stages of drug discovery, adequate evaluation of the potential drug-drug interactions (DDIs) of drug candidates is important. Several CYP3A activators are known to lead to underestimation of DDIs. These compounds affect midazolam 1'-hydroxylation but not midazolam 4-hydroxylation.We used both metabolic reactions of midazolam to evaluate the activation and inhibition of CYP3A activators simultaneously. For our CYP inhibition assay using cocktail probe substrates, simultaneous liquid chromatography-tandem mass spectrometry monitoring of 1'-hydroxymidazolam and 4-hydroxymidazolam for CYP3A was established in addition to monitoring of 4-hydroxydiclofenac and 1'-hydroxybufuralol for CYP2C9 and CYP2D6.The results of our cocktail inhibition assay were well correlated with those of a single inhibition assay, as were the estimated inhibition parameters for typical CYP3A inhibitors. In our assay, a proprietary compound that activated midazolam 1'-hydroxylation and tended to inhibit 4-hydroxylation was evaluated along with known CYP3A activators. All compounds were well characterised by comparison of the results of midazolam 1'- and 4-hydroxylation.In conclusion, our CYP cocktail inhibition assay can detect CYP3A activation and assess the direct and time-dependent inhibition potentials for CYP3A, CYP2C9, and CYP2D6. This method is expected to be very efficient in the early stages of drug discovery.
    MeSH term(s) Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP2C9/metabolism ; Tandem Mass Spectrometry/methods ; Midazolam/metabolism ; Microsomes, Liver/metabolism ; Chromatography, Liquid/methods ; Drug Interactions
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 120287-x
    ISSN 1366-5928 ; 0049-8254
    ISSN (online) 1366-5928
    ISSN 0049-8254
    DOI 10.1080/00498254.2024.2308818
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 782: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Subjective age and mortality in community-living Japanese older adults.

    Ikeuchi, Tomoko / Abe, Takumi / Taniguchi, Yu / Seino, Satoshi / Yokoyama, Yuri / Nofuji, Yu / Amano, Hidenori / Kitamura, Akihiko / Shinkai, Shoji / Fujiwara, Yoshinori

    Geriatrics & gerontology international

    2023  Volume 24 Suppl 1, Page(s) 404–405

    MeSH term(s) Humans ; Aged ; Japan/epidemiology ; Independent Living
    Language English
    Publishing date 2023-11-15
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14735
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
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