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  1. Article ; Online: Supraventrikuläre Tachykardien.

    Kleemann, Thomas

    Herz

    2023  Volume 48, Issue 1, Page(s) 72–86

    Abstract: Supraventricular tachycardia is a common occurrence in routine clinical practice. As a physician, one can encounter them everywhere, whether as a general practitioner or as an emergency doctor in a hospital. Some tachycardias might have robbed an on-call ...

    Title translation Supraventricular tachycardia.
    Abstract Supraventricular tachycardia is a common occurrence in routine clinical practice. As a physician, one can encounter them everywhere, whether as a general practitioner or as an emergency doctor in a hospital. Some tachycardias might have robbed an on-call doctor the night or the last nerve; however, supraventricular tachycardia is usually a benign condition that is easily treatable and, in many cases, even curable. This article covers the differential diagnoses of supraventricular tachycardia and its treatment options. Atrial fibrillation, also a supraventricular tachycardia, is not discussed in this article.
    MeSH term(s) Humans ; Tachycardia, Atrioventricular Nodal Reentry ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/therapy ; Atrial Fibrillation ; Wolff-Parkinson-White Syndrome/diagnosis ; Electrocardiography ; Atrial Flutter
    Language German
    Publishing date 2023-01-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-022-05153-3
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  2. Article: Akute Notfälle bei Schrittmacher- und ICD-Trägern

    Kleemann, Thomas

    Notaufnahme up2date

    2020  Volume 2, Issue 02, Page(s) 143–156

    Keywords Schrittmacher ; ICD ; ICD-Schock ; ICD-Dysfunktion ; Schrittmacherdysfunktion
    Language German
    Publishing date 2020-04-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-0965-7942
    Database Thieme publisher's database

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  3. Book ; Thesis: Untersuchung der aktivität des Kallikrein-Kinin-Systems bei der Autosomal Dominant Vererbten Polyzystischen Nierenerkrankung

    Kleemann, Thomas

    2000  

    Author's details vorgelegt von Thomas Kleemann
    Language German
    Size VI, 99 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2001
    HBZ-ID HT013178008
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 E 2827 order for loan Magazin

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  4. Article ; Online: The Management of Atrial Fibrillation with Oral Anticoagulant Drugs.

    Zeymer, Uwe / Schneider, Steffen / Hochadel, Matthias / Kleemann, Thomas / Borggrefe, Martin / Akin, Ibrahim / Katus, Hugo / Thomas, Dierk / Werdan, Karl / Senges, Jochen

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 18, Page(s) 324–325

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Anticoagulants/therapeutic use ; Administration, Oral ; Stroke
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-07-24
    Publishing country Germany
    Document type Letter
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0009
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  5. Article: Proof of Concept of Telemedicine-Assisted Abdominal Ultrasound Examinations to Improve the Quality of Patient Care in Rural Areas.

    Kleemann, Tobias / Müller, Denise / Güther, Carola / Duma, Alina / Mohamed, Awsan / Ernst, Helmut / Löbel, Madlen / Freund, Robert / Kleemann, Sven / Pannach, Sven / Stellke, Rutker / Briesemann, Dirk / Diepelt, Tina / Thomas, Ina / Ermisch, Viktoria / Aretakis, Dimitrios / Wree, Alexander / Tacke, Frank / Ortmann, Steffen /
    Schulz, Marten

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061721
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  6. Article ; Online: Rezidivierende Torsaden und Asystolie ohne strukturelle Herzerkrankung.

    Lamadé, Eva Kathrin / Zahn, Ralf / Kleemann, Thomas

    Herzschrittmachertherapie & Elektrophysiologie

    2021  Volume 32, Issue 3, Page(s) 383–388

    Abstract: We report on a 67-year-old female patient with recurrent syncope induced by asystole and polymorphic ventricular tachycardia without relevant structural heart disease. After secondary prophylactic ICD implantation, beta-blocker and flecainide therapy, ... ...

    Title translation Recurrent torsades and asystole without structural heart disease.
    Abstract We report on a 67-year-old female patient with recurrent syncope induced by asystole and polymorphic ventricular tachycardia without relevant structural heart disease. After secondary prophylactic ICD implantation, beta-blocker and flecainide therapy, the patient suffered from recurrent syncope and ICD shocks due to ventricular fibrillation. A rare cause of polymorphic ventricular tachycardia in patients without structural heart disease was found and successfully treated.
    MeSH term(s) Aged ; Death, Sudden, Cardiac ; Electrocardiography ; Female ; Heart Arrest/diagnosis ; Heart Arrest/therapy ; Humans ; Syncope/diagnosis ; Syncope/etiology ; Tachycardia, Ventricular/diagnosis ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/therapy
    Language German
    Publishing date 2021-07-19
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-021-00791-2
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    Zs.A 3286: Show issues Location:
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  7. Article ; Online: The role of trigger factors in the occurrence of appropriate ICD shocks and their clinical and prognostic implications.

    Lampropoulou, Eleni / Kouraki, Kleopatra / Strauss, Margit / Mohammad, Owais / Zahn, Ralf / Kleemann, Thomas

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 5, Page(s) 1241–1248

    Abstract: Background: The role of triggers in the occurrence of appropriate implantable cardioverter-defibrillator (ICD) shocks due to ventricular tachyarrhythmias is not well known. The aim of the study was to assess the prevalence of trigger factors in ... ...

    Abstract Background: The role of triggers in the occurrence of appropriate implantable cardioverter-defibrillator (ICD) shocks due to ventricular tachyarrhythmias is not well known. The aim of the study was to assess the prevalence of trigger factors in appropriate ICD shocks and to analyze their prognostic impact on clinical outcome.
    Methods: A total of 710 consecutive patients of a prospective single-center ICD-registry who received a first appropriate ICD shock between 2000 and 9/2021 were analyzed.
    Results: In 35% of ICD patients with first ICD shock, at least one of the following triggers was found: Ischemia (22%), Compliance (9%), Decompensation (38%), Stress (12%), Technical (5%), Electrolyte/endocrinological disorder (22%) and Medication side effects (4%). The trigger factors can be summarized under the acronym ICD-STEMi. The prospective application of the ICD-STEMi scheme increased the rate of identified triggers from 32% to 56% (p < .001). Patients with triggered first ICD shock had an increased 5-year mortality rate (50% vs. 38%, p < .001). Patients with triggers did not show different mortality outcomes or recurrent ICD shocks whether they received arrhythmia therapy or not.
    Conclusions: The evaluation of trigger factors after the occurrence of ICD shocks is mandatory and can be systematically evaluated using the acronym ICD-STEMi. Systematic evaluation of triggers using the ICD-STEMi scheme can identify triggers in about half of ICD patients with first appropriate ICD shock. Patients with triggered ICD shock have a 12% higher 5-year mortality rate.
    MeSH term(s) Humans ; Prognosis ; Defibrillators, Implantable/adverse effects ; ST Elevation Myocardial Infarction ; Arrhythmias, Cardiac/therapy ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/therapy ; Risk Factors
    Language English
    Publishing date 2023-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15906
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    Zs.A 2863: Show issues Location:
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  8. Article ; Online: Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution.

    Puhahn-Schmeiser, Barbara / Kleemann, Tobias / Jabbarli, Ramazan / Bock, Hans H / Beck, Jürgen / Freiman, Thomas M

    Hippocampus

    2022  Volume 32, Issue 7, Page(s) 517–528

    Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein Reelin, which ... ...

    Abstract Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein Reelin, which regulates neuron migration and dendrite outgrow. Reelin-deficient (reeler) mice show no layering, their granule cells are dispersed throughout the dentate gyrus. We studied granule cell dendritic orientation and distribution of postsynaptic spines in reeler mice and two mouse models of temporal lobe epilepsy, namely the p35 knockout mice, which show Reelin-independent neuronal migration defects, and mice with unilateral intrahippocampal kainate injection. Granule cells were Golgi-stained and analyzed, using a computerized camera lucida system. Granule cells in naive controls exhibited a vertically oriented dendritic arbor with a small bifurcation angle if positioned proximal to the hilus and a wider dendritic bifurcation angle, if positioned distally. P35 knockout- and kainate-injected mice showed a dispersed granule cell layer, granule cells showed basal dendrites with wider bifurcation angles, which lost position-specific differences. Reeler mice lacked dendritic orientation. P35 knockout- and kainate-injected mice showed increased dendritic spine density in the granule cell layer. Molecular layer dendrites showed a reduced spine density in kainate-injected mice only, whereas in p35 knockouts no reduced spine density was seen. Reeler mice showed a homogenous high spine density. We hypothesize that granule cells migrate in temporal lobe epilepsy, develop new dendrites which show a spread of the dendritic tree, create new spines in areas proximal to mossy fiber sprouting, which is present in p35 knockout- and kainate-injected mice and loose spines on distal dendrites if mossy cell death is present, as it was in kainate-injected mice only. These results are in accordance with findings in epilepsy patients.
    MeSH term(s) Animals ; Dendrites/metabolism ; Dentate Gyrus ; Disease Models, Animal ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/metabolism ; Humans ; Kainic Acid/toxicity ; Mice ; Mice, Neurologic Mutants ; Neurons/metabolism
    Chemical Substances Kainic Acid (SIV03811UC)
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.23447
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    Zs.A 3227: Show issues Location:
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  9. Article: Impact of atrial fibrillation on 1-year outcome in patients with implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator: results from the German DEVICE Registry.

    Feickert, Sebastian / Ewertsen, Niels Christian / Köbe, Julia / Kleemann, Thomas / Jehle, Joachim / Senges, Jochen / Hochadel, Matthias / Andresen, Dietrich / Stellbrink, Christoph / Eckardt, Lars / Spitzer, Stefan / Brachmann, Johannes / Ince, Hüseyin / D'Ancona, Giuseppe

    Journal of thoracic disease

    2024  Volume 16, Issue 3, Page(s) 1825–1835

    Abstract: Background: Atrial fibrillation (AF) is a cardiac arrhythmia frequently documented in patients requiring implantable cardioverter defibrillators (ICDs) and/or cardiac resynchronization therapy with defibrillator (CRT-D). Patients with diagnosed AF at ... ...

    Abstract Background: Atrial fibrillation (AF) is a cardiac arrhythmia frequently documented in patients requiring implantable cardioverter defibrillators (ICDs) and/or cardiac resynchronization therapy with defibrillator (CRT-D). Patients with diagnosed AF at the point of ICD or CRT-D implantation may have an impaired follow-up outcome.
    Methods: The German DEVICE I-II registry is a nationwide prospective multicentre database of patients implanted with ICD and CRT-D with clinical follow-up data. We analysed a 1-year follow up of implanted patients with AF and with sinus rhythm (SR).
    Results: A total of 4,929 ICD/CRT patients are included in the present analysis: 946 (19.2%) were in AF and 3,983 (80.8%) were SR at time of device implantation. AF patients had a significantly more comorbid profile including older age {72 [interquartile range (IQR), 66-77]
    Conclusions: Our clinical data on an extended cohort of contemporary patients confirm the significant impact of AF, and its associated comorbidities, upon mortality and major adverse events after implantation of ICD/CRT.
    Language English
    Publishing date 2024-03-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-274
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  10. Article ; Online: Management of implantable cardioverter-defibrillator patients with appropriate ICD shocks: A 3-step treatment concept.

    Kleemann, Thomas / Lampropoulou, Eleni / Kouraki, Kleopatra / Strauss, Margit / Fendt, Andràs / Zahn, Ralf

    Heart rhythm O2

    2021  Volume 2, Issue 5, Page(s) 537–540

    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2021.08.005
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