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  1. Book ; Thesis: Identifikation okularer Autoantigene bei juveniler idiopathischer Arthritis- assoziierte Uveitis

    Hilmers, Kira Leona / Heiligenhaus, Arnd

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Kira Leona Hilmers (geb. Wefelmeyer) ; 1. Gutachter: Herr Prof. Dr. med. A. Heiligenhaus, 2. Gutachter: Herr Priv.-Doz. Dr. med. M. Oeverhaus
    Language German
    Size 94 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2022
    HBZ-ID HT021750316
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Von Licht und Schatten: Tyndall und die Laser-Flare-Photometrie.

    Cursiefen, Claus / Heiligenhaus, Arnd

    Klinische Monatsblatter fur Augenheilkunde

    2023  Volume 240, Issue 5, Page(s) 648–649

    Title translation Of Light and Shadow: Tyndall and Laser Flare Photometry.
    MeSH term(s) Humans ; Lasers ; Photometry ; Light ; Aqueous Humor
    Language German
    Publishing date 2023-05-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2046-3961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ocular Involvement in Graft-versus-Host Disease.

    Tappeiner, Christoph / Heiligenhaus, Arnd / Dietrich-Ntoukas, Tina

    Klinische Monatsblatter fur Augenheilkunde

    2024  

    Abstract: In ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a ... ...

    Title translation Augenbeteiligung bei Graft-versus-Host-Erkrankung.
    Abstract In ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a pronounced wetting disorder of the ocular surface, conjunctival hyperemia, and corneal ulceration up to perforation. The ocular GVHD is associated with a high degree of suffering, such as pain, photophobia, and reduction in visual acuity. This review provides an overview of typical ophthalmological findings, topical and systemic therapeutic approaches, and concomitant measures (e.g., scleral lenses, punctum plugs) and the appropriate management of complications.
    Language German
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2218-0237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ocular Involvement in Selected Rheumatic Diseases - Clinical Manifestation in Adulthood.

    Baquet-Walscheid, Karoline / Rath, Thomas / Heiligenhaus, Arnd

    Klinische Monatsblatter fur Augenheilkunde

    2024  

    Abstract: Ocular manifestations of rheumatic diseases are common and contribute significantly to the morbidity and reduced quality of life of affected patients. Knowledge of typical clinical manifestations is important for the rheumatologist in order to support ... ...

    Title translation Augenbeteiligung bei ausgewählten rheumatischen Erkrankungen – Klinik im Erwachsenenalter.
    Abstract Ocular manifestations of rheumatic diseases are common and contribute significantly to the morbidity and reduced quality of life of affected patients. Knowledge of typical clinical manifestations is important for the rheumatologist in order to support the reference of patients with corresponding symptoms for ophthalmological consultation at an early stage of disease, or to initiate regular screening examinations (e.g. in patients with Behçet's syndrome). Conversely, a (possibly urgent) rheumatological assessment is crucial for certain ophthalmological diseases, in order not to overlook a (possibly fatal) systemic associated disease. Patients with rheumatic or inflammatory ocular diseases should always be informed by the treating physician about possible symptoms of other organ manifestations, in order to avoid a delayed diagnosis. "Classic" associations for uveitis are (HLA-B27-associated) spondyloarthritis and acute anterior uveitis, as well as retinal vasculitis with or without panuveitis and Behçet's syndrome. In patients with rheumatoid arthritis or ANCA-associated vasculitis, however, scleritis (with or without peripheral ulcerative keratitis) typically occurs, but a variety of other findings are also possible. Close interdisciplinary collaboration, particularly regarding therapeutic decisions, is crucial to ensuring a good prognosis for the patient.
    Language German
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2239-0412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Value of Laser Flare Photometry as a Monitoring Tool for Uveitis.

    Tappeiner, Christoph / Heiligenhaus, Arnd

    Klinische Monatsblatter fur Augenheilkunde

    2022  Volume 240, Issue 5, Page(s) 662–668

    Abstract: Laser flare (LF) photometry (P) is used to quantify the protein concentration in the aqueous humor, and therefore assess the blood-aqueous humor barrier. LFP is more reliable than the clinical assessment of the Tyndall effect, and is thus especially ... ...

    Title translation Der Stellenwert von Laser-Flare-Messungen zur Verlaufsbeurteilung von Uveitiden.
    Abstract Laser flare (LF) photometry (P) is used to quantify the protein concentration in the aqueous humor, and therefore assess the blood-aqueous humor barrier. LFP is more reliable than the clinical assessment of the Tyndall effect, and is thus especially useful in the follow-up of uveitis patients. In active uveitis, LFP correlates well with the anterior chamber cell grading. Various studies have shown that high LF values are associated with an increased risk of uveitic complications, such as macular edema, glaucoma, and posterior synechiae. LFP can also be used to assess the response to anti-inflammatory treatments as well as the optimal timing and selection of the surgical technique for intraocular surgeries.
    MeSH term(s) Humans ; Uveitis/diagnosis ; Uveitis/surgery ; Uveitis/complications ; Anterior Chamber ; Aqueous Humor ; Photometry/methods ; Lasers ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/surgery
    Language German
    Publishing date 2022-10-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1962-7422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Schwerpunktthema „Entzündliche Augenerkrankungen – Aktuelles zur Uveitis“.

    Cursiefen, Claus / Heiligenhaus, Arnd

    Klinische Monatsblatter fur Augenheilkunde

    2022  Volume 239, Issue 5, Page(s) 651–652

    Title translation Inflammatory Eye Disease - Uveitis Update.
    MeSH term(s) Conjunctival Diseases ; Humans ; Uveitis/diagnosis ; Uveitis/therapy ; Vision Disorders
    Language German
    Publishing date 2022-05-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1739-4020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Uveitis in Juvenile Idiopathic Arthritis - Case Reports on Guideline-based Diagnostic Work-up and Treatment.

    Heiligenhaus, Arnd / Deuter, Christoph

    Klinische Monatsblatter fur Augenheilkunde

    2022  Volume 239, Issue 5, Page(s) 676–685

    Abstract: Objectives: Case report based presentation of the current German interdisciplinary guideline on the diagnosis and management of juvenile idiopathic arthritis-associated (JIA) uveitis.: Material and methods: Guideline of the German Society of ... ...

    Title translation Uveitis bei juveniler idiopathischer Arthritis – leitliniengerechte Diagnostik und Therapie anhand von Kasuistiken.
    Abstract Objectives: Case report based presentation of the current German interdisciplinary guideline on the diagnosis and management of juvenile idiopathic arthritis-associated (JIA) uveitis.
    Material and methods: Guideline of the German Society of Ophthalmology, the Society of Paediatric and Adolescent Rheumatology, the German Society of Rheumatology, the Professional Association of German Ophthalmologists, with the participation of patient representatives. Recent primary publications were critically graduated for evidence and recommendations; the methodology included consensus building through Delphi rounds and external peer review. The outcomes are presented with typical case studies.
    Outcomes: Once JIA is first diagnosed, periodic ophthalmological check-ups should promptly be instituted ensuring that uveitis is diagnosed before irreversible sequelae become manifest. High-quality patient care can be provided depending on the severity of each uveitis case. At present, anti-inflammatory treatment relies on corticosteroids, conventional synthetic (cs), biological (b) and other disease-modifying anti-rheumatic drugs (DMARDs).
    Conclusions: Timely diagnosis and state-of-the-art guideline-based management can significantly improve the long-term outcome of JIA-associated uveitis.
    MeSH term(s) Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Juvenile/complications ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/drug therapy ; Child ; Humans ; Rheumatology ; Uveitis/diagnosis ; Uveitis/drug therapy
    Chemical Substances Anti-Inflammatory Agents ; Antirheumatic Agents
    Language German
    Publishing date 2022-03-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1686-5158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Authors reply to the 'Response to "Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany"'.

    Heiligenhaus, Arnd / Klotsche, Jens / Minden, Kirsten

    Arthritis research & therapy

    2023  Volume 25, Issue 1, Page(s) 52

    MeSH term(s) Humans ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/epidemiology ; Arthritis, Juvenile/immunology ; Disease Progression ; Germany/epidemiology ; Risk Factors ; Uveitis ; Uveitis, Anterior/epidemiology ; Uveitis, Anterior/immunology ; Antibodies, Antinuclear
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Letter
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-023-03017-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Augenbeteiligung bei Graft-versus-Host-Erkrankung

    Tappeiner, Christoph / Heiligenhaus, Arnd / Dietrich-Ntoukas, Tina

    Klinische Monatsblätter für Augenheilkunde

    2024  

    Abstract: ... sind insbesondere selbstreaktive T-Zellen des Spenders. Dies kann u. a. zu einer ausgeprägten ...

    Abstract Im Rahmen der okulären Graft-versus-Host-Erkrankung (GVHD) kommt es nach allogener hämatopoetischer Zelltransplantation zu einer Entzündungsreaktion an der Augenoberfläche. Verantwortlich hierfür sind insbesondere selbstreaktive T-Zellen des Spenders. Dies kann u. a. zu einer ausgeprägten Keratoconjunctivitis sicca, Bindehauthyperämie, Hornhautulzerationen und -einschmelzung bis hin zur Perforation führen. Die okuläre GVHD geht mit einem hohen Leidensdruck wie Schmerzen, Photophobie und Visusminderung einher. Diese Übersichtsarbeit gibt einen Überblick über typische ophthalmologische Befunde, topische und systemische Therapieansätze, begleitende Maßnahmen (z. B. Sklerallinsen, Punctum plugs) und das entsprechende Management von Komplikationen.

    In ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a pronounced wetting disorder of the ocular surface, conjunctival hyperemia, and corneal ulceration up to perforation. The ocular GVHD is associated with a high degree of suffering, such as pain, photophobia, and reduction in visual acuity. This review provides an overview of typical ophthalmological findings, topical and systemic therapeutic approaches, and concomitant measures (e.g., scleral lenses, punctum plugs) and the appropriate management of complications.
    Keywords Graft-versus-Host-Erkrankung (GVHD) ; allogene hämatopoetische Zelltransplantation (HCT) ; Diagnose ; Einteilung ; Therapie ; graft-versus-host disease (GVHD) ; allogeneic hematopoietic cell transplantation (HCT) ; diagnosis ; classification ; therapy
    Language German
    Publishing date 2024-01-23
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/a-2218-0237
    Database Thieme publisher's database

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  10. Article: Augenbeteiligung bei ausgewählten rheumatischen Erkrankungen – Klinik im Erwachsenenalter

    Baquet-Walscheid, Karoline / Rath, Thomas / Heiligenhaus, Arnd

    Klinische Monatsblätter für Augenheilkunde

    2024  

    Abstract: Okuläre Manifestationen rheumatischer Erkrankungen sind häufig und tragen wesentlich zur Morbidität und Reduktion der Lebensqualität der betroffenen Patienten bei. Die Kenntnis über typische Manifestationsformen ist bedeutsam für den Rheumatologen, um ... ...

    Abstract Okuläre Manifestationen rheumatischer Erkrankungen sind häufig und tragen wesentlich zur Morbidität und Reduktion der Lebensqualität der betroffenen Patienten bei. Die Kenntnis über typische Manifestationsformen ist bedeutsam für den Rheumatologen, um Patienten mit entsprechender Symptomatik frühzeitig ophthalmologisch vorstellen zu können oder auch regelmäßige Screeninguntersuchungen zu veranlassen (z. B. bei Behçet-Syndrom). Umgekehrt ist eine (ggf. auch dringliche) rheumatologische Mitbeurteilung bei bestimmten ophthalmologischen Krankheitsbildern entscheidend, um eine (u. U. letale) systemische assoziierte Erkrankung nicht zu übersehen. Patienten mit rheumatischen bzw. entzündlichen okulären Erkrankungen sollten immer durch den behandelnden Arzt über mögliche Symptome anderweitiger Organmanifestationen aufgeklärt werden, um eine verzögerte Diagnosestellung zu vermeiden. „Klassische“ Assoziationen für Uveitiden sind die (HLA-B27-assoziierten) Spondyloarthritiden und die akute anteriore Uveitis sowie die retinale Vaskulitis mit oder ohne Panuveitis und das Behçet-Syndrom. Bei Patienten mit rheumatoider Arthritis oder ANCA-assoziierten Vaskulitiden hingegen treten typischerweise Skleritiden (mit oder ohne periphere ulzerative Keratitis) auf, aber auch eine Vielzahl weiterer Befunde ist möglich. Die enge interdisziplinäre Zusammenarbeit insbesondere in der Therapiegestaltung ist entscheidend, um eine gute Prognose für den Patienten zu sichern.

    Ocular manifestations of rheumatic diseases are common and contribute significantly to the morbidity and reduced quality of life of affected patients. Knowledge of typical clinical manifestations is important for the rheumatologist in order to support the reference of patients with corresponding symptoms for ophthalmological consultation at an early stage of disease, or to initiate regular screening examinations (e.g. in patients with Behçetʼs syndrome). Conversely, a (possibly urgent) rheumatological assessment is crucial for certain ophthalmological diseases, in order not to overlook a (possibly fatal) systemic associated disease. Patients with rheumatic or inflammatory ocular diseases should always be informed by the treating physician about possible symptoms of other organ manifestations, in order to avoid a delayed diagnosis. “Classic” associations for uveitis are (HLA-B27-associated) spondyloarthritis and acute anterior uveitis, as well as retinal vasculitis with or without panuveitis and Behçetʼs syndrome. In patients with rheumatoid arthritis or ANCA-associated vasculitis, however, scleritis (with or without peripheral ulcerative keratitis) typically occurs, but a variety of other findings are also possible. Close interdisciplinary collaboration, particularly regarding therapeutic decisions, is crucial to ensuring a good prognosis for the patient.
    Keywords rheumatische Erkrankungen ; Uveitis ; Skleritis ; rheumatoide Arthritis ; Spondyloarthritis ; Vaskulitis ; rheumatic diseases ; uveitis ; scleritis ; rheumatoid arthritis ; spondyloarthritis ; vasculitis
    Language German
    Publishing date 2024-04-04
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/a-2239-0412
    Database Thieme publisher's database

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