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  1. Article ; Online: Gefapixant for Chronic Cough-Reply.

    Kum, Elena / Guyatt, Gordon H / Satia, Imran

    JAMA

    2024  Volume 331, Issue 6, Page(s) 530

    MeSH term(s) Humans ; Benzenesulfonamides/therapeutic use ; Chronic Cough/drug therapy ; Pyrimidines/therapeutic use ; Sulfonamides
    Chemical Substances Benzenesulfonamides ; Gefapixant (6K6L7E3F1L) ; Pyrimidines ; Sulfonamides
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.26029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study.

    Adatia, Adil / Moolji, Jalal / Satia, Imran

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

    2024  Volume 20, Issue 1, Page(s) 13

    Abstract: Background: Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studies showed a substantial decrease in ED visits for asthma in the decade preceding 2010, followed by a stabilization. This was ... ...

    Abstract Background: Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studies showed a substantial decrease in ED visits for asthma in the decade preceding 2010, followed by a stabilization. This was attributed to improvements in the pharmacologic and non-pharmacologic treatments for asthma during that period followed by a balance between epidemiologic drivers and protective factors in the population.
    Methods: We assessed whether this trend continued in Alberta from 2010 to 2022 using population level data for the volume of daily ED visits, acuity of asthma exacerbations in the ED, and hospitalization rate.
    Results: The mean number of ED visits decreased from 4.5 to 2.2 per million persons per day, but the acuity of exacerbations and the proportion requiring hospitalization increased. The number of patients presenting with the highest level of acuity increased by over 300%, and the percentage of patients requiring hospitalization increased from 6.8 to 11.3%.
    Conclusion: Total ED visits for asthma exacerbations continues to decline in Alberta. The reasons for an increase in more severe exacerbations requires further attention.
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434973-2
    ISSN 1710-1492 ; 1710-1484
    ISSN (online) 1710-1492
    ISSN 1710-1484
    DOI 10.1186/s13223-024-00872-0
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  3. Article ; Online: Corrigendum to "Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)" [Respir. Med. 219 (2013) 107431].

    Satia, Imran / Mayhew, Alexandra J / Sohel, Nazmul / Kurmi, Om / Killian, Kieran J / O'Byrne, Paul M / Raina, Parminder

    Respiratory medicine

    2024  Volume 223, Page(s) 107556

    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2024.107556
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  4. Article: Is there clinical value in performing capsaicin cough challenges in patients with severe asthma?

    King, Jenny / Wingfield Digby, James / Satia, Imran

    Breathe (Sheffield, England)

    2021  Volume 17, Issue 2, Page(s) 210034

    Abstract: Heightened capsaicin cough sensitivity is independently associated with poor asthma control in moderate-to-severe asthma ... ...

    Abstract Heightened capsaicin cough sensitivity is independently associated with poor asthma control in moderate-to-severe asthma patients
    Language English
    Publishing date 2021-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0034-2021
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  5. Article ; Online: Is tezepelumab more than just an anti-eosinophil drug?

    Adatia, Adil / Wahab, Mustafaa / Satia, Imran

    The European respiratory journal

    2021  Volume 59, Issue 1

    MeSH term(s) Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; Eosinophils ; Humans ; Pharmaceutical Preparations
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; Pharmaceutical Preparations ; tezepelumab (RJ1IW3B4QX)
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01700-2021
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  6. Article ; Online: The Role of Viral Infections on Severe Asthma Exacerbations: Present and Future.

    Ojanguren, Iñigo / Satia, Imran / Usmani, Omar S

    Archivos de bronconeumologia

    2021  Volume 58, Issue 9, Page(s) 632–634

    MeSH term(s) Asthma/complications ; Humans ; Respiratory Tract Infections ; Virus Diseases/complications
    Language Spanish
    Publishing date 2021-11-01
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2021.10.007
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  7. Article ; Online: Mini-review: Hypertussivity and allotussivity in chronic cough endotypes.

    Smith, Jaclyn A / Satia, Imran / Badri, Huda / Marsden, Paul

    Neuroscience letters

    2022  Volume 792, Page(s) 136934

    Abstract: In recent years our understanding of the neurophysiological basis of cough has increased substantially. In conjunction, concepts around the drivers of chronic coughing in patients have also significantly evolved. Increasingly it is recognised that ... ...

    Abstract In recent years our understanding of the neurophysiological basis of cough has increased substantially. In conjunction, concepts around the drivers of chronic coughing in patients have also significantly evolved. Increasingly it is recognised that dysregulation of the neuronal pathways mediating cough play an important role in certain phenotypes of chronic cough and therefore pathological processes affecting the nervous system are likely to represent key endotypes in patients. Taking inspiration from the study of neuropathic pain, the term hypertussia has been employed to describe the phenomenon of abnormal excessive coughing in response to airway irritation and allotussia to describe coughing in response to stimuli not normally provoking cough. This review aims to summarise current clinical evidence supporting a role for the hyperexcitability of neuronal pathways contributing to chronic coughing and suggest how these might align with the clinical features observed in patients.
    MeSH term(s) Humans ; Cough ; Chronic Disease ; Respiratory System ; Anxiety
    Language English
    Publishing date 2022-10-26
    Publishing country Ireland
    Document type Review ; Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2022.136934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1166: Show issues Location:
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  8. Article ; Online: Emerging drugs in the treatment of chronic cough.

    Brister, Danica / Wahab, Mustafaa / Rashad, Moaaz / Diab, Nermin / Kolb, Martin / Satia, Imran

    Expert opinion on emerging drugs

    2023  Volume 28, Issue 2, Page(s) 67–77

    Abstract: Introduction: Chronic cough is a debilitating condition that is among the most common reasons for seeking medical attention yet remains challenging to manage. Identifying an underlying respiratory, nasal, or upper gastrointestinal disease triggering ... ...

    Abstract Introduction: Chronic cough is a debilitating condition that is among the most common reasons for seeking medical attention yet remains challenging to manage. Identifying an underlying respiratory, nasal, or upper gastrointestinal disease triggering cough is the first step in assessment, but once this has been ruled out or adequately treated, many patients remain troubled with chronic cough.
    Areas covered: This narrative review discusses the role of existing treatments and describes the current research landscape for the development of new therapies for chronic cough greater than 8 weeks that is refractory (RCC) or unexplained (UCC). The literature search includes published studies found on pubmed and conference abstracts until 2023.
    Expert opinion: RCC/UCC can occur due to neuronal dysregulation of the vagus nerve or central nervous system. Hence, novel anti-tussives have targeted ion channels involved in the neuronal signaling which triggers cough. Although some therapies targeting receptors such as TRPV1 have failed to show efficacy, P2X3 antagonists have emerged as the most promising therapy for patients impacted by chronic cough. Disease-specific therapies such as for idiopathic pulmonary fibrosis are in early development.
    MeSH term(s) Humans ; Cough/drug therapy ; Cough/etiology ; Carcinoma, Renal Cell ; Chronic Disease ; Kidney Neoplasms
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2061369-6
    ISSN 1744-7623 ; 1472-8214
    ISSN (online) 1744-7623
    ISSN 1472-8214
    DOI 10.1080/14728214.2023.2203912
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  9. Article ; Online: Identifying a Neurophenotype in Severe Asthma.

    Satia, Imran / O'Byrne, Paul M

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 9, Page(s) 1024–1025

    MeSH term(s) Asthma ; Capsaicin ; Humans ; Severity of Illness Index
    Chemical Substances Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2020-03-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202002-0228ED
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  10. Article ; Online: Narrative Review of the Mechanisms and Treatment of Cough in Asthma, Cough Variant Asthma, and Non-asthmatic Eosinophilic Bronchitis.

    Diab, Nermin / Patel, Matthew / O'Byrne, Paul / Satia, Imran

    Lung

    2022  Volume 200, Issue 6, Page(s) 707–716

    Abstract: Chronic cough is a debilitating condition affecting 10-12% of the general population and is one of the leading causes for referral to secondary care. Many conditions have been associated with chronic cough, including asthma, gastro-esophageal reflux ... ...

    Abstract Chronic cough is a debilitating condition affecting 10-12% of the general population and is one of the leading causes for referral to secondary care. Many conditions have been associated with chronic cough, including asthma, gastro-esophageal reflux disease and upper airways cough syndrome. Inflammatory airway conditions including cough variant asthma (CVA) and non-asthmatic eosinophilic bronchitis (NAEB) contribute to a significant proportion of presentations with chronic cough, with differing diagnostic criteria and different responses to commonly used asthma therapy for their respective diagnoses. Mechanistic studies in both animal models and humans have identified increased neuronal sensitivity and subsequent central sensitization. These mechanisms include inflammatory-mediated nociceptor sensitization and alterations of afferent nerve terminal excitability, phenotypic changes in the vagal afferent neurons over time, and central neuroplasticity resulting from increased synaptic signalling from peripheral afferents. The aim of this review is to discuss the mechanisms, neurophysiology, and management approaches currently available for patients presenting with chronic cough with underlying asthma, CVA, and NAEB and to shed a light on areas of further research required to elucidate the mechanisms of cough in this patient population.
    MeSH term(s) Humans ; Animals ; Cough/complications ; Eosinophilia/diagnosis ; Bronchitis/complications ; Bronchitis/diagnosis ; Bronchitis/drug therapy ; Asthma/complications ; Bronchitis, Chronic ; Chronic Disease
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-022-00575-6
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