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Article ; Online: Sairaalan reaaliaikainen tilannekuva päivittäisessä johtamisessa

Minna Mykkänen / Merja Miettinen / Tiina Siponen / Kaija Saranto

Finnish Journal of eHealth and eWelfare, Vol 13, Iss

2021 Volume 4

Abstract: Tutkimuksessa kuvataan organisaation rekisteriaineistojen avulla sairaalan reaaliaikaisen tilannekuvan muodostumista, tilannetietoisuuden ja tilanneymmärryksen syntymistä. Tiedot perustuvat organisaation rakenteisiin tietovarantoihin. Tutkimusaineistot ... ...

Abstract	Tutkimuksessa kuvataan organisaation rekisteriaineistojen avulla sairaalan reaaliaikaisen tilannekuvan muodostumista, tilannetietoisuuden ja tilanneymmärryksen syntymistä. Tiedot perustuvat organisaation rakenteisiin tietovarantoihin. Tutkimusaineistot kerättiin potilashallinnon tiedoista, työvuorosuunnitelma-ohjelmasta ja sähköisestä potilaskertomusjärjestelmästä. Aineistot analysoitiin kuvailevin tilastollisin menetelmin. Tulosten perusteella koko sairaalan ja yksittäisen yksikön reaaliaikaisen ja visuaalisen tilannekuvan muodostaminen eri tietojärjestelmistä yhdeksi kokonaisuudeksi on mahdollista. Tietoja tulkitsemalla muodostuu tilanneymmärrys, jonka avulla syntyy käsitys siitä, miten tulevaisuudessa tulee toimia. Tietojen avulla sairaalan ja yksikön toimintaa voidaan myös kehittää tukemaan eri tasoisia toimintaprosesseja ja päätöksentekoa. Sosiaali- ja terveydenhuollon sähköisiä tietojärjestelmiä tulee kehittää siten, että ne palvelevat samanaikaisesti sekä tiedon ensisijaista, että toisiokäyttöä.
Keywords	sähköinen potilastietojärjestelmä ; rakenteinen tieto ; päivittäisjohtaminen ; tilannekuva ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Finnish Social and Health Informatics Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models.

Gering, Christine / Párraga, Jenny / Vuorenpää, Hanna / Botero, Lucía / Miettinen, Susanna / Kellomäki, Minna

Biomaterials advances

2022 Volume 143, Page(s) 213185

Abstract: Hydrogels are suitable soft tissue mimics and capable of creating pre-vascularized tissues, that are useful for in vitro tissue engineering and in vivo regenerative medicine. The polysaccharide gellan gum (GG) offers an intriguing matrix material but ... ...

Abstract	Hydrogels are suitable soft tissue mimics and capable of creating pre-vascularized tissues, that are useful for in vitro tissue engineering and in vivo regenerative medicine. The polysaccharide gellan gum (GG) offers an intriguing matrix material but requires bioactivation in order to support cell attachment and transfer of biomechanical cues. Here, four versatile modifications were investigated: Purified NaGG; avidin-modified NaGG combined with biotinylated fibronectin (NaGG-avd); oxidized GG (GGox) covalently modified with carbohydrazide-modified gelatin (gelaCDH) or adipic hydrazide-modified gelatin (gelaADH). All materials were subjected to rheological analysis to assess their viscoelastic properties, using a time sweep for gelation analysis, and subsequent amplitude sweep of the formed hydrogels. The sweeps show that NaGG and NaGG-avd are rather brittle, while gelatin-based hydrogels are more elastic. The degradation of preformed hydrogels in cell culture medium was analyzed with an amplitude sweep and show that gelatin-containing hydrogels degrade more dramatically. A co-culture of GFP-tagged HUVEC and hASC was performed to induce vascular network formation in 3D for up to 14 days. Immunofluorescence staining of the αSMA
MeSH term(s)	Rats ; Animals ; Hydrogels/pharmacology ; Gelatin/pharmacology ; Coculture Techniques ; Polysaccharides, Bacterial/pharmacology
Chemical Substances	Hydrogels ; gellan gum (7593U09I4D) ; Gelatin (9000-70-8) ; Polysaccharides, Bacterial
Language	English
Publishing date	2022-11-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2022.213185
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Article ; Online: Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells.

Hyväri, Laura / Vanhatupa, Sari / Ojansivu, Miina / Kelloniemi, Minna / Pakarinen, Toni-Karri / Hupa, Leena / Miettinen, Susanna

Cells

2023 Volume 12, Issue 2

Abstract: Bioactive glass (BaG) materials are increasingly used in clinics, but their regulatory mechanisms on osteogenic differentiation remain understudied. In this study, we elucidated the currently unknown role of the p38 MAPK downstream target heat shock ... ...

Abstract	Bioactive glass (BaG) materials are increasingly used in clinics, but their regulatory mechanisms on osteogenic differentiation remain understudied. In this study, we elucidated the currently unknown role of the p38 MAPK downstream target heat shock protein 27 (HSP27), in the osteogenic commitment of human mesenchymal stem cells (hMSCs), derived from adipose tissue (hASCs) and bone marrow (hBMSCs). Osteogenesis was induced with ionic extract of an experimental BaG in osteogenic medium (OM). Our results showed that BaG OM induced fast osteogenesis of hASCs and hBMSCs, demonstrated by enhanced alkaline phosphatase (ALP) activity, production of extracellular matrix protein collagen type I, and matrix mineralization. BaG OM stimulated early and transient activation of p38/HSP27 signaling by phosphorylation in hMSCs. Inhibition of HSP27 phosphorylation with SB202190 reduced the ALP activity, mineralization, and collagen type I production induced by BaG OM. Furthermore, the reduced pHSP27 protein by SB202190 corresponded to a reduced F-actin intensity of hMSCs. The phosphorylation of HSP27 allowed its co-localization with the cytoskeleton. In terminally differentiated cells, however, pHSP27 was found diffusely in the cytoplasm. This study provides the first evidence that HSP27 is involved in hMSC osteogenesis induced with the ionic dissolution products of BaG. Our results indicate that HSP27 phosphorylation plays a role in the osteogenic commitment of hMSCs, possibly through the interaction with the cytoskeleton.
MeSH term(s)	Humans ; Osteogenesis/physiology ; HSP27 Heat-Shock Proteins/metabolism ; Collagen Type I/metabolism ; Cell Differentiation/physiology ; Mesenchymal Stem Cells/metabolism
Chemical Substances	HSP27 Heat-Shock Proteins ; Collagen Type I
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12020224
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Article ; Online: In vitro biocompatibility of polylactide and polybutylene succinate blends for urethral tissue engineering.

Sartoneva, Reetta / Lyyra, Inari / Juusela, Maiju / Sharma, Vipul / Huhtala, Heini / Massera, Jonathan / Kellomäki, Minna / Miettinen, Susanna

Journal of biomedical materials research. Part B, Applied biomaterials

2023 Volume 111, Issue 10, Page(s) 1728–1740

Abstract: Surgical treatment of urothelial defects with autologous genital or extragenital tissue grafts is susceptible to complications. Tissue engineering utilizing novel biomaterials and cells such as human urothelial cells (hUC) for epithelial regeneration and ...

Abstract	Surgical treatment of urothelial defects with autologous genital or extragenital tissue grafts is susceptible to complications. Tissue engineering utilizing novel biomaterials and cells such as human urothelial cells (hUC) for epithelial regeneration and adipose stromal cells (hASC) for smooth muscle restoration might offer new treatment options for urothelial defects. Previously, polylactide (PLA) has been studied for urethral tissue engineering, however, as such, it is too stiff and rigid for the application. Blending it with ductile polybutylene succinate (PBSu) could provide suitable mechanical properties for the application. Our aim was to study the morphology, viability and proliferation of hUC and hASC when cultured on 100/0 PLA/PBSu, 75/25 PLA/PBSu blend, 50/50 PLA/PBSu blend, and 0/100 PLA/PBSu discs. The results showed that the hUCs were viable and proliferated on all the studied materials. The hUCs stained pancytokeratin at 7 and 14 days, suggesting maintenance of the urothelial phenotype. The hASCs retained their viability and morphology and proliferated on all the other discs, except on PLA. On the PLA, the hASCs formed large aggregates with each other rather than attached to the material. The early smooth muscle cell markers SM22α and α-SMA were stained in hASC at 7 and 14 day time points on all PBSu-containing materials, indicating that hASCs maintain their smooth muscle differentiation potential also on PBSu. As a conclusion, PBSu is a highly potential biomaterial for urothelial tissue engineering since it supports growth and phenotypic maintenance of hUC and smooth muscle differentiation of hASC.
MeSH term(s)	Humans ; Tissue Engineering/methods ; Polymers ; Polyesters/pharmacology ; Biocompatible Materials/pharmacology
Chemical Substances	bionole ; poly(lactide) (459TN2L5F5) ; Polymers ; Polyesters ; Biocompatible Materials
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35268
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Article ; Online: Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types.

Isosaari, Lotta / Vuorenpää, Hanna / Yrjänäinen, Alma / Kapucu, Fikret Emre / Kelloniemi, Minna / Pakarinen, Toni-Karri / Miettinen, Susanna / Narkilahti, Susanna

Cell communication and signaling : CCS

2023 Volume 21, Issue 1, Page(s) 132

Abstract: Background: Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues. Neurovascular interactions are vital for both tissue development and ... ...

Abstract	Background: Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues. Neurovascular interactions are vital for both tissue development and maintaining homeostasis in adulthood; these two network systems align and reciprocally communicate with one another. Although communication between network systems has been acknowledged, the lack of relevant in vitro models has hindered research at the mechanistic level. For example, the current used in vitro neurovascular models are typically established to be short-term (≤ 7 days) culture models, and they miss the supporting vascular mural cells. Methods: In this study, we utilized human induced pluripotent stem cell (hiPSC) -derived neurons, fluorescence tagged human umbilical vein endothelial cells (HUVECs), and either human bone marrow or adipose stem/stromal cells (BMSCs or ASCs) as the mural cell types to create a novel 3D neurovascular network-on-a-chip model. Collagen 1-fibrin matrix was used to establish long-term (≥ 14 days) 3D cell culture in a perfusable microphysiological environment. Results: Aprotinin-supplemented endothelial cell growth medium-2 (EGM-2) supported the simultaneous formation of neuronal networks, vascular structures, mural cell differentiation, and the stability of the 3D matrix. The formed neuronal and vascular networks were morphologically and functionally characterized. Neuronal networks supported vasculature formation based on direct cell contacts and by dramatically increasing the secretion of angiogenesis-related factors in multicultures in contrast to cocultures without neurons. Both utilized mural cell types supported the formation of neurovascular networks; however, the BMSCs seemed to boost neurovascular networks to greater extent. Conclusions: Overall, our study provides a novel human neurovascular network model that is applicable for creating in vivo-like tissue models with intrinsic neurovascular interactions. The 3D neurovascular network model on chip forms an initial platform for the development of vascularized and innervated organ-on-chip and further body-on-chip concepts and offers the possibility for mechanistic studies on neurovascular communication both under healthy and in disease conditions. Video Abstract.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Homeostasis ; Cell Differentiation ; Human Umbilical Vein Endothelial Cells ; Lab-On-A-Chip Devices
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01159-4
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Article ; Online: Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels.

Vuornos, Kaisa / Huhtala, Heini / Kääriäinen, Minna / Kuismanen, Kirsi / Hupa, Leena / Kellomäki, Minna / Miettinen, Susanna

Journal of biomedical materials research. Part B, Applied biomaterials

2019 Volume 108, Issue 4, Page(s) 1332–1342

Abstract: Lack of bone grafts appeals for bone augmentation solutions. We aimed at osteogenic differentiation of human adipose stem cells (hASCs) and microvascularization in coculture with human umbilical vein endothelial cells (HUVECs) embedded in three- ... ...

Abstract	Lack of bone grafts appeals for bone augmentation solutions. We aimed at osteogenic differentiation of human adipose stem cells (hASCs) and microvascularization in coculture with human umbilical vein endothelial cells (HUVECs) embedded in three-dimensional (3D) gellan gum (GG) and collagen type I (COL) hydrogel mixture. We compared endothelial growth medium-2 (EGM-2) and bioactive glass extract-based endothelial and osteogenic medium (BaG EM-OM) for vascularized bone-like graft development in vitro. Cell viability, cell number, and osteogenic and endothelial gene expression were analyzed. Mineralized hydroxyapatite residues, immunocytochemical staining of endothelial marker CD31 production and late osteogenic marker osteocalcin were imaged. With both media, good cell viability was observed within 3D hydrogel. EGM-2 condition induced significantly higher cell number compared to BaG EM-OM condition at both 7 and 14 days. Interestingly, both media supported osteogenic as well as endothelial marker gene expression. Moreover, formation of reticulated cellular structures was observed in both EGM-2 and BaG EM-OM conditions. However, hydroxyapatite mineralization and strong osteocalcin staining were detected only in BaG EM-OM condition. Importantly, strong production of CD31 and elongated tube-like structures were apparent in EGM-2 culture alone. In conclusion, we demonstrated efficient hASC osteogenic differentiation and microvessel-like network formation in coculture with HUVECs.
MeSH term(s)	Adipose Tissue/metabolism ; Antigens, Differentiation/biosynthesis ; Collagen/chemistry ; Glass/chemistry ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogels/chemistry ; Neovascularization, Physiologic ; Osteogenesis ; Polysaccharides, Bacterial/chemistry ; Stem Cells/metabolism
Chemical Substances	Antigens, Differentiation ; Hydrogels ; Polysaccharides, Bacterial ; gellan gum (7593U09I4D) ; Collagen (9007-34-5)
Language	English
Publishing date	2019-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.34482
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Article: Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel.

Koivunotko, Elle / Snirvi, Jasmi / Merivaara, Arto / Harjumäki, Riina / Rautiainen, Swarna / Kelloniemi, Minna / Kuismanen, Kirsi / Miettinen, Susanna / Yliperttula, Marjo / Koivuniemi, Raili

Biomedicines

2022 Volume 10, Issue 10

Abstract: Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies by having immunomodulatory behavior and tissue regenerative properties. Due to the capability of ASCs to differentiate into endothelial cells (ECs) and other ... ...

Abstract	Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies by having immunomodulatory behavior and tissue regenerative properties. Due to the capability of ASCs to differentiate into endothelial cells (ECs) and other angiogenic cell types, such as pericytes, ASCs are a highly valuable source for stimulating angiogenesis. However, cellular therapies in tissue engineering have faced challenges in poor survival of the cells after transplantation, which is why a protective biomaterial scaffold is required. In this work, we studied the potential of nanofibrillated cellulose (NFC) hydrogel to be utilized as a suitable matrix for three-dimensional (3D) cell culturing of human-derived ASCs (hASCs) and studied their angiogenic properties and differentiation potential in ECs and pericytes. In addition, we tested the effect of hASC-conditioned medium and stimulation with angiopoietin-1 (Ang-1) on human umbilical vein endothelial cells (HUVECs) to induce blood vessel-type tube formation in NFC hydrogel. The hASCs were successfully 3D cell cultured in NFC hydrogel as they formed spheroids and had high cell viability with angiogenic features. Most importantly, they showed angiogenic potential by having pericyte-like characteristics when differentiated in EC medium, and their conditioned medium improved HUVEC viability and tube formation, which recalls the active paracrine properties. This study recommends NFC hydrogel for future use as an animal-free biomaterial scaffold for hASCs in therapeutic angiogenesis and other cell therapy purposes.
Language	English
Publishing date	2022-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10102584
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Article ; Online: Accurate QT correction method from transfer entropy.

Räsänen, Esa / Pukkila, Teemu / Kanniainen, Matias / Miettinen, Minna / Duda, Rostislav / Kim, Jiyeong / Solanpää, Janne / Aalto-Setälä, Katriina / Potapov, Ilya

Cardiovascular digital health journal

2022 Volume 4, Issue 1, Page(s) 1–8

Abstract: Background: The QT interval in the electrocardiogram (ECG) is a fundamental risk measure for arrhythmic adverse cardiac events. However, the QT interval depends on the heart rate and must be corrected accordingly. The present QT correction (QTc) methods ...

Abstract	Background: The QT interval in the electrocardiogram (ECG) is a fundamental risk measure for arrhythmic adverse cardiac events. However, the QT interval depends on the heart rate and must be corrected accordingly. The present QT correction (QTc) methods are either simple models leading to under- or overcorrection, or impractical in requiring long-term empirical data. In general, there is no consensus on the best QTc method. Objective: We introduce a model-free QTc method-AccuQT-that computes QTc by minimizing the information transfer from R-R to QT intervals. The objective is to establish and validate a QTc method that provides superior stability and reliability without models or empirical data. Methods: We tested AccuQT against the most commonly used QT correction methods by using long-term ECG recordings of more than 200 healthy subjects from PhysioNet and THEW databases. Results: AccuQT overperforms the previously reported correction methods: the proportion of false-positives is reduced from 16% (Bazett) to 3% (AccuQT) for the PhysioNet data. In particular, the QTc variance is significantly reduced and thus the RR-QT stability is increased. Conclusion: AccuQT has significant potential to become the QTc method of choice in clinical studies and drug development. The method can be implemented in any device recording R-R and QT intervals.
Language	English
Publishing date	2022-11-26
Publishing country	United States
Document type	Journal Article
ISSN	2666-6936
ISSN (online)	2666-6936
DOI	10.1016/j.cvdhj.2022.10.006
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Article ; Online: Evaluation of scaffold microstructure and comparison of cell seeding methods using micro-computed tomography-based tools.

Palmroth, Aleksi / Pitkänen, Sanna / Hannula, Markus / Paakinaho, Kaarlo / Hyttinen, Jari / Miettinen, Susanna / Kellomäki, Minna

Journal of the Royal Society, Interface

2020 Volume 17, Issue 165, Page(s) 20200102

Abstract: Micro-computed tomography (micro-CT) provides a means to analyse and model three-dimensional (3D) tissue engineering scaffolds. This study proposes a set of micro-CT-based tools firstly for evaluating the microstructure of scaffolds and secondly for ... ...

Abstract	Micro-computed tomography (micro-CT) provides a means to analyse and model three-dimensional (3D) tissue engineering scaffolds. This study proposes a set of micro-CT-based tools firstly for evaluating the microstructure of scaffolds and secondly for comparing different cell seeding methods. The pore size, porosity and pore interconnectivity of supercritical CO
MeSH term(s)	Cell Culture Techniques ; Humans ; Polyesters ; Porosity ; Tissue Engineering ; Tissue Scaffolds ; X-Ray Microtomography
Chemical Substances	Polyesters
Language	English
Publishing date	2020-04-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2020.0102
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Article ; Online: Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells.

Mahmoud, Marwa / Juntunen, Miia / Adnan, Amna / Kummola, Laura / Junttila, Ilkka S / Kelloniemi, Minna / Tyrväinen, Tuula / Huhtala, Heini / Abd El Fattah, Abeer I / Amr, Khalda / El Erian, Alaa Mohamad / Patrikoski, Mimmi / Miettinen, Susanna

Stem cells (Dayton, Ohio)

2023 Volume 41, Issue 5, Page(s) 505–519

Abstract: For adipose stromal/stem cell (ASCs)-based immunomodulatory therapies, it is important to study how donor characteristics, such as obesity and type 2 diabetes (T2D), influence ASCs efficacy. Here, ASCs were obtained from 2 groups, donors with T2D and ... ...

Abstract	For adipose stromal/stem cell (ASCs)-based immunomodulatory therapies, it is important to study how donor characteristics, such as obesity and type 2 diabetes (T2D), influence ASCs efficacy. Here, ASCs were obtained from 2 groups, donors with T2D and obesity (dASCs) or nondiabetic donors with normal-weight (ndASCs), and then cultured with anti-CD3/CD28-stimulated allogeneic CD4 T cells. ASCs were studied for the expression of the immunomodulators CD54, CD274, and indoleamine 2, 3 dioxygenase 1 (IDO) in inflammatory conditions. CD4 T cells cultured alone or in cocultures were assessed to evaluate proliferation, activation marker surface expression, apoptosis, the regulatory T cells (Tregs; CD4+ CD25high FOXP3+) frequency, and intracellular cytokine expression using flow cytometry. Modulation of T-cell subset cytokines was explored via ELISA. In inflammatory conditions, the expression of CD54, CD274, and IDO was significantly upregulated in ASCs, with no significant differences between ndASCs and dASCs. dASCs retained the potential to significantly suppress CD4 T-cell proliferation, with a slightly weaker inhibitory effect than ndASCs, which was associated with significantly reduced abilities to decrease IL-2 production and increase IL-8 levels in cocultures. Such attenuated potentials were significantly correlated with increasing body mass index. dASCs and ndASCs comparably reduced CD4 T-cell viability, HLA-DR expression, and interferon-gamma production and conversely increased CD69 expression, the Tregs percentage, and IL-17A production. Considerable amounts of the immunomodulators prostaglandin E2 (PGE2) and IL-6 were detected in the conditioned medium of cocultures. These findings suggest that ASCs obtained from donors with T2D and obesity are receptive to the inflammatory environment and able to modulate CD4 T cells accordingly.
MeSH term(s)	Humans ; Adipose Tissue/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Mesenchymal Stem Cells/metabolism ; Cytokines/metabolism ; Immunomodulation ; Obesity/metabolism ; Cell Proliferation
Chemical Substances	Cytokines
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1093/stmcls/sxad021
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