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Article ; Online: Bevacizumab as treatment option for recurrent respiratory papillomatosis: a systematic review.

Pogoda, Louis / Ziylan, Fuat / Smeeing, Diederik P J / Dikkers, Frederik G / Rinkel, Rico N P M

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2022 Volume 279, Issue 9, Page(s) 4229–4240

Abstract: Purpose: To this day, there is no cure for recurrent respiratory papillomatosis (RRP). Multiple surgical procedures are performed to achieve symptom relief and prevention of airway obstruction. A promising drug for RRP is the vascular endothelial growth ...

Abstract	Purpose: To this day, there is no cure for recurrent respiratory papillomatosis (RRP). Multiple surgical procedures are performed to achieve symptom relief and prevention of airway obstruction. A promising drug for RRP is the vascular endothelial growth factor (VEGF) binding antibody bevacizumab. This chemotherapeutic agent has an angiogenesis-inhibiting effect which inhibits tumor growth. The objective of this review was to investigate the efficacy of bevacizumab as treatment option for RRP, and to explore the difference of its effects between intralesional and systemic treatment. Methods: A systematic search was conducted in Cochrane, PubMed, and Embase. Articles were included if bevacizumab treatment was given intralesionally and/or systemically. The methodological quality of the studies was assessed using the CAse REport (CARE) guidelines. Results: Of 585 unique articles screened by title and abstract, 15 studies were included, yielding a total of 64 patients. In 95% of the patients treated with systemic bevacizumab, the post-bevacizumab surgical interval was considerably prolonged. More than half of them did not need any surgical intervention during mean follow-up of 21.6 months. Treatment with intralesional bevacizumab showed a lower efficacy: in 62% of the patients, the post-bevacizumab surgical interval (mean, 1.8 months follow-up) was extended when compared to the interval before the treatment. Conclusion: Systemically and intralesionally administered bevacizumab are effective treatment options for severe RRP. A systemic administration might be the treatment of first choice. Further prospective research with long term follow-up is advocated to elucidate this important topic.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Humans ; Papillomavirus Infections/drug therapy ; Papillomavirus Infections/surgery ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/surgery ; Vascular Endothelial Growth Factor A
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2022-04-24
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review ; Systematic Review
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-022-07388-6
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Ul II Zs.50: Show issues

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Article ; Online: A new application of the Rotterdam Diabetic Foot Study Test Battery: grading pedal sensory loss to predict the risk of foot ulceration.

Rinkel, Willem D / Castro Cabezas, Manuel / Coert, J Henk

Diabetes research and clinical practice

2021 Volume 175, Page(s) 108836

Abstract: ... in a more precise risk stratification compared to the use of the 10 g monofilament according to current ...

Abstract	Aims: To assess the relationship between the degree of loss of foot sensation at baseline and incidence of foot ulceration (DFU). Methods: Diabetic patients (n = 416) participating in the observational Rotterdam Diabetic Foot (RDF) Study were followed prospectively (median 955.5 days (IQR, 841.5-1121)). Subjects underwent sensory testing of the feet (39-item RDF Study Test Battery) at baseline and were assessed regarding incident DFU. Seven groups of incremental degree of sensory loss were distinguished, according to the RDF-39 sum score. Kaplan-Meier and regression analyses were used to determine the independent hazard of baseline variables for new DFU. Results: 40 participants developed DFUs. The mean incident rate of new-onset ulceration from study start was 4.5 (95%CI: 3.3 to 6.1) per 100 person-years, which increased significantly from 0 to 67.70 in the seven groups (p < 0.0005). Predictors for DFUs were higher RDF-39 score (aHR: 1.173, p < 0.0005) and kidney function (aHR: 1.022, p = 0.016). Prior DFU suggests increased mortality risk. Conclusions: The degree of sensory loss at baseline was associated with progression to DFU during follow-up. Grading the loss of sensation using the RDF Study Test Battery may result in a more precise risk stratification compared to the use of the 10 g monofilament according to current guidelines.
MeSH term(s)	Aged ; Cohort Studies ; Diabetic Foot/epidemiology ; Diabetic Foot/pathology ; Female ; Foot Ulcer/epidemiology ; Foot Ulcer/pathology ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2021-04-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2021.108836
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Article ; Online: Lumbar puncture for treating acute hydrocephalus after aneurysmal subarachnoid haemorrhage.

Tack, R W P / Lindgren, A / Vergouwen, M D I / van der Zwan, A / van der Schaaf, I / Rinkel, G J E

Journal of the neurological sciences

2023 Volume 446, Page(s) 120566

Abstract: Background: External ventricular drainage (EVD) for acute hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH) carries a risk of complications. We studied the proportion of patients in whom EVD can be avoided by treating acute hydrocephalus ... ...

Abstract	Background: External ventricular drainage (EVD) for acute hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH) carries a risk of complications. We studied the proportion of patients in whom EVD can be avoided by treating acute hydrocephalus with ≥1 lumbar punctures (LP). Methods: From a prospectively collected database, we retrieved data on all aSAH patients admitted between 2007 and 2017 who developed acute hydrocephalus (i.e. neurological deterioration and ventricular enlargement <72 h after aSAH). Our regime is to consider LP as initial treatment. We calculated the proportions of patients (with corresponding 95% confidence interval (CI)) who improved after the initial LP and the extent of clinical improvement, the proportions of patients who were treated with only ≥1 LP(s), and those of patients needing continuous external ventricular or external lumbar drainage, or permanent ventriculoperitoneal or lumboperitoneal drainage. Results: Of 1391 consecutive aSAH patients, 473 (34%) had acute hydrocephalus, of whom 388 (82%) were treated. Of the 86 patients with LP as initial treatment, 70 (81% [95% CI 72-88]) showed initial improvement (with increase in median Glasgow Coma Score from 10 (IQR 7-12) to 12 (IQR 9-14) after initial LP), 39 (45% [95% CI 35-56]) improved with LP only, 41 (48% [95% CI 37-58]) needed continuous drainage and six (7% [95% CI 3-14]) needed permanent drainage. Conclusion: Around half the patients treated with LP for deterioration from acute hydrocephalus after aSAH does not require continuous extraventicular or extralumbar drainage.
MeSH term(s)	Humans ; Drainage/adverse effects ; Hydrocephalus/etiology ; Retrospective Studies ; Spinal Puncture/adverse effects ; Subarachnoid Hemorrhage/complications
Language	English
Publishing date	2023-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120566
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Zs.A 308: Show issues

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Article ; Online: What Is a Meaningful Difference When Using Infarct Volume as the Primary Outcome?: Results From the HERMES Database.

Rinkel, Leon A / Ospel, Johanna M / Brown, Scott B / Campbell, Bruce C V / Dippel, Diederik W J / Demchuk, Andrew M / Majoie, Charles B L M / Mitchell, Peter J / Bracard, Serge / Guillemin, Francis / Jovin, Tudor G / Muir, Keith W / White, Philip / Saver, Jeffrey L / Hill, Michael D / Goyal, Mayank

Stroke

2024 Volume 55, Issue 4, Page(s) 866–873

Abstract: Background: Ischemic stroke lesion volume at follow-up is an important surrogate outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion volume translate into meaningful clinical differences.: Methods: We used pooled ... ...

Abstract	Background: Ischemic stroke lesion volume at follow-up is an important surrogate outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion volume translate into meaningful clinical differences. Methods: We used pooled data from 7 trials investigating the efficacy of endovascular treatment for anterior circulation large vessel occlusion in acute ischemic stroke. We assessed 48-hour lesion volume follow-up computed tomography or magnetic resonance imaging. The primary outcome was a good functional outcome, defined as modified Rankin Scale (mRS) scores of 0 to 2. We performed multivariable logistic regression to predict the probability of achieving mRS scores of 0 to 2 and determined the differences in 48-hour lesion volume that correspond to a change of 1%, 5%, and 10% in the adjusted probability of achieving mRS scores of 0 to 2. Results: In total, 1665/1766 (94.2%) patients (median age, 68 [interquartile range, 57-76] years, 781 [46.9%] female) had information on follow-up ischemic lesion volume. Computed tomography was used for follow-up imaging in 83% of patients. The median 48-hour lesion volume was 41 (interquartile range, 14-120) mL. We observed a linear relationship between 48-hour lesion volume and mRS scores of 0 to 2 for adjusted probabilities between 65% and 20%/volumes <80 mL, although the curve sloped off for lower mRS scores of 0-2 probabilities/higher volumes. The median differences in 48-hour lesion volume associated with a 1%, 5%, and 10% increase in the probability of mRS scores of 0 to 2 for volumes <80 mL were 2 (interquartile range, 2-3), 10 (9-11), and 20 (18-23) mL, respectively. We found comparable associations when assessing computed tomography and magnetic resonance imaging separately. Conclusions: A difference of 2, 10, and 20 mL in 48-hour lesion volume, respectively, is associated with a 1%, 5%, and 10% absolute increase in the probability of achieving good functional outcome. These results can inform the design of future stroke trials that use 48-hour lesion volume as the primary outcome.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Ischemic Stroke ; Stroke/therapy ; Stroke/drug therapy ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed/methods ; Infarction ; Treatment Outcome ; Endovascular Procedures/methods ; Brain Ischemia/therapy ; Brain Ischemia/drug therapy
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.044353
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Zs.A 448: Show issues

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Article ; Online: Item reduction of the 39-item Rotterdam Diabetic Foot Study Test Battery using decision tree modelling.

Rinkel, Willem D / van der Oest, Mark J W / Coert, J Henk

Diabetes/metabolism research and reviews

2020 Volume 36, Issue 4, Page(s) e3291

Abstract: ... S1PD; eg, 10-g monofilament), and vibration sense and is included in the Rotterdam Diabetic Foot (RDF ...

Abstract	Aims: Pedal sensory loss due to diabetes-related neuropathy can be graded by testing static two-point discrimination (S2PD), moving two-point discrimination (M2PD), static one-point discrimination (S1PD; eg, 10-g monofilament), and vibration sense and is included in the Rotterdam Diabetic Foot (RDF) Study Test Battery. The aim of this study is to investigate if decision tree modelling is able to reduce the number of tests needed in estimating pedal sensation. Methods: The 39-item RDF Study Test Battery (RDF-39) scores were collected from the prospective RDF study and included baseline (n = 416), first follow-up (n = 364), and second follow-up (n = 135) measurements, supplemented with cross-sectional control data from a previous study (n = 196). Decision tree analysis was used to predict total RDF-39 scores using individual test item data. The tree was developed using baseline RDF study data and validated in follow-up and control data. Spearman correlation coefficients assessed the reliability between the decision tree and original RDF-39. Results: The tree reduced the number of items from 39 to 3 in estimating the RDF-39 sum score. M2PD (hallux), S2PD (first dorsal web, fifth toe), vibration sense (interphalangeal joint), and S1PD (first dorsal web, fifth toe) measurements proved to be predictive. The correlation coefficients to original scores were high (0.76 to 0.91). Conclusions: The decision tree was successful at reducing the number of RDF Test Battery items to only 3, with high correlation coefficients to the scores of the full test battery. The findings of this study aids medical decision making by time efficiently estimating pedal sensory status with fewer tests needed.
MeSH term(s)	Case-Control Studies ; Cross-Sectional Studies ; Decision Trees ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2/complications ; Diabetic Foot/diagnosis ; Diabetic Foot/epidemiology ; Diabetic Foot/etiology ; Diabetic Neuropathies/diagnosis ; Diabetic Neuropathies/epidemiology ; Diabetic Neuropathies/etiology ; Diagnostic Techniques, Neurological/statistics & numerical data ; Follow-Up Studies ; Humans ; Netherlands/epidemiology ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Sensation Disorders/diagnosis ; Sensation Disorders/epidemiology ; Severity of Illness Index
Language	English
Publishing date	2020-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3291
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Zs.A 2119: Show issues

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Article ; Online: Modeling diffusion-weighted imaging lesion expansion between 2 and 24 h after endovascular thrombectomy in acute ischemic stroke.

Rex, Nathaniel / Oueidat, Karim / Ospel, Johanna / McDonough, Rosalie / Rinkel, Leon / Baird, Grayson L / Collins, Scott / Jindal, Gaurav / Alvin, Matthew D / Boxerman, Jerrold / Barber, Phil / Jayaraman, Mahesh / Smith, Wendy / Amirault-Capuano, Amanda / Hill, Michael / Goyal, Mayank / McTaggart, Ryan

Neuroradiology

2024 Volume 66, Issue 4, Page(s) 621–629

Abstract: Purpose: Diffusion-weighted imaging (DWI) lesion expansion after endovascular thrombectomy (EVT) is not well characterized. We used serial diffusion-weighted magnetic resonance imaging (MRI) to measure lesion expansion between 2 and 24 h after EVT.: ... ...

Abstract	Purpose: Diffusion-weighted imaging (DWI) lesion expansion after endovascular thrombectomy (EVT) is not well characterized. We used serial diffusion-weighted magnetic resonance imaging (MRI) to measure lesion expansion between 2 and 24 h after EVT. Methods: In this single-center observational analysis of patients with acute ischemic stroke due to large vessel occlusion, DWI was performed post-EVT (< 2 h after closure) and 24-h later. DWI lesion expansion was evaluated using multivariate generalized linear mixed modeling with various clinical moderators. Results: We included 151 patients, of which 133 (88%) had DWI lesion expansion, defined as a positive change in lesion volume between 2 and 24 h. In an unadjusted analysis, median baseline DWI lesion volume immediately post-EVT was 15.0 mL (IQR: 6.6-36.8) and median DWI lesion volume 24 h post-EVT was 20.8 mL (IQR: 9.4-66.6), representing a median change of 6.1 mL (IQR: 1.5-17.7), or a 39% increase. There were no significant associations among univariable models of lesion expansion. Adjusted models of DWI lesion expansion demonstrated that relative lesion expansion (defined as final/initial DWI lesion volume) was consistent across eTICI scores (0-2a, 0.52%; 2b, 0.49%; 2c-3, 0.42%, p = 0.69). For every 1 mL increase in lesion volume, there was 2% odds of an increase in 90-day mRS (OR: 1.021, 95%CI [1.009, 1.034], p < 0.001). Conclusion: We observed substantial lesion expansion post-EVT whereby relative lesion expansion was consistent across eTICI categories, and greater absolute lesion expansion was associated with worse clinical outcome. Our findings suggest that alternate endpoints for cerebroprotectant trials may be feasible.
MeSH term(s)	Humans ; Stroke/pathology ; Ischemic Stroke ; Brain Ischemia/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Thrombectomy ; Endovascular Procedures ; Treatment Outcome
Language	English
Publishing date	2024-01-26
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-024-03294-2
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Zs.A 658: Show issues

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Article ; Online: Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae.

Rinkel, Jan / Köllner, Tobias G / Chen, Feng / Dickschat, Jeroen S

Chemical communications (Cambridge, England)

2019 Volume 55, Issue 88, Page(s) 13255–13258

Abstract: The products of three terpene synthases from two social amoebae, Dictyostelium discoideum and Dictyostelium purpureum, were identified, showing sesquiterpene synthase activity for one and diterpene synthase activity for the other two enzymes. Site- ... ...

Abstract	The products of three terpene synthases from two social amoebae, Dictyostelium discoideum and Dictyostelium purpureum, were identified, showing sesquiterpene synthase activity for one and diterpene synthase activity for the other two enzymes. Site-directed mutagenesis experiments revealed the importance of a newly identfied highly conserved residue for catalytic activity. For one of the enzyme products, β-araneosene, a bromonium ion induced transannular cyclisation was investigated, yielding the first brominated derivatives of this diterpene.
MeSH term(s)	Alkyl and Aryl Transferases/biosynthesis ; Alkyl and Aryl Transferases/metabolism ; Biocatalysis ; Dictyostelium/enzymology ; Molecular Structure ; Terpenes/chemistry ; Terpenes/metabolism
Chemical Substances	Terpenes ; Alkyl and Aryl Transferases (EC 2.5.-) ; terpene synthase (EC 2.5.1.-)
Language	English
Publishing date	2019-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc07681f
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Article ; Online: Higher risk of intracranial aneurysms and subarachnoid haemorrhage in siblings of families with intracranial aneurysms.

Zuurbier, Ccm / Greving, J P / Rinkel, Gje / Ruigrok, Y M

European stroke journal

2019 Volume 5, Issue 1, Page(s) 73–77

Abstract: Introduction: First-degree relatives of patients with familial aneurysmal subarachnoid hemorrhage have an increased risk of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage. We assessed whether the type of kinship of first-degree ...

Abstract	Introduction: First-degree relatives of patients with familial aneurysmal subarachnoid hemorrhage have an increased risk of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage. We assessed whether the type of kinship of first-degree relatives of aneurysmal subarachnoid hemorrhage patients influences this risk. Patients and methods: We used all available data from the prospectively collected database of families consulting our outpatient clinic between 1994-2016. We constructed pedigrees for all families with ≥2 first-degree relatives with aneurysmal subarachnoid hemorrhage or unruptured intracranial aneurysms. The proband was defined as the first family member with aneurysmal subarachnoid hemorrhage who sought medical attention. We compared both the proportion of aneurysmal subarachnoid hemorrhage and unruptured intracranial aneurysms in proband's first-degree relatives by calculating relative risks (RR) with children as the reference. Results: We studied 154 families with 1,105 first-degree relatives of whom 146 had aneurysmalsubarachnoid hemorrhage. Unruptured intracranial aneurysms were identified in 63 (19%) of the 326 screened relatives. Siblings had a higher risk of aneurysmal subarachnoid hemorrhage (RR:1.62, 95% CI:1.12-2.38) and parents a lower risk (RR:0.44, 95% CI:0.24-0.81) than children. Siblings also had a higher risk of unruptured intracranial aneurysms (RR:2.28, 95% CI:1.23-4.07, age-adjusted RR:2.04, 95% CI:1.07-3.92) than children.
Language	English
Publishing date	2019-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2851287-X
ISSN	2396-9881 ; 2396-9873
ISSN (online)	2396-9881
ISSN	2396-9873
DOI	10.1177/2396987319868048
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Article ; Online: Mechanistic divergence between (4

Xu, Houchao / Rinkel, Jan / Chen, Xinlu / Köllner, Tobias G / Chen, Feng / Dickschat, Jeroen S

Organic & biomolecular chemistry

2020 Volume 19, Issue 2, Page(s) 370–374

Abstract: The main product of DpTPS9 from the social amoeba Dictyostelium purpureum was identified as (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol that is also known as an intermediate of bacterial geosmin synthase, but the experimentally verified cyclisation ... ...

Abstract	The main product of DpTPS9 from the social amoeba Dictyostelium purpureum was identified as (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol that is also known as an intermediate of bacterial geosmin synthase, but the experimentally verified cyclisation mechanisms differ. Together with the low sequence identity this points to convergent evolution. The functionality of selected residues in DpTPS9 was investigated via site-directed mutagenesis experiments.
MeSH term(s)	Cyclization ; Dictyostelium/enzymology ; Ligases/genetics ; Ligases/metabolism ; Mutagenesis, Site-Directed ; Sesquiterpenes, Germacrane/metabolism ; Species Specificity ; Streptomyces coelicolor/enzymology
Chemical Substances	Sesquiterpenes, Germacrane ; Ligases (EC 6.-)
Language	English
Publishing date	2020-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d0ob02361b
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Article ; Online: Screening for intracranial aneurysms in persons ⩾35 years with hypertension and atherosclerotic disease who smoke(d).

Mensing, Liselore A / van Tuijl, Rick J / de Kort, Gerard A / van der Schaaf, Irene C / Visseren, Frank L / Rinkel, Gabriel Je / Velthuis, Birgitta K / Ruigrok, Ynte M

European stroke journal

2023 Volume 8, Issue 4, Page(s) 1071–1078

Abstract: ... subgroups (e.g. women older than 50 years of age) or other ethnic populations should be the subject ...

Abstract	Introduction: Lifetime risk of aneurysmal subarachnoid haemorrhage (aSAH) is high (7%) in persons ⩾35 years with hypertension who smoke(d). Whether screening for intracranial aneurysms (IAs) to prevent aSAH is effective in these patients is unknown. Patients and methods: Participants were retrieved from a cohort of patients with clinically manifest atherosclerotic vascular disease included between 2012 and 2019 at the University Medical Centre Utrecht (SMART-ORACLE, NCT01932671) in whom CT-angiography (CTA) of intracranial arteries was performed. We selected patients ⩾35 years with hypertension who smoke(d). CTAs were reviewed for the presence of IAs by experienced neuroradiologists. Patients with IAs were offered follow-up imaging to detect aneurysmal growth. We determined aneurysm prevalence and developed a diagnostic model for IA risk at screening using multivariable logistic regression. Results: IA were found in 25 of 500 patients (5.0% prevalence, 95%CI: 3.3%-7.3%). Median 5 year risk of rupture assessed with the PHASES score was 0.9% (IQR: 0.7%-1.3%). During a median follow-up of 57 months (IQR: 39-83 months) no patients suffered from aSAH. Aneurysmal growth was detected in one patient for whom preventive treatment was advised. IA risk at screening ranged between 1.6% and 13.4% with predictors being age, female sex and current smoking. Discussion and conclusion: IA prevalence in persons ⩾35 years with hypertension and atherosclerotic vascular disease who smoke(d) was 5%. Given the very small proportion of IA that needed preventive treatment, we currently do not advise screening for Caucasian persons older than 35 years of age who smoke and have hypertension in general. Whether screening may be effective for certain subgroups (e.g. women older than 50 years of age) or other ethnic populations should be the subject of future studies.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Hypertension/epidemiology ; Intracranial Aneurysm/diagnostic imaging ; Logistic Models ; Smoking/adverse effects ; Subarachnoid Hemorrhage/diagnostic imaging ; Middle Aged
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2851287-X
ISSN	2396-9881 ; 2396-9873
ISSN (online)	2396-9881
ISSN	2396-9873
DOI	10.1177/23969873231193296
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