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  1. Article ; Online: Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans.

    Zou, Jiaxi / Xu, Weiming / Li, Ziyun / Gao, Ping / Zhang, Fangyuan / Cui, Yuting / Hu, Jingqing

    Annals of medicine

    2023  Volume 55, Issue 1, Page(s) 2218105

    Abstract: Background: Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat ...

    Abstract Background: Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat thromboangiitis obliterans (TAO), consisting of four Chinese herbs:
    Methods: Components, as well as potential targets of SMYAD in TAO therapy, were downloaded from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Subsequently, with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) server, the gene ontology (GO) biological processes and the Kyoto encyclopedia of genes and genomes (KEGG) signalling pathways of the targets enrichment were performed. Next, based on STRING online database, the protein interaction network of vital targets was built and analysed. Molecular docking and calculation of the binding affinity were performed using AutoDock. The PyMOL software was employed to observe docking outcomes of active compounds and protein targets. Based on the predicted outcomes of network pharmacology,
    Results: In the network pharmacology analysis, we obtained 105 chemical components in SMYAD and 24 therapeutic targets. We found that the mechanism SMYAD in TAO therapy was primarily associated with inflammation and angiogenesis by constructing multiple networks. Quercetin, vestitol and beta-sitosterol were important compounds, and interleukin-6 (IL6), MMP9, and VEGFA were key targets. According to molecular docking, active compounds (quercetin, vestitol and beta-sitosterol) and targets (IL6, MMP9 and VEGFA) showed good binding interactions. In
    Conclusions: This study showed that SMYAD improves TAO symptoms and inhibits the development of TAO. The mechanism could be associated with anti-inflammatory and therapeutic angiogenesis.
    MeSH term(s) Humans ; Animals ; Rats ; Thromboangiitis Obliterans/drug therapy ; Matrix Metalloproteinase 9 ; Network Pharmacology ; Quercetin ; Endothelial Cells ; Interleukin-6 ; Lipopolysaccharides ; Molecular Docking Simulation
    Chemical Substances si-miao-yong-an decoction ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Quercetin (9IKM0I5T1E) ; Interleukin-6 ; Lipopolysaccharides
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2218105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

    Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1038273

    Abstract: ... Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact ...

    Abstract Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites.
    Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed
    Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera
    Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1038273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.

    Cui, Yuting / Zhang, Fangyuan / Xu, Weiming / Li, Ziyun / Zou, Jiaxi / Gao, Ping / Hu, Jingqing

    BMC complementary medicine and therapies

    2023  Volume 23, Issue 1, Page(s) 220

    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Published Erratum
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-023-04057-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.

    Cui, Yuting / Zhang, Fangyuan / Xu, Weiming / Li, Ziyun / Zou, Jiaxi / Gao, Ping / Hu, Jingqing

    BMC complementary medicine and therapies

    2023  Volume 23, Issue 1, Page(s) 180

    Abstract: ... linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula ...

    Abstract Background: Coronary Artery Disease (CAD) is primarily caused by inflammation which is closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula with anti-inflammatory properties that found to be effective against CAD. However, it is still unclear whether SMYA can modulate gut microbiota and whether it contributes to the improvement of CAD by reducing inflammation and regulating the gut microbiota.
    Methods: The identification of components in the SMYA extract was conducted using the HPLC method. A total of four groups of SD rats were orally administered with SMYA for 28 days. The levels of inflammatory biomarkers and myocardial damage biomarkers were measured through ELISA, while echocardiography was used to assess heart function. Histological alterations in the myocardial and colonic tissues were examined following H&E staining. Western blotting was performed to evaluate protein expression, whereas alterations in gut microbiota were determined by 16 s rDNA sequencing.
    Results: SMYA was found to enhance cardiac function and decrease the expression of serum CK-MB and LDH. SMYA was also observed to inhibit the TLR4/NF-κB signaling pathway by downregulating the protein expression of myocardial TLR4, MyD88, and p-P65, leading to a reduction in serum pro-inflammatory factors. SMYA modified the composition of gut microbiota by decreasing the Firmicutes/Bacteroidetes ratio, modulating Prevotellaceae_Ga6A1 and Prevotellaceae_NK3B3 linked to the LPS/TLR4/NF-κB pathway, and increasing beneficial microbiota such as Bacteroidetes, Alloprevotella, and other bacterial species. Moreover, SMYA was found to safeguard the intestinal mucosal and villi structures, elevate the expression of tight junction protein (ZO-1, occludin), and reduce intestinal permeability and inflammation.
    Conclusions: The results indicate that SMYA has the potential to modulate the gut microbiota and protect the intestinal barrier, thereby reducing the translocation of LPS into circulation. SMYA was also found to inhibit the LPS-induced TLR4/NF-κB signaling pathway, leading to a decrease in the release of inflammatory factors, which ultimately mitigated myocardial injury. Hence, SMYA holds promise as a therapeutic agent for the management of CAD.
    MeSH term(s) Rats ; Animals ; NF-kappa B/metabolism ; Toll-Like Receptor 4/metabolism ; Lipopolysaccharides/pharmacology ; Gastrointestinal Microbiome ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/metabolism ; Signal Transduction ; Inflammation
    Chemical Substances NF-kappa B ; si-miao-yong-an decoction ; Toll-Like Receptor 4 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Tlr4 protein, rat
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-023-04013-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Teasing and Internet Harassment among Adolescents: The Mediating Role of Envy and the Moderating Role of the Zhong-Yong Thinking Style.

    Wang, Qiong / Tu, Ruilin / Jiang, Yihe / Hu, Wei / Luo, Xiao

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: ... whether these associations are mediated by envy and moderated by the Zhong-Yong thinking style. A total of 1811 Chinese ...

    Abstract Extant research studies have documented that teen victims of traditional bullying are more likely to be perpetrators of Internet harassment. Teasing is a typical form of verbal bullying, but, unfortunately, its link with Internet harassment perpetration has rarely been investigated to date. Therefore, this study constructed two moderated mediation models to explore the relation between weight-related/competency-related teasing (the two main types of teasing) and Internet harassment, and whether these associations are mediated by envy and moderated by the Zhong-Yong thinking style. A total of 1811 Chinese adolescents (
    MeSH term(s) Adolescent ; Adolescent Behavior/psychology ; Bullying ; Humans ; Internet ; Jealousy
    Language English
    Publishing date 2022-05-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans

    Jiaxi Zou / Weiming Xu / Ziyun Li / Ping Gao / Fangyuan Zhang / Yuting Cui / Jingqing Hu

    Annals of Medicine, Vol 55, Iss

    2023  Volume 1

    Abstract: AbstractBackground Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula ...

    Abstract AbstractBackground Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat thromboangiitis obliterans (TAO), consisting of four Chinese herbs: Lonicerae japonicae Thunb. (Jinyinhua), Scrophularia ningpoensis Hemsl. (Xuanshen), Angelica sinensis (Oliv.) Diels (Danggui) and Glycyrrhiza uralensis Fisch. (Gancao). However, the mechanism of SMYAD in TAO treatment remains unclear.Methods Components, as well as potential targets of SMYAD in TAO therapy, were downloaded from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Subsequently, with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) server, the gene ontology (GO) biological processes and the Kyoto encyclopedia of genes and genomes (KEGG) signalling pathways of the targets enrichment were performed. Next, based on STRING online database, the protein interaction network of vital targets was built and analysed. Molecular docking and calculation of the binding affinity were performed using AutoDock. The PyMOL software was employed to observe docking outcomes of active compounds and protein targets. Based on the predicted outcomes of network pharmacology, in vivo and in vitro tests were performed for validation. In vivo experiment, the TAO rats model was established using sodium laurate injection into the femoral artery. The symptoms as well as pathological changes of the femoral artery were observed. Besides, the predicted targets were verified by the RT-qPCR, in vitro experiment. The cell viability in LPS-induced human umbilical vein endothelial cells (HUVECs) was detected using CCK-8 kit, and the predicted targets were also verified by the RT-qPCR.Results In the network pharmacology analysis, we obtained 105 chemical components in SMYAD and 24 therapeutic targets. We found that the mechanism SMYAD in TAO therapy was primarily associated with inflammation and angiogenesis by constructing multiple networks. Quercetin, vestitol and beta-sitosterol were important compounds, ...
    Keywords Si-Miao-Yong-An decoction ; thromboangiitis obliterans ; network pharmacology ; mechanism ; molecular docking ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway

    Yuting Cui / Fangyuan Zhang / Weiming Xu / Ziyun Li / Jiaxi Zou / Ping Gao / Jingqing Hu

    BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: ... closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal ...

    Abstract Abstract Background Coronary Artery Disease (CAD) is primarily caused by inflammation which is closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula with anti-inflammatory properties that found to be effective against CAD. However, it is still unclear whether SMYA can modulate gut microbiota and whether it contributes to the improvement of CAD by reducing inflammation and regulating the gut microbiota. Methods The identification of components in the SMYA extract was conducted using the HPLC method. A total of four groups of SD rats were orally administered with SMYA for 28 days. The levels of inflammatory biomarkers and myocardial damage biomarkers were measured through ELISA, while echocardiography was used to assess heart function. Histological alterations in the myocardial and colonic tissues were examined following H&E staining. Western blotting was performed to evaluate protein expression, whereas alterations in gut microbiota were determined by 16 s rDNA sequencing. Results SMYA was found to enhance cardiac function and decrease the expression of serum CK-MB and LDH. SMYA was also observed to inhibit the TLR4/NF-κB signaling pathway by downregulating the protein expression of myocardial TLR4, MyD88, and p-P65, leading to a reduction in serum pro-inflammatory factors. SMYA modified the composition of gut microbiota by decreasing the Firmicutes/Bacteroidetes ratio, modulating Prevotellaceae_Ga6A1 and Prevotellaceae_NK3B3 linked to the LPS/TLR4/NF-κB pathway, and increasing beneficial microbiota such as Bacteroidetes, Alloprevotella, and other bacterial species. Moreover, SMYA was found to safeguard the intestinal mucosal and villi structures, elevate the expression of tight junction protein (ZO-1, occludin), and reduce intestinal permeability and inflammation. Conclusions The results indicate that SMYA has the potential to modulate the gut microbiota and protect the intestinal barrier, thereby reducing the translocation of LPS into circulation. ...
    Keywords Ischemia/Reperfusion ; Si-Miao-Yong-an ; Gut microbiota ; Intestinal permeability ; TLR4/NF-κB ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book: Yao yong zhi wu de jie gou, fa yu yu yao yong cheng fen de guan xi

    Hu, Zhenghai

    Research and application on allelophathy of medicinal plants

    2014  

    Author's details Hu Zhenghai zhu bian
    MeSH term(s) Plants, Medicinal/anatomy & histology ; Plant Extracts/pharmacology
    Keywords China
    Language Chinese
    Size 2, 3, 10, 646, 20 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787547822159 ; 7547822150
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Bing zheng tong yong Zhong yao

    Hu, Aiping

    2006  

    Title translation Commonly used materia medica.
    Author's details Hu Aiping bian zhu
    MeSH term(s) Materia Medica ; Medicine, Chinese Traditional
    Language Chinese
    Size 3, 2, 475 p.
    Edition Di 1 ban.
    Publisher Ren min wei sheng
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117075213 ; 711707521X
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Shi yong yao yong dong wu yang zhi ji shu

    Hu, Yuanliang

    2001  

    Author's details Hu Yuanliang zhu bian
    Keywords Animal culture ; Animal breeding ; Materia medica, Animal
    Language Chinese
    Size 4, 409 p. ;, 19 cm.
    Edition Di 1 ban.
    Publisher Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing Shi
    Document type Book
    ISBN 7109067688 ; 9787109067684
    Database NAL-Catalogue (AGRICOLA)

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