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  1. Article ; Online: The translation of oncogenic mRNAs regulated by pseudouridylation: A new player in HCC.

    Nakagawa, Hayato / Lin, Aifu

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: Intramural Esophageal Hematoma.

    Hamada, Yasuhiko / Aota, Takumi / Nakagawa, Hayato

    Internal medicine (Tokyo, Japan)

    2024  

    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3117-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Treatment for nonalcoholic steatohepatitis -current status and future prospects of pharmacotherapy].

    Nakagawa, Hayato

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2021  Volume 118, Issue 9, Page(s) 829–839

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy
    Language Japanese
    Publishing date 2021-08-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.118.829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.34: Show issues Location:
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    Zs.MO 477: Show issues

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  4. Article ; Online: Au-catalyzed stereodivergent synthesis of 2,5-disubstituted pyrrolidines: total synthesis of (+)-monomorine I and (+)-indolizidine 195B.

    Nakagawa, Hayato / Fuwa, Haruhiko

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 67, Page(s) 10121–10124

    Abstract: Stereodivergent synthesis of 2,5-disubstituted pyrrolidines was ... ...

    Abstract Stereodivergent synthesis of 2,5-disubstituted pyrrolidines was achieved
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc02453a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emerging Roles of Spatial Transcriptomics in Liver Research.

    Fujiwara, Naoto / Kimura, Genki / Nakagawa, Hayato

    Seminars in liver disease

    2024  

    Abstract: Spatial transcriptomics, leveraging sequencing- and imaging-based techniques, has emerged as a groundbreaking technology for mapping gene expression within the complex architectures of tissues. This approach provides an in-depth understanding of cellular ...

    Abstract Spatial transcriptomics, leveraging sequencing- and imaging-based techniques, has emerged as a groundbreaking technology for mapping gene expression within the complex architectures of tissues. This approach provides an in-depth understanding of cellular and molecular dynamics across various states of healthy and diseased livers. Through the integration of sophisticated bioinformatics strategies, it enables detailed exploration of cellular heterogeneity, transitions in cell states, and intricate cell-cell interactions with remarkable precision. In liver research, spatial transcriptomics has been particularly revelatory, identifying distinct zonated functions of hepatocytes that are crucial for understanding the metabolic and detoxification processes of the liver. Moreover, this technology has unveiled new insights into the pathogenesis of liver diseases, such as the role of lipid-associated macrophages in steatosis and endothelial cell signals in liver regeneration and repair. In the domain of liver cancer, spatial transcriptomics has proven instrumental in delineating intratumor heterogeneity, identifying supportive microenvironmental niches and revealing the complex interplay between tumor cells and the immune system as well as susceptibility to immune checkpoint inhibitors. In conclusion, spatial transcriptomics represents a significant advance in hepatology, promising to enhance our understanding and treatment of liver diseases.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/a-2299-7880
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    Zs.A 1752: Show issues Location:
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  6. Article ; Online: Clinico-histological and molecular features of hepatocellular carcinoma from nonalcoholic fatty liver disease.

    Fujiwara, Naoto / Nakagawa, Hayato

    Cancer science

    2023  Volume 114, Issue 10, Page(s) 3825–3833

    Abstract: Patients with nonalcoholic fatty liver disease (NAFLD) continue to increase with the epidemics of obesity, and NAFLD is estimated to become the most prevalent etiology of hepatocellular carcinoma (HCC). Recently, NAFLD-HCC has been recognized to have ... ...

    Abstract Patients with nonalcoholic fatty liver disease (NAFLD) continue to increase with the epidemics of obesity, and NAFLD is estimated to become the most prevalent etiology of hepatocellular carcinoma (HCC). Recently, NAFLD-HCC has been recognized to have clinico-histologically and molecularly distinct features from those from other etiologies, including a lower incidence rate of HCC and less therapeutic efficacy to immune checkpoint inhibitors (ICIs). Consistent with the clinical observations that up to 50% of NAFLD-HCC occurs in the absence of cirrhosis, the imbalance of pro- and antitumorigenic hepatic stellate cells termed as myHSC and cyHSC can contribute to the creation of an HCC-prone hepatic environment, independent of the absolute fibrosis abundance. Immune deregulations by accumulated metabolites in NAFLD-affected livers, such as a fatty-acid-induced loss of cytotoxic CD4 T cells serving for immune surveillance and "auto-aggressive" CXCR6+ CD8 T cells, may promote hepatocarcinogenesis and diminish therapeutic response to ICIs. Steatohepatitic HCC (SH-HCC), characterized by the presence of fat accumulation in tumor cells, ballooned tumor cells, Mallory-Denk body, interstitial fibrosis, and intratumor immune cell infiltration, may represent a metabolic reprogramming for adapting to a lipid-rich tumor microenvironment by downregulating CPT2 and leveraging its intermediates as an "oncometabolite." Genome-wide analyses suggested that SH-HCC may be more responsive to ICIs given its mutual exclusiveness with β-catenin mutation/activation that promotes immune evasion. Thus, further understanding of NAFLD-specific hepatocarcinogenesis and HCC would enable us to improve the current daily practice and eventually the prognoses of patients with NAFLD.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15925
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  7. Article ; Online: Site preference and local structural stability of Bi(III) substitution in hydroxyapatite using first-principles simulations.

    Quindoza, Gerardo Martin / Nakagawa, Yasuhiro / Mizuno, Hayato Laurence / Anraku, Yasutaka / Espiritu, Richard / Ikoma, Toshiyuki

    Physical chemistry chemical physics : PCCP

    2024  

    Abstract: Bismuth (Bi(III)) substitution in hydroxyapatite (HAp) lattice confers unique properties such as antibacterial, catalytic, radiosensitization, and conductive properties while preserving the innate bioactivity. Understanding the local structural changes ... ...

    Abstract Bismuth (Bi(III)) substitution in hydroxyapatite (HAp) lattice confers unique properties such as antibacterial, catalytic, radiosensitization, and conductive properties while preserving the innate bioactivity. Understanding the local structural changes upon Bi
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d4cp00864b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early Uvular Cancer Detected by Esophagogastroduodenoscopy.

    Hamada, Yasuhiko / Tanaka, Kyosuke / Horiki, Noriyuki / Nakagawa, Hayato

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 20, Page(s) 3141–3142

    MeSH term(s) Endoscopy, Digestive System ; Humans ; Neoplasms ; Uvula
    Language English
    Publishing date 2022-03-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.9295-21
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    Zs.A 240: Show issues Location:
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  9. Article ; Online: Endoscopic submucosal dissection of an early-stage gastric tumor with minimal bleeding using full-time red dichromatic imaging.

    Ikenoyama, Yohei / Iri, Ayaka / Imai, Hajime / Nakagawa, Hayato

    Endoscopy

    2022  Volume 54, Issue S 02, Page(s) E1001–E1002

    Language English
    Publishing date 2022-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1887-6024
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    Zs.MO 162: Show issues

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  10. Article ; Online: Rectal Condyloma Acuminatum.

    Ikenoyama, Yohei / Hamada, Yasuhiko / Katoh, Daisuke / Nakagawa, Hayato

    Mayo Clinic proceedings

    2022  Volume 97, Issue 6, Page(s) 1156–1157

    MeSH term(s) Condylomata Acuminata/diagnosis ; Condylomata Acuminata/surgery ; Humans
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.03.007
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