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  1. Article: Coexistence of blaNDM and blaOXA-48 Genes in Carbapenem-Resistant Burkholderia pseudomallei Isolated From Pus: A Rare Phenomenon.

    Verma, Gaurav / Singh, Nipa / Mohanty, Ambika / Patro, A Raj Kumar / Pattnaik, Dipti

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50671

    Abstract: ... ...

    Abstract Burkholderia
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Perceived Barriers in Delivering Optimal Healthcare Services in a Dedicated COVID-19 Hospital: Perspectives of Health-Service Providers.

    Singh, Nipa / Mohapatra, Ipsa / Singh, Subhasish / Srivastava, Varsha / Mishra, Krishna

    Cureus

    2022  Volume 14, Issue 10, Page(s) e30188

    Abstract: Background The coronavirus disease 2019 (COVID-19) pandemic challenged the healthcare infrastructure, with health-service providers (HSPs) offering unconditional and unprejudiced service to admitted patients. During the first wave, due to the novelty of ... ...

    Abstract Background The coronavirus disease 2019 (COVID-19) pandemic challenged the healthcare infrastructure, with health-service providers (HSPs) offering unconditional and unprejudiced service to admitted patients. During the first wave, due to the novelty of the disease and the lack of clarity regarding its transmission in the initial phases of the evolution of the disease, the predominant fear was of contracting the disease while caring for patients. With the prevailing uncertainty in knowledge and management, this study was planned to identify the barriers to delivering optimal healthcare to COVID-19 patients. Methodology A cross-sectional study was conducted among HSPs working in the first phase of a dedicated 500-bed government COVID-19 hospital at Kalinga Institute of Medical Sciences using an online questionnaire with the following five aspects: workplace guidelines and support, protective equipment, access to information regarding updates on the epidemic, overall self-reported stress and workplace stress about self-infection with COVID-19 and family being infected, and demographics. All HSPs aged 18 years or above, who were working either on a full- or a part-time basis, were able to understand the English language, and who were working in the COVID-19 hospital and gave digital informed consent (via Google Forms) were included in the study. All data were collected, coded, tabulated, and analyzed using Google Forms in an Excel format and Epi Info software version 7.2.5.0. Results Of the 144 respondents contacted, 132 completed the survey, with a participation rate of 91.67%. About 52.27% of respondents were aged 21-30 years, 68.18% were females, and 56.06% were nurses. Challenges faced were "working in a new context" (40.91%), "the uncertainty and fear of being infected and infecting others"(31.06%), and "exhausted by the workload and protective gear" (18.94%). Moreover, 64.12% were aware of a workplace policy. Only 0.75% felt that their workload needed to be reduced; 2.27% felt the need for a penalty policy for hiding travel history, lack of quarantine compliance, avoiding the accumulation of face masks, and price inflation of face masks. The overall self-reported stress level was significantly associated with a lack of awareness of workplace policies and the fear of getting infected. Furthermore, 93.94% reported that they had an adequate supply of personal protective equipment. As high as 81.06% of the HSPs were "worried about being infected from COVID-19 during work," and 94.69% were "worried about their family being infected from COVID-19 due to their working in COVID-19 hospitals." Conclusions HSPs' perception of barriers in providing healthcare gave an insight into the problems being faced and helped improve the quality of services. The study highlighted the need of increasing awareness regarding the existing workplace policies among HSPs to promote preparedness during crisis management.
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Geometric morphometric analysis for sex determination using lateral cephalograms in Indian population: A preliminary study.

    Johnson, Abraham / Singh, Sraddha / Thomas, Anju / Chauhan, Nipa

    Journal of oral and maxillofacial pathology : JOMFP

    2021  Volume 25, Issue 2, Page(s) 364–367

    Abstract: Background: Orthodontic science centers primarily on the growth, development and advancement of the craniofacial structures. Geometric morphometrics (GMM) is a new approach for shape identification in forensic sciences.: Purpose: The aim of this ... ...

    Abstract Background: Orthodontic science centers primarily on the growth, development and advancement of the craniofacial structures. Geometric morphometrics (GMM) is a new approach for shape identification in forensic sciences.
    Purpose: The aim of this study was to examine the shape variation in the Indian sample in order to assess sexual dimorphism by application of two-dimensional GMM.
    Materials and methods: The sample comprised a total of 105 lateral cephalograms (54 males-51 females) of Angle's Class I malocclusion patients that were later subjected to principal component (PC) analysis and discriminant analysis.
    Results: The PC analysis showed over 96% of shape variation. The initial three PCs were statistically significant that depicted as 58.37% of total shape variability, with PC1 represent for the most significant variance 28.48%, PC2 described 18.83% and PC3 11.06%.
    Conclusion: Sex of an individual was clearly associated with occlusion of teeth and showed considerable variation. GMM is an alternative research tool and can be utilized for diagnosing individual characterization and classification of malocclusion.
    Language English
    Publishing date 2021-08-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/0973-029X.325242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Microbial Profile and Resistance Pattern of Pathogens Isolated From Long COVID Pneumonia Patients and Their Correlation to Clinical Outcome: Our Experience From a Tertiary Care Hospital.

    Rao, C Mohan / Rout, Pragyan / Pattnaik, Ashwini P / Singh, Nipa / Rajendran, Aarthi / Patro, Shubhransu

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23644

    Abstract: Background Coronavirus disease 2019 (COVID-19) patients with persistent symptoms for at least four weeks in spite of being reverse transcriptase-polymerase chain reaction (RTPCR) negative for COVID infection are defined as long COVID (wherein pulmonary ... ...

    Abstract Background Coronavirus disease 2019 (COVID-19) patients with persistent symptoms for at least four weeks in spite of being reverse transcriptase-polymerase chain reaction (RTPCR) negative for COVID infection are defined as long COVID (wherein pulmonary involvement is seen in a significant proportion of cases). The history of prolonged use of corticosteroids, broad-spectrum antibiotics, and associated comorbid conditions in these patients increases the possibility of infection with multidrug-resistant microbial strains. It may lead to a grave prognosis, hence appropriate microbiological evaluation and management at the earliest can have a better outcome. Methods A retrospective observational study was carried out among long COVID patients admitted to the Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India, a tertiary care hospital. Eighty-four patients admitted to the ICU or non-ICU ward in the hospital from April to October 2021 were included in the study. Antibiotics, as prescribed by our hospital antibiotic policy, were administered wherever required and were subsequently changed according to culture and sensitivity reports of the samples (sputum, endotracheal aspirates, or blood). An analysis of the antibiotic sensitivity patterns of the pathogens isolated was performed. The outcome after optimum medical management was assessed for survivors, discharge, or death. Results Out of the total of 84 patients, 41 samples (sputum, endotracheal aspirates or blood) were collected and sent for culture, of which 32 (78.1%) were found to be culture positive for pathogens. Among the pathogens isolated, there were 22 (69%) drug-resistant and 10 (31%) sensitive organisms. Among the 22 resistant pathogen isolates, 18 were Gram-negative species, the most common species being
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pathogens Isolated and Their Association With the Long-Term Outcome in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

    Rao, C Mohan / Sarbhai, Kinshuk / Subhankar, Saswat / Mohapatra, Amrut / Singh, Nipa / Panda, Prem S / Patro, Shubhransu / Pati, Sanghamitra

    Cureus

    2022  Volume 14, Issue 6, Page(s) e26174

    Abstract: Background: Most of the acute exacerbations of chronic obstructive pulmonary disease (COPD) are due to infections, mostly due to bacteria and viruses. There is a need to study the outcome of microbe-induced airway inflammation.: Materials and methods!# ...

    Abstract Background: Most of the acute exacerbations of chronic obstructive pulmonary disease (COPD) are due to infections, mostly due to bacteria and viruses. There is a need to study the outcome of microbe-induced airway inflammation.
    Materials and methods: It is an observational follow-up study from the pulmonary medicine department of Kalinga Institute of Medical Sciences with the participation of the Regional Medical Research
    Results: Out of 197 cases, the majority were elderly, males, smokers, and belonged to urban areas; in total, 102 (51.8%) microbes were isolated as etiological agents of infective exacerbation in which 19.79% were viruses and 23.35% were bacteria, while coinfection was found in 8.62% cases. Among the viruses, rhinovirus, influenza virus, and respiratory syncytial virus were the major isolates. Among the bacteria, mostly gram-negative organisms such as
    Conclusion:  Acute exacerbation of COPD was mostly seen in males in the age group of 61-80 years. Rhinovirus and influenza A virus were the two most common viral isolates, and among the bacterial isolates,
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.26174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical Course and Outcome of Critically Ill Clinical COVID-19 Pneumonia or Severe Acute Respiratory Illness.

    Rao, C Mohan / Jena, Sunil Kumar / Patnaik, Sibabratta / Singh, Nipa / Gupta, Saurabh / Priyadarshini, Subhadra / Pradhan, Sujit / Das, Sidhartha

    The Journal of the Association of Physicians of India

    2021  Volume 69, Issue 5, Page(s) 42–49

    MeSH term(s) COVID-19 ; Critical Illness ; Humans ; Intensive Care Units ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical, Laboratory and Radiological Profile of COVID-19 Patients during the Second Wave with Special Reference to Vaccination Status

    Debasis Behera / C Mohan Rao / Suman Kumar Jagaty / Nipa Singh / Saswat Subhankar / Vivek D Alone / Akash Deep / Sanghamitra Pati

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 5, Pp OC12-OC

    2022  Volume 16

    Abstract: Introduction: Coronavirus Disease-19 (COVID-19) has been creating havoc worldwide since the first report in December, 2019. Vaccination against the disease was thought to bring respite, reducing the severity of disease, morbidity and mortality. However, ... ...

    Abstract Introduction: Coronavirus Disease-19 (COVID-19) has been creating havoc worldwide since the first report in December, 2019. Vaccination against the disease was thought to bring respite, reducing the severity of disease, morbidity and mortality. However, considering the fact that no vaccine is fully efficient, people may get COVID-19 even after full vaccination. Aim: To determine the clinical, laboratory, radiological features of COVID-19 including the outcome and compare these between vaccinated and unvaccinated patients. Materials and Methods: The prospective observational study was conducted in a dedicated COVID-19 hospital in Odisha, India, from May 2021 to June 2021. Detailed history including symptoms and vaccination status, laboratory parameters, and radiological investigations were collected from 200 patients. The cases were classified as mild, moderate and severe as per the Ministry of Health and Family Welfare (MoHFW) guidelines. All the patients were followed till the end of hospital stay. The results were expressed as the mean±standard deviation and percentages. Chi-square test was used to compare the categorical variables, and unpaired t-test was used to compare two discrete variables. A p-value of less than 0.05 was considered significant. Results: Majority of the patients were unvaccinated (65%) and belonged to the age group of 39-59 years (58.5%). Among the non vaccinated patients, 32.3% had moderate disease, while 35.4% had severe disease. In the vaccinated group, 51.4% had moderate disease, whereas only 28.6% patients developed severe disease. Increased Neutrophil to Lymphocyte Ratio (NLR), D-dimer levels, and radiological evidence of pneumonia in chest radiology were witnessed in both groups. Inflammatory markers between the vaccinated and unvaccinated groups did not show any statistical significance (p>0.05). A total of 12 (6%) patients died, out of which five were vaccinated (p=0.6). Conclusion: Vaccination is found to be protective in terms of disease severity and mortality. Vaccination ...
    Keywords coronavirus disease-2019 ; morbidity ; mortality vaccines ; severe acute respiratory syndrome-coronavirus-2 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Bacteriological Profile of Pyoderma Cases Attending the Dermatology Department in a Tertiary Care Hospital

    Nipa Singh / Shakti Sovan Pradhan / Thana Sundar Sahoo / Ipsa Mohapatra / Jagadananda Jena / Dipti Pattnaik

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 12, Pp DC19-DC

    2020  Volume 23

    Abstract: Introduction: Pyoderma, a commonly found skin disease among the general population in developing countries, is a challenge to the dermatologists due to its changing spectrum and antibiotic susceptibility pattern. Aim: To know the prevalence of different ... ...

    Abstract Introduction: Pyoderma, a commonly found skin disease among the general population in developing countries, is a challenge to the dermatologists due to its changing spectrum and antibiotic susceptibility pattern. Aim: To know the prevalence of different types of pyoderma, causative organisms, their antibiotic susceptibility with special reference to prevalence of Methicillin-Resistant Staphylococcus aureus (MRSA). Materials and Methods: It was a prospective cross-sectional study which includes 402 clinically diagnosed cases of pyoderma who presented to the Department of Dermatology (both outdoor and indoor) from 15th May 2019-15th December 2019. Detailed history was taken and thorough clinical examination was done. Relevant investigations including bacterial culture and sensitivity were done. Descriptive statistics for both clinical and bacteriological characteristics were generated. Statistical comparison of categorical variables was undertaken using Chisquare test and a p-value of <0.05 was considered statistically significant. Results: The prevalence of pyoderma was 2.9%. Most of the pyoderma was observed in the 11-30 years of age group. Primary pyoderma (78.9%) was more common than secondary pyoderma, furuncle (45.1%) being the most common among primary pyodermas and infected eczema (43.5%) among secondary pyodermas. Staphylococcus aureus was the predominant organism isolated in 229 cases (out of 385 isolates, 59.5%). All the Staphylococcus aureus strains isolated were sensitive to vancomycin, 96.9% were sensitive to linezolid. Conclusion: Staphylococcus aureus was the primary pathogen causing pyodermas in this study. The antibiotic susceptibility pattern of the organisms isolated must be taken into account before starting therapeutic treatment.
    Keywords antibiotic susceptibility ; methicillin-resistant staphylococcus aureus ; primary and secondary pyoderma ; staphylococcus aureus ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Prevalence of ESBL in

    Singh, Nipa / Pattnaik, Dipti / Neogi, Dhruba Kumar / Jena, Jagadananda / Mallick, Bandana

    Journal of clinical and diagnostic research : JCDR

    2016  Volume 10, Issue 9, Page(s) DC19–DC22

    Abstract: Introduction: Resistance to common antibiotics is a matter of grave concern in treating infections in hospital settings especially in Intensive Care Units (ICUs). One of the most commonly used and effective group of antibiotics, cephalosporins, exhibit ... ...

    Abstract Introduction: Resistance to common antibiotics is a matter of grave concern in treating infections in hospital settings especially in Intensive Care Units (ICUs). One of the most commonly used and effective group of antibiotics, cephalosporins, exhibit resistance due to production of Extended Spectrum Beta- Lactamases (ESBLs). The prevalence of ESBL producing
    Aim: To determine the prevalence of ESBLs among
    Materials and methods: A cross sectional study was conducted over a period of 4 years (Sept 2011 to Sept 2015) in the Department of Microbiology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar. Consecutive non-duplicate isolates of
    Results: Out of 6800 samples, 1038 were
    Conclusion: This study has highlighted the high prevalence of ESBL producing
    Language English
    Publishing date 2016-09-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2016/21260.8544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prevalence of ESBL in Escherichia coli Isolates Among ICU Patients in a Tertiary Care Hospital

    Nipa Singh / Dipti Pattnaik / Dhruba Kumar Neogi / Jagadananda Jena / Bandana Mallick

    Journal of Clinical and Diagnostic Research, Vol 10, Iss 9, Pp DC19-DC

    2016  Volume 22

    Abstract: Introduction: Resistance to common antibiotics is a matter of grave concern in treating infections in hospital settings especially in Intensive Care Units (ICUs). One of the most commonly used and effective group of antibiotics, cephalosporins, exhibit ... ...

    Abstract Introduction: Resistance to common antibiotics is a matter of grave concern in treating infections in hospital settings especially in Intensive Care Units (ICUs). One of the most commonly used and effective group of antibiotics, cephalosporins, exhibit resistance due to production of Extended Spectrum BetaLactamases (ESBLs). The prevalence of ESBL producing Escherichia coli (E.coli) has increased throughout the world and is a major cause of treatment failure in ICUs. As per our knowledge studies were not available on the prevalence of ESBL producing E.coli in ICUs of this region. Aim: To determine the prevalence of ESBLs among Escherichia coli isolates in ICUs of a tertiary care hospital. Materials and Methods: A cross sectional study was conducted over a period of 4 years (Sept 2011 to Sept 2015) in the Department of Microbiology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar. Consecutive non-duplicate isolates of E.coli recovered from 6800 clinical samples of patients admitted to different Intensive Care Units (ICUs) were subjected to ESBL screening test and then to CLSI recommended Phenotypic Confirmatory Disc Diffusion Tests (PCDDT) for ESBL production determination. Results: Out of 6800 samples, 1038 were E.coli isolates and 452(44%) were resistant to third generation cephalosporins. ESBL producing Escherichia coli among them were 276 (61.1%). Paediatric ICU showed the highest prevalence of ESBL E.coli at 80.9%. The highest prevalence of ESBL E.coli was in urine samples (82.6%) followed by pus (9.8%). The most effective antibiotic for ESBL producers was imipenem (96.7% sensitive), followed by amikacin (88.4%) and piperacillin- tazobactum (87%). Conclusion: This study has highlighted the high prevalence of ESBL producing E.coli in the ICUs of our hospital. An in depth analysis of their antibiogram will be helpful in formulating the antibiotic policy and prevent spread of ESBL strains. It is recommended that ESBL testing should be done routinely to curtail antibiotic resistance and to effectively ...
    Keywords antibiogram ; imipenem ; phenotypic confirmatory disc diffusion test ; Medicine ; R
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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