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  1. Article ; Online: Prenatal Diagnosis of Lissencephaly Associated with Biallelic Pathologic Variants in the COQ2 Gene.

    Rosado Santos, Rita / Rodrigues, Márcia / Loureiro, Teresa

    Acta medica portuguesa

    2022  Volume 36, Issue 6, Page(s) 428–431

    Abstract: Primary CoQ10 deficiency comprises several clinical phenotypes. Nevertheless, there are no reports so far of lissencephaly linked to CoQ10 deficiency. Lissencephaly is a developmental condition associated with defective neuronal migration which may be ... ...

    Abstract Primary CoQ10 deficiency comprises several clinical phenotypes. Nevertheless, there are no reports so far of lissencephaly linked to CoQ10 deficiency. Lissencephaly is a developmental condition associated with defective neuronal migration which may be depicted on fetal neurosonography by persistence of a laminar pattern beyond 34 weeks and abnormal cortical sulcation. We report an index case of a male fetus diagnosed with abnormal lamination, characterized by the persistence of a laminar pattern during late pregnancy, following a normal second trimester scan. Post-natal whole exome sequencing revealed biallelic pathologic variants in the COQ2 gene which encodes an enzyme that is part of coenzyme Q10 (COQ10 or ubiquinone) pathway and is involved in the biosynthesis of CoQ, a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This case underscores the heterogeneity of the prenatal phenotypic presentation of pathogenic variants in the COQ2, namely lissencephaly.
    MeSH term(s) Female ; Humans ; Male ; Pregnancy ; Lissencephaly/diagnostic imaging ; Lissencephaly/genetics ; Prenatal Diagnosis ; Vitamins
    Chemical Substances Vitamins
    Language English
    Publishing date 2022-09-28
    Publishing country Portugal
    Document type Case Reports ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.18606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2343: Show issues Location:
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  2. Article ; Online: Uterine preservation with Alcides-Pereira's compressive sutures for postpartum uterine atony.

    Santos, Rita Rosado / Martins, Inês / Clode, Nuno / Santo, Susana

    European journal of obstetrics, gynecology, and reproductive biology

    2022  Volume 277, Page(s) 27–31

    Abstract: Introduction: Postpartum hemorrhage (PPH) is mostly caused by uterine atony and is the leading cause of maternal death. Hysterectomy may be necessary in severe cases, but uterine compressive sutures are an uterine-sparing alternative. In 2005, Alcides ... ...

    Abstract Introduction: Postpartum hemorrhage (PPH) is mostly caused by uterine atony and is the leading cause of maternal death. Hysterectomy may be necessary in severe cases, but uterine compressive sutures are an uterine-sparing alternative. In 2005, Alcides Pereira proposed a technique with serial superficial stiches around the uterus. To date, there were no further reports on its clinical use.
    Objective: To evaluate a tertiary center's experience with Alcides-Pereira's compressive uterine sutures for severe PPH due to uterine atony, reviewing its efficacy, morbidity, and impact on reproductive outcomes.
    Study design: An 11-year retrospective cohort study of Alcides-Pereira's sutures for PPH at a single tertiary hospital. Demographic and obstetric data were collected. Details of subsequent pregnancies and fertility plans were collected through a telephonic interview. Comparison between women in which the sutures were effective and ineffective to prevent hysterectomy was made.
    Results: Alcides-Pereira's sutures were applied in 23 patients with PPH due to uterine atony. The technique was successful in controlling the hemorrhage and avoiding hysterectomy in 20 patients (87%). When successful, the sutures avoided the need for any blood therapy in 55% (RR 0.45, 95% CI 0.28-0.73) of patients, intensive care unit admission in 80% (RR 0.2, 95% CI 0.08-0.48) and significantly shortened the length of hospital stay. All patients with preserved uterus resumed their usual menstrual pattern. One had a subsequent term vaginal delivery; one had three first trimester miscarriages. All other patients did not try to conceive.
    Conclusion: Alcides-Pereira's sutures are a feasible, uterine-sparing technique, providing an effective and safe option for PPH.
    MeSH term(s) Chlorine Compounds ; Female ; Humans ; Oxides ; Postpartum Hemorrhage/etiology ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/surgery ; Postpartum Period ; Pregnancy ; Retrospective Studies ; Suture Techniques/adverse effects ; Sutures/adverse effects ; Uterine Inertia/surgery ; Uterus/surgery
    Chemical Substances Chlorine Compounds ; Oxides ; chlorine dioxide (8061YMS4RM)
    Language English
    Publishing date 2022-08-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2022.08.008
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    Zs.A 837: Show issues Location:
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  3. Article ; Online: Prevalence of SARS-CoV-2 infection in asymtomatic pregnant women and their partners in a tertiary care hospital in Portugal.

    Rosado Santos, Rita / Martins, Inês / Ayres-de-Campos, Diogo

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2020  Volume 35, Issue 15, Page(s) 3014–3015

    MeSH term(s) COVID-19/epidemiology ; Female ; Humans ; Portugal/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnant Women ; Prevalence ; SARS-CoV-2 ; Tertiary Care Centers
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Letter
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2020.1793323
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    Zs.A 3510: Show issues Location:
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  4. Article ; Online: Stieleria tagensis sp. nov., a novel member of the phylum Planctomycetota isolated from Tagus River in Portugal.

    Godinho, Ofélia / Klimek, Dominika / Jackiewicz, Adrianna / Guedes, Bárbara / Almeida, Eduarda / Calisto, Rita / Vitorino, Inês Rosado / Santos, José Diogo Neves / González, Ignacio / Lobo-da-Cunha, Alexandre / Calusinska, Magdalena / Quinteira, Sandra / Lage, Olga Maria

    Antonie van Leeuwenhoek

    2023  Volume 116, Issue 11, Page(s) 1209–1225

    Abstract: A bacterial strain was isolated from a brackish water sample of Tagus river, Alcochete, Portugal and was designated ... ...

    Abstract A bacterial strain was isolated from a brackish water sample of Tagus river, Alcochete, Portugal and was designated TO1_6
    MeSH term(s) Rivers/microbiology ; Fatty Acids/analysis ; Phospholipids/analysis ; Planctomycetes ; Sequence Analysis, DNA ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Portugal ; DNA, Bacterial/genetics ; DNA, Bacterial/chemistry ; Bacterial Typing Techniques
    Chemical Substances Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; DNA, Bacterial
    Language English
    Publishing date 2023-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 214861-4
    ISSN 1572-9699 ; 0003-6072
    ISSN (online) 1572-9699
    ISSN 0003-6072
    DOI 10.1007/s10482-023-01877-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prevalence of SARS-CoV-2 infection in asymtomatic pregnant women and their partners in a tertiary care hospital in Portugal

    Rosado Santos, Rita / Martins, Inês / Ayres-de-Campos, Diogo

    J Matern Fetal Neonatal Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646892
    Database COVID19

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  6. Article ; Online: Prevalence of SARS-CoV-2 infection in asymtomatic pregnant women and their partners in a tertiary care hospital in Portugal

    Rosado Santos, Rita / Martins, Inês / Ayres-de-Campos, Diogo

    The Journal of Maternal-Fetal & Neonatal Medicine

    2020  , Page(s) 1–2

    Keywords Obstetrics and Gynaecology ; Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ISSN 1476-7058
    DOI 10.1080/14767058.2020.1793323
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation.

    Rosado-Ramos, Rita / Godinho-Pereira, Joana / Marques, Daniela / Figueira, Inês / Fleming Outeiro, Tiago / Menezes, Regina / Nunes Dos Santos, Cláudia

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 11

    Abstract: Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson's Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the ... ...

    Abstract Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson's Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the brain, and for concomitant cellular pathologies that include oxidative stress and neuroinflammation. Neuroprotective activity of fisetin, a dietary flavonoid, was evaluated against main hallmarks of PD in relevant cellular models. At physiologically relevant concentrations, fisetin protected SH-SY5Y cells against oxidative stress overtaken by
    Language English
    Publishing date 2021-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26113353
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    Zs.MO 81: Show issues

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  8. Article ; Online: Assessment of microbiota present on a Portuguese historical stone convent using high-throughput sequencing approaches.

    Rosado, Tânia / Dias, Luís / Lança, Mónica / Nogueira, Carla / Santos, Rita / Martins, Maria Rosário / Candeias, António / Mirão, José / Caldeira, Ana Teresa

    MicrobiologyOpen

    2020  Volume 9, Issue 6, Page(s) 1067–1084

    Abstract: The study performed on the stone materials from the Convent of Christ revealed the presence of a complex microbial ecosystem, emphasizing the determinant role of microorganisms on the biodecay of this built cultural heritage. In this case study, the ... ...

    Abstract The study performed on the stone materials from the Convent of Christ revealed the presence of a complex microbial ecosystem, emphasizing the determinant role of microorganisms on the biodecay of this built cultural heritage. In this case study, the presence of Rubrobacter sp., Arthrobacter sp., Roseomonas sp., and Marinobacter sp. seems to be responsible for colored stains and biofilm formation while Ulocladium sp., Cladosporium sp., and Dirina sp. may be related to structural damages. The implementation of high-throughput sequencing approaches on the Convent of Christ's biodecay assessment allowed us to explore, compare, and characterize the microbial communities, overcoming the limitations of culture-dependent techniques, which only identify the cultivable population. The application of these different tools and insights gave us a panoramic view of the microbiota thriving on the Convent of Christ and signalize the main biodeteriogenic agents acting on the biodecay of stone materials. This finding highlighted the importance of performing metagenomic studies due to the improvements and the reduced amount of sample DNA needed, promoting a deeper and more detailed knowledge of the microbiota present on these dynamic repositories that support microbial life. This will further enable us to perform prospective studies in quarry and applied stone context, monitoring biogenic and nonbiogenic agents, and also to define long-term mitigation strategies to prevent biodegradation/biodeterioration processes.
    MeSH term(s) Archaeology ; Bacteria/classification ; Bacteria/genetics ; Bacteria/metabolism ; Biodegradation, Environmental ; DNA, Bacterial/genetics ; DNA, Fungal/genetics ; DNA, Ribosomal/genetics ; Ecosystem ; Fungi/classification ; Fungi/genetics ; Fungi/metabolism ; Geologic Sediments/microbiology ; High-Throughput Nucleotide Sequencing ; Microbiota/genetics ; Portugal
    Chemical Substances DNA, Bacterial ; DNA, Fungal ; DNA, Ribosomal
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661368-2
    ISSN 2045-8827 ; 2045-8827
    ISSN (online) 2045-8827
    ISSN 2045-8827
    DOI 10.1002/mbo3.1030
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  9. Article ; Online: Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation

    Rita Rosado-Ramos / Joana Godinho-Pereira / Daniela Marques / Inês Figueira / Tiago Fleming Outeiro / Regina Menezes / Cláudia Nunes dos Santos

    Molecules, Vol 26, Iss 3353, p

    2021  Volume 3353

    Abstract: Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the ... ...

    Abstract Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the brain, and for concomitant cellular pathologies that include oxidative stress and neuroinflammation. Neuroprotective activity of fisetin, a dietary flavonoid, was evaluated against main hallmarks of PD in relevant cellular models. At physiologically relevant concentrations, fisetin protected SH-SY5Y cells against oxidative stress overtaken by tert -butyl hydroperoxide ( t -BHP) and against methyl-4-phenylpyridinuim (MPP + )-induced toxicity in dopaminergic neurons, the differentiated Lund human Mesencephalic (LUHMES) cells. In this cellular model, fisetin promotes the increase of the levels of dopamine transporter. Remarkably, fisetin reduced the percentage of cells containing αsyn inclusions as well as their size and subcellular localization in a yeast model of αsyn aggregation. Overall, our data show that fisetin exerts modulatory activities toward common cellular pathologies present in PD; remarkably, it modulates αsyn aggregation, supporting the idea that diets rich in this compound may prove beneficial.
    Keywords α-synuclein ; dopamine transporter ; flavonoid ; Parkinson’s Disease ; Organic chemistry ; QD241-441
    Subject code 500
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.

    Rosado-Ramos, Rita / Poças, Gonçalo M / Marques, Daniela / Foito, Alexandre / M Sevillano, David / Lopes-da-Silva, Mafalda / Gonçalves, Luís G / Menezes, Regina / Ottens, Marcel / Stewart, Derek / Ibáñez de Opakua, Alain / Zweckstetter, Markus / Seabra, Miguel C / Mendes, César S / Outeiro, Tiago Fleming / Domingos, Pedro M / Santos, Cláudia N

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1918

    Abstract: Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for ...

    Abstract Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in PD pathogenesis, namely α-synuclein (αSyn) toxicity, aggregation and clearance. PEF was now subjected to a bio-guided fractionation with the aim of identifying the critical bioactive compound. We identified genipin, an iridoid, which relieves αSyn toxicity and aggregation. Furthermore, genipin promotes metabolic alterations and modulates lipid storage and endocytosis. Importantly, genipin was able to prevent the motor deficits caused by the overexpression of αSyn in a Drosophila melanogaster model of PD. These findings widens the possibility for the exploitation of genipin for PD therapeutics.
    MeSH term(s) Animals ; alpha-Synuclein/metabolism ; Drosophila melanogaster/metabolism ; Parkinson Disease/metabolism ; Iridoids/pharmacology ; Phenols ; Lipids
    Chemical Substances alpha-Synuclein ; genipin (A3V2NE52YG) ; Iridoids ; Phenols ; Lipids
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37561-2
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