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Article: Qian-Zheng-San

Wang, Zhi-Yong / Qin, Li-Hua / Zhang, Wei-Guang / Zhang, Pei-Xun / Jiang, Bao-Guo

2019 Volume 14, Issue 4, Page(s) 683–691

Abstract: Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx ... However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury ... Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were ...

Abstract	Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury. Therefore, we used Sprague-Dawley rats to investigate this. A sciatic nerve crush injury model was induced by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian-Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were not administered Qian-Zheng-San. Rats in sham group did not undergo surgery and systemic therapy. Footprint analysis was used to assess nerve motor function. Electrophysiological experiments were used to detect nerve conduction function. Immunofluorescence staining was used to assess axon counts and morphological analysis. Immunohistochemical staining was used to observe myelin regeneration of the sciatic nerve and the number of motoneurons in the anterior horn of the spinal cord. At 2 and 4 weeks postoperatively, the sciatic nerve function index, nerve conduction velocity, the number of distant regenerated axons and the axon diameter of the sciatic nerve increased in the Qian-Zheng-San treatment group compared with the control group. At 2 weeks postoperatively, nerve fiber diameter, myelin thickness, and the number of motor neurons in the lumbar spinal cord anterior horn increased in the Qian-Zheng-San treatment group compared with the control group. These results indicate that Qian-Zheng-San has a positive effect on peripheral nerve regeneration.
Language	English
Publishing date	2019-01-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.247472
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum for Zheng et al., "Characterization of the First Cultured Representative of '

Zheng, Rikuan / Cai, Ruining / Wang, Chong / Liu, Rui / Sun, Chaomin

mBio

2022 Volume 13, Issue 2, Page(s) e0065722

Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00657-22
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Article ; Online: Redescription of both Goniogryllus bistriatus Wu & Wang, 1992 and Callogryllus yunnanus Wu & Zheng, 1992 (Orthoptera: Gryllidae, Gryllinae).

Dai, Jin-Hong / Wang, Rui / Jing, Kai / Ma, Li-Bin

Zootaxa

2023 Volume 5375, Issue 4, Page(s) 582–588

Abstract: ... since then. Callogryllus yunnanus Wu & Zheng, 1992 also has a similar situation. Although the holotype is a male ... Goniogryllus bistriatus Wu & Wang, 1992 was described at the end of the last century, based ...

Abstract	Goniogryllus bistriatus Wu & Wang, 1992 was described at the end of the last century, based on the female holotype, and there have been no further studies or reports related to this species since then. Callogryllus yunnanus Wu & Zheng, 1992 also has a similar situation. Although the holotype is a male, its external genitalia have been lost. These issues pose obstacles to subsequent taxonomic research. Recently, we have successively discovered these two species in Huize County, Yunnan Province, China. To address the aforementioned taxonomic problems, this article describes the male specimens of the G. bistriatus and redescribes the female; meanwhile, since the original description of C. yunnanus lacked male genital characteristics, and we have also conducted a complete redescription of this species based on the new specimen.
MeSH term(s)	Male ; Female ; Animals ; Gryllidae ; Orthoptera ; China ; Animal Distribution ; Animal Structures ; Body Size ; Organ Size
Language	English
Publishing date	2023-11-24
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5375.4.9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hu-Qi-Zheng-Xiao Decoction Inhibits the Metastasis of Hepatocellular Carcinoma Cells by Suppressing the HIF-1α Signaling Pathway to Inhibit EMT, LCSC, and Angiogenic Process.

Wang, Xuejing / Yin, Ling / Chai, Mengyin / Kou, Buxin / Liu, Xiaoni / Wang, Xiaojun

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354231226126

Abstract: ... of the digestive system. Hu-Qi-Zheng-Xiao (HQZX) decoction has been clinically found to prolong the survival of patients ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a common clinical malignant tumor of the digestive system. Hu-Qi-Zheng-Xiao (HQZX) decoction has been clinically found to prolong the survival of patients with hepatocellular carcinoma and improve the quality of patients' survival, but its antitumor biological mechanism is still unclear. Methods: A nude mouse hollow fiber hepatocellular carcinoma model was constructed to analyze the in vivo efficacy of HQZX decoction against 7 different hepatocellular carcinoma cells. The subcutaneous graft tumor model was again validated. In vitro, the effect of HQZX decoction on the growth and metastasis of the cell line with the highest growth inhibition was evaluated. The cell line with the best efficacy response screened was again used to construct a hollow fiber hepatocellular carcinoma model and hollow fiber conduit cells were extracted to detect the expression of HIF-1α, VEGF, EMT-related molecules, LCSCs-related molecules, and to observe the density of the subcutaneous vascular network of hollow fiber conduits. The liver metastasis model of splenic injection was constructed to observe the effect of HQZX decoction on tumor metastasis. Results: The hollow fiber hepatocellular carcinoma model was evaluated for the efficacy of HQZX decoction, and it was found to have the highest growth inhibition of LM3-luc cells. In vitro, the CCK8 assay revealed that HQZX decoction could inhibit tumor migration and invasion and promote apoptosis. In addition, the mechanism study of extracting cells from hollow fiber tubes found that HQZX decoction could inhibit metastasis-associated HIF-1α, VEGF, EMT-related molecules, and LCSCs-related molecules expression. capillary network around subcutaneous fiber tubes was reduced in the HQZX decoction gavage group of mice. It inhibited tumor metastasis in nude mice. Conclusions: HQZX decoction inhibited the growth of a variety of hepatocellular carcinoma cells. HQZX decoction suppressed the expression of metastasis-associated VEGF, EMT-related molecules, and LCSCs-related molecules and inhibited tumor angiogenesis and growth and metastasis, which may be related to the inhibition of the HIF-1α signaling pathway. It reveals that HQZX decoction may be a promising herbal compound for anti-HCC therapy, and also reveals the accurate feasibility of the hollow fiber hepatocellular carcinoma model for in vivo pharmacodynamic evaluation and mechanism study.
MeSH term(s)	Humans ; Mice ; Animals ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/metabolism ; Mice, Nude ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; Signal Transduction ; Cell Proliferation
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354231226126
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Zs.A 6026: Show issues

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Article ; Online: Interactions between nitrogen and phosphorus modulate the food quality of the marine crop Pyropia haitanensis (T. J. Chang & B. F. Zheng) N. Kikuchi & M. Miyata (Porphyra haitanensis).

Xu, Ningning / Xu, Kai / Xu, Yan / Ji, Dehua / Wang, Wenlei / Xie, Chaotian

Food chemistry

2024 Volume 448, Page(s) 138973

Abstract: The quality of Pyropia haitanensis (T. J. Chang & B. F. Zheng) N. Kikuchi & M. Miyata ...

Abstract	The quality of Pyropia haitanensis (T. J. Chang & B. F. Zheng) N. Kikuchi & M. Miyata (Porphyra haitanensis) is directly affected by nutrient availability. However, the molecular mechanism underlying the synergistic regulatory effects of nitrogen (N) and phosphorus (P) availability on P. haitanensis quality is unknown. Here, we performed physiological and multi-omics analyses to reveal the combined effects of N and P on P. haitanensis quality. The pigments accumulated under high N because of increases in N metabolism and porphyrin metabolism, ultimately resulting in intensely colored thalli. High N also promoted amino acid metabolism and inosine 5'-mononucleotide (IMP) synthesis, but inhibited carbohydrates accumulation. This resulted in increased amino acid, IMP and decreased agaro-carrageenan and cellulose contents, thereby improving the nutritional value and taste. Furthermore, high P promoted carbon metabolism and amino acid metabolism.This study provided the basis for elucidating the mechanism behind N and P regulating the seaweed quality.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138973
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Article ; Online: Ezh2 knockout in B cells impairs plasmablast differentiation and ameliorates lupus-like disease in MRL/lpr mice: comment on the article by Zheng et al.

Huang, An-Fang / Xu, Wang-Dong

Arthritis & rheumatology (Hoboken, N.J.)

2023 Volume 75, Issue 11, Page(s) 2064–2065

MeSH term(s)	Animals ; Mice ; Mice, Inbred MRL lpr ; B-Lymphocytes ; Plasma Cells ; Cell Differentiation ; Lupus Erythematosus, Systemic/genetics ; Mice, Knockout
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42551
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Zs.A 24: Show issues

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Article ; Online: Applying latent tree analysis to classify Traditional Chinese Medicine syndromes (Zheng) in patients with psoriasis vulgari.

Xu, Wen-Jie / Zhang, Nevin-L / Li, Ping / Wang, Tian-Fang / Chen, Wei-Wen / Liu, April-H / Mohler-Kuo, Meichun

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2022 Volume 42, Issue 1, Page(s) 132–139

Abstract: ... must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments ... to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists ... of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency ...

Abstract	Objective: To treat patients with psoriasis vulgaris using Traditional Chinese Medicine (TCM), one must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists for psoriasis vulgaris. The present paper aims to classify patients with psoriasis vulgaris into different subtypes via the analysis of clinical TCM symptom and sign data. Methods: A cross-sectional survey was carried out in Beijing from 2005-2008, collecting clinical TCM symptom and sign data from 2764 patients with psoriasis vulgaris. Roughly 108 symptoms and signs were initially analyzed using latent tree analysis, with a selection of the resulting latent variables then used as features to cluster patients into subtypes. Results: The initial latent tree analysis yielded a model with 43 latent variables. The second phase of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency and wind dryness'; 'blood heat'; and 'blood stasis'. Conclusions: Via two-phase analysis of clinic symptom and sign data, three different Zheng subtypes were identified for psoriasis vulgaris. Statistical characteristics of the three subtypes are presented. This constitutes an evidence-based solution to the syndromedifferentiation problem that exists with psoriasis vulgaris.
MeSH term(s)	Cross-Sectional Studies ; Hot Temperature ; Humans ; Medicine, Chinese Traditional/methods ; Psoriasis/diagnosis ; Psoriasis/therapy ; Syndrome
Language	English
Publishing date	2022-03-19
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 2564: Show issues

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Book ; Online: A network-based biomarkers discovery of Cold/Hot ZHENG chronic gastritis and Cold/Hot herbs of formulae

Wang, Boyang / Chen, Pan / Zhang, Peng / Li, Shao

2023

Abstract: Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG (syndrome ... into Cold ZHENG (Asthenic Cold) and Hot ZHENG (Excess Hot). However, the molecular features of Cold/Hot ... ZHENG in CG and the mechanism of Cold/Hot herbs in formulae for CG remained unclear. Methods: Based ...

Abstract	Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG (syndrome in traditional Chinese medicine) chronic gastritis (CG) and Cold/Hot herbs in traditional Chinese medicine (TCM) formulae on systematic biology. Background: CG is a common inflammatory disease and the diagnosis of CG in TCM can be classified into Cold ZHENG (Asthenic Cold) and Hot ZHENG (Excess Hot). However, the molecular features of Cold/Hot ZHENG in CG and the mechanism of Cold/Hot herbs in formulae for CG remained unclear. Methods: Based on data of 35 patients of Cold/Hot ZHENG CG and 3 scRNA-seq CG samples, we conduct analysis with transcriptomics datasets and algorithms, to discover biomarkers for Cold/Hot ZHENG CG. And we collected 25 formulae (with traditional effects related to Cold/Hot ZHENG) for CG and corresponding 89 Cold/Hot herbs (including Warm/Cool herbs) to discover features and construct target networks of Cold/Hot herbs on the basis of network target and enrichment analysis. Results: Biomarkers of Cold/Hot ZHENG CG represented by CCL2 and LEP suggested that Hot ZHENG CG might be characterized by over-inflammation and exuberant metabolism, and Cold ZHENG CG showed a trend of suppression in immune regulation and energy metabolism. And biomarkers of Cold/Hot ZHENG showed also significant changes in the progression of gastric cancer. And biomarkers and pathways of Hot herbs intend to regulate immune responses and energy metabolism, while those of Cold herbs were likely to participate in anti-inflammation effect. Conclusion: In this study, we found that the biomarkers and mechanism of Cold/Hot ZHENG CG and those of Cold/Hot herbs were closely related to the regulation of immune and metabolisms. These findings may reflect the mechanism, build bridges between multiple views of Cold/Hot ZHENG and Cold/Hot herbs, and provide a research paradigm for further achieving precision TCM. Comment: 17 pages (references not included), 7 figures
Keywords	Quantitative Biology - Other Quantitative Biology
Subject code	669
Publishing date	2023-02-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new species of the genus Aalatettix Zheng amp; Mao (Orthoptera, Tetrigoidea, Tetrigidae) from China.

Wang, Li-Ming / Lu, Ying / Luo, Han

Zootaxa

2021 Volume 4974, Issue 1, Page(s) 188190

Abstract: This paper provides a new species of the genus Aalatettix Zheng Mao, 2002. The type specimens are ...

Abstract	This paper provides a new species of the genus Aalatettix Zheng Mao, 2002. The type specimens are deposited in the Insect Collection of College of Life Sciences, Xinyang Normal University, Xinyang, China.
MeSH term(s)	Animals ; China ; Orthoptera/classification
Language	English
Publishing date	2021-05-19
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4974.1.9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Letter by Zheng et al Regarding Article, "Impact of Initial Imaging Protocol on Likelihood of Endovascular Stroke Therapy".

Zheng, Feng / Zhou, Jianfeng / Liu, Chubin / Wang, Cui'e / Li, Yasong / Hu, Weipeng / Krischek, Boris

Stroke

2021 Volume 52, Issue 2, Page(s) e87–e88

MeSH term(s)	Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Humans ; Probability ; Stroke/diagnostic imaging ; Stroke/therapy
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.120.032586
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