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  1. Article ; Online: Fibroblast-Cardiomyocyte Interaction in Pediatric Restrictive Cardiomyopathy.

    Sato, Tatsuyuki / Ito, Masamichi

    Circulation journal : official journal of the Japanese Circulation Society

    2021  Volume 85, Issue 5, Page(s) 687–689

    Language English
    Publishing date 2021-03-06
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0100
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  2. Article ; Online: The roles of HIF-1α signaling in cardiovascular diseases.

    Sato, Tatsuyuki / Takeda, Norihiko

    Journal of cardiology

    2022  Volume 81, Issue 2, Page(s) 202–208

    Abstract: Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is delivered to every organ in the body. In several cardiovascular diseases or anemia, local oxygen tension drops below its physiological level and tissue hypoxia develops. ...

    Abstract Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is delivered to every organ in the body. In several cardiovascular diseases or anemia, local oxygen tension drops below its physiological level and tissue hypoxia develops. In such conditions, the expression of hypoxia-responsive genes increases to alleviate the respective condition. The hypoxia-responsive genes include the genes coding erythropoietin (EPO), vascular endothelial growth factor-A, and glycolytic enzymes. Hypoxia-inducible factor (HIF)-1α, HIF-2α, and HIF-3α are transcription factors that regulate the hypoxia-responsive genes. The HIF-α proteins are continuously degraded by an oxygen-dependent degrading pathway involving HIF-prolyl hydroxylases (HIF-PHs) and von Hippel-Lindau tumor suppressor protein. However, upon hypoxia, this degradation ceases and the HIF-α proteins form heterodimers with HIF-1β (a constitutive subunit of HIF), which results in the induction of hypoxia responsive genes. HIF-1α and HIF-2α are potential therapeutic targets for renal anemia, where EPO production is impaired due to chronic kidney diseases. Small molecule HIF-PH inhibitors are currently used to activate HIF-α signaling and to increase plasma hemoglobin levels by restoring EPO production. In this review, we will discuss the current understanding of the roles of the HIF-α signaling pathway in cardiovascular diseases. This will include the roles of HIF-1α in cardiomyocytes as well as in stromal cells including macrophages.
    MeSH term(s) Humans ; Anemia/etiology ; Cardiovascular Diseases ; Hypoxia ; Oxygen ; Signal Transduction ; Vascular Endothelial Growth Factor A ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
    Chemical Substances Oxygen (S88TT14065) ; Vascular Endothelial Growth Factor A ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2022-09-17
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2022.09.002
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  3. Article: Biosynthetic ability of diverse basidiomycetous yeast strains to produce the natural antioxidant ergothioneine.

    Sato, Shun / Saika, Azusa / Ushimaru, Kazunori / Koshiyama, Tatsuyuki / Higashiyama, Yukihiro / Fukuoka, Tokuma / Morita, Tomotake

    AMB Express

    2024  Volume 14, Issue 1, Page(s) 20

    Abstract: Sixteen strains of basidiomycetous yeasts were evaluated for their capability to produce ergothioneine (EGT), an amino acid derivative with strong antioxidant activity. The cells were cultured in either two synthetic media or yeast mold (YM) medium for ... ...

    Abstract Sixteen strains of basidiomycetous yeasts were evaluated for their capability to produce ergothioneine (EGT), an amino acid derivative with strong antioxidant activity. The cells were cultured in either two synthetic media or yeast mold (YM) medium for 72 h, after which cytosolic constituents were extracted from the cells with hot water. After analyzing the extracts via liquid chromatography-mass spectrometry (LC-MS), we found that all strains produced varying amounts of EGT. The EGT-producing strains, including Ustilago siamensis, Anthracocystis floculossa, Tridiomyces crassus, Ustilago shanxiensis, and Moesziomyces antarcticus, were subjected to flask cultivation in YM medium. U. siamensis CBS9960 produced the highest amount of EGT at 49.5 ± 7.0 mg/L after 120 h, followed by T. crassus at 30.9 ± 1.8 mg/L. U. siamensis was also cultured in a jar fermenter and produced slightly higher amounts of EGT than under flask cultivation. The effects of culture conditions, particularly the addition of precursor amino acids, on EGT production by the selected strains were also evaluated. U. siamensis showed a 1.5-fold increase in EGT production with the addition of histidine, while U. shanxiensis experienced a 1.8-fold increase in EGT production with the addition of methionine. These results suggest that basidiomycetous yeasts could serve an abundant source for natural EGT producers.
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2621432-5
    ISSN 2191-0855
    ISSN 2191-0855
    DOI 10.1186/s13568-024-01672-w
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  4. Article ; Online: Neuregulin-4, an Adipokine, as a Residual Risk Factor of Atherosclerotic Coronary Artery Disease.

    Sato, Tatsuyuki / Minatsuki, Shun

    International heart journal

    2019  Volume 60, Issue 1, Page(s) 1–3

    MeSH term(s) Adipokines ; Atherosclerosis ; Coronary Artery Disease ; Humans ; Neuregulins ; Risk Factors
    Chemical Substances Adipokines ; Neuregulins ; neuregulin-4
    Language English
    Publishing date 2019-01-14
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2187806-7
    ISSN 1349-3299 ; 1349-2365
    ISSN (online) 1349-3299
    ISSN 1349-2365
    DOI 10.1536/ihj.18-654
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  5. Article ; Online: IlluminatedZoom: spatially varying magnified vision using periodically zooming eyeglasses and a high-speed projector.

    Ueda, Tatsuyuki / Iwai, Daisuke / Sato, Kosuke

    Optics express

    2021  Volume 29, Issue 11, Page(s) 16377–16395

    Abstract: Spatial zooming and magnification, which control the size of only a portion of a scene while maintaining its context, is an essential interaction technique in augmented reality (AR) systems. It has been applied in various AR applications including ... ...

    Abstract Spatial zooming and magnification, which control the size of only a portion of a scene while maintaining its context, is an essential interaction technique in augmented reality (AR) systems. It has been applied in various AR applications including surgical navigation, visual search support, and human behavior control. However, spatial zooming has been implemented only on video see-through displays and not been supported by optical see-through displays. It is not trivial to achieve spatial zooming of an observed real scene using near-eye optics. This paper presents the first optical see-through spatial zooming glasses which enables interactive control of the perceived sizes of real-world appearances in a spatially varying manner. The key to our technique is the combination of periodically fast zooming eyeglasses and a synchronized high-speed projector. We stack two electrically focus-tunable lenses (ETLs) for each eyeglass and sweep their focal lengths to modulate the magnification periodically from one (unmagnified) to higher (magnified) at 60 Hz in a manner that prevents a user from perceiving the modulation. We use a 1,000 fps high-speed projector to provide high-resolution spatial illumination for the real scene around the user. A portion of the scene that is to appear magnified is illuminated by the projector when the magnification is greater than one, while the other part is illuminated when the magnification is equal to one. Through experiments, we demonstrate the spatial zooming results of up to 30% magnification using a prototype system. Our technique has the potential to expand the application field of spatial zooming interaction in optical see-through AR.
    MeSH term(s) Equipment Design ; Eyeglasses/standards ; Humans ; Light ; Optics and Photonics ; Refraction, Ocular/physiology ; User-Computer Interface
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.427616
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  6. Article ; Online: Lipid-lowering statin therapy is beneficial in elderly female patients with hypercholesterolaemia and diabetic retinopathy.

    Saito, Yoshihiro / Nakayama, Atsuko / Sato, Tatsuyuki / Morita, Hiroyuki / Kawahara, Takuya / Itoh, Hiroshi / Komuro, Issei

    European journal of preventive cardiology

    2021  Volume 28, Issue 8, Page(s) e7–e9

    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487320920761
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    Zs.A 4686: Show issues Location:
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  7. Article ; Online: Hyperpolarized

    Stewart, Neil J / Sato, Tatsuyuki / Takeda, Norihiko / Hirata, Hiroshi / Matsumoto, Shingo

    Antioxidants & redox signaling

    2021  Volume 36, Issue 1-3, Page(s) 81–94

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Inflammation/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Oxidation-Reduction ; Oxidative Stress
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2021.0139
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    Zs.A 5488: Show issues Location:
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  8. Article ; Online: A J-shaped Relationship between Sleep Duration and the Risk of Insulin Resistance in a General Japanese Population.

    Adachi, Hisashi / Matsumura, Akiko / Enomoto, Mika / Fukami, Ako / Morikawa, Nagisa / Nohara, Yume / Yamamoto, Maki / Sato, Hiromi / Kakuma, Tatsuyuki / Fukumoto, Yoshihiro

    Internal medicine (Tokyo, Japan)

    2023  Volume 62, Issue 4, Page(s) 511–517

    Abstract: Objective Data on the role of sleep in the risk of insulin resistance (IR) are lacking. We therefore examined the association between sleep duration and IR in a general Japanese population. Methods Data of 1,344 individuals 34 to 89 years old from the ... ...

    Abstract Objective Data on the role of sleep in the risk of insulin resistance (IR) are lacking. We therefore examined the association between sleep duration and IR in a general Japanese population. Methods Data of 1,344 individuals 34 to 89 years old from the Tanushimaru Study were analysed. IR was calculated using the fasting plasma glucose level×fasting insulin level/405, i.e. the homeostasis model assessment of IR (HOMA-IR). IR was defined as a HOMA-IR ≥1.73 based on the diagnostic criteria used in Japan. Information regarding sleep duration was collected via questionnaire. Results The frequencies of IR and metabolic syndrome (MetS) were 36.7% and 26.9%, respectively. A J-shaped relationship between sleep duration and IR was observed, and the same relationship was also shown between sleep duration and MetS; however, the relationship with MetS disappeared after adjusting for age, sex, and other confounding factors. Conclusion A J-shaped relationship was observed between sleep duration and the risks of IR in a general Japanese population.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Insulin Resistance ; Sleep Duration ; East Asian People ; Metabolic Syndrome/epidemiology ; Sleep ; Insulin
    Chemical Substances Insulin
    Language English
    Publishing date 2023-02-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.9538-22
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  9. Article ; Online: Illuminated Focus: Vision Augmentation using Spatial Defocusing via Focal Sweep Eyeglasses and High-Speed Projector.

    Ueda, Tatsuyuki / Iwai, Daisuke / Hiraki, Takefumi / Sato, Kosuke

    IEEE transactions on visualization and computer graphics

    2020  Volume 26, Issue 5, Page(s) 2051–2061

    Abstract: Aiming at realizing novel vision augmentation experiences, this paper proposes the IlluminatedFocus technique, which spatially defocuses real-world appearances regardless of the distance from the user's eyes to observed real objects. With the proposed ... ...

    Abstract Aiming at realizing novel vision augmentation experiences, this paper proposes the IlluminatedFocus technique, which spatially defocuses real-world appearances regardless of the distance from the user's eyes to observed real objects. With the proposed technique, a part of a real object in an image appears blurred, while the fine details of the other part at the same distance remain visible. We apply Electrically Focus-Tunable Lenses (ETL) as eyeglasses and a synchronized high-speed projector as illumination for a real scene. We periodically modulate the focal lengths of the glasses (focal sweep) at more than 60 Hz so that a wearer cannot perceive the modulation. A part of the scene to appear focused is illuminated by the projector when it is in focus of the user's eyes, while another part to appear blurred is illuminated when it is out of the focus. As the basis of our spatial focus control, we build mathematical models to predict the range of distance from the ETL within which real objects become blurred on the retina of a user. Based on the blur range, we discuss a design guideline for effective illumination timing and focal sweep range. We also model the apparent size of a real scene altered by the focal length modulation. This leads to an undesirable visible seam between focused and blurred areas. We solve this unique problem by gradually blending the two areas. Finally, we demonstrate the feasibility of our proposal by implementing various vision augmentation applications.
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2020.2973496
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  10. Article ; Online: Successful Transvenous Pacemaker Implantation via Re-Directed Left Superior Vena Cava.

    Sato, Tatsuyuki / Ishida, Junichi / Kojima, Toshiya / Komuro, Issei

    Circulation journal : official journal of the Japanese Circulation Society

    2019  Volume 83, Issue 10, Page(s) 2082

    MeSH term(s) Adult ; Atrioventricular Block/diagnosis ; Atrioventricular Block/etiology ; Atrioventricular Block/physiopathology ; Atrioventricular Block/therapy ; Cardiac Pacing, Artificial ; Cardiac Surgical Procedures/adverse effects ; Heterotaxy Syndrome/complications ; Heterotaxy Syndrome/diagnostic imaging ; Heterotaxy Syndrome/surgery ; Humans ; Male ; Pacemaker, Artificial ; Treatment Outcome ; Vena Cava, Superior/abnormalities ; Vena Cava, Superior/diagnostic imaging ; Vena Cava, Superior/surgery
    Language English
    Publishing date 2019-03-29
    Publishing country Japan
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-19-0010
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