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Article ; Online: ECG of the Month.

Owens, Eric J / LeBlanc, Nicole L / Santilli, Roberto A / Scollan, Katherine F

Journal of the American Veterinary Medical Association

2021 Volume 258, Issue 4, Page(s) 375–378

MeSH term(s)	Animals ; Electrocardiography/veterinary
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.258.4.375
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Article ; Online: A study of the inter- and intra-operator variability on selected echocardiographic measurements in dogs.

Ghilardi, Sara / Pradelli, Danitza / Rizzi, Rita / Polli, Michele / Bagardi, Mara / Santilli, Roberto A / Brambilla, Paola G / Bussadori, Claudio M

Veterinary research communications

2023 Volume 47, Issue 4, Page(s) 2323–2331

Abstract: Standard transthoracic echocardiography is considered the non-invasive gold standard for the diagnosis of most cardiac diseases. Defining reproducibility, repeatability, and reliability of this exam is imperative to reduce errors in clinical evaluations. ...

Abstract	Standard transthoracic echocardiography is considered the non-invasive gold standard for the diagnosis of most cardiac diseases. Defining reproducibility, repeatability, and reliability of this exam is imperative to reduce errors in clinical evaluations. The present study aimed at: (1) evaluating the reproducibility and repeatability of 15 echocardiographic parameters in dogs by analyzing measurements obtained from several operators with different levels of experience and comparing them to the ones obtained from two board-certified operators (gold standards - GSs); (2) assessing whether different formative paths have an influence on the variability of the echocardiographic measurements. Fifty-one operators have been included in this study, along with two diplomates of the European College of Veterinary Internal Medicine - Cardiology. Ten dogs were enrolled, 5 Golden Retrievers and 5 Cavalier King Charles Spaniels. Echocardiographic examination was performed on each dog by one GS and several operators on the same day. Results show the highest deviation from the GS and a poor inter-operator reproducibility for the M-mode measurements of the interventricular septum and the left ventricular free wall. Differently, M-mode-obtained internal diameters of the left ventricle in systole and diastole, and measurements of the aortic annulus and root show moderate to excellent intra- and inter-operator reliability and a good concordance with the GSs, demonstrating that all the operators correctly assess left ventricular systolic function and dilation, and evaluate the aortic valve. Furthermore, a specialist clinical activity, more than the acquired theoretical knowledge, affects the reliability of the echocardiographic examination by reducing the difference from the GS' measurements.
MeSH term(s)	Humans ; Dogs ; Animals ; Reproducibility of Results ; Echocardiography/veterinary ; Echocardiography/methods ; Ventricular Function, Left ; Systole
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-023-10154-6
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Zs.A 3453: Show issues

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Article ; Online: Localization and characterization of atrial depolarization waves on the surface electrocardiogram in dogs with rapid supraventricular tachycardia.

Battaia, Stefano / Perego, Manuela / Cavallini, Damiano / Santilli, Roberto

Journal of veterinary internal medicine

2023 Volume 37, Issue 6, Page(s) 1992–2002

Abstract: Background: Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations.: Objectives: To locate and characterize atrial deflections ( ... ...

Abstract	Background: Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations. Objectives: To locate and characterize atrial deflections (ADs) on 12-lead electrocardiograms in dogs with sustained rapid SVT and assess the utility of different electrocardiographic variables in differentiating types of tachycardia. Animals: Ninety-two dogs with orthodromic atrioventricular reciprocating tachycardia, 17 with atrial flutter, 33 with focal atrial tachycardia recorded and confirmed by electrophysiological study, and 40 dogs with sinus tachycardia. Methods: Atrial deflection position on the 12-lead surface electrocardiogram was assessed according to the sequence of intracardiac activation. Its features were evaluated together with the relationship between AD and QRS complex interval (AD-R) and QRS complex and AD interval (R-AD). Results: Orthodromic atrioventricular reciprocating tachycardia was characterized by an AD-AD interval of 213 ± 30 ms, mean electrical axis (MEA) of AD of -90 (-90/-78)°, R-AD interval of 75 (65-80) ms, and R-AD/AD-R of 0.54 (0.45-0.64). Atrial flutter was characterized by an AD-AD interval of 199 ± 57 ms, MEA of 76° (72/81), R-AD of 120 (72-144) ms, and R-AD/AD-R of 0.81 (0.63-1.13). Focal atrial tachycardia was characterized by an AD-AD interval of 270 ± 38 ms, MEA of 49 (-72/76)°, R-AD of 160 (120-200) ms, and R-AD/AD-R of 1.45 (0.92-1.67). Sinus tachycardia was characterized by an AD-AD interval of 292 ± 31 ms, MEA of 66° (52/73), R-AD of 215 (192-222) ms, and R-AD/AD-R of 2.68 (2.25-3.08). Conclusions and clinical importance: Analyzing AD on 12-lead electrocardiogram is helpful in differentiating the most common SVTs in dogs.
MeSH term(s)	Dogs ; Animals ; Atrial Flutter/veterinary ; Tachycardia, Sinus/diagnosis ; Tachycardia, Sinus/veterinary ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/veterinary ; Tachycardia/veterinary ; Electrocardiography/veterinary ; Tachycardia, Reciprocating/veterinary ; Dog Diseases/diagnosis
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16845
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Zs.A 4095: Show issues

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Article ; Online: ECG of the Month.

Sarcinella, Fabio / Dukes-McEwan, Joanna / Bode, Elizabeth F / Santilli, Roberto A

Journal of the American Veterinary Medical Association

2020 Volume 256, Issue 9, Page(s) 984–988

MeSH term(s)	Animals ; Electrocardiography/veterinary
Language	English
Publishing date	2020-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.256.9.984
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Zs.A 423: Show issues

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Article ; Online: ECG of the Month.

Pariaut, Romain / Oxford, Eva M / Santilli, Roberto A

Journal of the American Veterinary Medical Association

2018 Volume 252, Issue 11, Page(s) 1350–1353

MeSH term(s)	Animals ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/therapy ; Arrhythmias, Cardiac/veterinary ; Cardiac Resynchronization Therapy Devices/veterinary ; Cardiotonic Agents/therapeutic use ; Dogs ; Electrocardiography/veterinary ; Heart Diseases/diagnosis ; Heart Diseases/therapy ; Heart Diseases/veterinary ; Heart Failure/drug therapy ; Heart Failure/veterinary ; Male
Chemical Substances	Cardiotonic Agents
Language	English
Publishing date	2018-05-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.252.11.1350
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunofluorescent Localization of Plakoglobin Is Altered in Endomyocardial Biopsy Samples from Dogs with Clinically Relevant Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC).

Oxford, Eva M / Pariaut, Romain / Tursi, Massimiliano / Fox, Philip R / Santilli, Roberto A

Veterinary sciences

2021 Volume 8, Issue 11

Abstract: Diagnosing the early stages of canine Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is complicated by day-to-day arrhythmia variability, and absence of reliable, transthoracic echocardiographic features. Definitive diagnosis requires ... ...

Abstract	Diagnosing the early stages of canine Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is complicated by day-to-day arrhythmia variability, and absence of reliable, transthoracic echocardiographic features. Definitive diagnosis requires histopathologic identification of transmural fibrofatty replacement of the right ventricle. Reduction of immunofluorescent signal for plakoglobin (PG) at the intercalated disc (ID) is reported in ARVC-affected humans and boxers. Our objective was to determine whether reduced immunofluorescent signal for PG in endomyocardial biopsy samples (EMBs) correspond with a histopathologic diagnosis of ARVC. Here, 49 dogs were evaluated: 43 with advanced cardiac disease and 6 non-clinical boxers with mild to moderate ventricular arrhythmia (VA) burden. EMBs were obtained from all dogs; samples were prepared with antibodies recognizing cadherin (PC) and PG and evaluated with confocal microscopy. Investigators were blinded to breed and clinical status. ARVC was histopathologically diagnosed in 8 out of 49 dogs. Of these, three out of eight had clinical signs consistent with ARVC (two boxers, one English bulldog) and reduced PG signal at ID; five out of eight were non-clinical boxers with moderate VA and no reduction in PG. A total of 41 out of 49 dogs were histopathologically diagnosed with non-ARVC cardiac disease; 1 out of 41 showed reduction of PG at ID, while 40 out of 41 had no PG reduction. These results suggest that EMB PG signal is reduced in dogs with advanced ARVC, but not in the occult phase of the disease. Additionally, presence of PG at ID supports a diagnosis of non-ARVC cardiac disease in dogs with clinical signs. These results may offer an additional test that helps differentiate advanced ARVC from other myocardial diseases.
Language	English
Publishing date	2021-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci8110248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Electrocardiography of the dog and cat

Santilli, Roberto

2017

Language	English
Edition	second edition
Document type	Book
ISBN	9788821447846 ; 8821447847
Database	Special collection on veterinary medicine and general parasitology

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Article ; Online: Left Atrial Tachycardia and Third-Degree Atrioventricular Block in a Dog.

Côté, Etienne / O'Sullivan, M Lynne / Agarwal, Deepmala / Santilli, Roberto

CASE (Philadelphia, Pa.)

2022 Volume 6, Issue 2, Page(s) 83–86

Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2021.12.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunofluorescent Localization of Plakoglobin Is Altered in Endomyocardial Biopsy Samples from Dogs with Clinically Relevant Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Eva M. Oxford / Romain Pariaut / Massimiliano Tursi / Philip R. Fox / Roberto A. Santilli

Veterinary Sciences, Vol 8, Iss 248, p

2021 Volume 248

Abstract	Diagnosing the early stages of canine Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is complicated by day-to-day arrhythmia variability, and absence of reliable, transthoracic echocardiographic features. Definitive diagnosis requires histopathologic identification of transmural fibrofatty replacement of the right ventricle. Reduction of immunofluorescent signal for plakoglobin (PG) at the intercalated disc (ID) is reported in ARVC-affected humans and boxers. Our objective was to determine whether reduced immunofluorescent signal for PG in endomyocardial biopsy samples (EMBs) correspond with a histopathologic diagnosis of ARVC. Here, 49 dogs were evaluated: 43 with advanced cardiac disease and 6 non-clinical boxers with mild to moderate ventricular arrhythmia (VA) burden. EMBs were obtained from all dogs; samples were prepared with antibodies recognizing cadherin (PC) and PG and evaluated with confocal microscopy. Investigators were blinded to breed and clinical status. ARVC was histopathologically diagnosed in 8 out of 49 dogs. Of these, three out of eight had clinical signs consistent with ARVC (two boxers, one English bulldog) and reduced PG signal at ID; five out of eight were non-clinical boxers with moderate VA and no reduction in PG. A total of 41 out of 49 dogs were histopathologically diagnosed with non-ARVC cardiac disease; 1 out of 41 showed reduction of PG at ID, while 40 out of 41 had no PG reduction. These results suggest that EMB PG signal is reduced in dogs with advanced ARVC, but not in the occult phase of the disease. Additionally, presence of PG at ID supports a diagnosis of non-ARVC cardiac disease in dogs with clinical signs. These results may offer an additional test that helps differentiate advanced ARVC from other myocardial diseases.
Keywords	boxer ; English bulldog ; intercalated disc ; arrhythmias ; Veterinary medicine ; SF600-1100
Subject code	610 ; 630
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Localization and characterization of atrial depolarization waves on the surface electrocardiogram in dogs with rapid supraventricular tachycardia

Stefano Battaia / Manuela Perego / Damiano Cavallini / Roberto Santilli

Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 1992-

2023 Volume 2002

Abstract: Abstract Background Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations. Objectives To locate and characterize atrial deflections ...

Abstract	Abstract Background Supraventricular tachycardias (SVTs), despite having various anatomical substrates and pathophysiological mechanisms, frequently show similar electrocardiographic presentations. Objectives To locate and characterize atrial deflections (ADs) on 12‐lead electrocardiograms in dogs with sustained rapid SVT and assess the utility of different electrocardiographic variables in differentiating types of tachycardia. Animals Ninety‐two dogs with orthodromic atrioventricular reciprocating tachycardia, 17 with atrial flutter, 33 with focal atrial tachycardia recorded and confirmed by electrophysiological study, and 40 dogs with sinus tachycardia. Methods Atrial deflection position on the 12‐lead surface electrocardiogram was assessed according to the sequence of intracardiac activation. Its features were evaluated together with the relationship between AD and QRS complex interval (AD‐R) and QRS complex and AD interval (R‐AD). Results Orthodromic atrioventricular reciprocating tachycardia was characterized by an AD‐AD interval of 213 ± 30 ms, mean electrical axis (MEA) of AD of −90 (−90/−78)°, R‐AD interval of 75 (65‐80) ms, and R‐AD/AD‐R of 0.54 (0.45‐0.64). Atrial flutter was characterized by an AD‐AD interval of 199 ± 57 ms, MEA of 76° (72/81), R‐AD of 120 (72‐144) ms, and R‐AD/AD‐R of 0.81 (0.63‐1.13). Focal atrial tachycardia was characterized by an AD‐AD interval of 270 ± 38 ms, MEA of 49 (−72/76)°, R‐AD of 160 (120‐200) ms, and R‐AD/AD‐R of 1.45 (0.92‐1.67). Sinus tachycardia was characterized by an AD‐AD interval of 292 ± 31 ms, MEA of 66° (52/73), R‐AD of 215 (192‐222) ms, and R‐AD/AD‐R of 2.68 (2.25‐3.08). Conclusions and Clinical Importance Analyzing AD on 12‐lead electrocardiogram is helpful in differentiating the most common SVTs in dogs.
Keywords	atrial flutter ; electrocardiography ; electrophysiology ; focal atrial tachycardia ; orthodromic atrioventricular reciprocating tachycardia ; sinus tachycardia ; Veterinary medicine ; SF600-1100
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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