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  1. Article: Implementing Hospital Pharmacy Service Guideline in Nepal: A Critical Analysis.

    Khadka, Sitaram / Dc, Mahima / Maleku, Kabin / Thapa, Panna

    Hospital pharmacy

    2023  Volume 58, Issue 6, Page(s) 527–529

    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787231172383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical Pharmacy Practice in Low-and Middle-income Countries; Special Focus on Nepal

    Sitaram Khadka / Mahesh Khatri / Sabitri Lamichhane / Sagar Dhakal

    Journal of Karnali Academy of Health Sciences, Vol 5, Iss

    2022  Volume 1

    Abstract: The paradigm shift of pharmacy practice from the conventional compounding and dispensing role towards more advanced patient-centered care has a positive impact on the health care system. Not only has it rendered safe, appropriate, and cost-effective drug ...

    Abstract The paradigm shift of pharmacy practice from the conventional compounding and dispensing role towards more advanced patient-centered care has a positive impact on the health care system. Not only has it rendered safe, appropriate, and cost-effective drug therapy, but it also has optimized the therapeutic outcome. Though there is optimal growth of clinical pharmacy practice in the developed world, incorporating these new models into action has become a challenge for low-and middle-income countries (LMICs) like Nepal. Notably, the existing pharmacy curriculum is not updated to meet the current healthcare needs. Currently, the job opportunities are limited to manufacturing roles in pharmaceutical industries and as dispensers in community and retail pharmacies. Pharmacists and pharmacy practice have to evolve with the latest trends in demographics, epidemiology, societal factors, economy, and technological advances. It is high time that the policy-making bodies prepare and implement guidelines for strengthening clinical pharmacy practice in LMICs. The clinical pharmacy practice assures the rationalization of therapeutic outcomes with proper protocols, effort from the pharmacists, sound academic background and related training, and professional attitudes. This review sought to explore and expand the role of clinical pharmacists in healthcare settings, particularly in LMICs like Nepal.
    Keywords Pharmacists ; Developing Countries ; Nepal ; Professionalism ; Patient-Centered Care ; Medicine (General) ; R5-920
    Subject code 300
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Karnali Academy of Health Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Preventing COVID-19 in low- and middle-income countries.

    Khadka, Sitaram / Hashmi, Furqan K / Usman, Muhammad

    Drugs & therapy perspectives : for rational drug selection and use

    2020  Volume 36, Issue 6, Page(s) 250–252

    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1197107-1
    ISSN 1179-1977 ; 1172-0360
    ISSN (online) 1179-1977
    ISSN 1172-0360
    DOI 10.1007/s40267-020-00728-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Association of urinary albumin-to-creatinine ratio with lipid abnormalities and glycemic control in patients with type 2 diabetes mellitus.

    Khadka, Sitaram / Yadav, Gopal K / Subedi, Prativa / Amgain, Kapil / Sharma, Arun / Joshi, Rinku

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 9, Page(s) 4329–4333

    Abstract: Introduction: While proteinuria aggravates dyslipidemia in diabetic patients, dyslipidemia further worsens proteinuria via inflammatory cytokines-mediated glomerular damage. Urinary albumin creatinine ratio (ACR) is an easy and reliable method of ... ...

    Abstract Introduction: While proteinuria aggravates dyslipidemia in diabetic patients, dyslipidemia further worsens proteinuria via inflammatory cytokines-mediated glomerular damage. Urinary albumin creatinine ratio (ACR) is an easy and reliable method of detecting proteinuria. This study aims to determine the association of ACR with lipid abnormalities and glycemic control in the Nepalese population.
    Methods: This was a cross-sectional study conducted among 201 diabetes patients visiting the outpatient department of internal medicine. Based on ACR values, patients were categorized as nonalbuminuric (less than 300 μg/mg) or albuminuric (more than 300 μg/mg). An unpaired
    Results: Albuminuric patients had higher mean cholesterol (192.8±53.5 vs. 184.2± 37.6;
    Conclusions: Urine ACR of more than 30 mg/gram was associated with higher triglyceride and low-density lipoprotein levels and lower high-density lipoprotein levels. The HbA1c level strongly correlates with the development of albuminuria.
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000001045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute Conjunctivitis among Patients Visiting the Outpatient Department of Ophthalmology in a Tertiary Care Centre.

    Shrestha, Ram / Rijal, Roshija Khanal / Kausar, Neyaz / Shrestha, Oshan / Rajkarnikar, Sagar / Chaudhary, Raina / Shrestha, Kabindra Lal / Khadka, Sitaram

    JNMA; journal of the Nepal Medical Association

    2024  Volume 62, Issue 269, Page(s) 24–26

    Abstract: Introduction: Conjunctivitis is a highly prevalent ocular disease that flares up every year. The humidity and high temperature favour the causative agents responsible for the epidemic. Acute infective conjunctivitis may be either viral or bacterial, a ... ...

    Abstract Introduction: Conjunctivitis is a highly prevalent ocular disease that flares up every year. The humidity and high temperature favour the causative agents responsible for the epidemic. Acute infective conjunctivitis may be either viral or bacterial, a distinct type of condition with unique clinical features and treatment approaches. The aim of the study was to find out the prevalence of acute conjunctivitis among patients visiting the outpatient Department of Ophthalmology in a tertiary care centre.
    Methods: This descriptive cross-sectional study was conducted among the patients visiting the outpatient Department of Ophthalmology. Data of 30 August 2023 to 30 September 2023 was collected between 21 November 2023 to 24 November 2023. All patients presenting in the Ophthalmology Department having complete hospital record were included in the study. Patients having missing data on the medical records of the hospital were excluded. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.
    Results: Among 5,507 patients, acute conjunctivitis was seen in 1240 (22.52%) (21.42-23.62, 95% Confidence Interval). The majority were male 732 (59.03%) and adults 760 (61.29%) with a mean age of 32.56±18.74 years.
    Conclusions: The prevalence of conjunctivitis among patients visiting the outpatient Department of Opthalmology was found to be higher than other studies done in similar settings.
    Keywords: conjunctivitis; disease outbreaks; enterovirus.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Adolescent ; Young Adult ; Middle Aged ; Outpatients ; Tertiary Care Centers ; Cross-Sectional Studies ; Conjunctivitis/epidemiology ; Acute Disease
    Language English
    Publishing date 2024-01-02
    Publishing country Nepal
    Document type Journal Article
    ZDB-ID 2209910-4
    ISSN 1815-672X ; 0028-2715
    ISSN (online) 1815-672X
    ISSN 0028-2715
    DOI 10.31729/jnma.8391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pharmacometrics: A New Era of Pharmacotherapy and Drug Development in Low- and Middle-Income Countries.

    Usman, Muhammad / Khadka, Sitaram / Saleem, Mohammad / Rasheed, Huma / Kunwar, Bimal / Ali, Moshin

    Advances in pharmacological and pharmaceutical sciences

    2023  Volume 2023, Page(s) 3081422

    Abstract: Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low- and middle-income countries (LMICs) although stupendous amounts of data are available regularly. The process of drug development is time-consuming, costly, and is ... ...

    Abstract Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low- and middle-income countries (LMICs) although stupendous amounts of data are available regularly. The process of drug development is time-consuming, costly, and is also associated with loads of hurdles related to the safety concerns of the compounds. This review was conducted with the objective to emphasize the role of pharmacometrics in pharmacotherapy and the drug development process in LMICs for rational drug therapy. Pharmacometrics is widely applied for the rational clinical pharmacokinetic (PK) practice through the population pharmacokinetic (popPK) modeling and physiologically based pharmacokinetic (PBPK) modeling approach. The scope of pharmacometrics practice is getting wider day by day with the untiring efforts of pharmacometricians. The basis for pharmacometrics analysis is the computer-based modeling and simulation of pharmacokinetics/pharmacodynamics (PK/PD) data supplemented by characterization of important aspects of drug safety and efficacy. Pharmacometrics can be considered an invaluable tool not only for new drug development with maximum safety and efficacy but also for dose optimization in clinical settings. Due to the convenience of using sparse and routine patient data, a significant advantage exists in this regard for LMICs which would otherwise lag behind in clinical trials.
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3026687-7
    ISSN 2633-4690 ; 2633-4682 ; 2633-4690
    ISSN (online) 2633-4690 ; 2633-4682
    ISSN 2633-4690
    DOI 10.1155/2023/3081422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Outcome of phacoemulsification without anti-vascular endothelial growth factor in patients with treatment naïve diabetic retinopathy.

    Rijal, Roshija Khanal / Adiga, Sushant / Pokharel, Kaushal / Dhakal, Sabin / Rijal, Thaneshwar / Khadka, Sitaram

    Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

    2023  Volume 14, Issue 28, Page(s) 33–40

    Abstract: Introduction: This retrospective, non-randomized, observational study was conducted at ASG Eye Hospital, Kathmandu to evaluate the outcome of phacoemulsification without anti-Vascular Endothelial Growth Factor (VEGF) in patients with treatment naïve ... ...

    Abstract Introduction: This retrospective, non-randomized, observational study was conducted at ASG Eye Hospital, Kathmandu to evaluate the outcome of phacoemulsification without anti-Vascular Endothelial Growth Factor (VEGF) in patients with treatment naïve diabetic retinopathy.
    Materials and methods: Records of all patients who underwent phacoemulsification without Bevacizumab in treatment of naïve patients with any grade of non-proliferative Diabetic Retinopathy (NPDR) were seen. Pre-operative and post-operative visual acuity along with central macular thickness (CMT) was compared.
    Results: The study comprised 32 eyes of 20 patients with treatment naïve non-proliferative Diabetic Retinopathy who underwent phacoemulsification. Twelve were men and eight were women with an average age of 69.2 years (range 55 years to 83 years). The average preoperative central macular thickness as measured on optical coherence tomography was 254.63± 20.25 microns and 1-month postoperative central macular thickness was 254.72± 19.96 microns; the study did not find any significant difference (p-value 0.918). The average difference in the central macular thickness between the 1-month postoperative and preoperative values was 0.09 microns.
    Conclusion: Uneventful phacoemulsification in eyes with treatment naïve diabetic retinopathy does not cause an increase in central macular thickness after surgery and thus anti-Vascular Endothelial Growth Factor as an adjunct is not mandatory.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Cataract Extraction ; Diabetes Mellitus ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/surgery ; Phacoemulsification ; Retrospective Studies ; Vascular Endothelial Growth Factors/antagonists & inhibitors ; Aged ; Aged, 80 and over
    Chemical Substances Vascular Endothelial Growth Factors
    Language English
    Publishing date 2023-08-08
    Publishing country Nepal
    Document type Observational Study ; Journal Article
    ZDB-ID 2596436-7
    ISSN 2091-0320 ; 2091-0320
    ISSN (online) 2091-0320
    ISSN 2091-0320
    DOI 10.3126/nepjoph.v14i2.46706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Health seeking behavior and self-medication practice among undergraduate medical students of a teaching hospital: A cross-sectional study.

    Khadka, Sitaram / Shrestha, Oshan / Koirala, Gaurab / Acharya, Utshab / Adhikari, Gopal

    Annals of medicine and surgery (2012)

    2022  Volume 78, Page(s) 103776

    Abstract: Introduction: Health seeking behavior is any activity undertaken by individuals who find themselves with a health-related problem with the aim of seeking an appropriate remedy. It includes decision making that is not homogenous among all as it is ... ...

    Abstract Introduction: Health seeking behavior is any activity undertaken by individuals who find themselves with a health-related problem with the aim of seeking an appropriate remedy. It includes decision making that is not homogenous among all as it is determined by different demographic factors. Self-medication and alternative medicine are also choices made by an individual that comes under health care seeking behavior. This study aimed to put light on the health seeking behavior of undergraduate medical students and to assess how they deal with their illnesses, including the practise of self-medication.
    Methods: In this web-based cross-sectional study, conducted among undergraduate medical students, a total of 210 students were selected through a systematic sampling method. The data were analyzed using SPSS version 20. Frequency was calculated for all the variables. The Mann-Whitney U or Kruskal-Wallis H test was used to see if any difference existed in the response. A significant association was declared at a p-value less than 0.05.
    Results: Response from 208 respondents was received and among those 88.9% of the respondents were aware of physical, mental and social aspects of health; about 40.8% of the respondents sought help only when their symptoms got worse; while 27.4% of them sought the help of alternative medicine. Around 74.2% of the respondents took medicines without a proper prescription and the commonly self-medicated drug group was NSAIDs.
    Conclusions: The knowledge of medical science has not satisfactorily ensured better health-seeking behavior and good practices. Also, there is high prevalence of self-medication practice among medical students.
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute Conjunctivitis among Patients Visiting the Outpatient Department of Ophthalmology in a Tertiary Care Centre

    Ram Shrestha / Roshija Khanal Rijal / Neyaz Kausar / Oshan Shrestha / Sagar Rajkarnikar / Raina Chaudhary / Kabindra Lal Shrestha / Sitaram Khadka

    Journal of Nepal Medical Association, Vol 62, Iss

    2024  Volume 269

    Abstract: Introduction: Conjunctivitis is a highly prevalent ocular disease that flares up every year. The humidity and high temperature favour the causative agents responsible for the epidemic. Acute infective conjunctivitis may be either viral or bacterial, a ... ...

    Abstract Introduction: Conjunctivitis is a highly prevalent ocular disease that flares up every year. The humidity and high temperature favour the causative agents responsible for the epidemic. Acute infective conjunctivitis may be either viral or bacterial, a distinct type of condition with unique clinical features and treatment approaches. The aim of the study was to find out the prevalence of acute conjunctivitis among patients visiting the outpatient Department of Ophthalmology in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among the patients visiting the outpatient Department of Ophthalmology. Data of 30 August 2023 to 30 September 2023 was collected between 21 November 2023 to 24 November 2023. All patients presenting in the Ophthalmology Department having complete hospital record were included in the study. Patients having missing data on the medical records of the hospital were excluded. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 5,507 patients, acute conjunctivitis was seen in 1240 (22.52%) (21.42-23.62, 95% Confidence Interval). The majority were male 732 (59.03%) and adults 760 (61.29%) with a mean age of 32.56±18.74 years. Conclusions: The prevalence of conjunctivitis among patients visiting the outpatient Department of Opthalmology was found to be higher than other studies done in similar settings.
    Keywords conjunctivitis ; disease outbreaks ; enterovirus ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nepal Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Assessment of rational use of antimicrobials: a cross-sectional study among people of Nepal.

    Khadka, Sitaram / Khadka, Sulochana / Yadav, Gopal K / Sharma, Arun / Giri, Santoshi / Joshi, Rinku / Amgain, Kapil

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 7, Page(s) 3372–3380

    Abstract: Inappropriate antimicrobial use leading to antimicrobial resistance is a matter of public health concern globally. This research was conducted with the objective of preventing antimicrobial misuse across knowledge, behavior, and practice domains among ... ...

    Abstract Inappropriate antimicrobial use leading to antimicrobial resistance is a matter of public health concern globally. This research was conducted with the objective of preventing antimicrobial misuse across knowledge, behavior, and practice domains among the general people of Nepal.
    Methods: It was a cross-sectional survey conducted among 385 participants visiting tertiary care center from all over Nepal from February 2022 to May 2022. Modified Bloom's cut-off point was utilized to categorize the participants' overall knowledge, behavior, and practice. The chi-square (
    Results: More than three-fifths of the participants (248, 64.42%) demonstrated good behavior, whereas less than half of the participants showed good knowledge (137, 35.58%) and practice (161, 41.82%) about rational use of antimicrobials. Health professionals had higher knowledge (OR: 1.07, 95% CI: 0.70-1.62) and good behavior (OR: 0.42, 95% CI: 0.27-0.64) than other professionals (
    Conclusions: The findings imply the demand for effective legislature, strict enforcement of the drug act, and proper implementation of plans and policies to curb antimicrobials misuse. Lack of execution of existing laws and the unawareness of the public led to the extravagant use of antimicrobials.
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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