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  1. Article ; Online: Intelligent-Critic-Based Tracking Control of Discrete-Time Input-Affine Systems and Approximation Error Analysis With Application Verification.

    Wang, Ding / Gao, Ning / Ha, Mingming / Zhao, Mingming / Wu, Junlong / Qiao, Junfei

    IEEE transactions on cybernetics

    2023  Volume PP

    Abstract: In recent years, the application of function approximators, such as neural networks and polynomials, has ushered in a new stage of development in solving optimal control problems. However, considering the existence of approximation errors, the stability ... ...

    Abstract In recent years, the application of function approximators, such as neural networks and polynomials, has ushered in a new stage of development in solving optimal control problems. However, considering the existence of approximation errors, the stability of the controlled system cannot be guaranteed. Therefore, in view of the prevalence of approximation errors, we investigate optimal tracking control problems for discrete-time systems. First, a novel value function is introduced into the intelligent critic framework. Second, an implicit method is utilized to demonstrate the boundedness of the iterative value functions with approximation errors. An explicit method is applied to prove the stability of the system with approximation errors. Furthermore, an evolving policy is designed to iteratively tackle the optimal tracking control problem and demonstrate the stability of the system. Finally, the effectiveness of the developed method is verified through numerical as well as practical examples.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2023.3312320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway.

    Ning, Tao / Guo, Huihui / Ma, Mingming / Zha, Zhengang

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 876

    Abstract: Background: Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression. Bromodomain-containing protein 4 (BRD4) is an important regulator for osteogenic ... ...

    Abstract Background: Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression. Bromodomain-containing protein 4 (BRD4) is an important regulator for osteogenic differentiation. Therefore, its role and mechanism in osteogenic differentiation process deserve further investigation.
    Methods: hBMSCs osteogenic differentiation was evaluated by flow cytometry, alkaline phosphatase assay and alizarin red staining. Western blot was used to test osteogenic differentiation-related proteins, BRD4 protein, WNT family members-4 (WNT4)/NF-κB-related proteins, and glycolysis-related proteins. Metabolomics techniques were used to detect metabolite changes and metabolic pathways. BRD4 and WNT4 mRNA levels were determined using quantitative real-time PCR. Dual-luciferase reporter assay and chromatin immunoprecipitation assay were performed to detect BRD4 and WNT4 interaction. Glycolysis ability was assessed by testing glucose uptake, lactic acid production, and ATP levels.
    Results: After successful induction of osteogenic differentiation, the expression of BRD4 was increased significantly. BRD4 knockdown inhibited hBMSCs osteogenic differentiation. Metabolomics analysis showed that BRD4 expression was related to glucose metabolism in osteogenic differentiation. Moreover, BRD4 could directly bind to the promoter of the WNT4 gene. Further experiments confirmed that recombinant WNT4 reversed the inhibition effect of BRD4 knockdown on glycolysis, and NF-κB inhibitors (Bardoxolone Methyl) overturned the suppressive effect of BRD4 knockdown on hBMSCs osteogenic differentiation.
    Conclusion: BRD4 promoted hBMSCs osteogenic differentiation by inhibiting NF-κB pathway via enhancing WNT4 expression.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Osteogenesis ; Nuclear Proteins/metabolism ; MicroRNAs/genetics ; Cell Differentiation ; Mesenchymal Stem Cells/metabolism ; Cells, Cultured ; Bone Marrow Cells/metabolism ; Wnt4 Protein/metabolism ; Wnt4 Protein/pharmacology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Cell Cycle Proteins
    Chemical Substances NF-kappa B ; Nuclear Proteins ; MicroRNAs ; WNT4 protein, human ; Wnt4 Protein ; BRD4 protein, human ; Transcription Factors ; Cell Cycle Proteins
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-04335-x
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  3. Article ; Online: Effects of fluorine bonding and nonbonding interactions on

    Lu, Yang / Sun, Mingming / Xi, Ning

    RSC advances

    2022  Volume 12, Issue 49, Page(s) 32082–32096

    Abstract: ... ...

    Abstract 19
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06660b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploration of cardiopulmonary resuscitation teamwork training for maternal cardiac arrest using the SimMan intelligent simulation platform: A simulation teaching study.

    Zhang, Ruirui / Liu, Yu / Zhang, Mingming / Ning, Kejuan / Bai, Hongliang / Guo, Litao

    Health science reports

    2024  Volume 7, Issue 4, Page(s) e2027

    Abstract: Background and aims: Maternal cardiac arrest is the most urgent clinical event in obstetrics and can lead to serious consequences, such as maternal or fetal death. Therefore, the training of team cardiopulmonary resuscitation (CPR) skills for ... ...

    Abstract Background and aims: Maternal cardiac arrest is the most urgent clinical event in obstetrics and can lead to serious consequences, such as maternal or fetal death. Therefore, the training of team cardiopulmonary resuscitation (CPR) skills for obstetricians is essential. The aim of this study was to investigate the effect of applying intelligent simulation to CPR in maternal cardiac arrest teamwork training for obstetricians.
    Methods: Twenty-four obstetricians who participated in the "Maternal First Aid Workshop," organized by our hospital in 2018, were selected as training participants. The SimMan intelligent comprehensive patient simulator was used to train the CPR team collaboration with first-aid skills. Each team participating in the training was assessed before and after the training using a questionnaire survey.
    Results: The evaluation of the results after the training showed that all four teams were qualified and that the timing of the cesarean section was 100% correct. The mean score, team collaboration score, and chest compression fraction were significantly higher than before training. Teamwork CPR assessment time, interruption time of chest compressions, and artificial airway establishment time were significantly shorter than before training. The questionnaire survey showed that 95.8% of the physicians reported that the training was rewarding and helpful to their clinical work, and 100% of the physicians believed that obstetricians require similar training.
    Conclusion: Using the SimMan intelligent comprehensive patient simulator to train obstetricians for CPR of maternal cardiac arrest teamwork first-aid skills can significantly improve the training effect, clinical first-aid skills, and teamwork awareness.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.2027
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  5. Article ; Online: Experimental study and finite element analysis of heavy-duty escalator truss under full load conditions.

    Li, Ning / Cao, Zhongxi / Bao, Wei / Lin, Suixian / Zou, Tao / Yan, Mingming

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4825

    Abstract: The performance of the heavy-duty escalator truss greatly affects the stability and service life of the whole escalator system, and the manufacturing cost of truss structure accounts for more than 1/5. Thus, how to design the truss structure reasonably ... ...

    Abstract The performance of the heavy-duty escalator truss greatly affects the stability and service life of the whole escalator system, and the manufacturing cost of truss structure accounts for more than 1/5. Thus, how to design the truss structure reasonably is a pivotal issue drawing the attention of numerous engineers and researchers. In this work, the experimental research of heavy-duty escalators under full load conditions were performed in terms of the end restraints, the docking port clearances, and the deflection. Based on the experimental results, the three-dimensional simulation model of truss structure was created, and the influences of various factors such as the internal chamfer of truss member, the lower deviation of truss member, the dead weight of escalator, and the pretension force of each bolt at the docking port were analyzed and quantified. Finally, the finite element model which can almost completely characterize the actual structure was obtained with slight difference. The conclusions drawn in this work provide the basis for the efficient design, correct simulation, low cost production and rapid installation of the heavy-duty escalator truss.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55175-6
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  6. Article ; Online: Combined Transcriptomics and Metabolomics Identify Regulatory Mechanisms of Porcine Vertebral Chondrocyte Development In Vitro.

    Xue, Mingming / Huang, Ning / Luo, Yabiao / Yang, Xiaoyang / Wang, Yubei / Fang, Meiying

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Porcine body length is closely related to meat production, growth, and reproductive performance, thus playing a key role in the profitability of the pork industry. Cartilage development is critical to longitudinal elongation of individual vertebrae. This ...

    Abstract Porcine body length is closely related to meat production, growth, and reproductive performance, thus playing a key role in the profitability of the pork industry. Cartilage development is critical to longitudinal elongation of individual vertebrae. This study isolated primary porcine vertebral chondrocytes (PVCs) to clarify the complex mechanisms of elongation. We used transcriptome and target energy metabolome technologies to confirm crucial genes and metabolites in primary PVCs at different differentiation stages (0, 4, 8, and 12 days). Pairwise comparisons of the four stages identified 4566 differentially expressed genes (DEGs). Time-series gene cluster and functional analyses of these DEGs revealed four clusters related to metabolic processes, cartilage development, vascular development, and cell cycle regulation. We constructed a transcriptional regulatory network determining chondrocyte maturation. The network indicated that significantly enriched transcription factor (TF) families, including zf-C2H2, homeobox, TF_bZIP, and RHD, are important in cell cycle and differentiation processes. Further, dynamic network biomarker (DNB) analysis revealed that day 4 was the tipping point for chondrocyte development, consistent with morphological and metabolic changes. We found 24 DNB DEGs, including the TFs
    MeSH term(s) Humans ; Swine ; Animals ; Chondrocytes ; Metabolomics ; Cell Differentiation/genetics ; Gene Expression Profiling ; Genes, Homeobox ; Transcription Factors
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021189
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  7. Article ; Online: Enhancing the Photoluminescence and Electroluminescence of Graphitic Carbon Nitride via Atomic and Molecular Co-modification.

    Zhang, Kai / Song, Ruili / Wu, Ning / Wang, Yunhu / Zhang, Mingming / Chen, Xilei / Wang, Lei / Xing, Jun

    The journal of physical chemistry letters

    2024  Volume 15, Issue 4, Page(s) 925–932

    Abstract: Graphitic carbon nitride (g-CN) materials exhibit attractive optoelectronic physical properties; however, their low photoluminescence quantum yields (PLQYs) limit their applications in luminescent devices. Here, boron-doped aromatic carbon nitride (B- ... ...

    Abstract Graphitic carbon nitride (g-CN) materials exhibit attractive optoelectronic physical properties; however, their low photoluminescence quantum yields (PLQYs) limit their applications in luminescent devices. Here, boron-doped aromatic carbon nitride (B-PhCN
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03409
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  8. Article ; Online: Organizing Photosensitive and Photothermal Single-Sites Uniformly in a Trimetallic Metal-Organic Framework for Efficient Photocatalytic Hydrogen Evolution.

    Zhang, Shiqi / Lu, Lele / Jiang, Jialong / Liu, Ning / Zhao, Bin / Xu, Mingming / Cheng, Peng / Shi, Wei

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2403464

    Abstract: Effective combination of the photosensitivity and photothermal property in photocatalyst is vital to achieve the maximum light utilization for superior photocatalytic efficiency. Herein, this work successfully organizes photosensitive Cd-NS single-sites ... ...

    Abstract Effective combination of the photosensitivity and photothermal property in photocatalyst is vital to achieve the maximum light utilization for superior photocatalytic efficiency. Herein, this work successfully organizes photosensitive Cd-NS single-sites and photothermal Ni-NS single-sites uniformly at a molecular level within a tailored trimetallic metal-organic framework. The optimized Ho
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202403464
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  9. Article ; Online: Programmable Multistimuli-Responsive and Multimodal Polymer Actuator Based on a Designed Energy Transduction Network.

    Yan, Xiunan / Chen, Qing / Huo, Ziyu / Zhang, Ning / Ma, Mingming

    ACS applied materials & interfaces

    2022  Volume 14, Issue 11, Page(s) 13768–13777

    Abstract: A polymer actuator typically responds to only one or two types of stimuli, where sensing and actuation are simultaneously exerted by the same responsive polymer. In cells, sensing and actuation are exerted separately by different biomolecules, which are ... ...

    Abstract A polymer actuator typically responds to only one or two types of stimuli, where sensing and actuation are simultaneously exerted by the same responsive polymer. In cells, sensing and actuation are exerted separately by different biomolecules, which are integrated into nanoscale assemblies to construct the signaling network, making cells a multistimuli responsive and multimodal system. Inspired by the structure-function relationship of the signaling network in cells, we have developed a strategy to select and assemble proper functional polymers into assemblies, where sensing and actuation are exerted by different polymers, and the assemblies can present novel functions beyond that of each polymer component. Three polymers [polyaniline, PANi; poly(
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c01549
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  10. Article ; Online: Electrostatic effects on 19F NMR chemical shifts in N-phenyl γ-lactam derivatives

    Xi, Ning / Sun, Mingming / Lu, Yang / Bai, Changlin

    Tetrahedron 2022 May 7, v. 113, p. 132733

    2022  , Page(s) 132733

    Abstract: Covalently identical ortho-F nuclei display dual ¹⁹F NMR signals in di-ortho-F substituted N-phenyl γ-lactams. Structural variations at C9-substituent on the γ-lactam lead to larger chemical shift changes at downfield ¹⁹F signals (δdₒwₙ) than those at ... ...

    Abstract Covalently identical ortho-F nuclei display dual ¹⁹F NMR signals in di-ortho-F substituted N-phenyl γ-lactams. Structural variations at C9-substituent on the γ-lactam lead to larger chemical shift changes at downfield ¹⁹F signals (δdₒwₙ) than those at upfield ¹⁹F signals (δᵤₚ). A “reverse” correlation between downfield ¹⁹F chemical shifts and electron-withdrawing abilities of C9-phenylamides is observed. Electrostatic effects are the major forces between C9-substituents and ortho-F nuclei, and Hammett parameters can be used to describe such through-space interactions. Structural factors influencing ortho-¹⁹F shielding among diverse C9-substituted N-phenyl γ-lactams are discussed.
    Keywords F-19 NMR spectroscopy ; N-phenyl lactam ; Rotamers ; Hammett equation ; Fluorinated compounds
    Language English
    Dates of publication 2022-0507
    Size p. 132733
    Publishing place Pergamon Press.
    Document type Article ; Online
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2022.132733
    Database NAL-Catalogue (AGRICOLA)

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