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  1. Book ; Online: Edward Thomas

    Wiśniewski, Jacek

    a mirror of England

    2009  

    Abstract: Edward Thomas volunteered when he was 37 years old and a father of three and was killed ... Though all his poems had been written "under storm's wing", Thomas was not a war poet in the sense that Owen, Sassoon ...

    Author's details by Jacek Wiśniewski
    Abstract Edward Thomas volunteered when he was 37 years old and a father of three and was killed, as an artillery officer, during the first hour of the Arras offensive, on April 9th, 1917. In the two years before his death, he wrote the 144 poems which ensured a place for him among the poets of his generation. Though all his poems had been written "under storm's wing", Thomas was not a war poet in the sense that Owen, Sassoon or Rosenberg were war poets. Before he turned to poetry in December 1914, he
    Language English
    Size Online-Ressource (x, 356 p.)
    Publisher Cambridge Scholars
    Publishing place Newcastle upon Tyne
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 1282043048 ; 1282043285 ; 1443802107 ; 9781282043282 ; 9781443802109 ; 9781443802468 ; 9781282043046 ; 1443802468
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article: Gait dysfunction in Alzheimer disease.

    Wisniewski, Thomas / Masurkar, Arjun V

    Handbook of clinical neurology

    2023  Volume 196, Page(s) 267–274

    Abstract: Alzheimer's disease (AD) is the most common cause of age-associated dementia and will exponentially rise in prevalence in the coming decades, supporting the parallel development of the early stage detection and disease-modifying strategies. While ... ...

    Abstract Alzheimer's disease (AD) is the most common cause of age-associated dementia and will exponentially rise in prevalence in the coming decades, supporting the parallel development of the early stage detection and disease-modifying strategies. While primarily considered as a cognitive disorder, AD also features motor symptoms, primarily gait dysfunction. Such gait abnormalities can be phenotyped across classic clinical syndromes as well as by quantitative kinematic assessments to address subtle dysfunction at preclinical and prodromal stages. As such, certain measures of gait can predict the future cognitive and functional decline. Moreover, cross-sectional and longitudinal studies have associated gait abnormalities with imaging, biofluid, and genetic markers of AD across all stages. This suggests that gait assessment is an important tool in the clinical assessment of patients across the AD spectrum, especially to help identify at-risk individuals.
    MeSH term(s) Humans ; Alzheimer Disease/complications ; Cross-Sectional Studies ; Cognition Disorders ; Cognitive Dysfunction ; Gait
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Review ; Journal Article
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-98817-9.00013-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Follow-up of active Aβ immunization in Alzheimer disease.

    Wisniewski, Thomas

    Nature reviews. Neurology

    2019  Volume 15, Issue 9, Page(s) 495–496

    MeSH term(s) Alzheimer Disease/immunology ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/immunology ; Amyloid beta-Peptides/therapeutic use ; Brain/pathology ; Disease Progression ; Follow-Up Studies ; Humans ; Treatment Outcome ; Vaccination
    Chemical Substances AN-1792 ; Amyloid beta-Peptides
    Language English
    Publishing date 2019-07-22
    Publishing country England
    Document type News
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-019-0239-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: GATA1-Mediated Transcriptional Regulation of the γ-Secretase Activating Protein Increases Aβ Formation in Down Syndrome.

    Chu, Jin / Wisniewski, Thomas / Pratico, Domenico

    Annals of neurology

    2023  Volume 93, Issue 5, Page(s) 1050

    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder.

    Wegiel, Jarek / Chadman, Kathryn / London, Eric / Wisniewski, Thomas / Wegiel, Jerzy

    Autism research : official journal of the International Society for Autism Research

    2024  

    Abstract: This review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, ... ...

    Abstract This review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, neuronal growth, differentiation, and arborization, as well as defective neuronal circuit formation in the cortex, subcortical structures, brainstem, and cerebellum of autistic subjects. In autism, defects in regulation of neuronal growth are the most frequent and ubiquitous developmental changes associated with impaired neuron differentiation, smaller size, distorted shape, loss of spatial orientation, and distortion of cortex organization. Common developmental defects of the brain in autism include multiregional focal dysplastic changes contributing to local neuronal circuit distortion, epileptogenic activity, and epilepsy. There is a discrepancy between more than 500 reports demonstrating the contribution of the serotonergic system to autism's behavioral anomalies, highlighted by lack of studies of autistic subjects' brainstem raphe nuclei, the center of brain serotonergic innervation, and of the contribution of the serotonergic system to the diagnostic features of autism spectrum disorder (ASD). Discovery of severe fetal brainstem auditory system neuronal deficits and other anomalies leading to a spectrum of hearing deficits contributing to a cascade of behavioral alterations, including deficits of social and verbal communication in individuals with autism, is another argument to intensify postmortem studies of the type and topography of, and the severity of developmental defects in raphe nuclei and their contribution to abnormal brain development and to the broad spectrum of functional deficits and comorbid conditions in ASD.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Numerical flow experiment for assessing predictors for cerebrovascular accidents in patients with PHACES syndrome.

    Wiśniewski, Karol / Tyfa, Zbigniew / Reorowicz, Piotr / Brandel, Michael G / Adel, Thomas / Obidowski, Damian / Jóźwik, Krzysztof / Levy, Michael L

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5161

    Abstract: There is an increased risk of cerebrovascular accidents (CVA) in individuals with PHACES, yet the precise causes are not well understood. In this analysis, we aimed to examine the role of arteriopathy in PHACES syndrome as a potential contributor to CVA. ...

    Abstract There is an increased risk of cerebrovascular accidents (CVA) in individuals with PHACES, yet the precise causes are not well understood. In this analysis, we aimed to examine the role of arteriopathy in PHACES syndrome as a potential contributor to CVA. We analyzed clinical and radiological data from 282 patients with suspected PHACES syndrome. We analyzed clinical features, including the presence of infantile hemangioma and radiological features based on magnetic resonance angiography or computed tomography angiography, in individuals with PHACES syndrome according to the Garzon criteria. To analyze intravascular blood flow, we conducted a simulation based on the Fluid-Structure Interaction (FSI) method, utilizing radiological data. The collected data underwent statistical analysis. Twenty patients with PHACES syndrome were included. CVAs were noted in 6 cases. Hypoplasia (p = 0.03), severe tortuosity (p < 0.01), absence of at least one main cerebral artery (p < 0.01), and presence of persistent arteries (p = 0.01) were associated with CVAs, with severe tortuosity being the strongest predictor. The in-silico analysis showed that the combination of hypoplasia and severe tortuosity resulted in a strongly thrombogenic environment. Severe tortuosity, combined with hypoplasia, is sufficient to create a hemodynamic environment conducive to thrombus formation and should be considered high-risk for cerebrovascular accidents (CVAs) in PHACES patients.
    MeSH term(s) Humans ; Stroke/diagnostic imaging ; Cerebral Arteries/pathology ; Magnetic Resonance Angiography ; Hemangioma/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55345-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vigorous, regular physical exercise may slow disease progression in Alzheimer's disease.

    Devanand, Davangere P / Masurkar, Arjun V / Wisniewski, Thomas

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 4, Page(s) 1592–1597

    Abstract: Introduction: Mild to moderate exercise may decrease Alzheimer's disease (AD) risk, but the effects of vigorous, regular physical exercise remain unclear.: Methods: Two patients with initial diagnoses of amnestic mild cognitive impairment (MCI) ... ...

    Abstract Introduction: Mild to moderate exercise may decrease Alzheimer's disease (AD) risk, but the effects of vigorous, regular physical exercise remain unclear.
    Methods: Two patients with initial diagnoses of amnestic mild cognitive impairment (MCI) demonstrated positive AD biomarkers throughout 16 and 8 years of follow-up, with final diagnoses of mild AD and amnestic MCI, respectively.
    Results: Patient 1 was diagnosed with amnestic MCI at age 64. Neuropsychological testing, magnetic resonance imaging (MRI), fluorodeoxyglucose-positron emission tomography (FDG-PET), amyloid imaging PET, and cerebrospinal fluid (CSF) biomarkers during follow-ups remained consistent with AD. By age 80, progression was minimal with Montreal Cognitive Assessment (MoCA) 26 of 30. Patient 2 was diagnosed with amnestic MCI at age 72. Neuropsychological testing, MRI, FDG-PET, and amyloid imaging PET during follow-ups remained consistent with AD. At age 80, MoCA was 27 of 30 with no clinical progression. Both patients regularly performed vigorous, regular exercise that increased after retirement/work reduction.
    Discussion: Vigorous, regular exercise may slow disease progression in biomarker-positive amnestic MCI and mild AD.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Fluorodeoxyglucose F18 ; Disease Progression ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis ; Exercise ; Amyloid beta-Peptides/cerebrospinal fluid ; Neuropsychological Tests
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Biomarkers ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Neurological and Neuroscientific Evidence in Aged COVID-19 Patients.

    Frontera, Jennifer A / Wisniewski, Thomas

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 774318

    Language English
    Publishing date 2021-10-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.774318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reader Response: Blood Biomarkers of Traumatic Brain Injury and Cognitive Impairment in Older Veterans.

    Wisniewski, Thomas / Fossati, Silvia

    Neurology

    2021  Volume 97, Issue 2, Page(s) 101

    MeSH term(s) Aged ; Biomarkers ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/epidemiology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Humans ; Veterans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000012255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial.

    Frontera, Jennifer A / Betensky, Rebecca A / Pirofski, Liise-Anne / Wisniewski, Thomas / Yoon, Hyunah / Ortigoza, Mila B

    Neurology(R) neuroimmunology & neuroinflammation

    2024  Volume 11, Issue 3, Page(s) e200227

    Abstract: Background and objectives: Chronic systemic inflammation has been hypothesized to be a mechanistic factor leading to post-acute cognitive dysfunction after COVID-19. However, little data exist evaluating longitudinal inflammatory markers.: Methods: ... ...

    Abstract Background and objectives: Chronic systemic inflammation has been hypothesized to be a mechanistic factor leading to post-acute cognitive dysfunction after COVID-19. However, little data exist evaluating longitudinal inflammatory markers.
    Methods: We conducted a secondary analysis of data collected from the CONTAIN randomized trial of convalescent plasma in patients hospitalized for COVID-19, including patients who completed an 18-month assessment of cognitive symptoms and PROMIS Global Health questionnaires. Patients with pre-COVID-19 dementia/cognitive abnormalities were excluded. Trajectories of serum cytokine panels, D-dimer, fibrinogen, C-reactive peptide (CRP), ferritin, lactate dehydrogenase (LDH), and absolute neutrophil counts (ANCs) were evaluated over 18 months using repeated measures and Friedman nonparametric tests. The relationships between the area under the curve (AUC) for each inflammatory marker and 18-month cognitive and global health outcomes were assessed.
    Results: A total of 279 patients (N = 140 received plasma, N = 139 received placebo) were included. At 18 months, 76/279 (27%) reported cognitive abnormalities and 78/279 (28%) reported fair or poor overall health. PROMIS Global Mental and Physical Health T-scores were 0.5 standard deviations below normal in 24% and 51% of patients, respectively. Inflammatory marker levels declined significantly from hospitalization to 18 months for all markers (IL-2, IL-2R, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, INFγ, TNFα, D-dimer, fibrinogen, ferritin, LDH, CRP, neutrophils; all
    Discussion: At 18 months posthospitalization for COVID-19, cognitive abnormalities were reported in 27% of patients, and below average PROMIS Global Mental and Physical Health scores occurred in 24% and 51%, respectively. However, there were no associations with measured inflammatory markers, which decreased over time.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; COVID-19 Serotherapy ; Inflammation ; Fibrinogen ; Ferritins ; Cognition
    Chemical Substances Fibrinogen (9001-32-5) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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