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  1. Book: Nutrition and Metabolism

    Schols, Annemie M. W. J. / Roche, Helen M. / Macdonald, Ian A. / Lanham-New, Susan A.

    2024  

    Size 496 p.
    Publisher John Wiley & Sons Ltd
    Document type Book
    Note PDA Manuell_25
    Format 255 x 204 x 31
    ISBN 9781119840237 ; 1119840236
    Database PDA

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  2. Book: Nutrition and metabolism

    Lanham-New, Susan / Macdonald, Ian / Roche, Helen M.

    (The Nutrition Society textbook series)

    2011  

    Institution Nutrition Society
    Author's details ed. by Susan A. Lanham-New ; Ian M. Macdonald ; Helen M. Roche. The Nutrition Society
    Series title The Nutrition Society textbook series
    Keywords Nutritional Physiological Phenomena ; Metabolism
    Language English
    Size XII, 431 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    Note Hier auch später erschienene, unveränderte Nachdrucke
    HBZ-ID HT016616526
    ISBN 978-1-4051-6808-3 ; 1-4051-6808-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 6248 order for loan Magazin

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  3. Article ; Online: Lessons learned from research on choroideremia.

    MacDonald, Ian M

    Ophthalmic genetics

    2022  , Page(s) 1–8

    Abstract: Having devoted over 35 years of my professional life to various projects on choroideremia (CHM), I began to reflect on the many lessons that I learned along the way. One of the most important is: we should pay careful attention to possible, unintended ... ...

    Abstract Having devoted over 35 years of my professional life to various projects on choroideremia (CHM), I began to reflect on the many lessons that I learned along the way. One of the most important is: we should pay careful attention to possible, unintended psychological harm in clinical research. This lesson was learned early and then reinforced when I engaged CHM patients in an investigator-sponsored Phase IB clinical trial of ocular gene therapy for choroideremia. My second lesson came from the trial itself in that preliminary data may not be sufficient to predict the risks to patients in a clinical trial. In the significant push to begin a gene therapy trial for CHM patients, writing grants, recruiting personnel, interacting with regulatory authorities, acquiring research equipment to test outcome measures, I missed a third lesson. There is significant bias when the principal investigator of an investigator-sponsored clinical trial is also the treating physician in the trial. Ideally, those two roles should be kept separate. Finally, having completed the clinical trial, I learned that gene replacement with an AAV vector may not be the only genetic therapy for CHM; an antisense oligonucleotide therapy may be possible in select cases.
    Language English
    Publishing date 2022-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2022.2025608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: (Table 1) Hydrocarbon gas composition of sediment and gas hydrate collected in video-guided grabs from Chapopote, supplementary data to: MacDonald, Ian R; Bohrmann, Gerhard; Escobar, E; Abegg, Friedrich; Blanchon, P; Blinova, Valentina N; Brueckmann, Warner; Drews, Manuela; Eisenhauer, Anton; Han, X; Heeschen, Katja U; Meier, F; Mortera, C; Naehr, T; Orcutt, B; Bernard, B; Brroks, J; de Far?go, M (2004): Asphalt volcanism and chemosynthetic life, Campache Knolls, Gulf of Mexico. Science, 304(5673), 999-1002

    MacDonald, Ian R / Abegg, Friedrich / Blanchon, P / Blinova, Valentina N / Bohrmann, Gerhard / Brueckmann, Warner / Drews, Manuela / Eisenhauer, Anton / Escobar, E / al., et

    2004  

    Abstract: In the Campeche Knolls, in the southern Gulf of Mexico, lava-like flows of solidified asphalt cover more than 1 square kilometer of the rim of a dissected salt dome at a depth of 3000 meters below sea level. Chemosynthetic tubeworms and bivalves colonize ...

    Abstract In the Campeche Knolls, in the southern Gulf of Mexico, lava-like flows of solidified asphalt cover more than 1 square kilometer of the rim of a dissected salt dome at a depth of 3000 meters below sea level. Chemosynthetic tubeworms and bivalves colonize the sea floor near the asphalt, which chilled and contracted after discharge. The site also includes oil seeps, gas hydrate deposits, locally anoxic sediments, and slabs of authigenic carbonate. Asphalt volcanism creates a habitat for chemosynthetic life that may be widespread at great depth in the Gulf of Mexico.
    Language English
    Dates of publication 2004-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1126/science.1097154
    DOI 10.1594/PANGAEA.770076
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    Full text online

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  5. Article ; Online: Body Composition, Sarcopenic Obesity, and Cognitive Function in Older Adults: Findings From the National Health and Nutrition Examination Survey (NHANES) 1999-2002 and 2011-2014.

    Booranasuksakul, Uraiporn / Macdonald, Ian A / Stephan, Blossom C M / Siervo, Mario

    Journal of the American Nutrition Association

    2024  , Page(s) 1–14

    Abstract: Objective: Sarcopenic-obesity (SO) is characterized by the concomitant presence of low muscle mass and high adiposity. This study explores the association of body composition and SO phenotypes with cognitive function in older adults.: Methods: Cross- ... ...

    Abstract Objective: Sarcopenic-obesity (SO) is characterized by the concomitant presence of low muscle mass and high adiposity. This study explores the association of body composition and SO phenotypes with cognitive function in older adults.
    Methods: Cross-sectional data in older adults (≥60 years) from NHANES 1999-2002 and 2011-2014 were used. In the 1999-2002 cohort, phenotypes were derived from body mass index (BMI) and dual-X-ray-absorptiometry, and cognition was assessed the by Digit-Symbol-Substitution-Test (DSST). In the 2011-2014 cohort, phenotypes were derived from BMI, waist-circumference (WC), and hand-grip-strength (HGS). Cognition was assessed using four tests: DSST, Animal Fluency, the Consortium-to-Establish-a-Registry-for-Alzheimer's-Disease-Delayed-Recall, and Word Learning. Mediation analysis was conducted to evaluate the contribution of inflammation (C-reactive-protein, CRP) and insulin resistance (Homeostatic-Model-Assessment-for-Insulin-Resistance, HOMA-IR) to the association between body composition and cognitive outcomes.
    Results: The SO phenotype had the lowest DSST mean scores (
    Conclusions: The SO phenotype was associated with a higher risk of cognitive impairment in older adults. Insulin resistance and inflammation may represent key mechanisms linking SO to the development of cognitive impairment.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ISSN 2769-707X
    ISSN (online) 2769-707X
    DOI 10.1080/27697061.2024.2333310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pseudoxanthoma elasticum and retinitis pigmentosa in a patient with a novel mutation in the

    Mishra, Amit V / Martens, Rosanna / MacDonald, Ian M

    Ophthalmic genetics

    2023  Volume 45, Issue 1, Page(s) 108–111

    Abstract: Background: Pseudoxanthoma elasticum (PXE) is an autosomal recessive condition caused by mutations in the : Case: A 37-year-old female presented with decreased peripheral vision and nyctalopia. Ocular imaging revealed angioid streaks emanating from ... ...

    Abstract Background: Pseudoxanthoma elasticum (PXE) is an autosomal recessive condition caused by mutations in the
    Case: A 37-year-old female presented with decreased peripheral vision and nyctalopia. Ocular imaging revealed angioid streaks emanating from the optic nerve as well as peripheral pigmentary changes and bone spicules. Genetic testing revealed two mutations in
    Conclusion: We present a rare case with ocular findings of PXE and RP in a patient with a novel
    MeSH term(s) Female ; Humans ; Adult ; Pseudoxanthoma Elasticum/complications ; Pseudoxanthoma Elasticum/diagnosis ; Pseudoxanthoma Elasticum/genetics ; Angioid Streaks/diagnosis ; Angioid Streaks/genetics ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/genetics ; Mutation ; Fundus Oculi ; Multidrug Resistance-Associated Proteins/genetics
    Chemical Substances ABCC6 protein, human ; Multidrug Resistance-Associated Proteins
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2023.2219737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Breaking bad news in ophthalmology: a pilot skills workshop for residents.

    Papp, Kimberly M / MacDonald, Ian M

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  

    Abstract: Objective: To design and implement a formal skills workshop for ophthalmology residents to practice breaking bad news.: Methods: A 2-session workshop was developed for 7 ophthalmology residents at the University of Alberta based on a workshop ... ...

    Abstract Objective: To design and implement a formal skills workshop for ophthalmology residents to practice breaking bad news.
    Methods: A 2-session workshop was developed for 7 ophthalmology residents at the University of Alberta based on a workshop published by Ohio State University. Residents discussed the SPIKES protocol for breaking bad news, practiced mock cases with standardized patients, and listened to shared experiences from patients who had received ocular diagnoses.
    Results: All the residents (n = 6; p = 0.03) at the University of Alberta reported an increase in confidence in 3 measures of an encounter in which they had to break bad news, one of which shared the significant improvement reported by the Ohio State group (n = 9; p = 0.01): setting realistic expectations without destroying hope. Standardized patients discussed their satisfaction with their case training and suggested the provision of eye models or printouts to enhance the realism in the examination rooms. The University of Alberta workshop results replicated those from Ohio State in that the SPIKES lecture and standardized patient session were ranked highly in efficacy (median, 4 of 5). The University of Alberta panel discussion was ranked lower than at Ohio State University, which may have resulted from 1 of 2 patient guest speakers being unexpectedly unable to attend.
    Conclusion: The pilot Breaking Bad News Workshop was well received overall and may serve to inform future incorporation of soft skills development in a formal residency curriculum.
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.09.009
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  8. Article ; Online: X-linked ocular albinism: mapping and cloning the gene.

    MacDonald, Ian M

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2019  Volume 54, Issue 6, Page(s) 645–646

    MeSH term(s) Albinism, Ocular/genetics ; Albinism, Ocular/history ; Canada ; Chromosome Mapping ; Chromosomes, Human, X/genetics ; Cloning, Molecular ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/history ; History, 19th Century ; History, 20th Century ; Humans
    Language English
    Publishing date 2019-07-15
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2019.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Breaking Bad News in Eye Care.

    Papp, Kimberly M / Gracie, Sara K / Macdonald, Ian M

    American journal of ophthalmology

    2021  Volume 238, Page(s) xiii–xiv

    MeSH term(s) Communication ; Humans ; Physician-Patient Relations ; Truth Disclosure
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2021.11.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Upward saccadic intrusions as the presenting feature for incomplete congenital stationary night blindness.

    Aghazadeh, Helya / MacDonald, Ian M / Jivraj, Imran

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2022  Volume 27, Issue 1, Page(s) 47–49

    Abstract: We describe the case of a 9-month-old boy presenting with isolated intermittent vertical eye movements most in keeping with upward saccadic pulses, a form of saccadic intrusions. Full-field electroretinogram was consistent with a generalized retinal ... ...

    Abstract We describe the case of a 9-month-old boy presenting with isolated intermittent vertical eye movements most in keeping with upward saccadic pulses, a form of saccadic intrusions. Full-field electroretinogram was consistent with a generalized retinal dystrophy, and genetic testing revealed a hemizygous pathogenic mutation in the CACNA1F gene, confirming the diagnosis of incomplete congenital stationary night blindness (iCSNB). This case describes vertical saccadic pulses as the sole presenting sign of a retinal dystrophy.
    MeSH term(s) Male ; Humans ; Infant ; Night Blindness/congenital ; Eye Diseases, Hereditary/diagnosis ; Myopia/diagnosis ; Genetic Diseases, X-Linked/genetics ; Mutation ; Electroretinography ; Ocular Motility Disorders ; Retinal Dystrophies
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2022.09.011
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