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  1. Article: Development of a Statistical Crop Model to Explain the Relationship between Seed Yield and Phenotypic Diversity within the Brassica napus Genepool

    Cook, Samantha / Eastmond, Peter / Roberts, Jeremy / Wagstaff, Carol

    Agronomy, 7(2):31

    2017  

    Abstract: Plants are extremely versatile organisms that respond to the environment in which they find themselves, but a large part of their development is under genetic regulation. The links between developmental parameters and yield are poorly understood in ... ...

    Abstract Plants are extremely versatile organisms that respond to the environment in which they find themselves, but a large part of their development is under genetic regulation. The links between developmental parameters and yield are poorly understood in oilseed rape; understanding this relationship will help growers to predict their yields more accurately and breeders to focus on traits that may lead to yield improvements. To determine the relationship between seed yield and other agronomic traits, we investigated the natural variation that already exists with regards to resource allocation in 37 lines of the crop species Brassica napus. Over 130 different traits were assessed; they included seed yield parameters, seed composition, leaf mineral analysis, rates of pod and leaf senescence and plant architecture traits. A stepwise regression analysis was used to model statistically the measured traits with seed yield per plant. Above-ground biomass and protein content together accounted for 94.36% of the recorded variation. The primary raceme area, which was highly correlated with yield parameters (0.65), provides an early indicator of potential yield. The pod and leaf photosynthetic and senescence parameters measured had only a limited influence on seed yield and were not correlated with each other, indicating that reproductive development is not necessarily driving the senescence process within field-grown B. napus. Assessing the diversity that exists within the B. napus gene pool has highlighted architectural, seed and mineral composition traits that should be targeted in breeding programmes through the development of linked markers to improve crop yields.
    Keywords oilseed rape ; seed composition ; statistical crop model ; plant development ; yield
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: Exploring the feasibility of a cluster pilot randomised control trial to improve children's 24-hour movement behaviours and dietary intake: Happy homework.

    Donnelly, Samantha / Buchan, Duncan S / McLellan, Gillian / Roberts, Ross / Arthur, Rosie

    Journal of sports sciences

    2024  Volume 41, Issue 19, Page(s) 1787–1800

    Abstract: We aimed to explore the feasibility, acceptability, and potential efficacy of Happy Homework (HH); an 8-week home-focussed intervention, with the purpose of encouraging children's positive dietary behaviours and engagement in positive physical activity ( ... ...

    Abstract We aimed to explore the feasibility, acceptability, and potential efficacy of Happy Homework (HH); an 8-week home-focussed intervention, with the purpose of encouraging children's positive dietary behaviours and engagement in positive physical activity (PA) and sleep behaviours. We randomised four Scottish schools (
    MeSH term(s) Child ; Humans ; Pilot Projects ; Feasibility Studies ; Diet ; Exercise ; Eating ; Vegetables ; Schools
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2023.2300562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating the feasibility and acceptability of virtual group exercise for older adults delivered by trained volunteers

    Helen Roberts / Kinda Ibrahim / Esther Clift / Stephen Eu Ruen Lim / Samantha Meredith / Samantha Agnew

    BMJ Open, Vol 12, Iss

    the ImPACt study protocol

    2022  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Screening for Anxiety and Depression Symptoms Using Concussion Symptom Scales Among Varsity Athletes.

    Roberts, Samantha D / Champigny, Claire / Feldman, Samantha J / Flora, David B / Wojtowicz, Magdalena

    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

    2023  Volume 34, Issue 2, Page(s) 105–111

    Abstract: Objective: This study examined associations between Sport Concussion Assessment Tool-5 (SCAT-5) symptom reporting and gold-standard measures of anxiety and depression, and explored the utility SCAT-5 symptom subscales to identify anxiety and depression ... ...

    Abstract Objective: This study examined associations between Sport Concussion Assessment Tool-5 (SCAT-5) symptom reporting and gold-standard measures of anxiety and depression, and explored the utility SCAT-5 symptom subscales to identify anxiety and depression symptomology.
    Design: Prospective cross-sectional study.
    Setting: York University in Toronto, Canada.
    Participants: Preseason data were collected for varsity athletes (N = 296) aged between 17 and 25 years ( M = 20.01 years, SD = 1.69 years; 52% male).
    Main outcome measures: The SCAT-5 symptom evaluation scale was used to assess baseline symptoms. The Generalized Anxiety Disorder Index-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) were used to assess symptoms of anxiety and depression, respectively.
    Results: Endorsement of SCAT-5 symptoms of feeling anxious, sadness, irritability, and feeling more emotional had the strongest correlations with the GAD-7 ( r' s > 0.400; P' s < 0.001). Sadness, trouble falling asleep, concentration problems, feeling slowed down, anxious, irritability, mental fog, fatigue, and memory problems had the highest correlations with the PHQ-9 ( r' s >0 .400; P' s < 0.001). The Emotional subscale from the SCAT-5 predicted mild to severe anxiety on the GAD-7 ( P < 0.001). The Sleep, Cognitive, and Emotional subscales predicted mild to severe depression on the PHQ-9 ( P' s < 0.05).
    Conclusions: These findings provide better delineation of symptoms endorsed on the SCAT-5 symptoms that aid in identification of athletes with symptoms of anxiety or depression who may be at risk for developing a clinical disorder or experiencing persistent symptoms after a concussion.
    MeSH term(s) Humans ; Male ; Adolescent ; Young Adult ; Adult ; Female ; Depression/diagnosis ; Athletic Injuries/diagnosis ; Athletic Injuries/psychology ; Prospective Studies ; Cross-Sectional Studies ; Brain Concussion/diagnosis ; Brain Concussion/psychology ; Anxiety/diagnosis ; Anxiety Disorders ; Athletes
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062530-6
    ISSN 1536-3724 ; 1050-642X
    ISSN (online) 1536-3724
    ISSN 1050-642X
    DOI 10.1097/JSM.0000000000001181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessment of blacklip rock oyster, Saccostrea lineage J, spat growth and survival in recirculating upweller and downweller nursery systems

    Nowland, Samantha J. / Roberts, Brien H.

    Molluscan Research. 2023 Apr. 03, v. 43, no. 2 p.101-108

    2023  

    Abstract: The blacklip rock oyster, Saccostrea lineage J, has the potential to support new aquaculture developments throughout its range in the tropical Indo-Pacific region, but lack of research investment in understanding basic biology has been a key failure ... ...

    Abstract The blacklip rock oyster, Saccostrea lineage J, has the potential to support new aquaculture developments throughout its range in the tropical Indo-Pacific region, but lack of research investment in understanding basic biology has been a key failure point in the past. This study assessed Saccostrea lineage J spat growth and survival in downweller and upweller nursery systems, with the aim of establishing baseline biological information and evaluating spat performance to support commercialisation efforts. Downweller and upweller nursery systems were similarly effective at rearing spat, with mean dorsoventral measurement in both systems reaching a 5 mm deployment size at 59 days post hatch. Growth rates reported in this study of 0.19 and 0.20 mm day⁻¹ in the downweller and upweller, respectively, are comparable to other hatchery-produced tropical and subtropical bivalve spat. Based on the results of this study, it is recommended that spat be held in nurseries for approximately two months to reach a 5 mm deployment size. The information obtained in this study is the first documentation of Saccostrea lineage J spat growth and survival, and the methods used provide a basis for commercial production of this species.
    Keywords Saccostrea ; aquaculture ; commercialization ; oysters ; research ; hatchery ; mollusc ; tropical oyster
    Language English
    Dates of publication 2023-0403
    Size p. 101-108.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1448-6067
    DOI 10.1080/13235818.2023.2217677
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: A scoping review of military and Veteran families within international suicidality and suicide prevention research.

    DuBois, Denise / Richmond, Rachel / Stephanie Roberts, Lauren / Mahar, Alyson / Fear, Nicola / Gill, Kamaldeep / Samantha Leroux, Janette / Cramm, Heidi

    Preventive medicine reports

    2023  Volume 33, Page(s) 102206

    Abstract: The impacts of suicidality on families are well known, which is particularly relevant in at-risk populations, such as active duty military personnel and Veteran communities. This scoping review describes how military and Veteran families have been ... ...

    Abstract The impacts of suicidality on families are well known, which is particularly relevant in at-risk populations, such as active duty military personnel and Veteran communities. This scoping review describes how military and Veteran families have been conceptualized within suicide prevention research. A systematic, multi-database search was conducted, and 4,835 studies were screened. All included studies underwent quality assessment.
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2023.102206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Maximizing Regulatory Review Efficiency: The Evolution of the FDA OCE RTOR Pilot.

    Gao, Ya Grace / Roberts, Samantha / Guy, Allison

    Therapeutic innovation & regulatory science

    2022  Volume 56, Issue 2, Page(s) 212–219

    Abstract: To promote the efficient review of oncology drug applications, the US Food and Drug Administration (FDA) Oncology Center of Excellence (OCE) launched the Real-Time Oncology Review (RTOR) pilot program in 2018. RTOR allows FDA to review individual ... ...

    Abstract To promote the efficient review of oncology drug applications, the US Food and Drug Administration (FDA) Oncology Center of Excellence (OCE) launched the Real-Time Oncology Review (RTOR) pilot program in 2018. RTOR allows FDA to review individual sections of eCTD modules of a drug application for oncology drugs in contrast to requiring the applicant to submit complete modules or the complete application before review is initiated. Initially, the program accepted only supplemental applications with simple study designs and easily interpretable endpoints, but the scope has since been expanded to include applications for New Molecular Entities (NME), and other applications with more complex features. Though many applicants experience faster approvals under RTOR, it is difficult to isolate the effect of the RTOR program on review timelines as its contribution is masked by other expedited programs like priority review and breakthrough therapy designation (BTD). This article discusses the expanded scope of RTOR, its interplay with other OCE initiatives to modernize regulatory review, summarizes Genentech's experiences in planning RTOR submissions from February 2019 to July 2021, and provides considerations for the future of the program.
    MeSH term(s) Drug Approval ; Pharmaceutical Preparations ; Research Design ; United States ; United States Food and Drug Administration
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-021-00371-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluating the feasibility and acceptability of virtual group exercise for older adults delivered by trained volunteers: the ImPACt study protocol.

    Lim, Stephen Eu Ruen / Meredith, Samantha / Agnew, Samantha / Clift, Esther / Ibrahim, Kinda / Roberts, Helen

    BMJ open

    2022  Volume 12, Issue 2, Page(s) e052631

    Abstract: Introduction: Physical activity is important for healthy ageing. Despite strong evidence on the benefits of physical activity for health and well-being, physical inactivity remains a significant problem among older adults. This study aims to determine ... ...

    Abstract Introduction: Physical activity is important for healthy ageing. Despite strong evidence on the benefits of physical activity for health and well-being, physical inactivity remains a significant problem among older adults. This study aims to determine the feasibility and acceptability of implementing an online volunteer-led group exercise for older adults.
    Methods: A quasi-experimental mixed-methods approach will be used in this study. A training programme will be developed to train volunteers to deliver online group exercises to older adults aged >65 years (n=30). The primary outcome is the feasibility of implementing the intervention. This will be assessed by the number of volunteers recruited, trained, and retained at the end of the study, and the number of exercise sessions delivered and completed by participants. Secondary outcomes include physical activity levels measured using the Community Health Model Activities Programme for Seniors questionnaire, Barthel Index, EQ-5D-5L as a measure of health-related quality of life, SARC-F to determine sarcopenia status, and PRIMSA-7 to determine frailty status. Outcomes will be measured at baseline and at 6 months.Qualitative interviews will be conducted with volunteers(n=5), older adults (n=10) and family members (n=5) to explore their views on the intervention.
    Analysis: Simple descriptive statistics will be used to describe participant characteristics, the feasibility of the study and the impact of the intervention on health outcomes. Parametric(t-test) or non-parametric(Mann-Whitney U test) statistics will be used to analyse continuous variables. χ
    Ethics and dissemination: This study received ethical approval from the University of Southampton Faculty of Medicine Ethics Committee and Research Integrity and Governance committee (ID: 52 967 .A1). Study findings will be made available to service users, voluntary organisations and other researchers who may be interested in implementing the intervention.
    Trial registration number: NCT04672200.
    MeSH term(s) Aged ; Exercise ; Exercise Therapy/methods ; Feasibility Studies ; Frailty ; Humans ; Quality of Life
    Language English
    Publishing date 2022-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-052631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies.

    Ayoub, Samantha M / Holloway, Breanna M / Miranda, Alannah H / Roberts, Benjamin Z / Young, Jared W / Minassian, Arpi / Ellis, Ronald J

    Current HIV/AIDS reports

    2024  

    Abstract: Purpose of review: Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population's high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable ... ...

    Abstract Purpose of review: Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population's high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
    Recent findings: Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use). Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-024-00698-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inter-Rater and Intra-Rater Reliability of the Kansas University Sitting Balance Scale.

    Franc, Ingrid A / Mauldin, Samantha / Roberts, Magdalena / Rosa-DiStefano, Gregoria

    Occupational therapy in health care

    2022  Volume 37, Issue 4, Page(s) 595–605

    Abstract: Kluding et al., ... ...

    Abstract Kluding et al., created
    MeSH term(s) Adult ; Humans ; Reproducibility of Results ; Kansas ; Sitting Position ; Universities ; Occupational Therapy
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 639184-9
    ISSN 1541-3098 ; 0738-0577
    ISSN (online) 1541-3098
    ISSN 0738-0577
    DOI 10.1080/07380577.2022.2082000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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