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  1. Article ; Online: Prevention and Treatment of Skin Damage Caused by Personal Protective Equipment: Experience of the First-Line Clinicians Treating 2019-nCoV Infection.

    Zhou, Nuo-Ya / Yang, Liu / Dong, Li-Yun / Li, Yan / An, Xiang-Jie / Yang, Jing / Huang, Chang-Zheng / Tao, Juan

    International journal of dermatology and venereology

    2020  

    Language English
    Publishing date 2020-03-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3045655-1
    ISSN 2641-8746 ; 2096-5540
    ISSN (online) 2641-8746
    ISSN 2096-5540
    DOI 10.1097/JD9.0000000000000085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevention and Treatment of Skin Damage Caused by Personal Protective Equipment: Experience of the First-Line Clinicians Treating 2019-nCoV Infection

    Zhou, Nuo-Ya / Yang, Liu / Dong, Li-Yun / Li, Yan / An, Xiang-Jie / Yang, Jing / Huang, Chang-Zheng / Tao, Juan

    International Journal of Dermatology and Venereology

    Keywords covid19
    Publisher PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #10162
    DOI 10.1097/jd9.0000000000000085
    Database COVID19

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  3. Article: Prevention and Treatment of Skin Damage Caused by Personal Protective Equipment: Experience of the First-Line Clinicians Treating 2019-nCoV Infection

    Zhou, Nuo-Ya / Yang, Liu / Dong, Li-Yun / Li, Yan / An, Xiang-Jie / Yang, Jing / Huang, Chang-Zheng / Tao, Juan

    International Journal of Dermatology and Venereology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #10162
    Database COVID19

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  4. Article ; Online: Prevention and Treatment of Skin Damage Caused by Personal Protective Equipment

    Zhou, Nuo-Ya / Yang, Liu / Dong, Li-Yun / Li, Yan / An, Xiang-Jie / Yang, Jing / Huang, Chang-Zheng / Tao, Juan

    International Journal of Dermatology and Venereology

    Experience of the First-Line Clinicians Treating SARS-CoV-2 Infection

    2020  Volume 3, Issue 2, Page(s) 70–75

    Keywords covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3045655-1
    ISSN 2641-8746 ; 2096-5540
    ISSN (online) 2641-8746
    ISSN 2096-5540
    DOI 10.1097/jd9.0000000000000085
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years.

    Huang, Le-Jun / Lan, Jin-Xia / Wang, Jin-Hua / Huang, Hao / Lu, Kuo / Zhou, Zhi-Nuo / Xin, Su-Ya / Zhang, Zi-Yun / Wang, Jing-Yang / Dai, Ping / Chen, Xiao-Mei / Hou, Wen

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116406

    Abstract: Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, ...

    Abstract Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, antiosteoporosis, neuroprotective, and antipathogenic microorganism activities. In this paper, recent progress on the biological activity and mechanism of action of sanguinarine and its derivatives over the past ten years is reviewed. The results showed that the biological activities of hematarginine and its derivatives are related mainly to the JAK/STAT, PI3K/Akt/mTOR, NF-κB, TGF-β, MAPK and Wnt/β-catenin signaling pathways. The limitations of using sanguinarine in clinical application are also discussed, and the research prospects of this subject are outlined. In general, sanguinarine, a natural medicine, has many pharmacological effects, but its toxicity and safety in clinical application still need to be further studied. This review provides useful information for the development of sanguinarine-based bioactive agents.
    MeSH term(s) Phosphatidylinositol 3-Kinases/metabolism ; Benzophenanthridines/pharmacology ; Alkaloids/metabolism ; Isoquinolines/pharmacology
    Chemical Substances sanguinarine (AV9VK043SS) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Benzophenanthridines ; Alkaloids ; Isoquinolines
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Bioactivities and Action Mechanisms of Ellipticine Derivatives Reported Prior to 2023.

    Hou, Wen / Xu, Xin-Liang / Huang, Le-Jun / Zhang, Zhen-Yu / Zhou, Zhi-Nuo / Wang, Jin-Yang / Ouyang, Xi / Xin, Su-Ya / Zhang, Zi-Yun / Xiong, Yi / Huang, Hao / Lan, Jin-Xia

    Chemistry & biodiversity

    2024  , Page(s) e202400210

    Abstract: Currently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are ... ...

    Abstract Currently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its derivatives as bioactive molecules over the last 60 years. Publications focused mainly on the total synthesis of alkaloids of this type without any evaluation of bioactivity have been excluded. We have reviewed papers dealing with the synthesis, bioactivity evaluation and mechanism of action of ellipticine and its derivatives. It was found that ellipticine and its derivatives showed cytotoxicity, antimicrobial ability, and anti-inflammatory activity, among which cytotoxicity toward cancer cell lines was the most investigated aspect. The inhibition of DNA topoisomerase II was the most relevant mechanism for cytotoxicity. The PI3K/AKT pathway, p53 pathway, and MAPK pathway were also closely related to the antiproliferative ability of these compounds. In addition, the structure-activity relationship was deduced, and future prospects were outlined. We are confident that these findings will lay a scientific foundation for ellipticine-based drug development, especially for anticancer agents.
    Language English
    Publishing date 2024-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Design, Synthesis and Antitumor Activity of FAK/PLK1 Dual Inhibitors with Quinazolinone as the Skeleton.

    Sun, Juan / Fang, Ze-Yu / Tao, Yi-Nuo / Zhang, Yi-Heng / Zhang, Yao / Sun, Hai-Ya / Zhou, Yang / Wu, Yuan-Feng

    Chemistry & biodiversity

    2023  Volume 20, Issue 4, Page(s) e202300146

    Abstract: Febrifugine is a kind of quinazolinone compound with high biological activity from a Chinese herb called Chang Shan (Dichroa febrifuga). Febrifugine and its derivatives possess extensive biological activities, some of which exhibited anti-tumor ... ...

    Abstract Febrifugine is a kind of quinazolinone compound with high biological activity from a Chinese herb called Chang Shan (Dichroa febrifuga). Febrifugine and its derivatives possess extensive biological activities, some of which exhibited anti-tumor activities as FAK inhibitors. However, they are not very effective at inhibiting tumor metastasis, perhaps because tumors gain energy through compensatory activation of other signaling pathways that promote cell migration and invasion. Therefore, seventeen novel febrifugine derivatives with quinazolinone skeleton were designed, synthesized and acted as potential FAK/PLK1 dual inhibitors. These compounds were determined by
    MeSH term(s) Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation ; Drug Design ; Drug Screening Assays, Antitumor ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Quinazolinones/chemistry ; Quinazolinones/pharmacology ; Skeleton ; Structure-Activity Relationship ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Polo-Like Kinase 1
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Quinazolinones ; PTK2 protein, human (EC 2.7.10.2) ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; febrifugine (89UWD0FH2I)
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202300146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect of renin-angiotensin-aldosterone system inhibitors on all-cause mortality and major cardiovascular events in patients with diabetes: A meta-analysis focusing on the number needed to treat and minimal clinical effect.

    Yang, Xiao-Chun / Shao, Li-Li / Mi, Ying-Jun / Zhang, Wen-Hao / Liu, Nuo-Ya / Liu, Ruo-Bin / Zhou, Xiao-Xi / Zhang, Wei-Hong / Tian, Qing-Bao

    Journal of diabetes and its complications

    2020  Volume 35, Issue 3, Page(s) 107830

    Abstract: Aims: To assess the effectiveness of renin-angiotensin-aldosterone system (RAAS) inhibitors, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) separately to prevent all-cause mortality, myocardial infarction ( ... ...

    Abstract Aims: To assess the effectiveness of renin-angiotensin-aldosterone system (RAAS) inhibitors, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) separately to prevent all-cause mortality, myocardial infarction (MI), stroke and heart failure (HF) in patients with diabetes considering the number needed to treat (NNT) and minimal clinical effect (MCE).
    Methods: Data from 17 morbidity-mortality trials in patients with diabetes were used to calculate NNTs and evaluate MCE to prevent all-cause mortality, myocardial infarction, stroke, and heart failure.
    Results: A total of 17 trials involving 42,037 patients were included in this meta-analysis. Mean follow-up was 3.7 years. ACEIs significantly reduced the risk of all-cause mortality, MI and HF; the corresponding mean NNTBs were 48, 62 and 78, respectively, but ARBs were only associated with a reduction in heart failure. The clinical significance assessment of the included trials indicated that most of the statistically significant trial results had no definitive clinical significance, and only some of them had possible clinical significance.
    Conclusions: Among patients with diabetes, ACEIs reduced all-cause mortality, MI and HF, whereas ARBs could only prevent HF. However, none of the results of these trials had clear clinical significance, and most had only possible clinical significance.
    MeSH term(s) Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Diabetes Mellitus/epidemiology ; Heart Failure/epidemiology ; Heart Failure/prevention & control ; Humans ; Mortality ; Myocardial Infarction/epidemiology ; Myocardial Infarction/prevention & control ; Renin-Angiotensin System/drug effects ; Stroke/epidemiology ; Stroke/prevention & control
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2020.107830
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2225: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A novel non‐invasive identification of genome editing mutants from insect exuviae

    Wang, Xiao‐Xiao / Li, Jing / Wang, Tong‐Xin / Yang, Yi‐Nuo / Zhang, Hai‐Kang / Zhou, Meng / Kang, Le / Wei, Li‐Ya

    Insect science. 2022 Feb., v. 29, no. 1

    2022  

    Abstract: With the wide application of genome editing in insects, a simple and efficient identification method is urgently needed to meet the increasing demand for mutation detection. Here, taking migratory locusts as a model system, we developed a non‐invasive ... ...

    Abstract With the wide application of genome editing in insects, a simple and efficient identification method is urgently needed to meet the increasing demand for mutation detection. Here, taking migratory locusts as a model system, we developed a non‐invasive method to accurately identify genome‐edited mutants by using DNA from insect exuviae. We compared the quantity and quality of genomic DNA from exuviae in five instar hoppers and found that the 1st instar exuviae had the highest DNA yield and content, while the 3rd instar exuviae had the best quality. Consensus genotypes were identified from genomic DNA of hoppers at different developmental stages in the same individuals. Moreover, we demonstrated that the amplification products from DNA extracted from locust exuviae are the consensus sequences with those from the hemolymph and foreleg pre‐tarsus. Therefore, non‐invasive samples provide the same genotyping results as minimally invasive and invasive samples of the same individuals. Furthermore, this identification method that uses genomic DNA from exuviae can be used for early screening of positive genome‐edited individuals in each generation for adult crossing. In our study, the non‐invasive identification method was not only simpler and provided results earlier than existing methods, but also had a better reproducibility and accuracy. This non‐invasive identification approach using genomic DNA from exuviae can be adapted to meet the growing demand for genetic analysis and will find wide application in insect genome editing research.
    Keywords DNA ; adults ; crossing ; genetic analysis ; genome ; genotyping ; hemolymph ; instars ; integument ; legs ; migratory behavior ; mutation
    Language English
    Dates of publication 2022-02
    Size p. 21-32.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2179775-4
    ISSN 1744-7917 ; 1672-9609
    ISSN (online) 1744-7917
    ISSN 1672-9609
    DOI 10.1111/1744-7917.12914
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A novel non-invasive identification of genome editing mutants from insect exuviae.

    Wang, Xiao-Xiao / Li, Jing / Wang, Tong-Xin / Yang, Yi-Nuo / Zhang, Hai-Kang / Zhou, Meng / Kang, Le / Wei, Li-Ya

    Insect science

    2021  Volume 29, Issue 1, Page(s) 21–32

    Abstract: With the wide application of genome editing in insects, a simple and efficient identification method is urgently needed to meet the increasing demand for mutation detection. Here, taking migratory locusts as a model system, we developed a non-invasive ... ...

    Abstract With the wide application of genome editing in insects, a simple and efficient identification method is urgently needed to meet the increasing demand for mutation detection. Here, taking migratory locusts as a model system, we developed a non-invasive method to accurately identify genome-edited mutants by using DNA from insect exuviae. We compared the quantity and quality of genomic DNA from exuviae in five instar hoppers and found that the 1st instar exuviae had the highest DNA yield and content, while the 3rd instar exuviae had the best quality. Consensus genotypes were identified from genomic DNA of hoppers at different developmental stages in the same individuals. Moreover, we demonstrated that the amplification products from DNA extracted from locust exuviae are the consensus sequences with those from the hemolymph and foreleg pre-tarsus. Therefore, non-invasive samples provide the same genotyping results as minimally invasive and invasive samples of the same individuals. Furthermore, this identification method that uses genomic DNA from exuviae can be used for early screening of positive genome-edited individuals in each generation for adult crossing. In our study, the non-invasive identification method was not only simpler and provided results earlier than existing methods, but also had a better reproducibility and accuracy. This non-invasive identification approach using genomic DNA from exuviae can be adapted to meet the growing demand for genetic analysis and will find wide application in insect genome editing research.
    MeSH term(s) Animals ; DNA ; Gene Editing ; Genome ; Insecta ; Reproducibility of Results
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2021-04-16
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179775-4
    ISSN 1744-7917 ; 1672-9609
    ISSN (online) 1744-7917
    ISSN 1672-9609
    DOI 10.1111/1744-7917.12914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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