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Article ; Online: Teicoplanin-Decorated Reduced Graphene Oxide Incorporated Silk Protein Hybrid Hydrogel for Accelerating Infectious Diabetic Wound Healing and Preventing Diabetic Foot Osteomyelitis.

Bakadia, Bianza Moise / Zheng, Ruizhu / Qaed Ahmed, Abeer Ahmed / Shi, Zhijun / Babidi, Bakamona Lyna / Sun, Tun / Li, Ying / Yang, Guang

Advanced healthcare materials

2024 , Page(s) e2304572

Abstract: Developing hybrid hydrogel dressings with anti-inflammatory, antioxidant, angiogenetic, and antibiofilm activities with higher bone tissue penetrability to accelerate diabetic wound healing and prevent diabetic foot osteomyelitis (DFO) is highly ... ...

Abstract	Developing hybrid hydrogel dressings with anti-inflammatory, antioxidant, angiogenetic, and antibiofilm activities with higher bone tissue penetrability to accelerate diabetic wound healing and prevent diabetic foot osteomyelitis (DFO) is highly desirable in managing diabetic wounds. Herein, the glycopeptide teicoplanin is used for the first time as a green reductant to chemically reduce graphene oxide (GO). The resulting teicoplanin-decorated reduced graphene oxide (rGO) is incorporated into a mixture of silk proteins (SP) and crosslinked with genipin to yield a physicochemically crosslinked rGO-SP hybrid hydrogel. This hybrid hydrogel exhibits high porosity, self-healing, shear-induced thinning, increased cell proliferation and migration, and mechanical properties suitable for tissue engineering. Moreover, the hybrid hydrogel eradicates bacterial biofilms with a high penetrability index in agar and hydroxyapatite disks covered with biofilms, mimicking bone tissue. In vivo, the hybrid hydrogel accelerates the healing of noninfected wounds in a diabetic rat and infected wounds in a diabetic mouse by upregulating anti-inflammatory cytokines and downregulating matrix metalloproteinase-9, promoting M2 macrophage polarization and angiogenesis. The implantation of hybrid hydrogel into the infected site of mouse tibia improves bone regeneration. Hence, the rGO-SP hybrid hydrogel can be a promising wound dressing for treating infectious diabetic wounds, providing a further advantage in preventing DFO.
Language	English
Publishing date	2024-04-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202304572
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study of the SARS-CoV-2 genomic data generation to evaluate the introduction of genomics in epidemiological surveillance and public health decision making.

Souho, Tiatou / Lamboni, Lallepak / Bakadia, Bianza Moise / Taale, Essodolom / Palanga, Koffi Kibalou / Amouzou, Sabiba Kou'santa

The Pan African medical journal

2022 Volume 41, Page(s) 55

Abstract: Introduction: the limited number of equipped laboratories and the lack of expertise left Africa lagging behind in terms of contribution in genomic data generation. The COVID-19 pandemic has drawn the attention of all public health stakeholders so that ... ...

Abstract	Introduction: the limited number of equipped laboratories and the lack of expertise left Africa lagging behind in terms of contribution in genomic data generation. The COVID-19 pandemic has drawn the attention of all public health stakeholders so that it can be used as a marker of the efforts that public health systems can produced. The main purpose of the present analytical study was to evaluate the contribution of the African continent in the genomic surveillance of SARS-CoV-2. Methods: data from the two most popular genomic databases on SARS-CoV-2 (GISAID EpiCov and NCBI Virus) were extracted and analyzed. Comparisons were made using the sequencing ratio which represents the number of genomic sequence published over one thousands confirmed cases. Results: considering continental blocks, the Africa occupied the fourth place after Oceania, Europe and North America based on sequencing ratios. However, when the considered comparison parameter is the number of sequences, the African continent was the fifth contributor after Europe, North America, Asia and South America. Conclusion: the study showed that African countries have effectively integrated the genomic data generation in the public health response strategies but the effective use of these data for a perfect surveillance is not clearly established. There is a need for capacity building in genomic data analyses for a better response to public health threats in Africa.
MeSH term(s)	COVID-19/epidemiology ; Decision Making ; Genome, Viral ; Genomics ; Humans ; Pandemics ; Public Health ; SARS-CoV-2/genetics
Language	English
Publishing date	2022-01-20
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2022.41.55.32344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Bakadia, Bianza Moise / Boni, Biaou Oscar Ode / Ahmed, Abeer Ahmed Qaed / Yang, Guang

Life sciences. 2021 Jan. 01, v. 264

2021

Abstract: The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a substantial stressor that is greatly impacting environmental sustainability. Besides, the different pre-existing environmental stressors and coronavirus ... ...

Abstract	The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a substantial stressor that is greatly impacting environmental sustainability. Besides, the different pre-existing environmental stressors and coronavirus disease-2019 (COVID-19)-related stressors are further worsening the effects of the viral disease by inducing the generation of oxidative stress. The generated oxidative stress results in nucleic acid damage associated with viral mutations, that could potentially reduce the effectiveness of COVID-19 management, including the vaccine approach. The current review is aimed to overview the impact of the oxidative stress damage induced by various environmental stressors on COVID-19. The available data regarding the COVID-19-related stressors and the effects of oxidative stress damage induced by the chronic stress, exposure to free radicals, and malnutrition are also analyzed to showcase the promising options, which could be investigated further for sustainable control of the pandemic.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; environmental sustainability ; malnutrition ; nucleic acids ; oxidative stress ; pandemic ; vaccines
Language	English
Dates of publication	2021-0101
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118653
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In Situ Synthesized Porous Bacterial Cellulose/Poly(vinyl alcohol)-Based Silk Sericin and Azithromycin Release System for Treating Chronic Wound Biofilm.

Bakadia, Bianza Moise / Boni, Biaou Oscar Ode / Ahmed, Abeer Ahmed Qaed / Zheng, Ruizhu / Shi, Zhijun / Ullah, Muhammad Wajid / Lamboni, Lallepak / Yang, Guang

Macromolecular bioscience

2022 Volume 22, Issue 10, Page(s) e2200201

Abstract: Chronic wounds are associated with infectious microbial complex communities called biofilms. The management of chronic wound infection is limited by the complexity of selecting an appropriate antimicrobial dressing with antibiofilm activity due to ... ...

Abstract	Chronic wounds are associated with infectious microbial complex communities called biofilms. The management of chronic wound infection is limited by the complexity of selecting an appropriate antimicrobial dressing with antibiofilm activity due to antimicrobial resistance in biofilms. Herein, the in situ developed bacterial cellulose/poly(vinyl alcohol) (BC-PVA) composite is ex situ modified with genipin-crosslinked silk sericin (SS) and azithromycin (AZM) (SSga). The composite is evaluated as a wound dressing material for preventing the development, dispersion, and/or eradication of microbial biofilm. Fourier transform infrared spectroscopy confirms the intermolecular interactions between the components of BC-PVA@SSga scaffolds. The addition of PVA during BC production significantly increases the porosity from 53.5% ± 2.3% to 83.5% ± 2.9%, the pore size from 2.3 ± 1.9 to 16.8 ± 4.5 µm, the fiber diameter from 35.5 ± 10 to 120 ± 27.4 nm, and improves the thermal stability and flexibility. Studies using bacteria and fungi indicate high inhibition and disruption of biofilms upon AZM addition. In vitro biocompatibility analysis confirms the nontoxic nature of BC-PVA@SSga toward HaCaT and NIH3T3 cells, whereas the addition of SS enhances cell proliferation. The developed BC-PVA@SSga accelerates wound healing in the infected mouse model, thus can be a promising wound dressing biomaterial.
MeSH term(s)	Animals ; Anti-Infective Agents ; Azithromycin/pharmacology ; Bacteria ; Biocompatible Materials ; Biofilms ; Cellulose/pharmacology ; Mice ; NIH 3T3 Cells ; Polyvinyl Alcohol/chemistry ; Polyvinyl Alcohol/pharmacology ; Porosity ; Sericins/chemistry ; Sericins/pharmacology
Chemical Substances	Anti-Infective Agents ; Biocompatible Materials ; Sericins ; Azithromycin (83905-01-5) ; Polyvinyl Alcohol (9002-89-5) ; Cellulose (9004-34-6)
Language	English
Publishing date	2022-08-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202200201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Engineering homologous platelet-rich plasma, platelet-rich plasma-derived exosomes, and mesenchymal stem cell-derived exosomes-based dual-crosslinked hydrogels as bioactive diabetic wound dressings.

Bakadia, Bianza Moise / Qaed Ahmed, Abeer Ahmed / Lamboni, Lallepak / Shi, Zhijun / Mutu Mukole, Biampata / Zheng, Ruizhu / Pierre Mbang, Mazono / Zhang, Bi / Gauthier, Mario / Yang, Guang

Bioactive materials

2023 Volume 28, Page(s) 74–94

Abstract: The management of diabetic wounds remains a critical therapeutic challenge. Platelet-rich plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated therapeutic potential in wound treatment. ...

Abstract	The management of diabetic wounds remains a critical therapeutic challenge. Platelet-rich plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated therapeutic potential in wound treatment. Unfortunately, their poor mechanical properties, the short half-lives of growth factors (GFs), and the burst release of GFs and exosomes have limited their clinical applications. Furthermore, proteases in diabetic wounds degrade GFs, which hampers wound repair. Silk fibroin is an enzyme-immobilization biomaterial that could protect GFs from proteases. Herein, we developed novel dual-crosslinked hydrogels based on silk protein (SP) (sericin and fibroin), including SP@PRP, SP@MSC-Exos, and SP@PRP-Exos, to promote diabetic wound healing synergistically. SP@PRP was prepared from PRP and SP using calcium gluconate/thrombin as agonist, while SP@PRP-Exos and SP@MSC-Exos were derived from exosomes and SP with genipin as crosslinker. SP provided improved mechanical properties and enabled the sustained release of GFs and exosomes, thereby overcoming the limitations of PRP and exosomes in wound healing. The dual-crosslinked hydrogels displayed shear-induced thinning, self-healing, and eradication of microbial biofilms in a bone-mimicking environment.
Language	English
Publishing date	2023-05-17
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of oxidative stress damage induced by the environmental stressors on COVID-19.

Bakadia, Bianza Moise / Boni, Biaou Oscar Ode / Ahmed, Abeer Ahmed Qaed / Yang, Guang

Life sciences

2020 Volume 264, Page(s) 118653

Abstract	The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a substantial stressor that is greatly impacting environmental sustainability. Besides, the different pre-existing environmental stressors and coronavirus disease-2019 (COVID-19)-related stressors are further worsening the effects of the viral disease by inducing the generation of oxidative stress. The generated oxidative stress results in nucleic acid damage associated with viral mutations, that could potentially reduce the effectiveness of COVID-19 management, including the vaccine approach. The current review is aimed to overview the impact of the oxidative stress damage induced by various environmental stressors on COVID-19. The available data regarding the COVID-19-related stressors and the effects of oxidative stress damage induced by the chronic stress, exposure to free radicals, and malnutrition are also analyzed to showcase the promising options, which could be investigated further for sustainable control of the pandemic.
MeSH term(s)	Antioxidants/therapeutic use ; COVID-19/virology ; DNA Damage/genetics ; Diet, Healthy ; Disease Management ; Healthy Lifestyle ; Humans ; Mutation ; Oxidative Stress/genetics ; Pandemics ; SARS-CoV-2/genetics ; COVID-19 Drug Treatment
Chemical Substances	Antioxidants
Keywords	covid19
Language	English
Publishing date	2020-10-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118653
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immune Response to Silk Sericin-Fibroin Composites: Potential Immunogenic Elements and Alternatives for Immunomodulation.

Ode Boni, Biaou Oscar / Bakadia, Bianza Moïse / Osi, Amarachi Rosemary / Shi, Zhijun / Chen, Hong / Gauthier, Mario / Yang, Guang

Macromolecular bioscience

2021 Volume 22, Issue 1, Page(s) e2100292

Abstract: The unique properties of silk proteins (SPs), particularly silk sericin (SS) and silk fibroin (SF), have attracted attention in the design of scaffolds for tissue engineering over the past decades. Since SF has good mechanical properties, while SS ... ...

Abstract	The unique properties of silk proteins (SPs), particularly silk sericin (SS) and silk fibroin (SF), have attracted attention in the design of scaffolds for tissue engineering over the past decades. Since SF has good mechanical properties, while SS displays bioactivity, scaffolds combining both proteins should exhibit complementary properties enhancing the potential of these materials. Unfortunately, SS-SF composites can generate chronic immune responses and their immunogenic element is not completely clear. The potential of SS-SF composites in tissue engineering, elements which may contribute to their immunogenicity, and alternatives for their preparation and design, to modulate the immune response and take advantage of their useful properties, are discussed in this review. It is known that SS can enhance β-sheet formation in SF, which may act as hydrophobic regions with a strong affinity for adsorption proteins inducing the chronic recruitment of inflammatory cells. Therefore, tailoring the exposure of hydrophobic regions at the scaffold surface should represent a viable strategy to modulate the immune response. This can be achieved by coating SS-SF composites with SS or other hydrophilic polymers, to take advantage of their antibiofouling properties. Research is still needed to realize the full potential of these composites for tissue engineering.
MeSH term(s)	Fibroins/chemistry ; Fibroins/pharmacology ; Immunity ; Immunomodulation ; Sericins/chemistry ; Sericins/pharmacology ; Silk/chemistry ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Sericins ; Silk ; Fibroins (9007-76-5)
Language	English
Publishing date	2021-11-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202100292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Bakadia, Bianza Moise / Boni, Biaou Oscar Ode / Ahmed, Abeer Ahmed Qaed / Yang, Guang

Life Sciences

2020 , Page(s) 118653

Keywords	General Pharmacology, Toxicology and Pharmaceutics ; General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118653
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Bakadia, Bianza Moise / Boni, Biaou Oscar Ode / Ahmed, Abeer Ahmed Qaed / Yang, Guang

Life Sci

Abstract	The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a substantial stressor that is greatly impacting environmental sustainability. Besides, the different pre-existing environmental stressors and coronavirus disease-2019 (COVID-19)-related stressors are further worsening the effects of the viral disease by inducing the generation of oxidative stress. The generated oxidative stress results in nucleic acid damage associated with viral mutations, that could potentially reduce the effectiveness of COVID-19 management, including the vaccine approach. The current review is aimed to overview the impact of the oxidative stress damage induced by various environmental stressors on COVID-19. The available data regarding the COVID-19-related stressors and the effects of oxidative stress damage induced by the chronic stress, exposure to free radicals, and malnutrition are also analyzed to showcase the promising options, which could be investigated further for sustainable control of the pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #894106
Database	COVID19

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Article ; Online: The impact of ExHp-CD (outer membrane vesicles) released from Helicobacter pylori SS1 on macrophage RAW 264.7 cells and their immunogenic potential.

Ahmed, Abeer Ahmed Qaed / Qi, Fuyu / Zheng, Ruizhu / Xiao, Lin / Abdalla, Ahmed M E / Mao, Lin / Bakadia, Bianza Moise / Liu, Li / Atta, Omar Mohammad / Li, Xiaohong / Shi, Zhijun / Yang, Guang

Life sciences

2021 Volume 279, Page(s) 119644

Abstract: Bacterial-derived extracellular vesicles could play a major role in attenuating and treating diseases. They play a major anti-infection role by modulating immune responses against pathogens and preventing infection by inhibiting pathogen localization and ...

Abstract	Bacterial-derived extracellular vesicles could play a major role in attenuating and treating diseases. They play a major anti-infection role by modulating immune responses against pathogens and preventing infection by inhibiting pathogen localization and proliferation. In this study, outer membrane vesicles (ExHp-CD) released by Helicobacter pylori SS1 (H. pylori) and total antigens isolated from H. pylori SS1 (AgHp) were evaluated for their immunogenic potential and their effect on macrophage RAW 264.7 cells. Results demonstrated that both ExHp-CD and AgHp induced T helper 2 (Th2) immune response, which was reported to be important in immune protection against H. pylori infections. Both ExHp-CD and AgHp produced high levels of IL-10 and IL-4, while no significant levels of IL-12 p70 or IFN-γ were detected. However, ExHp-CD showed a better effect on macrophage RAW 264.7 cells compared to AgHp. Macrophage RAW 264.7 cells stimulated with 5, and 10 μg/mL of ExHp-CD showed an increased ratio of CD206 (M2 phenotype marker) and a decreased ratio of CD86 (M1 phenotype marker). Moreover, results suggested that the immunogenic effect that ExHp-CD possesses was attributed to their cargo of Epimerase_2 domain-containing protein (Epi_2D), Probable malate:quinone oxidoreductase (Pro_mqo), and Probable cytosol aminopeptidase (Pro_ca). Results demonstrated that ExHp-CD possesses an immunological activity to induce Th2 immune response against H. pylori infection with results comparable to AgHp. However, ExHp-CD showed higher efficacy regarding safety, biocompatibility, lack of toxicity, and hemocompatibility. Thus, it could serve as an immunogenic candidate with more desired characteristics.
MeSH term(s)	Animals ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Extracellular Vesicles/immunology ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter pylori/immunology ; Host-Pathogen Interactions ; Immunity, Cellular/immunology ; Macrophages/immunology ; Mice ; RAW 264.7 Cells
Chemical Substances	Antigens, Bacterial ; Bacterial Proteins
Language	English
Publishing date	2021-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119644
Database	MEDical Literature Analysis and Retrieval System OnLINE

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