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  1. Article ; Online: How we changed our approach to venous thromboembolism.

    Ageno, Walter

    Haematologica

    2022  Volume 107, Issue 10, Page(s) 2286–2287

    MeSH term(s) Humans ; Pulmonary Embolism ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology
    Language English
    Publishing date 2022-10-01
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treatment of Atypical Clots.

    Ageno, Walter

    Hamostaseologie

    2022  Volume 42, Issue 1, Page(s) 10–18

    Abstract: The term unusual site thrombosis refers to the occurrence of venous thromboembolism outside of the lower limbs and the pulmonary arteries. Unusual site thrombosis can virtually affect any venous segment, with the most common and/or clinically relevant ... ...

    Abstract The term unusual site thrombosis refers to the occurrence of venous thromboembolism outside of the lower limbs and the pulmonary arteries. Unusual site thrombosis can virtually affect any venous segment, with the most common and/or clinically relevant sites including the upper limbs veins, the retinal veins, the splanchnic veins and the cerebral veins. Clinical features are obviously heterogeneous, while many predisposing factors are common, though with different prevalence among the various disorders. Antithrombotic therapy is prescribed to most patients, but the type, intensity, and duration of treatment vary both within and among patient groups. Increasing evidence is supporting the use of the direct oral anticoagulants in patients with upper limb deep vein thrombosis, cerebral vein thrombosis, and with splanchnic vein thrombosis. This article will review available evidence on the treatment of venous thrombosis occurring in unusual sites.
    MeSH term(s) Anticoagulants/therapeutic use ; Humans ; Risk Factors ; Venous Thromboembolism/drug therapy ; Venous Thrombosis/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1669-3336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1631: Show issues Location:
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  3. Article ; Online: Difficult challenges in vascular medicine: an overview.

    Ageno, Walter

    Minerva medica

    2021  Volume 112, Issue 6, Page(s) 698–700

    MeSH term(s) Cardiology ; Humans ; Venous Thromboembolism/therapy
    Language English
    Publishing date 2021-07-08
    Publishing country Italy
    Document type Editorial
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.21.07702-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Treatment of Atypical Clots

    Ageno, Walter

    Hämostaseologie

    2022  Volume 42, Issue 01, Page(s) 10–18

    Abstract: The term unusual site thrombosis refers to the occurrence of venous thromboembolism outside of the lower limbs and the pulmonary arteries. Unusual site thrombosis can virtually affect any venous segment, with the most common and/or clinically relevant ... ...

    Abstract The term unusual site thrombosis refers to the occurrence of venous thromboembolism outside of the lower limbs and the pulmonary arteries. Unusual site thrombosis can virtually affect any venous segment, with the most common and/or clinically relevant sites including the upper limbs veins, the retinal veins, the splanchnic veins and the cerebral veins. Clinical features are obviously heterogeneous, while many predisposing factors are common, though with different prevalence among the various disorders. Antithrombotic therapy is prescribed to most patients, but the type, intensity, and duration of treatment vary both within and among patient groups. Increasing evidence is supporting the use of the direct oral anticoagulants in patients with upper limb deep vein thrombosis, cerebral vein thrombosis, and with splanchnic vein thrombosis. This article will review available evidence on the treatment of venous thrombosis occurring in unusual sites.
    Keywords venous thrombosis ; unusual site thrombosis ; anticoagulation ; direct oral anticoagulants
    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1669-3336
    Database Thieme publisher's database

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  5. Article ; Online: Anticoagulation in Patients with Isolated Distal Deep Vein Thrombosis: Bringing the Puzzle Together.

    Potere, Nicola / Yamashita, Yugo / Ageno, Walter

    Thrombosis and haemostasis

    2024  

    Language English
    Publishing date 2024-02-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2250-3298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of artificial intelligence and radiomics for risk stratification in patients with pulmonary embolism: New tools for an old problem.

    Santagata, Davide / Donadini, Marco Paolo / Ageno, Walter

    European journal of clinical investigation

    2024  Volume 54, Issue 5, Page(s) e14171

    MeSH term(s) Humans ; Artificial Intelligence ; Radiomics ; Risk Assessment ; Pulmonary Embolism/diagnostic imaging
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Editorial
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14171
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    Zs.A 677: Show issues Location:
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  7. Article ; Online: How to manage splanchnic vein thrombosis in patients with liver disease.

    Riva, Nicoletta / Ageno, Walter

    Hematology. American Society of Hematology. Education Program

    2023  Volume 2023, Issue 1, Page(s) 281–288

    Abstract: Liver cirrhosis and splanchnic vein thrombosis (SVT) are strictly correlated. Portal vein thrombosis, the most common location of SVT, is frequently diagnosed in liver cirrhosis (pooled incidence 4.6 per 100 patient-years), and liver cirrhosis is a ... ...

    Abstract Liver cirrhosis and splanchnic vein thrombosis (SVT) are strictly correlated. Portal vein thrombosis, the most common location of SVT, is frequently diagnosed in liver cirrhosis (pooled incidence 4.6 per 100 patient-years), and liver cirrhosis is a common risk factor for SVT (reported in 24%-28% of SVT patients). In cirrhosis-associated SVT, anticoagulant treatment reduces mortality rates, thrombosis extension, and major bleeding, and increases the rates of recanalization, compared to no treatment. Achieving vessel recanalization improves the prognosis of cirrhotic patients by reducing liver-related complications (such as variceal bleeding, ascites, hepatic encephalopathy). Anticoagulation should be therefore routinely prescribed to cirrhotic patients with acute SVT unless contraindicated by active bleeding associated with hemodynamic impairment or by excessively high bleeding risk. Of note, early treatment is associated with higher probability of achieving vessel recanalization. The standard treatment consists of low-molecular-weight heparin, followed by oral anticoagulants (eg, vitamin K antagonists or direct oral anticoagulants), if not contraindicated by severe liver dysfunction. Cirrhotic patients with SVT should be treated long-term (especially if candidate for liver transplantation) since liver cirrhosis is a persistent risk factor for recurrent thrombosis. In this review, we discuss the management of SVT in patients with liver cirrhosis, with a focus on the anticoagulant treatment in terms of indications, timing, drugs, duration, and particular scenarios, such as gastroesophageal varices and thrombocytopenia.
    MeSH term(s) Humans ; Esophageal and Gastric Varices/chemically induced ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/drug therapy ; Gastrointestinal Hemorrhage/etiology ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology ; Anticoagulants/therapeutic use ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Thrombosis/drug therapy ; Splanchnic Circulation
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2023000481
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  8. Article ; Online: How to treat isolated distal deep vein thrombosis.

    Potere, Nicola / Ageno, Walter

    Polish archives of internal medicine

    2023  Volume 133, Issue 7-8

    Abstract: Isolated distal deep vein thrombosis (IDDVT) is a frequent manifestation of venous thromboembolism (VTE), accounting for up to 50% cases of lower‑extremity deep vein thrombosis (DVT). As compared with proximal DVT, IDDVT is more frequently associated ... ...

    Abstract Isolated distal deep vein thrombosis (IDDVT) is a frequent manifestation of venous thromboembolism (VTE), accounting for up to 50% cases of lower‑extremity deep vein thrombosis (DVT). As compared with proximal DVT, IDDVT is more frequently associated with transient risk factors and less often occurs unprovoked or in the presence of permanent risk factors. IDDVT generally carries a significantly lower risk of proximal extension, post‑thrombotic syndrome, and recurrence than proximal DVT. Nevertheless, some patient subgroups, such as those with active cancer, other predisposing permanent risk factors, prior VTE, unprovoked IDDVT, persistently restricted mobility, and trifurcation or bilateral involvement, exhibit a non‑negligible recurrence risk. Unlike in proximal DVT, the optimal therapeutic management of IDDVT remains uncertain. In clinical practice, the vast majority of IDDVT patients are managed with anticoagulation rather than with surveillance serial compression ultrasonography, which tends to be reserved to individuals at a high bleeding risk. Available data seem to favor anticoagulant therapy over no anticoagulation, thanks to a significant reduction in the risk for proximal extension and recurrence, without increased bleeding risk. Recent results of the RIDTS (Rivaroxaban for the Treatment of Symptomatic Isolated Distal Deep Vein Thrombosis) randomized clinical trial with rivaroxaban further support the use of anticoagulant therapy for 3 months over shorter durations (eg, ≤6 weeks). In this review, we offer an updated overview of the epidemiology, risk factors, and clinical course of IDDVT, with a focus on the therapeutic management in light of current guideline recommendations and most recent evidence. We also present real‑life clinical cases of IDDVT with proposed therapeutic approaches, and highlight major challenges and gaps in this field.
    MeSH term(s) Humans ; Venous Thromboembolism/epidemiology ; Rivaroxaban/therapeutic use ; Recurrence ; Venous Thrombosis/drug therapy ; Anticoagulants/therapeutic use ; Hemorrhage ; Randomized Controlled Trials as Topic
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Anticoagulants
    Language English
    Publishing date 2023-08-07
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 360: Show issues Location:
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  9. Book: Reversal of anticoagulants

    Beyer-Westendorf, Jan / Marten, Sandra / Ageno, Walter / Ay, Cihan

    2018  

    Author's details Jan Beyer-Westendorf ; Co-Authors: Sandra Marten, Walter Ageno, Cihan Ay
    Keywords Antikoagulans ; Blutung
    Subject Hämorrhagie ; Blutungen ; Anticoagulans ; Gerinnungshemmendes Mittel ; Gerinnungshemmer ; Blutgerinnungshemmendes Mittel ; Thrombininhibitor ; Blutgerinnungshemmer
    Subject code 616.135061
    Language English
    Size 80 Seiten, Illustrationen, 25 cm
    Edition 1st edition
    Publisher UNI-MED Verlag AG
    Publishing place Bremen ; London ; Boston
    Publishing country Germany
    Document type Book
    HBZ-ID HT019802654
    ISBN 978-3-8374-2389-1 ; 3-8374-2389-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2018 A 1506 available for loan (reading room) Lesesaal EG

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  10. Article ; Online: The Legacy of Edwards and Steptoe and the Windy Roads of Assisted Reproduction: Where Do We Stand with Venous Thromboembolism?

    Grandone, Elvira / Ageno, Walter

    Thrombosis and haemostasis

    2022  Volume 123, Issue 3, Page(s) 267–269

    MeSH term(s) Humans ; Venous Thromboembolism ; Reproduction ; Fertilization in Vitro
    Language English
    Publishing date 2022-12-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1996-1341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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