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Article ; Online: Trust me, I'm a wreck doctors at large, an 11 part series on BBC2, looks at how a group of doctors have fared 14 years on from their acceptance at medical school. David fitzmaurice says future medics should be forced to watch the series in one sitting

Fitzmaurice

1998 Volume 316, Issue 7140, Page(s) 1325

Language	English
Publishing date	1998-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.316.7140.1325
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Article ; Online: Gods and Heroes.

Fitzmaurice, David Andrew

The British journal of general practice : the journal of the Royal College of General Practitioners

2015 Volume 65, Issue 637, Page(s) 423

MeSH term(s)	General Practice ; History, 19th Century ; History, 20th Century ; Humans ; Paintings/history
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	1043148-2
ISSN	1478-5242 ; 0035-8797 ; 0960-1643
ISSN (online)	1478-5242
ISSN	0035-8797 ; 0960-1643
DOI	10.3399/bjgp15X686257
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Article ; Online: ICSH guidance for INR and D-dimer testing using point of care testing in primary care.

Fitzmaurice, David A / Geersing, Geert-Jan / Armoiry, Xavier / Machin, Sam / Kitchen, Steve / Mackie, Ian

International journal of laboratory hematology

2023 Volume 45, Issue 3, Page(s) 276–281

Abstract: This guideline has been written on behalf of the International Council for Standardisation in Haematology (ICSH) and focuses on two point of care haematology tests used within primary care, namely International Normalised Ratio (INR) and D-dimer. Primary ...

Abstract	This guideline has been written on behalf of the International Council for Standardisation in Haematology (ICSH) and focuses on two point of care haematology tests used within primary care, namely International Normalised Ratio (INR) and D-dimer. Primary care covers out of hospital settings and can include General Practice (GP), Pharmacy and other non-hospital settings (although these guidelines would also be applicable to hospital out-patient settings). The recommendations are based on published data in peer reviewed literature and expert opinion; they should supplement regional requirements, regulations or standards.
MeSH term(s)	Humans ; International Normalized Ratio ; Hematologic Tests ; Point-of-Care Testing ; Primary Health Care
Chemical Substances	fibrin fragment D
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14051
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Article ; Online: Optimising prediction of mortality, stroke, and major bleeding for patients with atrial fibrillation: validation of the GARFIELD-AF tool in UK primary care electronic records.

Apenteng, Patricia N / Prieto-Merino, David / Hee, Siew Wan / Lobban, Trudie Ca / Caleyachetty, Rishi / Fitzmaurice, David A

The British journal of general practice : the journal of the Royal College of General Practitioners

2023 Volume 73, Issue 736, Page(s) e816–e824

Abstract: Background: The GARFIELD-AF tool is a novel risk tool that simultaneously assesses the risk of all-cause mortality, stroke or systemic embolism, and major bleeding in patients with atrial fibrillation (AF).: Aim: To validate the GARFIELD-AF tool ... ...

Abstract	Background: The GARFIELD-AF tool is a novel risk tool that simultaneously assesses the risk of all-cause mortality, stroke or systemic embolism, and major bleeding in patients with atrial fibrillation (AF). Aim: To validate the GARFIELD-AF tool using UK primary care electronic records. Design and setting: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD) linked with Hospital Episode Statistics data and Office for National Statistics mortality data. Method: Discrimination was evaluated using the area under the curve (AUC) and calibration was evaluated using calibration-in-the-large regression and calibration plots. Results: A total of 486 818 patients aged ≥18 years with incident diagnosis of non-valvular AF between 2 January 1998 and 31 July 2020 were included; 50.6% ( Conclusion: The GARFIELD-AF models were superior to the CHA
MeSH term(s)	Humans ; Adolescent ; Adult ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Retrospective Studies ; Anticoagulants/therapeutic use ; Risk Factors ; Risk Assessment ; Stroke/epidemiology ; Hemorrhage ; United Kingdom/epidemiology ; Primary Health Care ; Electronics ; Registries
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1043148-2
ISSN	1478-5242 ; 0035-8797 ; 0960-1643
ISSN (online)	1478-5242
ISSN	0035-8797 ; 0960-1643
DOI	10.3399/BJGP.2023.0082
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Zs.B 576: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Lung Cancer in the Republic of Ireland.

Keogh, Rachel J / Barr, Martin P / Keogh, Anna / McMahon, David / Baird, Anne-Marie / Cotter, Seamus / Breen, David / Fitzmaurice, Gerard J / Fitzpatrick, David / O'Brien, Cathal / Finn, Stephen P / Naidoo, Jarushka

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2023 Volume 18, Issue 7, Page(s) 851–857

MeSH term(s)	Humans ; Ireland/epidemiology ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Editorial
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2023.03.027
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Zs.A 6664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Atrial fibrillation and coagulation: who and when?

Fitzmaurice, David

Blood reviews

2009 Volume 23, Issue 6, Page(s) 241–244

Abstract: Atrial fibrillation is an independent risk factor for stroke and is also associated with increased mortality above the age of 65 in both males and females. Various factors increase the stroke risk, with the most widely used risk assessment tool being the ...

Abstract	Atrial fibrillation is an independent risk factor for stroke and is also associated with increased mortality above the age of 65 in both males and females. Various factors increase the stroke risk, with the most widely used risk assessment tool being the CHADS2 score which incorporates, heart failure, hypertension, age, diabetes and hitroys of previous stroke or transient ischaemic attack. Despite good evidence for the effectiveness of warfarin in preventing stroke and reducing mortality in atrial fibrillation, there remain a large proportion of patients who do not receive appropriate treatment. All patients with atrial fibrillation should be considered for warfarin therapy aiming for an INR of 2.5. Whilst newer agents may replace warfarin in the future, the evidence for anti-platelet therapy is poor and aspirin should be reserved only for patients who have very low stroke risk or those patients who cannot tolerate warfarin therapy.
MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Blood Coagulation/drug effects ; Female ; Humans ; Male ; Risk Factors ; Stroke/complications
Chemical Substances	Anticoagulants
Language	English
Publishing date	2009-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639015-8
ISSN	1532-1681 ; 0268-960X
ISSN (online)	1532-1681
ISSN	0268-960X
DOI	10.1016/j.blre.2009.07.006
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Zs.A 2207: Show issues

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Article ; Online: Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.

Ji, Xiaojie / Zhao, Lihong / Umapathy, Ankita / Fitzmaurice, Bernard / Wang, Jieping / Williams, David S / Chang, Bo / Naggert, Jürgen K / Nishina, Patsy M

PloS one

2022 Volume 17, Issue 3, Page(s) e0254469

Abstract: Chediak-Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ... ...

Abstract	Chediak-Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of lysosomes and lysosome-related organelles. Although recent studies have suggested that Lyst mutations impair the regulation of sizes of lysosome and lysosome-related organelle, the underlying pathogenic mechanism of Chediak-Higashi syndrome is still unclear. Here we show striking evidence that deficiency in LYST protein function leads to accumulation of photoreceptor outer segment phagosomes in retinal pigment epithelial cells, and reduces adhesion between photoreceptor outer segment and retinal pigment epithelial cells in a mouse model of Chediak-Higashi syndrome. In addition, we observe elevated levels of cathepsins, matrix metallopeptidase (MMP) 3 and oxidative stress markers in the retinal pigment epithelium of Lyst mutants. Previous reports showed that impaired degradation of photoreceptor outer segment phagosomes causes elevated oxidative stress, which could consequently lead to increases of cysteine cathepsins and MMPs in the extracellular matrix. Taken together, we conclude that the loss of LYST function causes accumulation of phagosomes in the retinal pigment epithelium and elevation of several extracellular matrix-remodeling proteases through oxidative stress, which may, in turn, reduce retinal adhesion. Our work reveals previously unreported pathogenic events in the retinal pigment epithelium caused by Lyst deficiency. The same pathogenic events may be conserved in other professional phagocytic cells, such as macrophages in the immune system, contributing to overall Chediak-Higashi syndrome pathology.
MeSH term(s)	Peptide Hydrolases
Chemical Substances	Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0254469
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Article ; Online: Two-year outcomes of UK patients newly diagnosed with atrial fibrillation: findings from the prospective observational cohort study GARFIELD-AF.

Apenteng, Patricia N / Virdone, Saverio / Hobbs, Fd Richard / Camm, A John / Fox, Keith Aa / Pieper, Karen S / Kayani, Gloria / Fitzmaurice, David

The British journal of general practice : the journal of the Royal College of General Practitioners

2022

Abstract: Background: The outcomes of patients newly diagnosed with atrial fibrillation (AF) following the introduction of direct-acting oral anticoagulants are not well known.: Aim: To determine the 2-year outcomes of patients newly diagnosed with AF, and the ...

Abstract	Background: The outcomes of patients newly diagnosed with atrial fibrillation (AF) following the introduction of direct-acting oral anticoagulants are not well known. Aim: To determine the 2-year outcomes of patients newly diagnosed with AF, and the effectiveness of oral anticoagulants in everyday practice. Design and setting: This was a prospective observational cohort study in UK primary care. Method: In total, 3574 patients aged ≥18 years with a new AF diagnosis were enrolled. A propensity score was applied using an overlap weighting scheme to obtain unbiased estimates of the treatment effect of anticoagulation versus no anticoagulation on the occurrence of death, non-haemorrhagic stroke/systemic embolism, and major bleeding within 2 years of diagnosis. Results: Overall, 65.8% received anticoagulant therapy, 20.8% received an antiplatelet only, and 13.4% received neither. During the study period, the overall incidence rates of all-cause mortality, non-haemorrhagic stroke/systemic embolism, and major bleeding were 4.15 (95% confidence interval [CI] = 3.69 to 4.65), 1.45 (95% CI = 1.19 to 1.77), and 1.21 (95% CI = 0.97 to 1.50) per 100 person-years, respectively. Anticoagulation treatment compared with no anticoagulation treatment was associated with significantly lower all-cause mortality adjusted hazard ratio (aHR) 0.70 (95% CI = 0.53 to 0.93), significantly lower risk of non-haemorrhagic stroke/systemic embolism (aHR 0.39, 95% CI = 0.24 to 0.62), and a non-significant higher risk of major bleeding (aHR 1.31, 95% CI = 0.77 to 2.24). Conclusion: The data support a benefit of anticoagulation in reducing stroke and death, without an increased risk of a major bleed in patients with new-onset AF. Anticoagulation treatment in patients at high risk of stroke who are not receiving anticoagulation may further improve outcomes.
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1043148-2
ISSN	1478-5242 ; 0035-8797 ; 0960-1643
ISSN (online)	1478-5242
ISSN	0035-8797 ; 0960-1643
DOI	10.3399/BJGP.2021.0548
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Article ; Online: Routine screening for detection of atrial fibrillation?

Fitzmaurice, David A

Future cardiology

2009 Volume 5, Issue 3, Page(s) 213–214

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Female ; Humans ; Male ; Mass Screening ; Middle Aged ; Prevalence ; State Medicine ; United Kingdom/epidemiology
Language	English
Publishing date	2009-05
Publishing country	England
Document type	Editorial
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca.09.3
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Article ; Online: The Value-of-Information and Value-of-Implementation from Clinical Trials of Diagnostic Tests for HIV-Associated Tuberculosis: A Modeling Analysis.

Pei, Pamela P / Fitzmaurice, Kieran P / Le, Mylinh H / Panella, Christopher / Jones, Michelle L / Pandya, Ankur / Horsburgh, C Robert / Freedberg, Kenneth A / Weinstein, Milton C / Paltiel, A David / Reddy, Krishna P

MDM policy & practice

2023 Volume 8, Issue 2, Page(s) 23814683231198873

Abstract: Objectives.: Highlights: In conventional VOI analysis, it is assumed that the optimal decision will always be adopted even without a trial. This can potentially lead to an underestimation of the value of trials when adoption requires new clinical ... ...

Abstract	Objectives. Highlights: In conventional VOI analysis, it is assumed that the optimal decision will always be adopted even without a trial. This can potentially lead to an underestimation of the value of trials when adoption requires new clinical trial evidence. To capture the influence that a trial may have on decision makers' willingness to adopt the optimal decision, we also consider value-of-implementation (VOM), a metric quantifying the benefit of new study information in promoting wider adoption of the optimal strategy. The overall value-of-a-trial (VOT) includes both VOI and VOM.Our model-based analysis suggests that the information obtained from a trial of screening strategies for HIV-associated tuberculosis in South Africa would have no value, when measured using traditional methods of VOI assessment. A novel strategy, which includes the urine FujiLAM test, is optimal from a health economic standpoint but is underutilized. A trial would reduce uncertainties around downstream health outcomes but likely would not change the optimal decision. The high VOT (nearly $700 million over 5 y) lies solely in promoting uptake of FujiLAM, represented as VOM.Our results highlight the importance of employing a more comprehensive approach for evaluating prospective trials, as conventional VOI methods can vastly underestimate their value. Trialists and funders can and should assess the VOT metric instead when considering trial designs and costs. If VOI is low, the VOM and cost of a trial can be compared with the benefits and costs of other outreach programs to determine the most cost-effective way to improve uptake.
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2861432-X
ISSN	2381-4683 ; 2381-4683
ISSN (online)	2381-4683
ISSN	2381-4683
DOI	10.1177/23814683231198873
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