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  1. Article ; Online: Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories.

    Ciornei, Radu Tudor

    Frontiers in immunology

    2020  Volume 11, Page(s) 1762

    MeSH term(s) Aged ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Cytokines/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/diet therapy ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Dietary Supplements ; Female ; Genotype ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Inflammation/diet therapy ; Inflammation/drug therapy ; Inflammation/virology ; Insulin/pharmacology ; Insulin/therapeutic use ; Male ; Middle Aged ; Pandemics/prevention & control ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Renin-Angiotensin System ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Cytokines ; Hypoglycemic Agents ; Insulin ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories

    Radu Tudor Ciornei

    Frontiers in Immunology, Vol

    2020  Volume 11

    Keywords COVID-19 ; SARS-CoV-2 ; Coronavirus ; probiotics ; low-grade inflammation ; type 2 diabetes ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Corrigendum to "Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia" [Cell. Immunol. 304-305 (2016) 16-26].

    Ciornei, Radu Tudor / Hong, So-Hee / Fang, Yujiang / Zhu, Ziwen / Braley-Mullen, Helen

    Cellular immunology

    2016  Volume 310, Page(s) 214

    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2016.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia.

    Ciornei, Radu Tudor / Hong, So-Hee / Fang, Yujiang / Zhu, Ziwen / Braley-Mullen, Helen

    Cellular immunology

    2016  Volume 304-305, Page(s) 16–26

    Abstract: IFN-γ(-/-) NOD.H-2h4 mice develop autoimmune disease with extensive hyperplasia and proliferation of thyroid epithelial cells (TEC H/P) and fibrosis. Splenic T cells from donors with severe TEC H/P transfer TEC H/P to SCID recipients. The goal of this ... ...

    Abstract IFN-γ(-/-) NOD.H-2h4 mice develop autoimmune disease with extensive hyperplasia and proliferation of thyroid epithelial cells (TEC H/P) and fibrosis. Splenic T cells from donors with severe TEC H/P transfer TEC H/P to SCID recipients. The goal of this study was to determine what factors control TEC H/P development/progression by examining T cells, markers of apoptosis, senescence and proliferation in thyroids of SCID recipients over time. At 28days, T cell infiltration was maximal, thyrocytes were proliferating, and fibrosis was moderate. At days 60 and 90, thyroids were larger with more fibrosis. T cells, cytokines and thyrocyte proliferation decreased, and cell cycle inhibitor proteins, and anti-apoptotic molecules increased. T cells and thyrocytes had foci of phosphorylated histone protein H2A.X, indicative of cellular senescence, when TEC H/P progressed and thyrocyte proliferation declined. Some thyrocytes were regenerating at day 90, with irregularly shaped empty follicles and ciliated epithelium. Proliferating thyrocytes were thyroid transcription factor (TTF1)-positive, suggesting they derived from epithelial cells and not brachial cleft remnants.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Cellular Senescence ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Fibrosis ; Histones/metabolism ; Humans ; Hyperplasia ; Interferon-gamma/genetics ; Mice ; Mice, Knockout ; Mice, SCID ; T-Lymphocytes/immunology ; Thyroid Epithelial Cells/metabolism ; Thyroid Epithelial Cells/pathology ; Thyroid Gland/pathology ; Thyroiditis, Autoimmune/metabolism ; Thyroiditis, Autoimmune/pathology ; Transcription Factors
    Chemical Substances Cytokines ; DNA-Binding Proteins ; H2AX protein, mouse ; Histones ; Transcription Factors ; Ttf1 protein, mouse ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2016-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2016.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Calcitonin gene-related peptide inhibits early B cell development in vivo.

    Schlomer, Jerome J / Storey, Benjamin B / Ciornei, Radu-Tudor / McGillis, Joseph P

    Journal of leukocyte biology

    2007  Volume 81, Issue 3, Page(s) 802–808

    Abstract: Recent in vitro studies suggest that calcitonin gene-related peptide (CGRP) inhibits early B cell differentiation; however, there is no evidence in the intact animal for a role for CGRP in B cell development. Here, we show that in vivo treatment of mice ... ...

    Abstract Recent in vitro studies suggest that calcitonin gene-related peptide (CGRP) inhibits early B cell differentiation; however, there is no evidence in the intact animal for a role for CGRP in B cell development. Here, we show that in vivo treatment of mice with CGRP reduces the number of IL-7 responsive B cell progenitors in bone marrow. A single CGRP treatment reduces IL-7-responsive B cell progenitors by up to 40% for up to 72 h. The reduction is dose-dependent and can be blocked by a CGRP receptor antagonist, CGRP(8-37). CGRP in serum following injection is highly elevated at 30 min but returns to basal levels by 4 h, suggesting that a single injection of CGRP has long-lasting effects on B cell development. This report provides the first direct in vivo evidence that CGRP, a neuropeptide with multiple effects on mature lymphocytes, also plays a regulatory role in early B cell development in the bone marrow.
    MeSH term(s) Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Bone Marrow/immunology ; Calcitonin Gene-Related Peptide/administration & dosage ; Calcitonin Gene-Related Peptide/blood ; Calcitonin Gene-Related Peptide/pharmacology ; Cell Proliferation/drug effects ; Colony-Forming Units Assay ; Injections, Intravenous ; Interleukin-7/antagonists & inhibitors ; Interleukin-7/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/immunology ; Structure-Activity Relationship
    Chemical Substances Interleukin-7 ; Calcitonin Gene-Related Peptide (83652-28-2)
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.0306229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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