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Article: A Series of Intestinal Preparations.

Sutherland, L R

2018 Volume 48, Issue 2, Page(s) 85–94

Language	English
Publishing date	2018-11-14
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	414084-9
ISSN	0367-4800
ISSN	0367-4800
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Article: Fluorescent carbazole-derived α-amino acids: structural mimics of tryptophan.

Clarke, Rebecca / Zeng, Liyao / Atkinson, Bethany C / Kadodwala, Malcolm / Thomson, Andrew R / Sutherland, Andrew

Chemical science

2024 Volume 15, Issue 16, Page(s) 5944–5949

Abstract: ... containing carbazole side-chains designed to mimic l-tryptophan and thus, readily incorporated into peptides ...

Abstract	Fluorescent tags are commonly used for imaging of proteins and peptides during biological events; however, the large size of dyes can disrupt protein structure and function, and typically require the use of a chemical spacer. Herein, we report the synthesis of a new class of fluorescent unnatural α-amino acid, containing carbazole side-chains designed to mimic l-tryptophan and thus, readily incorporated into peptides. The amino acids were constructed using a Negishi cross-coupling reaction as the key step and exhibited strong fluorescent emission, with high quantum yields in both organic solvents and water. Compatible with solid phase peptide synthesis, the carbazole amino acids were used to replace tryptophan in a β-hairpin model peptide and shown to be a close structural mimic with retention of conformation. They were also found to be effective fluorescent molecular reporters for biological events. Incorporation into a proline-rich ligand of the WW domain protein demonstrated that the fluorescent properties of a carbazole amino acid could be used to measure the protein-protein binding interaction of this important biological signalling process.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d4sc01173b
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Article ; Online: Infectious mononucleosis - should we routinely assess liver function in acute presentation and follow up?

Simpson, L / Sutherland, E / Wilkinson, D / Saman, R / Edafe, O

The Journal of laryngology and otology

2022 Volume 137, Issue 3, Page(s) 319–322

Abstract: Objective: Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. ... ...

Abstract	Objective: Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. This study aimed to evaluate the utility of liver function tests and abdominal ultrasound in infectious mononucleosis. Methods: This was a retrospective study of all adult patients admitted under ENT with infectious mononucleosis over a five-year period. Results: A total of 153 patients were included; 80 per cent had abnormal liver function test results at presentation. Around 50 per cent had at least one liver function test assessment following discharge. Median (interquartile range) time to resolution of liver function test results was 32 days (20-50 days); maximum time was 10 months. Six patients had in-patient abdominal ultrasound: all showed a normal liver and biliary tree. No patient developed any liver disease sequelae. Conclusion: The findings suggest that serial assessment of liver function is not required in immunocompetent adults with subclinical derangement in liver function.
MeSH term(s)	Adult ; Humans ; Infectious Mononucleosis/complications ; Infectious Mononucleosis/diagnosis ; Retrospective Studies ; Follow-Up Studies ; Disease Progression ; Liver/diagnostic imaging
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215122000639
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Article ; Online: Retrospective analysis of clinical characteristics and outcomes of patients with carcinoma of unknown primary from three tertiary centers in Australia.

Boys, Emma L / Gao, Bo / Grimison, Peter / Sutherland, Sarah / MacKenzie, Karen L / Reddel, Roger R / Liu, Jia

Cancer medicine

2024 Volume 13, Issue 6, Page(s) e7052

Abstract: Background: Carcinoma of unknown primary (CUP) remains an important tumor entity and a disproportionate cause of cancer mortality. Little is known about the contemporary clinical characteristics, treatment patterns, and outcomes of CUP patients based on ...

Abstract	Background: Carcinoma of unknown primary (CUP) remains an important tumor entity and a disproportionate cause of cancer mortality. Little is known about the contemporary clinical characteristics, treatment patterns, and outcomes of CUP patients based on updated international classification guidelines. We evaluated a contemporary CUP cohort to provide insight into current clinical practice and the impact of tissue of origin assignment, site-specific and empirical therapy in a real-world setting. Methods: We conducted a retrospective cohort study of CUP patients, as defined by the updated European Society of Medical Oncology (ESMO) 2023 guidelines, across three tertiary referral centers in Australia between 2015 and 2022. We analyzed clinical characteristics, treatment patterns, and survival outcomes using the Kaplan-Meier method and Cox regression proportional hazard model between favorable and unfavorable risk groups. Results: We identified a total of 123 CUP patients (n = 86 unfavorable, n = 37 favorable risk as per the 2023 ESMO guidelines). Sixty-four patients (52%) were assigned a tissue of origin by the treating clinician. Median progression free survival (PFS) was 6.8 (95% confidence interval (CI) 5.1-12.1) months and overall survival (OS) 10.2 (95% CI 6.0-18.5) months. Unfavorable risk (hazard ratio [HR] 2.9, p = 0.006), poor performance status (HR 2.8, p < 0.001), and non-squamous histology (HR 2.5, p < 0.05) were associated with poor survival outcome. A total of 70 patients (57%) proceeded to systemic therapy. In patients with non-squamous histology and unfavorable risk, site-specific therapy compared to empirical chemotherapy did not improve outcome (median OS 8.2 vs. 11.8 months, p = 0.7). Conclusions: In this real-world cohort, CUP presentations were heterogenous. Overall survival and rates of systemic treatment were poor. Poor performance status and unfavorable risk were associated with worse survival. For most patients, site-specific therapy did not improve survival outcome. Improved and timely access to diagnostic tests and therapeutics for this group of patients is urgently required.
MeSH term(s)	Humans ; Retrospective Studies ; Neoplasms, Unknown Primary/therapy ; Neoplasms, Unknown Primary/pathology ; Carcinoma ; Proportional Hazards Models ; Progression-Free Survival
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7052
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Article ; Online: Unpacking the cost of the lunchbox for Australian families: a secondary analysis.

Manson, Alexandra C / Johnson, Brittany J / Wolfenden, Luke / Sutherland, Rachel / Golley, Rebecca K

Health promotion international

2024 Volume 39, Issue 1

Abstract: Ninety per cent of Australian school children bring a home-packed lunch to school, with 44% of the food consumed during school hours being unhealthy. Among other factors, cost is a key consideration for food provision; however, the costs to Australian ... ...

Abstract	Ninety per cent of Australian school children bring a home-packed lunch to school, with 44% of the food consumed during school hours being unhealthy. Among other factors, cost is a key consideration for food provision; however, the costs to Australian families are not well understood. Therefore, we aimed to determine what families are currently paying for school lunchboxes in Australian primary schools and to examine associations between food costs and socio-demographic factors with dietary quality. An audit of local retail outlets was used to determine the food costs of lunchbox contents. Costs (AUD) were adjusted for inflation as of early 2023. The lunchboxes of 1026 children aged 4-12 years at 12 Catholic primary schools in New South Wales, Australia, were assessed at the start of the day, using photography assessment methods and a validated School Food Checklist. The mean cost of lunchbox contents was $4.48 AUD (SD 1.53), containing a mean energy of 2699 kJ (SD 859), with 37.3% (SD 23.9) of energy sourced from unhealthy foods. Multiple linear regression analyses found that the strongest predictors of higher lunchbox cost (P < 0.05) were a higher proportion of energy from unhealthy foods (B = 0.016) and lower Socio-Economic Indexes for Areas (B = -0.178), when controlling for child socio-demographics. The results indicated that lunchbox food costs to Australian families are comparable to alternative school food service models in Australia and internationally. Results demonstrate the cost of food is not the only barrier to providing a healthy school lunchbox. Demonstrating a need for cost-considerate systematic interventions addressing food provision challenges and socio-economic disparities faced by families.
MeSH term(s)	Child ; Humans ; Australia ; New South Wales ; Food ; Food Services ; Marketing
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1027448-0
ISSN	1460-2245 ; 0957-4824
ISSN (online)	1460-2245
ISSN	0957-4824
DOI	10.1093/heapro/daad194
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Zs.A 2178: Show issues

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Article ; Online: Impact on life expectancy was the most important information to clients when considering whether to take action for an overweight or obese dog.

Davies, Abby R / Sutherland, Katja A / Groves, Catherine N H / Grant, Lauren E / Shepherd, Megan L / Coe, Jason B

Journal of the American Veterinary Medical Association

2024 , Page(s) 1–10

Abstract: Objective: To determine dog owner preferences for information communicated during veterinarian-client obesity-related conversations within companion animal practice.: Sample: Dog owners recruited using snowball sampling.: Methods: A cross- ... ...

Abstract	Objective: To determine dog owner preferences for information communicated during veterinarian-client obesity-related conversations within companion animal practice. Sample: Dog owners recruited using snowball sampling. Methods: A cross-sectional online questionnaire was distributed to dog owners. A discrete choice experiment was used to determine the relative importance, to participating dog owners, of information about selected weight-related attributes that would encourage them to pursue weight management for a dog when diagnosed as overweight by a veterinarian. Results: A total of 1,108 surveys were analyzed, with most participating dog owners residing in Canada. The most important weight-related attribute was life expectancy (relative importance, 28.56%), followed by the timeline for developing arthritis (19.24%), future quality of life (18.91%), change to cost of food (18.90%), and future mobility (14.34%). Clinical relevance: Results suggest that dog owners may consider information relating to an extension of their dog's life as the most important aspect of an obesity-related veterinary recommendation. By integrating dog owner preferences into discussions between clients and veterinary professionals about obesity, there is the potential to encourage more clients to engage in weight management efforts for their overweight or obese dog.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.23.12.0697
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Zs.A 423: Show issues

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Article ; Online: Retrospective evaluation of surgical treatment of linear and discrete gastrointestinal foreign bodies in cats: 2009-2021.

Gollnick, Hailey R / Schmiedt, Chad W / Wallace, Mandy L / Sutherland, Brian J / Grimes, Janet A

Journal of feline medicine and surgery

2023 Volume 25, Issue 6, Page(s) 1098612X231178140

Abstract: Objectives: Gastrointestinal foreign bodies (FBs) are an important cause of emergency surgical intervention in cats, but little information exists in the literature evaluating the risks and outcomes in this species. The study purpose was to describe ... ...

Abstract	Objectives: Gastrointestinal foreign bodies (FBs) are an important cause of emergency surgical intervention in cats, but little information exists in the literature evaluating the risks and outcomes in this species. The study purpose was to describe cases of feline FBs and compare perioperative factors and outcomes between linear foreign body (LFB) and discrete foreign body (DFB) surgery in cats. Methods: The medical records from the University of Georgia Veterinary Teaching Hospital were searched for cats that had undergone surgery for FB removal between August 2009 and August 2021. Perioperative data were collected and described. Data were compared between cats with an LFB and cats with a DFB. A binomial probability series was used to estimate the likelihood of postoperative septic peritonitis or mortality in an additional cat in the series. Results: A total of 56 cats were included in this study; 38 cats had a DFB and 18 had an LFB. No cats developed postoperative septic peritonitis, and all cats survived. The likelihood of postoperative septic peritonitis or mortality in an additional cat was estimated to be <5.2%. Cats with an LFB were found to have a significantly higher body condition score ( Conclusions and relevance: Cats undergoing surgery for gastrointestinal FBs had a low incidence of postoperative complications. Cats with LFBs had longer surgeries and were more likely to develop postoperative SSIs.
MeSH term(s)	Animals ; Cats ; Retrospective Studies ; Hospitals, Animal ; Hospitals, Teaching ; Postoperative Complications/epidemiology ; Postoperative Complications/veterinary ; Foreign Bodies/surgery ; Foreign Bodies/veterinary ; Foreign Bodies/epidemiology ; Peritonitis/veterinary ; Cat Diseases/surgery
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2049047-1
ISSN	1532-2750 ; 1098-612X
ISSN (online)	1532-2750
ISSN	1098-612X
DOI	10.1177/1098612X231178140
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Article ; Online: Development and piloting of a Community of Practice to support learning and improvement in health promotion practice within NSW local health district.

Barnes, Courtney / Sutherland, Rachel / Jones, Gavin / Kingon, Nina / Wolfenden, Luke

Public health research & practice

2023 Volume 33, Issue 3

Abstract: Objectives: Health Promotion Units within New South Wales (NSW) local health districts (LHDs) frequently collaborate and test innovations to address priority health issues or approaches to support the implementation of a health promotion program in a ... ...

Abstract	Objectives: Health Promotion Units within New South Wales (NSW) local health districts (LHDs) frequently collaborate and test innovations to address priority health issues or approaches to support the implementation of a health promotion program in a way that is consistent with the needs, resources, and contexts of their regions. Compatible with learning health system approaches, mechanisms to facilitate the exchange of evidence and expertise across districts could improve the collective impact of health promotion services across the state. This study aimed to assess the use of a health promotion Community of Practice (CoP) model as a strategy to achieve this. Type of program or service: This paper describes and shares experiences from the development and piloting process of a CoP model to develop, evaluate and exchange learnings to improve approaches to support the adoption of an effective healthy lunchbox program ('SWAP IT') across three LHDs. Results: The functioning of the CoP was supported by key activities, funding and infrastructure over a 2-year period, including: planning workshops, implementation check-ins, and knowledge exchange meetings. A particularly novel aspect of the CoP was the harmonised evaluation of different, locally developed strategies to facilitate program adoption across the three LHDs. The alignment of the CoP with local and state priorities, as well as the operation of the CoP in a way that did not impose significant time demands, was seen as important for the sustainability of the CoP. Lessons learnt: Findings from the piloting process suggest that a formalised CoP shows promise as an effective model to enhance health promotion collaboration, information sharing and practice across LHDs, which may be suitable for broader application across the state.
MeSH term(s)	Humans ; New South Wales ; Community Health Services ; Health Priorities ; Health Promotion ; Information Dissemination
Language	English
Publishing date	2023-09-13
Publishing country	Australia
Document type	Journal Article
ISSN	2204-2091
ISSN (online)	2204-2091
DOI	10.17061/phrp3332326
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Article ; Online: Assessment of advanced clinical practitioners.

Wallis, Lucy / Locke, Rachel / Sutherland, Clare / Harden, Beverley

Journal of interprofessional care

2022 Volume 36, Issue 6, Page(s) 946–950

Abstract: To continue growing the advanced clinical practitioner (ACP) role nationally, and similar roles internationally, there must be widely held trust in the level of practice and the roles worked in service by ACPs. This requires infrastructure to support ... ...

Abstract	To continue growing the advanced clinical practitioner (ACP) role nationally, and similar roles internationally, there must be widely held trust in the level of practice and the roles worked in service by ACPs. This requires infrastructure to support ACPs through their training and ensure they are fit to qualify. This short report focuses on an evaluation of assessment processes in the acute sector in a county in England, to understand their feasibility and suitability. The qualitative research design was attendance at assessment panels and 17 semi-structured interviews with assessors and ACP trainees, from nursing, physiotherapy, paramedicine and operating department practice backgrounds based at two hospitals. Key themes identified through thematic analysis were the different approaches to assessment and the support required to engage effectively with assessment. One hospital had a well understood process, including ACPs with a clear identity. The other hospital had a credible assessment process that continues to be developed. The insights from this study enabled lessons to be drawn for those responsible for workforce development who are key to the future development of the ACP role and to ensure high standards of interprofessional care.
MeSH term(s)	Humans ; Interprofessional Relations ; Qualitative Research ; England
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1099758-1
ISSN	1469-9567 ; 0884-3988 ; 1356-1820
ISSN (online)	1469-9567
ISSN	0884-3988 ; 1356-1820
DOI	10.1080/13561820.2021.1997950
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Article: A Series of Specimens Illustrative of Certain Congenital Affections of the Urinary Apparatus.

Sutherland, L R / Edington, G H

Glasgow medical journal

2018 Volume 49, Issue 2, Page(s) 81–105

Language	English
Publishing date	2018-11-14
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	414084-9
ISSN	0367-4800
ISSN	0367-4800
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