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  1. Book ; Thesis: Vergleich der Lebensqualität nach konventioneller Axilla-Dissektion gegenüber Sentinel-Node-Biopsie im Rahmen der brusterhaltenden Therapie des Mammakarzinoms

    Henkel, Anna-Katharina

    2010  

    Author's details vorgelegt von : Anna-Katharina Henkel
    Subject code 616.994
    Language German
    Size 102 Bl. : Ill., graph. Darst., 31 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Greifswald, Univ., Diss., 2010
    HBZ-ID HT016645429
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 19 order for loan Magazin

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  2. Article ; Online: Initiating medical abortion in an emergency department in the United States.

    Preiksaitis, Carl / Saxena, Monica / Henkel, Andrea

    BMJ sexual & reproductive health

    2024  

    Abstract: ... frameworks that allow emergency physicians to take a greater role in providing this care should be considered. ...

    Abstract Objectives: The primary objective of this study was to assess the feasibility of initiating medical abortions in a large, academic emergency department (ED) in the United States.
    Methods: A retrospective case series analysis was conducted to evaluate a protocol for initiating medical abortion in the ED implemented from January 2020 to October 2023 at an academic, tertiary care hospital in California, USA. Participants included ED patients diagnosed with pregnancies in the first trimester that were undesired and who opted for medical abortion. The medical abortion protocol was collaboratively designed by a multidisciplinary team and follow-up was conducted by our institution's gynaecology department. Data were sourced from a data repository of electronic health records and subjected to descriptive statistical analysis.
    Results: A total of 27 eligible patients initiated medical abortions in the ED during the study period. The cohort was diverse in terms of racial and ethnic backgrounds and almost evenly split between private and public insurance. No patients had significant complications identified in the medical record. Two patients required uterine aspiration by the gynaecology team; one patient in clinic and one during a return visit to the ED.
    Conclusions: Data from this case series suggest that initiating medical abortion in the ED is feasible. The ED may be considered as an additional access point for abortion care services, especially in areas where other care options are not readily available. Educational, legal and regulatory frameworks that allow emergency physicians to take a greater role in providing this care should be considered.
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ISSN 2515-2009
    ISSN (online) 2515-2009
    DOI 10.1136/bmjsrh-2023-202149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of replication-induced chromosomal copy numbers in spatio-temporal gene regulation and evolutionary chromosome plasticity.

    Teufel, Marc / Henkel, Werner / Sobetzko, Patrick

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1119878

    Abstract: For a coherent response to environmental changes, bacterial evolution has formed a complex transcriptional regulatory system comprising classical DNA binding proteins sigma factors and modulation of DNA topology. In this study, we investigate replication- ...

    Abstract For a coherent response to environmental changes, bacterial evolution has formed a complex transcriptional regulatory system comprising classical DNA binding proteins sigma factors and modulation of DNA topology. In this study, we investigate replication-induced gene copy numbers - a regulatory concept that is unlike the others not based on modulation of promoter activity but on replication dynamics. We show that a large fraction of genes are predominantly affected by transient copy numbers and identify cellular functions and central pathways governed by this mechanism in
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1119878
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  4. Article ; Online: Somatic-Immune Cells Crosstalk In-The-Making of Testicular Immune Privilege.

    Dutta, Sulagna / Sandhu, Narpal / Sengupta, Pallav / Alves, Marco G / Henkel, Ralf / Agarwal, Ashok

    Reproductive sciences (Thousand Oaks, Calif.)

    2021  Volume 29, Issue 10, Page(s) 2707–2718

    Abstract: Immunological infertility contributes significantly to the etiology of idiopathic male infertility. Shielding the spermatogenic cells from systemic immune responses is fundamental to secure normal production of spermatozoa. The body's immune system is ... ...

    Abstract Immunological infertility contributes significantly to the etiology of idiopathic male infertility. Shielding the spermatogenic cells from systemic immune responses is fundamental to secure normal production of spermatozoa. The body's immune system is tuned with the host self-components since the early postnatal period, while sperm first develops during puberty, thus rendering spermatogenic proteins as 'non-self' or 'antigenic.' Development of antibodies to these antigens elicits autoimmune responses affecting sperm motility, functions, and fertility. Therefore, the testes need to establish a specialized immune-privileged microenvironment to protect the allogenic germ cells by orchestration of various testicular cells and resident immune cells. This is achieved through sequestration of antigenic germ cells by blood-testis barrier and actions of various endocrine, paracrine, immune-suppressive, and immunomodulatory mechanisms. The various mechanisms are very complex and need conceptual integration to disclose the exact physiological scenario, and to facilitate detection and management of immunogenic infertility caused by disruption of testicular immune regulation. The present review aims to (a) discuss the components of testicular immune privilege; (b) explain testicular somatic and immune cell interactions in establishing and maintaining the testicular immune micro-environment; and (c) illustrate the integration of multiple mechanisms involved in the control of immune privilege of the testis.
    MeSH term(s) Humans ; Immune Privilege ; Infertility, Male/metabolism ; Male ; Semen ; Sexual Maturation ; Sperm Motility ; Spermatogenesis ; Testis/metabolism
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-021-00721-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4113: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A Spring in the Desert: Infertility and Merciful Accompaniment.

    Henkel, Kimberly / Koshute, Ann M / Huneck, Stacey

    The Linacre quarterly

    2022  Volume 89, Issue 4, Page(s) 435–449

    Abstract: ... for her pain. This turn toward science, if not integrated into the larger framework of overall health and ... that it is necessary to integrate the pain of infertility into a framework of ...

    Abstract The mystery of love as it unfolds in marriage is an adventure filled with wonder and anticipation for what the future holds. Such is the excitement and optimism of the couple embarking on family life by actively trying to conceive a child. For the couple struggling with infertility, however, joyful anticipation can soon devolve into anguish as they realize that their hoped-for children might not come. Though the pain of infertility is a shared experience in marriage, it is to the woman that evaluation, testing, and treatment is often directed. She may experience infertility as an assault on her feminine identity, her marriage, and her faith, leaving her vulnerable to reliance on scientific and technological solutions as the only relief for her pain. This turn toward science, if not integrated into the larger framework of overall health and well-being, has the danger of making the natural, good desire for a child into a quest to achieve a single-minded goal. When the child becomes a "goal," husband, wife, and potential offspring become (unintentionally) objectified, and the woman's identity and the future of her marriage rest precariously on the shoulders of an ideal. It is within the context of the authors' lived experience of infertility, as well as hundreds of encounters with women in the Springs in the Desert community, that the authors contend that it is necessary to integrate the pain of infertility into a framework of
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604903-5
    ISSN 2050-8549 ; 0024-3639
    ISSN (online) 2050-8549
    ISSN 0024-3639
    DOI 10.1177/00243639221124482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Swimming exercise enhances brain plasticity in fish.

    Mes, Daan / Palstra, Arjan P / Henkel, Christiaan V / Mayer, Ian / Vindas, Marco A

    Royal Society open science

    2020  Volume 7, Issue 1, Page(s) 191640

    Abstract: It is well-established that sustained exercise training can enhance brain plasticity and boost cognitive performance in mammals, but this phenomenon has not received much attention in fish. The aim of this study was to determine whether sustained ... ...

    Abstract It is well-established that sustained exercise training can enhance brain plasticity and boost cognitive performance in mammals, but this phenomenon has not received much attention in fish. The aim of this study was to determine whether sustained swimming exercise can enhance brain plasticity in juvenile Atlantic salmon. Brain plasticity was assessed by both mapping the whole telencephalon transcriptome and conducting telencephalic region-specific microdissections on target genes. We found that 1772 transcripts were differentially expressed between the exercise and control groups. Gene ontology (GO) analysis identified 195 and 272 GO categories with a significant overrepresentation of up- or downregulated transcripts, respectively. A multitude of these GO categories was associated with neuronal excitability, neuronal signalling, cell proliferation and neurite outgrowth (i.e. cognition-related neuronal markers). Additionally, we found an increase in
    Language English
    Publishing date 2020-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.191640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Darstellung der Agent-based Computational Economics und Anwendung auf ausgewählte Märkte

    Henkel, Marco

    2010  

    Author's details Marco Henkel
    Keywords Marktmodell ; Elektrizitätsmarkt ; Mehragentensystem ; Agentenbasierte Modellierung ; Simulation ; Lernprozess ; Fischmarkt ; Elektrizitätswirtschaft ; Marktstruktur ; Theorie ; Deutschland
    Language German
    Size XVI, 242 S., graph. Darst., 210 mm x 148 mm
    Edition [1. Aufl.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Halle, Univ., Juristische und Wirtschaftswissenschaftliche Fakultät, Diss., 2009
    ISBN 9783869910529 ; 3869910526
    Database ECONomics Information System

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  8. Article ; Online: A transdisciplinary review and framework of consumer interactions with embodied social robots

    Blaurock, Marah / Čaić, Martina / Okan, Mehmet / Henkel, Alexander P.

    Design, delegate, and deploy

    2022  

    Abstract: ... empirical research articles were identified. Emanating from these data, an organizing meta‐framework is advanced (D3 ... design, delegate, and deploy). Leveraging this D3 framework, a comprehensive overview ... of several dimensions of the literature is provided, and key insights for each framework dimension are presented. Based ...

    Abstract Social robots are gradually entering the organizational frontline, and research is beginning to unveil the implications for consumer–firm interactions. While empirical studies on human–robot service interaction (HRSI) are scarce in business literature, other scientific fields have generated an abundance of empirical findings that can inform consumer research on successfully integrating embodied social robots in consumer‐facing services. In this light, a systematic literature review was conducted across scientific fields, screening over 13,500 research articles. Through a thorough review process, 199 service‐relevant empirical research articles were identified. Emanating from these data, an organizing meta‐framework is advanced (D3: design, delegate, and deploy). Leveraging this D3 framework, a comprehensive overview of several dimensions of the literature is provided, and key insights for each framework dimension are presented. Based on this overview, implications for whether, how, and when to integrate social robots in practice and a comprehensive future research agenda are developed.
    Keywords ddc:330 ; consumers ; embodied social robots ; future research agenda ; human–robot service interactions ; systematic literature review
    Subject code 629
    Language English
    Publisher Hoboken, NJ: Wiley
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Swimming exercise enhances brain plasticity in fish

    Daan Mes / Arjan P. Palstra / Christiaan V. Henkel / Ian Mayer / Marco A. Vindas

    Royal Society Open Science, Vol 7, Iss

    2020  Volume 1

    Abstract: It is well-established that sustained exercise training can enhance brain plasticity and boost cognitive performance in mammals, but this phenomenon has not received much attention in fish. The aim of this study was to determine whether sustained ... ...

    Abstract It is well-established that sustained exercise training can enhance brain plasticity and boost cognitive performance in mammals, but this phenomenon has not received much attention in fish. The aim of this study was to determine whether sustained swimming exercise can enhance brain plasticity in juvenile Atlantic salmon. Brain plasticity was assessed by both mapping the whole telencephalon transcriptome and conducting telencephalic region-specific microdissections on target genes. We found that 1772 transcripts were differentially expressed between the exercise and control groups. Gene ontology (GO) analysis identified 195 and 272 GO categories with a significant overrepresentation of up- or downregulated transcripts, respectively. A multitude of these GO categories was associated with neuronal excitability, neuronal signalling, cell proliferation and neurite outgrowth (i.e. cognition-related neuronal markers). Additionally, we found an increase in proliferating cell nuclear antigen (pcna) after both three and eight weeks of exercise in the equivalent to the hippocampus in fish. Furthermore, the expression of the neural plasticity markers synaptotagmin (syt) and brain-derived neurotrophic factor (bdnf) were also increased due to exercise in the equivalent to the lateral septum in fish. In conclusion, this is the first time that swimming exercise has been directly linked to increased telencephalic neurogenesis and neural plasticity in a teleost, and our results pave the way for future studies on exercise-induced neuroplasticity in fish.
    Keywords bdnf ; pcna ; neurogenesis ; atlantic salmon ; hippocampus ; dorsolateral pallium ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: FDG PET Data is Associated with Cognitive Performance in Patients from a Memory Clinic.

    Henkel, Rebecca / Brendel, Matthias / Paolini, Marco / Brendel, Eva / Beyer, Leonie / Gutzeit, Andreas / Pogarell, Oliver / Rominger, Axel / Blautzik, Janusch

    Journal of Alzheimer's disease : JAD

    2020  Volume 78, Issue 1, Page(s) 207–216

    Abstract: Background: Various reasons may lead to cognitive symptoms in elderly, including the development of cognitive decline and dementia. Often, mixed pathologies such as neurodegeneration and cerebrovascular disease co-exist in these patients. Diagnostic ... ...

    Abstract Background: Various reasons may lead to cognitive symptoms in elderly, including the development of cognitive decline and dementia. Often, mixed pathologies such as neurodegeneration and cerebrovascular disease co-exist in these patients. Diagnostic work-up commonly includes imaging modalities such as FDG PET, MRI, and CT, each delivering specific information.
    Objective: To study the informative value of neuroimaging-based data supposed to reflect neurodegeneration (FDG PET), cerebral small vessel disease (MRI), and cerebral large vessel atherosclerosis (CT) with regard to cognitive performance in patients presenting to our memory clinic.
    Methods: Non-parametric partial correlations and an ordinal logistic regression model were run to determine relationships between scores for cortical hypometabolism, white matter hyperintensities, calcified plaque burden, and results from Mini-Mental State Examination (MMSE). The final study group consisted of 162 patients (female: 94; MMSE: 6-30).
    Results: Only FDG PET data was linked to and predicted cognitive performance (r(157) = -0.388, p < 0.001). Overall, parameters linked to cerebral small and large vessel disease showed no significant association with cognition. Further findings demonstrated a relationship between white matter hyperintensities and FDG PET data (r(157) = 0.230, p = 0.004).
    Conclusion: Only FDG PET imaging mirrors cognitive performance, presumably due to the examination's ability to reflect neurodegeneration and vascular dysfunction, thus capturing a broader spectrum of pathologies. This makes the examination a useful imaging-based diagnostic tool in the work-up of patients presenting to a memory clinic. Parameters of vascular dysfunction alone as depicted by conventional MRI and CT are less adequate in such a situation, most likely because they reflect one pathology complex only.
    Language English
    Publishing date 2020-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-200826
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    Zs.A 6084: Show issues Location:
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