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  1. Article ; Online: Preventive Medication for COVID-19 Infection.

    Malani, Angela G / Malani, Anurag N

    JAMA

    2022  Volume 328, Issue 11, Page(s) 1152

    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/prevention & control ; Humans ; Patient Acceptance of Health Care ; SARS-CoV-2
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.13214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Methods for integration site distribution analyses in animal cell genomes.

    Ciuffi, Angela / Ronen, Keshet / Brady, Troy / Malani, Nirav / Wang, Gary / Berry, Charles C / Bushman, Frederic D

    Methods (San Diego, Calif.)

    2008  Volume 47, Issue 4, Page(s) 261–268

    Abstract: The question of where retroviral DNA becomes integrated in chromosomes is important for understanding (i) the mechanisms of viral growth, (ii) devising new anti-retroviral therapy, (iii) understanding how genomes evolve, and (iv) developing safer methods ...

    Abstract The question of where retroviral DNA becomes integrated in chromosomes is important for understanding (i) the mechanisms of viral growth, (ii) devising new anti-retroviral therapy, (iii) understanding how genomes evolve, and (iv) developing safer methods for gene therapy. With the completion of genome sequences for many organisms, it has become possible to study integration targeting by cloning and sequencing large numbers of host-virus DNA junctions, then mapping the host DNA segments back onto the genomic sequence. This allows statistical analysis of the distribution of integration sites relative to the myriad types of genomic features that are also being mapped onto the sequence scaffold. Here we present methods for recovering and analyzing integration site sequences.
    MeSH term(s) Animals ; Chromosomes/genetics ; DNA, Viral/genetics ; Gene Targeting/methods ; Genome, Viral/genetics ; Humans ; Intracellular Space/virology ; Virus Integration/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2008-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2008.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing.

    Meylan, Sylvain / Groner, Anna C / Ambrosini, Giovanna / Malani, Nirav / Quenneville, Simon / Zangger, Nadine / Kapopoulou, Adamandia / Kauzlaric, Annamaria / Rougemont, Jacques / Ciuffi, Angela / Bushman, Frederic D / Bucher, Philipp / Trono, Didier

    BMC genomics

    2011  Volume 12, Page(s) 378

    Abstract: Background: KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors ... ...

    Abstract Background: KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the formation of facultative heterochromatin. We have recently shown that KRAB/KAP1 can mediate long-range transcriptional repression through heterochromatin spreading, but also demonstrated that this process is at times countered by endogenous influences.
    Method: To investigate this issue further we used an ectopic KRAB-based repressor. This system allowed us to tether KRAB/KAP1 to hundreds of euchromatic sites within genes, and to record its impact on gene expression. We then correlated this KRAB/KAP1-mediated transcriptional effect to pre-existing genomic and chromatin structures to identify specific characteristics making a gene susceptible to repression.
    Results: We found that genes that were susceptible to KRAB/KAP1-mediated silencing carried higher levels of repressive histone marks both at the promoter and over the transcribed region than genes that were insensitive. In parallel, we found a high enrichment in euchromatic marks within both the close and more distant environment of these genes.
    Conclusion: Together, these data indicate that high levels of gene activity in the genomic environment and the pre-deposition of repressive histone marks within a gene increase its susceptibility to KRAB/KAP1-mediated repression.
    MeSH term(s) Chromatin/genetics ; Gene Silencing ; Genomics ; HeLa Cells ; Histones/genetics ; Humans ; Repressor Proteins/metabolism ; Transcription, Genetic/genetics ; Tripartite Motif-Containing Protein 28
    Chemical Substances Chromatin ; Histones ; Repressor Proteins ; ZNF350 protein, human ; TRIM28 protein, human (EC 2.3.2.27) ; Tripartite Motif-Containing Protein 28 (EC 2.3.2.27)
    Language English
    Publishing date 2011-07-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/1471-2164-12-378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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