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Book ; Online: Chapter Earth Observation Technologies: Low-End-Market Disruptive Innovation

García-Almiñana, Daniel / Huyton, Claire / Ghizoni, Leonardo / Traub, C. / Smith, Kate / Edmondson, Steve / Toshiyuki Abrao Oiko, Vitor / Sinpetru, Luciana / Kataria, Dhiren / Crisp, Nicholas / Chan, Y. / Dominguez, R. M. / Rodriguez-Donaire, Silvia / Villain, Rachel / Belkouchi, B. / Becedas, J. / Bay, Kristian / Morsbøl, Jonas / Romano, Francesco /

Sureda, M. / Sierra, Eloi / Heißerer, B. / Outlaw, R. / Livadiotti, Sabrina / Roberts, Peter

2020

Keywords	Earth sciences ; disruptive innovation, low-end market, micro- and nano-satellites, new space, Earth Observation
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047977
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Characterization of Commercially Available Human Primary Alveolar Epithelial Cells.

Herbst, Christopher J / Lopez-Rodriguez, Elena / Gluhovic, Vladimir / Schulz, Sabrina / Brandt, Raphael / Timm, Sara / Abledu, Jubilant / Falivene, Juliana / Pennitz, Peter / Kirsten, Holger / Nouailles, Geraldine / Witzenrath, Martin / Ochs, Matthias / Kuebler, Wolfgang M

American journal of respiratory cell and molecular biology

2024 Volume 70, Issue 5, Page(s) 339–350

Abstract: ... In ... ...

Abstract	In vitro
MeSH term(s)	Humans ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/cytology ; Alveolar Epithelial Cells/ultrastructure ; Cell Differentiation ; Transcriptome ; Cells, Cultured ; Pulmonary Alveoli/metabolism ; Pulmonary Alveoli/cytology ; Tight Junctions/metabolism
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2023-0320MA
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Article ; Online: Music-based interventions for community-dwelling people with dementia: A systematic review.

Hofbauer, Lena M / Ross, Sabrina D / Rodriguez, Francisca S

Health & social care in the community

2022 Volume 30, Issue 6, Page(s) 2186–2201

Abstract: The majority of people with dementia (PwD) live in the community. Compared to institutionalised PwD, their access to formalised music therapy is limited. Initial works suggest that non-therapist-led music-based interventions (MBIs) may be an accessible ... ...

Abstract	The majority of people with dementia (PwD) live in the community. Compared to institutionalised PwD, their access to formalised music therapy is limited. Initial works suggest that non-therapist-led music-based interventions (MBIs) may be an accessible and effective alternative. The aim of this review was, therefore, to synthesise evidence on MBIs for community-dwelling PwD. We systematically searched electronic databases (PubMed, PsycInfo, Web of Science) for records reporting on controlled studies of MBIs delivered to community-dwelling PwD. Two reviewers independently screened records according to inclusion/exclusion criteria. A total of 15 relevant publications reporting on 14 studies were initially identified and assessed using the Cochrane risk-of-bias tool for randomised trials (RoB 2) and the risk of bias. In non-randomised studies of interventions (ROBINS-I) tool. A total of 11 records of 10 studies, with a total of n = 327 PwD, were included in the synthesis. MBIs consisted either of singing or music listening interventions and were variable in duration. MBIs had immediate positive effects on cognition. Short-term MBIs (lasting 1-4 months) benefited cognition, anxiety and pain. Evidence on depressive symptoms was conflicting. The benefits of longer term MBIs (lasting 6+ months) were less apparent. According to GRADE criteria, the overall quality of evidence was moderate to low. The inconsistency in designs, procedures and measures prevents specific conclusions at this stage. Still, the diversity observed in existing studies suggests that there are multiple interesting avenues for researchers to pursue, including the involvement of informal caregivers in MBI delivery. Future studies need to ensure adequate reporting to facilitate continued development. The protocol of this review was pre-registered with the Prospective Register of Systematic Reviews (PROSPERO, Registration Number: CRD42020191606).
MeSH term(s)	Humans ; Dementia/therapy ; Independent Living ; Music ; Music Therapy/methods
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.13895
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Article ; Online: Coping strategies for memory problems in everyday life of people with cognitive impairment and older adults: A systematic review.

Ross, Sabrina D / Hofbauer, Lena M / Rodriguez, Francisca S

International journal of geriatric psychiatry

2022 Volume 37, Issue 5

Abstract: Objectives: Dealing with memory loss is a major challenge for older people. Coping strategies for memory problems could enable cognitively impaired people to live independently for longer. We conducted a systematic review to summarize evidence on coping ...

Abstract	Objectives: Dealing with memory loss is a major challenge for older people. Coping strategies for memory problems could enable cognitively impaired people to live independently for longer. We conducted a systematic review to summarize evidence on coping strategies for older people and people with cognitive impairment to stabilize everyday life functioning. Methods: We systematically searched the databases PubMed, PsychInfo, Scopus and WebofScience using a well-defined search string. Studies were included if they were published between January 1990 and February 2021 and written in English, German, Spanish, French, or Swedish language. Two blind researchers independently checked the studies for inclusion and exclusion criteria and evaluated the quality of the studies using Critical Appraisal Skills Programme-checklists. Evidence was summarized in a narrative synthesis. Results: A total of 16 relevant studies with adequate quality were identified. These studies reported on three categories of strategies: external, internal, and behavioral coping strategies. External strategies included reminder systems and integrated features in the environment and were used by people with and without cognitive impairments. Internal strategies such as visualization, verbalization, active remembering, and systematic thinking were reported less often by people with cognitive impairment than those without cognitive impairment. Behavioral strategies such as reducing expectations and acceptance of support was most frequently reported by people with cognitive impairment. Conclusions: The findings of our systematic review show a great number of coping strategies, which seem to depend on cognitive status. Appropriate training tools incorporating these strategies should be developed.
MeSH term(s)	Adaptation, Psychological ; Aged ; Amnesia ; Cognitive Dysfunction/psychology ; Humans ; Memory Disorders
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5701
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Article: Effectiveness of Tranexamic Acid in Trauma Patients: A Systematic Review.

Meza Monge, Kenneth / Domene, Sabrina S / Diaz Mendoza, Diana L / Vidal-Gallardo, Andrea / Alfaro Llique, Adriana M / Rodriguez, Miguel / Premchandra, Pooja / Anwar Pandya, Samira / Arruarana, Victor S / Aleman Paredes, Kenneth / Calderon Martinez, Ernesto

Cureus

2024 Volume 16, Issue 1, Page(s) e52111

Abstract: Tranexamic acid (TXA), a fibrinolytic agent, effectively inhibits plasminogen activation, thereby reducing fibrinolysis and hemorrhage. This study focused on its application in trauma patients undergoing emergency surgery, a critical area due to trauma's ...

Abstract	Tranexamic acid (TXA), a fibrinolytic agent, effectively inhibits plasminogen activation, thereby reducing fibrinolysis and hemorrhage. This study focused on its application in trauma patients undergoing emergency surgery, a critical area due to trauma's significant role in mortality. Our investigation involved a meticulous screening of randomized controlled trials from databases including Scopus, PubMed, Web of Science, and Cochrane. The findings indicate that TXA intervention is promising in enhancing outcomes for trauma patients. However, the drug's effectiveness may vary based on the specific nature of the medical condition. In summary, robust evidence suggests that TXA can diminish blood loss, lower transfusion rates, reduce complications, and improve hemoglobin and hematocrit levels in surgical patients. Consequently, TXA should be considered a crucial medication, readily available to mitigate morbidity and mortality in surgical settings. Future research should explore factors influencing TXA's effectiveness in traumatic brain injury cases and across a broad spectrum of surgical scenarios in diverse patient populations. This would further guide clinicians in refining and optimizing the use of TXA.
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measuring Children's Emotion Knowledge: Steps Toward an Anti-Racist Approach to Early Childhood Assessments.

Kamboukos, Dimitra / Ursache, Alexandra / Cheng, Sabrina / Rodriguez, Vanessa / Gelb, Gena / Barajas-Gonzalez, R Gabriela / Dawson-McClure, Spring / Brotman, Laurie M

Affective science

2022 Volume 3, Issue 1, Page(s) 62–68

Abstract: Emotion knowledge (EK) is a malleable set of skills that is central to social interactions and school success during early childhood. The current study describes an anti-racist approach to adapting an EK measure that assesses knowledge of facial ... ...

Abstract	Emotion knowledge (EK) is a malleable set of skills that is central to social interactions and school success during early childhood. The current study describes an anti-racist approach to adapting an EK measure that assesses knowledge of facial expressions to be ecologically valid for young children of color attending pre-Kindergarten (pre-K) programs in a large urban school district. This approach involved (1) attending to race/ethnicity in selection of visual stimuli, (2) ensuring appropriate translation and language for administration, and (3) exploring the functioning of the measure within a racially, ethnically, and linguistically diverse group of children. A total of 235 children (67.4% Latinx, 14.1% non-Latinx Black, 7.1% non-Latinx White, 7.8% Asian, 3.6% another racial/ethnicity) were assessed in English (74%) or Spanish (26%) during the fall of pre-K (mean age = 4.4). Both English and Spanish versions appear to have similar reliability, although accuracy levels were lower when administered in Spanish. No differences in mean accuracy scores were found across racial/ethnic groups or for boys versus girls. This study contributes to the growing literature necessary to advance anti-racist research in affective science. Supplementary information: The online version contains supplementary material available at 10.1007/s42761-022-00105-w.
Language	English
Publishing date	2022-03-19
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2978299-5
ISSN	2662-205X ; 2662-2041
ISSN (online)	2662-205X
ISSN	2662-2041
DOI	10.1007/s42761-022-00105-w
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Article: Coping strategies for memory problems in everyday life of people with cognitive impairment and older adults

Ross, Sabrina D. / Hofbauer, Lena M. / Rodriguez, Francisca S.

International Journal of Geriatric Psychiatry

A systematic review

2022 Volume 37, Issue 5, Page(s) 1–18

Title translation	Bewältigungsstrategien für Gedächtnisprobleme im Alltag von Menschen mit kognitiven Einschränkungen und älteren Erwachsenen: Eine systematische Übersicht (DeepL)
Abstract	Objectives: Dealing with memory loss is a major challenge for older people. Coping strategies for memory problems could enable cognitively impaired people to live independently for longer. We conducted a systematic review to summarize evidence on coping strategies for older people and people with cognitive impairment to stabilize everyday life functioning. Methods: We systematically searched the databases PubMed, PsychInfo, Scopus and WebofScience using a well-defined search string. Studies were included if they were published between January 1990 and February 2021 and written in English, German, Spanish, French, or Swedish language. Two blind researchers independently checked the studies for inclusion and exclusion criteria and evaluated the quality of the studies using Critical Appraisal Skills Programme-checklists. Evidence was summarized in a narrative synthesis. Results: A total of 16 relevant studies with adequate quality were identified. These studies reported on three categories of strategies: external, internal, and behavioral coping strategies. External strategies included reminder systems and integrated features in the environment and were used by people with and without cognitive impairments. Internal strategies such as visualization, verbalization, active remembering, and systematic thinking were reported less often by people with cognitive impairment than those without cognitive impairment. Behavioral strategies such as reducing expectations and acceptance of support was most frequently reported by people with cognitive impairment. Conclusions: The findings of our systematic review show a great number of coping strategies, which seem to depend on cognitive status. Appropriate training tools incorporating these strategies should be developed.
Keywords	Bewältigungsstil ; Bewältigungsverhalten ; Cognitive Impairment ; Coping Behavior ; Coping Style ; Gedächtnisstörungen ; Kognitive Beeinträchtigung ; Memory Disorders
Language	English
Document type	Article
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5701
Database	PSYNDEX

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Article: Music-based interventions for community-dwelling people with dementia

Hofbauer, Lena M. / Ross, Sabrina D. / Rodriguez, Francisca S.

Health & Social Care in the Community

A systematic review

2022 Volume 30, Issue 6, Page(s) 2186–2201

Title translation	Musikbasierte Interventionen für in der Gemeinschaft lebende Menschen mit Demenz: Eine systematische Überprüfung (DeepL)
Abstract	The majority of people with dementia (PwD) live in the community. Compared to institutionalised PwD, their access to formalised music therapy is limited. Initial works suggest that non-therapist-led music-based interventions (MBIs) may be an accessible and effective alternative. The aim of this review was, therefore, to synthesise evidence on MBIs for community-dwelling PwD. We systematically searched electronic databases (PubMed, PsycInfo, Web of Science) for records reporting on controlled studies of MBIs delivered to community-dwelling PwD. Two reviewers independently screened records according to inclusion/exclusion criteria. A total of 15 relevant publications reporting on 14 studies were initially identified and assessed using the Cochrane risk-of-bias tool for randomised trials (RoB 2) and the risk of bias. In non-randomised studies of interventions (ROBINS-I) tool. A total of 11 records of 10 studies, with a total of n = 327 PwD, were included in the synthesis. MBIs consisted either of singing or music listening interventions and were variable in duration. MBIs had immediate positive effects on cognition. Short-term MBIs (lasting 1-4 months) benefited cognition, anxiety and pain. Evidence on depressive symptoms was conflicting. The benefits of longer term MBIs (lasting 6+ months) were less apparent. According to GRADE criteria, the overall quality of evidence was moderate to low. The inconsistency in designs, procedures and measures prevents specific conclusions at this stage. Still, the diversity observed in existing studies suggests that there are multiple interesting avenues for researchers to pursue, including the involvement of informal caregivers in MBI delivery. Future studies need to ensure adequate reporting to facilitate continued development. The protocol of this review was pre-registered with the Prospective Register of Systematic Reviews (PROSPERO, Registration Number: CRD42020191606).
Keywords	Alzheimer's Disease ; Alzheimersche Krankheit ; Angst ; Anxiety ; Dementia ; Demenz ; Intervention ; Music ; Music Therapy ; Musik ; Musiktherapie ; Pain ; Schmerz ; Singen ; Singing ; Systematic Review ; Systematischer Literaturüberblick
Language	English
Document type	Article
DOI	10.1111/hsc.13895
Database	PSYNDEX

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Article: Inflammation durably imprints memory CD4+ T cells.

Gray-Gaillard, Sophie L / Solis, Sabrina / Chen, Han M / Monteiro, Clarice / Ciabattoni, Grace / Samanovic, Marie I / Cornelius, Amber R / Williams, Tijaana / Geesey, Emilie / Rodriguez, Miguel / Ortigoza, Mila Brum / Ivanova, Ellie N / Koralov, Sergei B / Mulligan, Mark J / Herati, Ramin Sedaghat

bioRxiv : the preprint server for biology

2023

Abstract: Adaptive immune responses are induced by vaccination and infection, yet little is known about how CD4+ T cell memory differs when primed in these two contexts. Notably, viral infection is generally associated with higher levels of systemic inflammation ... ...

Abstract	Adaptive immune responses are induced by vaccination and infection, yet little is known about how CD4+ T cell memory differs when primed in these two contexts. Notably, viral infection is generally associated with higher levels of systemic inflammation than is vaccination. To assess whether the inflammatory milieu at the time of CD4+ T cell priming has long-term effects on memory, we compared Spike-specific memory CD4+ T cells in 22 individuals around the time of the participants' third SARS-CoV-2 mRNA vaccination, with stratification by whether the participants' first exposure to Spike was via virus or mRNA vaccine. Multimodal single-cell profiling of Spike-specific CD4+ T cells revealed 755 differentially expressed genes that distinguished infection- and vaccine-primed memory CD4+ T cells. Spike-specific CD4+ T cells from infection-primed individuals had strong enrichment for cytotoxicity and interferon signaling genes, whereas Spike-specific CD4+ T cells from vaccine-primed individuals were enriched for proliferative pathways by gene set enrichment analysis. Moreover, Spike-specific memory CD4+ T cells established by infection had distinct epigenetic landscapes driven by enrichment of IRF-family transcription factors, relative to T cells established by mRNA vaccination. This transcriptional imprint was minimally altered following subsequent mRNA vaccination or breakthrough infection, reflecting the strong bias induced by the inflammatory environment during initial memory differentiation. Together, these data suggest that the inflammatory context during CD4+ T cell priming is durably imprinted in the memory state at transcriptional and epigenetic levels, which has implications for personalization of vaccination based on prior infection history.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.11.15.516351
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PAM-flexible genome editing with an engineered chimeric Cas9.

Nature communications

2023 Volume 14, Issue 1, Page(s) 6175

Abstract: CRISPR enzymes require a defined protospacer adjacent motif (PAM) flanking a guide RNA-programmed target site, limiting their sequence accessibility for robust genome editing applications. In this study, we recombine the PAM-interacting domain of SpRY, a ...

Abstract	CRISPR enzymes require a defined protospacer adjacent motif (PAM) flanking a guide RNA-programmed target site, limiting their sequence accessibility for robust genome editing applications. In this study, we recombine the PAM-interacting domain of SpRY, a broad-targeting Cas9 possessing an NRN > NYN (R = A or G, Y = C or T) PAM preference, with the N-terminus of Sc + +, a Cas9 with simultaneously broad, efficient, and accurate NNG editing capabilities, to generate a chimeric enzyme with highly flexible PAM preference: SpRYc. We demonstrate that SpRYc leverages properties of both enzymes to specifically edit diverse PAMs and disease-related loci for potential therapeutic applications. In total, the approaches to generate SpRYc, coupled with its robust flexibility, highlight the power of integrative protein design for Cas9 engineering and motivate downstream editing applications that require precise genomic positioning.
MeSH term(s)	Gene Editing ; CRISPR-Cas Systems/genetics ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Genome
Chemical Substances	CRISPR-Associated Protein 9 (EC 3.1.-)
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41829-y
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