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  1. Book ; Online ; E-Book: SARS-CoV-2 spike protein convergent evolution

    Focosi, Daniele

    impact of virus variants on efficacy of COVID-19 therapeutics and vaccines

    (Springer briefs in microbiology series)

    2021  

    Author's details Daniele Focosi
    Series title Springer briefs in microbiology series
    Language English
    Size 1 Online-Ressource (xiii, 136 Seiten), Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021120081
    ISBN 978-3-030-87324-0 ; 9783030873233 ; 3-030-87324-2 ; 3030873234
    DOI 10.1007/978-3-030-87324-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Resistance to tyrosine kinase inhibitors

    Focosi, Daniele

    (Resistance to targeted anti-cancer therapeutics ; volume 10)

    2016  

    Author's details Daniele Focosi editor
    Series title Resistance to targeted anti-cancer therapeutics ; volume 10
    Collection
    Language English
    Size 1 Online-Ressource (xiii, 188 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019153957
    ISBN 978-3-319-46091-8 ; 9783319460901 ; 3-319-46091-9 ; 3319460900
    DOI 10.1007/978-3-319-46091-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article: From Co-Administration to Co-Formulation: The Race for New Vaccines against COVID-19 and Other Respiratory Viruses.

    Focosi, Daniele

    Vaccines

    2023  Volume 11, Issue 1

    Abstract: Combined (concomitant or synchronous) vaccination is crucial to increasing the compliance rate during mass campaigns by reducing the time to deployment (i [ ... ]. ...

    Abstract Combined (concomitant or synchronous) vaccination is crucial to increasing the compliance rate during mass campaigns by reducing the time to deployment (i [...].
    Language English
    Publishing date 2023-01-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Web Tool to Estimate Baseline Anti-Spike Monoclonal Antibody Efficacy Based on Regional Genomic Surveillance.

    Focosi, Daniele

    Viruses

    2023  Volume 15, Issue 5

    Abstract: Drug appropriateness is a pillar of modern evidence-based medicine, but the turnaround times of genomic sequencing are not compatible with the urgent need to deliver treatments against microorganisms. Massive worldwide genomic surveillance has created an ...

    Abstract Drug appropriateness is a pillar of modern evidence-based medicine, but the turnaround times of genomic sequencing are not compatible with the urgent need to deliver treatments against microorganisms. Massive worldwide genomic surveillance has created an unprecedented landscape for exploiting viral sequencing for therapeutic purposes. When it comes to therapeutic antiviral antibodies, using IC
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/genetics ; Genomics ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/therapeutic use ; Antiviral Agents ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Antiviral Agents ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molnupiravir: From Hope to Epic Fail?

    Focosi, Daniele

    Viruses

    2022  Volume 14, Issue 11

    Abstract: Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far. However, it has recently been associated with very poor clinical ... ...

    Abstract Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far. However, it has recently been associated with very poor clinical efficacy, the risk of creating novel SARS-CoV-2 variants of concern, and long-term risk for mutagenicity in humans. The latter two are severe concerns, especially in the indicated population, i.e., long-replicating, immunodeficient patients. We conclude that, at this point, alternative antivirals should be preferred over molnupiravir.
    MeSH term(s) Humans ; SARS-CoV-2 ; Virus Replication ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances molnupiravir (YA84KI1VEW) ; Antiviral Agents
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Towards the identification of the correct place for convalescent plasma among COVID-19 therapies.

    Franchini, Massimo / Focosi, Daniele

    Infectious diseases (London, England)

    2024  Volume 56, Issue 6, Page(s) 421–422

    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Editorial
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2024.2333977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Hyperimmune Plasma and Immunoglobulins against COVID-19: A Narrative Review.

    Franchini, Massimo / Focosi, Daniele

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Since late 2019, the new SARS-CoV-2 virus belonging to ... ...

    Abstract Since late 2019, the new SARS-CoV-2 virus belonging to the
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14020214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Innovative Therapies for Acquired Hemophilia A.

    Franchini, Massimo / Focosi, Daniele

    Seminars in thrombosis and hemostasis

    2024  

    Abstract: Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder which can be life-threatening. AHA is due to autoantibodies against coagulation factor VIII. Disease onset may be idiopathic (approximately half of the cases) or triggered by autoimmune ... ...

    Abstract Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder which can be life-threatening. AHA is due to autoantibodies against coagulation factor VIII. Disease onset may be idiopathic (approximately half of the cases) or triggered by autoimmune disorders, cancers, drugs, infections, or pregnancy. Besides treating the underlying disorder, specific AHA treatments include management of bleeding and inhibitor eradication. Various first-line and second-line hemostatic and immunosuppressive agents are currently available for the management of AHA. Recently, the hemostatic drug emicizumab and the immunosuppressive drug rituximab have been the object of intense research from investigators as innovative promising therapies for AHA. This narrative review will be focused on the current status of the clinical use of these two off-label therapeutic agents in AHA.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0044-1779737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
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  9. Article ; Online: COVID-19 convalescent plasma retains value for immunocompromised patients.

    Focosi, Daniele / Franchini, Massimo

    Leukemia

    2023  Volume 37, Issue 8, Page(s) 1762–1763

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Serotherapy ; SARS-CoV-2 ; Immunocompromised Host
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Letter
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-023-01939-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
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  10. Article ; Online: Anti-A isohaemagglutinin titres and SARS-CoV-2 neutralization: implications for children and convalescent plasma selection.

    Focosi, Daniele

    British journal of haematology

    2020  Volume 190, Issue 3, Page(s) e148–e150

    MeSH term(s) Betacoronavirus ; Blood Group Antigens ; COVID-19 ; Child ; Coronavirus Infections ; Hemagglutinins ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Blood Group Antigens ; Hemagglutinins
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16932
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