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  1. AU=Ribeiro Heriks Gomes
  2. AU="Wattal, B L"
  3. AU="Davis, Madison J"
  4. AU="Tatsuya Sato"
  5. AU="Berg, G P A"
  6. AU=Corti Davide
  7. AU="Pilcher"
  8. AU=Brown D M
  9. AU="Donald Bellgrau"
  10. AU=Shorter Edward
  11. AU=Pham Minh Tan
  12. AU="Caniglia, John L"
  13. AU="Rao, Jiajia"
  14. AU="Vincent, Steve"
  15. AU="Oguntade, Habibat A"
  16. AU="Shah, Nikita Chetan"
  17. AU="Usherwood, Tim"
  18. AU="Petr Kala"
  19. AU=Talmage David A
  20. AU="Alessandro Achilli"
  21. AU="Julià Blanco"
  22. AU=Pardee Arthur B
  23. AU="Moossy, John J"
  24. AU="Ledger, Elizabeth V"
  25. AU="Abichandani, Deepa"
  26. AU="Piccinelli, Fabio"
  27. AU="Malinova, Tsveta S"
  28. AU="Harwood, Janet"
  29. AU=Buscombe John R
  30. AU=Meyer-Rusenberg Birthe
  31. AU="Jiang, Weiyan"
  32. AU="Mills, W"
  33. AU="Pintó, Rosa M."
  34. AU="Voisin, Tiphaine"
  35. AU="Takahashi, Hiromi"
  36. AU="Lin, Johnny"
  37. AU="Lee, Yu-Ru"
  38. AU="Safrankova, J."
  39. AU="Lanting, Linda L"
  40. AU=Koushik Nikhil S
  41. AU="Culhane, John"
  42. AU="Chippada, Appa Rao"
  43. AU="Hiroki Sato" AU="Hiroki Sato"
  44. AU="Al-Amer Eshraq"
  45. AU="Thanacoody, Ruben"
  46. AU="Lin, Chi-Wei"
  47. AU="Chidambaram, Vignesh"

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  1. Artikel ; Online: Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology.

    Ribeiro, Heriks Gomes / Galdino, Ony Araújo / de Souza, Karla Simone Costa / Rosa Neta, Antonia Pereira / Lin-Wang, Hui Tzu / Cunha-Neto, Edecio / Rezende, Adriana Augusto de / Silbiger, Vivian Nogueira

    PLoS neglected tropical diseases

    2024  Band 18, Heft 2, Seite(n) e0011865

    Abstract: Background: Chagas cardiomyopathy (ChCM) is a severe form of Chagas disease and a major cause of cardiovascular morbidity and mortality. The dysregulation of the immune response leads to cardiac remodeling and functional disruptions, resulting in life- ... ...

    Abstract Background: Chagas cardiomyopathy (ChCM) is a severe form of Chagas disease and a major cause of cardiovascular morbidity and mortality. The dysregulation of the immune response leads to cardiac remodeling and functional disruptions, resulting in life-threatening complications. Conventional diagnostic methods have limitations, and therapeutic response evaluation is challenging. MicroRNAs (miRNAs), important regulators of gene expression, show potential as biomarkers for diagnosis and prognosis.
    Aim: This review aims to summarize experimental findings on miRNA expression in ChCM and explore the potential of these miRNAs as biomarkers of Chagas disease.
    Methods: The search was conducted in the US National Library of Medicine MEDLINE/PubMed public database using the terms "Chagas cardiomyopathy" OR "Chagas disease" AND "microRNA" OR "miRNA" OR "miR." Additionally, bioinformatics analysis was performed to investigate miRNA-target interactions and explore enrichment pathways of gene ontology biological processes and molecular functions.
    Results: The miR-21, miR-146b, miR-146a, and miR-155 consistently exhibited up-regulation, whereas miR-145 was down-regulated in ChCM. These specific miRNAs have been linked to fibrosis, immune response, and inflammatory processes in heart tissue. Moreover, the findings from various studies indicate that these miRNAs have the potential as biomarkers for the disease and could be targeted in therapeutic strategies for ChCM.
    Conclusion: In this review, we point out miR-21, miR-146b, miR-146a, miR-155, and miR-145-5p role in the complex mechanisms of ChCM. These miRNAs have been shown as potential biomarkers for precise diagnosis, reliable prognostic evaluation, and effective treatment strategies in the ChCM.
    Mesh-Begriff(e) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Chagas Cardiomyopathy/diagnosis ; Chagas Cardiomyopathy/genetics ; Chagas Cardiomyopathy/metabolism ; Biomarkers/metabolism ; Up-Regulation ; Chagas Disease
    Chemische Substanzen MicroRNAs ; Biomarkers ; MIRN145 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011865
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Circulating Exosomal miRNAs as Biomarkers for the Diagnosis and Prognosis of Colorectal Cancer

    Katiusse Alves dos Santos / Isabelle Cristina Clemente dos Santos / Carollyne Santos Silva / Hériks Gomes Ribeiro / Igor de Farias Domingos / Vivian Nogueira Silbiger

    International Journal of Molecular Sciences, Vol 22, Iss 346, p

    2021  Band 346

    Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors in the gastrointestinal tract. It is a multifactorial disease that involves environmental factors, genetic factors, and lifestyle factors. Due to the absence of specific and sensitive ... ...

    Abstract Colorectal cancer (CRC) is one of the most common malignant tumors in the gastrointestinal tract. It is a multifactorial disease that involves environmental factors, genetic factors, and lifestyle factors. Due to the absence of specific and sensitive biomarkers, CRC patients are usually diagnosed at an advanced stage and consequently suffer from a low 5-year overall survival rate. Despite improvements in surgical resection and adjuvant chemotherapy, the prognosis of patients with CRC remains unfavorable due to local and distant metastases. Several studies have shown that small noncoding RNAs, such as microRNAs packed in exosomes, are potential biomarkers in various types of cancers, including CRC, and that they can be detected in a stable form in both serum and plasma. In this review, we report the potential of circulating exosomal miRNAs to act as biomarkers for the diagnosis and prognosis of CRC.
    Schlagwörter colorectal cancer ; biomarkers ; exosomal ; miRNAs ; circulating ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Circulating Exosomal miRNAs as Biomarkers for the Diagnosis and Prognosis of Colorectal Cancer.

    Alves Dos Santos, Katiusse / Clemente Dos Santos, Isabelle Cristina / Santos Silva, Carollyne / Gomes Ribeiro, Hériks / de Farias Domingos, Igor / Nogueira Silbiger, Vivian

    International journal of molecular sciences

    2020  Band 22, Heft 1

    Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors in the gastrointestinal tract. It is a multifactorial disease that involves environmental factors, genetic factors, and lifestyle factors. Due to the absence of specific and sensitive ... ...

    Abstract Colorectal cancer (CRC) is one of the most common malignant tumors in the gastrointestinal tract. It is a multifactorial disease that involves environmental factors, genetic factors, and lifestyle factors. Due to the absence of specific and sensitive biomarkers, CRC patients are usually diagnosed at an advanced stage and consequently suffer from a low 5-year overall survival rate. Despite improvements in surgical resection and adjuvant chemotherapy, the prognosis of patients with CRC remains unfavorable due to local and distant metastases. Several studies have shown that small noncoding RNAs, such as microRNAs packed in exosomes, are potential biomarkers in various types of cancers, including CRC, and that they can be detected in a stable form in both serum and plasma. In this review, we report the potential of circulating exosomal miRNAs to act as biomarkers for the diagnosis and prognosis of CRC.
    Mesh-Begriff(e) Biomarkers, Tumor/genetics ; Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Exosomes/genetics ; Humans ; Prognosis
    Chemische Substanzen Biomarkers, Tumor ; Circulating MicroRNA
    Sprache Englisch
    Erscheinungsdatum 2020-12-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22010346
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection.

    Ribeiro, Heriks Gomes / Dantas-Komatsu, Raquel Costa Silva / Medeiros, Jeane Franco Pires / Carvalho, Maria Clara da Cruz / Soares, Victor de Lima / Reis, Bruna Zavarize / Luchessi, André Ducati / Silbiger, Vivian Nogueira

    Clinica chimica acta; international journal of clinical chemistry

    2021  Band 522, Seite(n) 8–13

    Abstract: Background: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25( ... ...

    Abstract Background: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25(OH)D) concentrations and lipid profile prior to the SARS-CoV-2 tests in a population from a sunny region in Brazil (5 degrees S, 35 degrees W).
    Methods: This retrospective cohort study enrolled 1634 patients tested for SARS-CoV-2 of a private medical laboratory with 25(OH)D concentration and lipid profile measured ≥ 7 days before the date of the first SARS-CoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥30 ng/mL) or insufficiency (<30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive tests for SARS-CoV-2.
    Results: Average serum 25(OH)D was 33.6 ng/mL. Vitamin D deficiency (<20 ng/mL) was only found in 2.6% of the participants. Multivariate analysis demonstrated that patients > 49 y with insufficient 25(OH)D (<30 ng/mL) presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95 %CI: 1.15 to 3.55, P = 0.015). The same is observed among those with total cholesterol > 190 mg/dL (OR: 1.90, 95 %CI: 1.10 to 3.28, P = 0.020).
    Conclusions: Previous insufficient 25(OH)D (<30 ng/mL) concentration and high total cholesterol were associated with SARS-CoV-2 infection among adults > 48 y in the study population. Further studies should be conducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who are more susceptible to COVID-19.
    Mesh-Begriff(e) Adult ; COVID-19 ; Cholesterol ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency/epidemiology
    Chemische Substanzen Vitamin D (1406-16-2) ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2021-08-05
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2021.08.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Avaliação andrológica em jumento da raça Pêga utilizando sêmen coletado com vagina artificial artesanal

    Juan Debs Martins Rosa / Kayla Gabriella Satin de Lima Antunes / Diekson Mateus Klem da Silva / Pedro Herik de Oliveira Alves / Laisa Gomes Medeiros Ribeiro / Amanda Ferreira Maciel Cavalcante / Letícia dos Santos Rebelo

    Pubvet, Vol 18, Iss

    2023  Band 01

    Abstract: A importância do jumento Pêga na produção de asininos e muares é notório. No entanto, apesar da sua relevância, não há um padrão de parâmetros do exame andrológico definido para a espécie, além do alto custo e difícil acesso das vaginas artificiais ... ...

    Abstract A importância do jumento Pêga na produção de asininos e muares é notório. No entanto, apesar da sua relevância, não há um padrão de parâmetros do exame andrológico definido para a espécie, além do alto custo e difícil acesso das vaginas artificiais comerciais, que são utilizadas para a coleta de sêmen. Dessa forma, o objetivo desse trabalho foi confeccionar uma vagina artificial artesanal e coletar dados sobre os parâmetros espermáticos de um jumento. No presente trabalho, foi utilizado um jumento da raça Pêga, de 11 anos, submetido a um exame físico geral, no qual se coletou dados dos parâmetros vitais do animal e, posteriormente, foi realizada uma avaliação do aparelho reprodutor do animal, aferindo consistência, diâmetro, comprimento, largura, volume e índice testiculares, além da avaliação da integridade do epidídimo. Para a coleta do sêmen, foi utilizada uma vagina artificial artesanal, confeccionada utilizando um cano de PVC de 50 cm de comprimento, revestido de uma câmara de ar, com a inserção de um registro na sua porção superficial, permitindo a colocação de água e ar, para conferir temperatura e pressão semelhantes à vagina de uma fêmea. O sêmen foi coletado e foi avaliado quanto aos aspectos macroscópicos e microscópicos. Em suma, a vagina artificial confeccionada obteve êxito na coleta de sêmen, permitindo assim, a obtenção de resultados acerca dos parâmetros espermáticos asininos, contribuindo com os baixos dados registrados na literatura sobre a espécie.
    Schlagwörter asinino ; coleta ; sêmen ; espermatozoide ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Editora MV Valero
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Sunflower cake associated with crude glycerin in white laying hens diets: Performance and quality, antioxidant activity and lipid oxidation of eggs.

    de Oliveira Costa, Monik Kelly / Nepomuceno, Rafael Carlos / Souza, Davyd Herik / de Melo, Marcelle Craveiro Abreu / de Souza, Otoniel Félix / Silva, Valquíria Sousa / Gomes, Thalles Ribeiro / Watanabe, Pedro Henrique / Freitas, Ednardo Rodrigues

    Research in veterinary science

    2023  Band 164, Seite(n) 105038

    Abstract: The objective of this study was to evaluate the effects of sunflower cake inclusion and its association with crude glycerin in the diet of laying hens. A total of 320 laying hens with 39 weeks of age were distributed in a completely randomized design in ... ...

    Abstract The objective of this study was to evaluate the effects of sunflower cake inclusion and its association with crude glycerin in the diet of laying hens. A total of 320 laying hens with 39 weeks of age were distributed in a completely randomized design in a 4 × 2 factorial scheme with 5 replications of 8 birds. The studied factors were 4 inclusion levels of sunflower cake and 2 levels of crude glycerin. The inclusion of 210 g/kg of sunflower cake reduced egg mass and worsened feed conversion, and after the level 70 g/kg there was reduction in yolk coloration and specific density of eggs with or without the addition of glycerin in the diet. The addition of 70 g/kg of crude glycerin reduced the specific density of eggs in all levels of sunflower cake. There was increase in phenolic compounds, antioxidant capacity and antioxidant activity in eggs and reduction in lipid oxidation of yolks from fresh and stored eggs, with the inclusion of sunflower cake. The addition of crude glycerin increased the lipid oxidation of egg yolks. Therefore, it is possible to include up to 140 g/kg sunflower cake in the diet of laying hens, with or without crude glycerin, without impairing performance and egg quality, obtaining higher antioxidant capacity of eggs and lower lipid oxidation in yolks from fresh and stored eggs. The inclusion of 70 g/kg crude glycerin does not affect laying hens performance, however, it worsens shell quality and increases lipid oxidation in the liver and egg yolks.
    Mesh-Begriff(e) Animals ; Female ; Animal Feed/analysis ; Antioxidants/pharmacology ; Chickens ; Diet/veterinary ; Dietary Supplements ; Egg Yolk ; Eggs ; Glycerol/pharmacology ; Helianthus ; Lipids/pharmacology ; Ovum
    Chemische Substanzen Antioxidants ; Glycerol (PDC6A3C0OX) ; Lipids
    Sprache Englisch
    Erscheinungsdatum 2023-10-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial, Veterinary
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2023.105038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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