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  1. Article ; Online: QnAs with Baldomero M. Olivera. Interview by Beth Azar.

    Olivera, Baldomero M

    Proceedings of the National Academy of Sciences of the United States of America

    2012  Volume 109, Issue 34, Page(s) 13470

    MeSH term(s) Animals ; Biology/history ; Drug Design ; History, 20th Century ; History, 21st Century ; Humans ; Mice ; Mollusk Venoms ; Neurons/metabolism
    Chemical Substances Mollusk Venoms
    Language English
    Publishing date 2012-07-30
    Publishing country United States
    Document type Historical Article ; Interview
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1211581109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  2. Article ; Online: A Serendipitous Path to Pharmacology.

    Olivera, Baldomero M

    Annual review of pharmacology and toxicology

    2021  Volume 61, Page(s) 9–23

    Abstract: My path to research in neuropharmacology has been a coalescing of my training as a molecular biologist and my intense interest in an esoteric group of animals, the fish-hunting cone snails. Attempting to bridge these two disparate worlds has led me to an ...

    Abstract My path to research in neuropharmacology has been a coalescing of my training as a molecular biologist and my intense interest in an esoteric group of animals, the fish-hunting cone snails. Attempting to bridge these two disparate worlds has led me to an idiosyncratic career as a pharmacologist.
    MeSH term(s) Animals ; Conus Snail ; Humans
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-030320-113510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na

    Kimball, Ian H / Nguyen, Phuong T / Olivera, Baldomero M / Sack, Jon T / Yarov-Yarovoy, Vladimir

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1156855

    Abstract: The voltage-gated sodium ( ... ...

    Abstract The voltage-gated sodium (Na
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1156855
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  4. Article: Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework.

    Chase, Kevin / Watkins, Maren / Safavi-Hemami, Helena / Olivera, Baldomero M

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 784419

    Abstract: The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom ... ...

    Abstract The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom peptides from species conventionally assigned to the genus
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.784419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework

    Kevin Chase / Maren Watkins / Helena Safavi-Hemami / Baldomero M. Olivera

    Frontiers in Molecular Biosciences, Vol

    2022  Volume 9

    Abstract: The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom ... ...

    Abstract The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom peptides from species conventionally assigned to the genus Turris was correlated to a phylogenetic analysis. Nucleotide sequences of multiple genes from transcriptomes were used to assess the phylogenetic relationships across a diverse set of species. The resulting tree shows that as conventionally defined, the conoidean genus Turris, is polyphyletic. We describe a new genus, Purpuraturris gen. nov., that comprises the outlier species. In addition to morphological distinctions, molecular data reveal that this group is divergent from Turris sensu stricto. The correlation between phylogenetic information and a family of peptide sequences was used to highlight those peptides mostly likely to be unique and intimately associated with biological diversity. The plethora of peptide sequences available requires two prioritization decisions: which subset of peptides to initially characterize, and after these are characterized, which to comprehensively investigate for potential biomedical applications such as drug developments.Life Science Identifiers: urn:lsid:zoobank.org; pub: 60D46561-28F0-4C39-BAC4-66DC8B4EAEA4
    Keywords turripeptides ; conoidean venoms ; phylogenetics ; peptide libraries ; Turris ; Purpuraturris ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: A toxin-based approach to neuropeptide and peptide hormone discovery.

    Koch, Thomas Lund / Torres, Joshua P / Baskin, Robert P / Salcedo, Paula Flórez / Chase, Kevin / Olivera, Baldomero M / Safavi-Hemami, Helena

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1176662

    Abstract: Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules that control essential processes in animals. Despite breakthroughs in peptide discovery, many signaling peptides remain undiscovered. Recently, we demonstrated the ... ...

    Abstract Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules that control essential processes in animals. Despite breakthroughs in peptide discovery, many signaling peptides remain undiscovered. Recently, we demonstrated the use of somatostatin-mimicking toxins from cone snails to identify the invertebrate ortholog of somatostatin. Here, we show that this toxin-based approach can be systematically applied to discover other unknown secretory peptides that are likely to have signaling function. Using large sequencing datasets, we searched for homologies between cone snail toxins and secreted proteins from the snails' prey. We identified and confirmed expression of five toxin families that share strong similarities with unknown secretory peptides from mollusks and annelids and in one case also from ecdysozoans. Based on several lines of evidence we propose that these peptides likely act as signaling peptides that serve important physiological functions. Indeed, we confirmed that one of the identified peptides belongs to the family of crustacean hyperglycemic hormone, a peptide not previously observed in Spiralia. We propose that this discovery pipeline can be broadly applied to other systems in which one organism has evolved molecules to manipulate the physiology of another.
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1176662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus.

    McMahon, Kirsten L / O'Brien, Henrik / Schroeder, Christina I / Deuis, Jennifer R / Venkatachalam, Dhananjeyan / Huang, Di / Green, Brad R / Bandyopadhyay, Pradip K / Li, Qing / Yandell, Mark / Safavi-Hemami, Helena / Olivera, Baldomero M / Vetter, Irina / Robinson, Samuel D

    Cellular and molecular life sciences : CMLS

    2023  Volume 80, Issue 10, Page(s) 287

    Abstract: Voltage-gated sodium ( ... ...

    Abstract Voltage-gated sodium (Na
    MeSH term(s) Humans ; Animals ; Conus Snail ; Conotoxins/pharmacology ; Toxins, Biological ; Membrane Proteins ; Sodium Channels/genetics
    Chemical Substances Conotoxins ; Toxins, Biological ; Membrane Proteins ; Sodium Channels
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-04935-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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  8. Article ; Online: Integration of the pSLT Plasmid into the

    Wozniak, Christopher E / Hendriksen, Jordan J / Olivera, Baldomero M / Roth, John R / Hughes, Kelly T

    Journal of bacteriology

    2020  Volume 202, Issue 20

    Abstract: ... A mutant ... ...

    Abstract A mutant of
    MeSH term(s) Chromosomes, Bacterial/genetics ; DNA Replication ; DNA, Bacterial/genetics ; Gene Deletion ; Mutagenesis, Insertional ; Plasmids/genetics ; Salmonella typhimurium/genetics ; Salmonella typhimurium/growth & development ; Temperature ; Virulence
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00380-20
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  9. Article ; Online: Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from

    Neves, Jorge L B / Urcino, Cristoval / Chase, Kevin / Dowell, Cheryl / Hone, Arik J / Morgenstern, David / Chua, Victor M / Ramiro, Iris Bea L / Imperial, Julita S / Leavitt, Lee S / Phan, Jasmine / Fisher, Fernando A / Watkins, Maren / Raghuraman, Shrinivasan / Tun, Jortan O / Ueberheide, Beatrix M / McIntosh, J Michael / Vasconcelos, Vitor / Olivera, Baldomero M /
    Gajewiak, Joanna

    Marine drugs

    2024  Volume 22, Issue 3

    Abstract: The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ... ...

    Abstract The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs. Here, we describe the discovery and characterization of a novel conotoxin from
    MeSH term(s) Animals ; Mice ; Conus Snail ; Conotoxins ; Calcium ; Receptors, Nicotinic ; Amino Acid Sequence ; alpha7 Nicotinic Acetylcholine Receptor
    Chemical Substances Conotoxins ; Calcium (SY7Q814VUP) ; Receptors, Nicotinic ; alpha7 Nicotinic Acetylcholine Receptor
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22030118
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  10. Article ; Online: Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.

    Gajewiak, Joanna / Christensen, Sean B / Dowell, Cheryl / Hararah, Fuaad / Fisher, Fernando / Huynh, Peter N / Olivera, Baldomero M / McIntosh, J Michael

    Journal of medicinal chemistry

    2021  Volume 64, Issue 13, Page(s) 9271–9278

    Abstract: Venom-derived compounds are of broad interest in neuropharmacology and drug development. α-Conotoxins are small disulfide-containing peptides ... ...

    Abstract Venom-derived compounds are of broad interest in neuropharmacology and drug development. α-Conotoxins are small disulfide-containing peptides from
    MeSH term(s) Analgesics/chemical synthesis ; Analgesics/chemistry ; Analgesics/pharmacology ; Conotoxins/chemical synthesis ; Conotoxins/chemistry ; Conotoxins/pharmacology ; Dose-Response Relationship, Drug ; Drug Development ; Humans ; Molecular Structure ; Neuralgia/drug therapy ; Neuralgia/metabolism ; Nicotinic Antagonists/chemical synthesis ; Nicotinic Antagonists/chemistry ; Nicotinic Antagonists/pharmacology ; Receptors, Nicotinic/metabolism ; Structure-Activity Relationship
    Chemical Substances Analgesics ; Conotoxins ; Nicotinic Antagonists ; Receptors, Nicotinic
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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