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  1. Article ; Online: Smooth versus textured tissue expanders in breast reconstruction - A retrospective review of post-operative surgical site infections.

    Tevlin, Ruth / Cemaj, Sophie L / Azad, Amee D / Borrelli, Mimi R / Silverstein, Max L / Posternak, Victoria / Nguyen, Dung / Lee, Gordon K / Nazerali, Rahim S

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2022  Volume 75, Issue 9, Page(s) 3060–3067

    Abstract: Background: Textured tissue expanders (TTEs) were introduced to limit migration and reduce capsular contracture, which were inherent to smooth tissue expanders (STEs). Previous reports suggest that textured devices have increased rates of bacterial ... ...

    Abstract Background: Textured tissue expanders (TTEs) were introduced to limit migration and reduce capsular contracture, which were inherent to smooth tissue expanders (STEs). Previous reports suggest that textured devices have increased rates of bacterial contamination and biofilm formation in comparison with smooth devices. Recently, the relative increased association of anaplastic large cell lymphoma (ALCL) with textured versus smooth devices has led to increased adoption of smooth devices. The aim of our study is to evaluate the post-operative surgical site infection (SSI) rates of STEs versus TTEs.
    Methods: A retrospective case series was conducted at a single academic teaching hospital from April 2016 to December 2019. The primary outcome variable was the development of a post-operative SSI.
    Results: One hundred seventy-seven breasts underwent reconstruction with TTEs and 109 breasts underwent reconstruction with STE. In total, 54 SSIs were recorded (n = 34 TTE; n = 20 STE), with the majority of infections occurring within the first 30 post-operative days (TTE 65%, STE 70%). There was no statistically significant difference in overall post-operative infection rates between TTE and STE groups when broken down into the following time points: <30 day, 30-60 days, and >90 days (p = 0.924). There was no statistically significant difference between infection type (superficial vs. deep, p = 0.932), infection management (medical, surgical, or both, p = 0.409) or salvage results (p = 0.078) seen in STE versus TTE cohort. On multivariate analysis, seroma history was associated with SSI development (OR 3.18, p = 0.041).
    Conclusion: There was no significant difference in the rate of post-operative SSI following breast reconstruction with STE relative to TTE.
    MeSH term(s) Breast Implants/adverse effects ; Breast Neoplasms/surgery ; Female ; Humans ; Mammaplasty/methods ; Retrospective Studies ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Tissue Expansion Devices
    Language English
    Publishing date 2022-05-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2022.04.087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.157: Show issues Location:
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  2. Article ; Online: Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis.

    Silverstein, Sophie R

    Dermatology online journal

    2005  Volume 11, Issue 1, Page(s) 5

    Abstract: Primary amyloidosis may present with skin lesions as a primary or sole expression of underlying plasma-cell dyscrasia. Classic skin lesions of primary, systemic amyloidosis are listed, and features suggestive of the diagnosis are discussed. Where this ... ...

    Abstract Primary amyloidosis may present with skin lesions as a primary or sole expression of underlying plasma-cell dyscrasia. Classic skin lesions of primary, systemic amyloidosis are listed, and features suggestive of the diagnosis are discussed. Where this condition is considered in the dermatologist's differential, the investigations described may lead to an early diagnosis. When therapy can be initiated before the onset of organ failure, survival may be prolonged.
    MeSH term(s) Aged ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Biopsy ; Diagnosis, Differential ; Early Diagnosis ; Humans ; Middle Aged ; Skin Diseases/diagnosis ; Skin Diseases/therapy
    Language English
    Publishing date 2005-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
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  3. Article ; Online: Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children.

    Whangbo, Jennifer S / Kim, Haesook T / Mirkovic, Nikola / Leonard, Lauren / Poryanda, Samuel / Silverstein, Sophie / Kim, Soomin / Reynolds, Carol G / Rai, Sharmila C / Verrill, Kelly / Lee, Michelle A / Margossian, Steven / Duncan, Christine / Lehmann, Leslie / Huang, Jennifer / Nikiforow, Sarah / Alyea, Edwin P / Armand, Philippe / Cutler, Corey S /
    Ho, Vincent T / Blazar, Bruce R / Antin, Joseph H / Soiffer, Robert J / Ritz, Jerome / Koreth, John

    Blood advances

    2019  Volume 3, Issue 17, Page(s) 2550–2561

    Abstract: Low-dose interleukin-2 (IL-2) therapy for chronic graft-versus-host disease (cGVHD) generates a rapid rise in plasma IL-2 levels and ... ...

    Abstract Low-dose interleukin-2 (IL-2) therapy for chronic graft-versus-host disease (cGVHD) generates a rapid rise in plasma IL-2 levels and CD4
    MeSH term(s) Adult ; Cell Proliferation/drug effects ; Child ; Chronic Disease ; Female ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/pathology ; Humans ; Immunotherapy/methods ; Interleukin-2/administration & dosage ; Interleukin-2/pharmacology ; Killer Cells, Natural/cytology ; Lung Diseases/drug therapy ; Male ; Maximum Tolerated Dose ; Skin Diseases/drug therapy ; T-Lymphocytes, Regulatory/cytology
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2019000631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007).

    Kenney, Eileen M / Rozanski, Elizabeth A / Rush, John E / deLaforcade-Buress, Armelle M / Berg, John R / Silverstein, Deborah C / Montealegre, Catalina D / Jutkowitz, L Ari / Adamantos, Sophie / Ovbey, Dianna H / Boysen, Soren R / Shaw, Scott P

    Journal of the American Veterinary Medical Association

    2010  Volume 236, Issue 1, Page(s) 83–87

    Abstract: Objective: To determine whether multiple organ dysfunction syndrome (MODS) could be identified in dogs with sepsis secondary to gastrointestinal tract leakage, and whether the number of affected organ systems was significantly associated with mortality ... ...

    Abstract Objective: To determine whether multiple organ dysfunction syndrome (MODS) could be identified in dogs with sepsis secondary to gastrointestinal tract leakage, and whether the number of affected organ systems was significantly associated with mortality rate.
    Design: Multicenter retrospective case series.
    Animals: 114 dogs.
    Procedures: Medical records for dogs treated surgically because of sepsis secondary to gastrointestinal tract leakage between 2003 and 2007 were reviewed. Sepsis was diagnosed on the basis of results of bacterial culture of peritoneal fluid, gross evidence of gastrointestinal tract leakage at surgery, or both. Renal dysfunction was defined as a > or = 0.5 mg/dL increase in serum creatinine concentration after surgery. Cardiovascular dysfunction was defined as hypotension requiring vasopressor treatment. Respiratory dysfunction was defined as a need for supplemental oxygen administration or mechanical ventilation. Hepatic dysfunction was defined as a serum bilirubin concentration > 0.5 mg/dL. Dysfunction of coagulation was defined as prolonged prothrombin time, prolonged partial thromboplastin time, or platelet count < or = 100,000/microL.
    Results: 89 (78%) dogs had dysfunction of 1 or more organ systems, and 57 (50%) dogs had MODS. Mortality rate increased as the number of dysfunctional organ systems increased. Mortality rate was 70% (40/57) for dogs with MODS and 25% (14/57) for dogs without.
    Conclusions and clinical relevance: Results indicated that MODS, defined as dysfunction of at least 2 organ systems, can be identified in dogs with sepsis and that organ system dysfunction increased the odds of death.
    MeSH term(s) Animals ; Dog Diseases/epidemiology ; Dog Diseases/mortality ; Dog Diseases/pathology ; Dogs ; Female ; Gastrointestinal Tract/injuries ; Male ; Multiple Organ Failure/epidemiology ; Multiple Organ Failure/mortality ; Multiple Organ Failure/pathology ; Multiple Organ Failure/veterinary ; Prognosis ; Retrospective Studies ; Sepsis/epidemiology ; Sepsis/mortality ; Sepsis/pathology ; Sepsis/veterinary ; Severity of Illness Index
    Language English
    Publishing date 2010-01-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.236.1.83
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 423: Show issues Location:
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  5. Article: Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003–2007)

    Kenney, Eileen M / Rozanski, Elizabeth A / Rush, John E / deLaforcade-Buress, Armelle M / Berg, John R / Silverstein, Deborah C / Montealegre, Catalina D / Jutkowitz, L. Ari / Adamantos, Sophie / Ovbey, Dianna H / Boysen, Soren R / Shaw, Scott P

    Journal of the American Veterinary Medical Association. 2010 Jan. 1, v. 236, no. 1

    2010  

    Keywords dogs ; dog diseases ; digestive system diseases ; gastrointestinal system ; lesions (animal) ; complications ; sepsis (infection) ; liver ; kidneys ; heart ; respiratory system ; risk assessment ; epidemiological studies ; bacterial infections ; pathophysiology ; disease severity ; disease course ; mortality
    Language English
    Dates of publication 2010-0101
    Size p. 83-87.
    Document type Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.

    Moler, Frank W / Silverstein, Faye S / Holubkov, Richard / Slomine, Beth S / Christensen, James R / Nadkarni, Vinay M / Meert, Kathleen L / Browning, Brittan / Pemberton, Victoria L / Page, Kent / Gildea, Marianne R / Scholefield, Barnaby R / Shankaran, Seetha / Hutchison, Jamie S / Berger, John T / Ofori-Amanfo, George / Newth, Christopher J L / Topjian, Alexis / Bennett, Kimberly S /
    Koch, Joshua D / Pham, Nga / Chanani, Nikhil K / Pineda, Jose A / Harrison, Rick / Dalton, Heidi J / Alten, Jeffrey / Schleien, Charles L / Goodman, Denise M / Zimmerman, Jerry J / Bhalala, Utpal S / Schwarz, Adam J / Porter, Melissa B / Shah, Samir / Fink, Ericka L / McQuillen, Patrick / Wu, Theodore / Skellett, Sophie / Thomas, Neal J / Nowak, Jeffrey E / Baines, Paul B / Pappachan, John / Mathur, Mudit / Lloyd, Eric / van der Jagt, Elise W / Dobyns, Emily L / Meyer, Michael T / Sanders, Ronald C / Clark, Amy E / Dean, J Michael

    The New England journal of medicine

    2017  Volume 376, Issue 4, Page(s) 318–329

    Abstract: Background: Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after in-hospital cardiac arrest are limited.: Methods: In a trial conducted at ... ...

    Abstract Background: Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after in-hospital cardiac arrest are limited.
    Methods: In a trial conducted at 37 children's hospitals, we compared two temperature interventions in children who had had in-hospital cardiac arrest. Within 6 hours after the return of circulation, comatose children older than 48 hours and younger than 18 years of age were randomly assigned to therapeutic hypothermia (target temperature, 33.0°C) or therapeutic normothermia (target temperature, 36.8°C). The primary efficacy outcome, survival at 12 months after cardiac arrest with a score of 70 or higher on the Vineland Adaptive Behavior Scales, second edition (VABS-II, on which scores range from 20 to 160, with higher scores indicating better function), was evaluated among patients who had had a VABS-II score of at least 70 before the cardiac arrest.
    Results: The trial was terminated because of futility after 329 patients had undergone randomization. Among the 257 patients who had a VABS-II score of at least 70 before cardiac arrest and who could be evaluated, the rate of the primary efficacy outcome did not differ significantly between the hypothermia group and the normothermia group (36% [48 of 133 patients] and 39% [48 of 124 patients], respectively; relative risk, 0.92; 95% confidence interval [CI], 0.67 to 1.27; P=0.63). Among 317 patients who could be evaluated for change in neurobehavioral function, the change in VABS-II score from baseline to 12 months did not differ significantly between the groups (P=0.70). Among 327 patients who could be evaluated for 1-year survival, the rate of 1-year survival did not differ significantly between the hypothermia group and the normothermia group (49% [81 of 166 patients] and 46% [74 of 161 patients], respectively; relative risk, 1.07; 95% CI, 0.85 to 1.34; P=0.56). The incidences of blood-product use, infection, and serious adverse events, as well as 28-day mortality, did not differ significantly between groups.
    Conclusions: Among comatose children who survived in-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia, did not confer a significant benefit in survival with a favorable functional outcome at 1 year. (Funded by the National Heart, Lung, and Blood Institute; THAPCA-IH ClinicalTrials.gov number, NCT00880087 .).
    MeSH term(s) Adolescent ; Body Temperature ; Child ; Child, Preschool ; Coma/complications ; Female ; Heart Arrest/complications ; Heart Arrest/mortality ; Heart Arrest/therapy ; Hospitalization ; Hospitals, Pediatric ; Humans ; Hypothermia, Induced ; Infant ; Infant, Newborn ; Male ; Survival Analysis ; Treatment Failure
    Language English
    Publishing date 2017-01-24
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1610493
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: Central cell-derived peptides regulate early embryo patterning in flowering plants.

    Costa, Liliana M / Marshall, Eleanor / Tesfaye, Mesfin / Silverstein, Kevin A T / Mori, Masashi / Umetsu, Yoshitaka / Otterbach, Sophie L / Papareddy, Ranjith / Dickinson, Hugh G / Boutiller, Kim / VandenBosch, Kathryn A / Ohki, Shinya / Gutierrez-Marcos, José F

    Science (New York, N.Y.)

    2014  Volume 344, Issue 6180, Page(s) 168–172

    Abstract: Plant embryogenesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms accompanying this early event remain unclear. Here, we show that a small cysteine-rich peptide family is required for formation of the zygotic ...

    Abstract Plant embryogenesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms accompanying this early event remain unclear. Here, we show that a small cysteine-rich peptide family is required for formation of the zygotic basal cell lineage and proembryo patterning in Arabidopsis. EMBRYO SURROUNDING FACTOR 1 (ESF1) peptides accumulate before fertilization in central cell gametes and thereafter in embryo-surrounding endosperm cells. Biochemical and structural analyses revealed cleavage of ESF1 propeptides to form biologically active mature peptides. Further, these peptides act in a non-cell-autonomous manner and synergistically with the receptor-like kinase SHORT SUSPENSOR to promote suspensor elongation through the YODA mitogen-activated protein kinase pathway. Our findings demonstrate that the second female gamete and its sexually derived endosperm regulate early embryonic patterning in flowering plants.
    MeSH term(s) Amino Acid Sequence ; Arabidopsis/embryology ; Arabidopsis/genetics ; Arabidopsis Proteins/chemistry ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Body Patterning ; Endosperm/embryology ; Endosperm/genetics ; Flowers/embryology ; Flowers/genetics ; Gene Duplication ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Plant ; Gene Knockout Techniques ; Interleukin-1 Receptor-Associated Kinases/metabolism ; MAP Kinase Kinase Kinases/metabolism ; Molecular Sequence Data ; Peptides/chemistry ; Peptides/genetics ; Peptides/metabolism ; Seeds/embryology ; Seeds/genetics
    Chemical Substances Arabidopsis Proteins ; ESF1.1 protein, Arabidopsis ; ESF1.2 protein, Arabidopsis ; ESF1.3 protein, Arabidopsis ; Peptides ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1) ; SSP protein, Arabidopsis (EC 2.7.11.1) ; MAP Kinase Kinase Kinases (EC 2.7.11.25) ; YODA protein, Arabidopsis (EC 2.7.11.25)
    Language English
    Publishing date 2014-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1243005
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