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Article ; Online: Imaging and clinical end points in brain metastases trials.

Soffietti, Riccardo / Chiavazza, Carlotta / Rudà, Roberta

CNS oncology

2017 Volume 6, Issue 4, Page(s) 243–246

MeSH term(s)	Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/psychology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Humans ; Neuroimaging ; Research Design ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2017-10-06
Publishing country	England
Document type	Journal Article
ISSN	2045-0915
ISSN (online)	2045-0915
DOI	10.2217/cns-2017-0017
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Article ; Online: Germination Performances of 14 Wildflowers Screened for Shaping Urban Landscapes in Mountain Areas

Matteo Caser / Sonia Demasi / Eric Mozzanini / Paola Maria Chiavazza / Valentina Scariot

Sustainability, Vol 14, Iss 2641, p

2022 Volume 2641

Abstract: ... from northern west Italian alpine and subalpine areas. Seed germination in Petri dishes at 25 °C was performed ...

Abstract	Despite the high biodiversity in the Mediterranean region, the use of wildflowers from mountain areas in urban landscaping projects is hampered by the limited information on their seed germination performances. This research evaluated germination traits of 14 native herbaceous wildflower species from northern west Italian alpine and subalpine areas. Seed germination in Petri dishes at 25 °C was performed, applying two different photoperiod conditions (light/dark at 0/24 h or 12/12 h). A high rate and rapid germination are key features for seed and seedling nursery production; thus, the main germination indices were evaluated: the final germination percentage, the index of germination relative to light, the time of first germination, the time to reach 50% of germinated seeds, the germination period, and the mean germination time. Overall, Bellis perennis L., Leucanthemum vulgare Lam., and Taraxacum officinale Weber, from mesophilic mountainous hilly grasslands, and Dianthus carthusianorum L. and Lavandula angustifolia Mill. from higher altitudes, turned out to be interesting. Particular attention could be paid to D. carthusianorum for germination synchrony in both growth conditions, high speed, and short germination period (8.5 and 16.2 days in the dark and in the light, respectively).
Keywords	alpine plant species ; final germination percentage ; germinability ; germination period ; native flowering species ; native plants biodiversity ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	580 ; 630
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring.

Chiavazza, C / Pellerino, A / Ferrio, F / Cistaro, A / Soffietti, R / Rudà, R

BioMed research international

2018 Volume 2018, Page(s) 3606970

Abstract: Primary Central Nervous System Lymphoma (PCNSL) is a rare neoplasm that can involve brain, eye, leptomeninges, and rarely spinal cord. PCNSL lesions most typically enhance homogeneously on T1-weighted magnetic resonance imaging (MRI) and appear T2- ... ...

Abstract	Primary Central Nervous System Lymphoma (PCNSL) is a rare neoplasm that can involve brain, eye, leptomeninges, and rarely spinal cord. PCNSL lesions most typically enhance homogeneously on T1-weighted magnetic resonance imaging (MRI) and appear T2-hypointense, but high variability in MRI features is commonly encountered. Neurological symptoms and MRI findings may mimic high grade gliomas (HGGs), tumefactive demyelinating lesions (TDLs), or infectious and granulomatous diseases. Advanced MRI techniques (MR diffusion, spectroscopy, and perfusion) and metabolic imaging, such as Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) or amino acid PET (usually employing methionine), may be useful in distinguishing these different entities and monitoring the disease course. Moreover, emerging data suggest a role for cerebrospinal fluid (CSF) markers in predicting prognosis and response to treatments. In this review, we will address the challenges in PCNSL diagnosis, assessment of response to treatments, and evaluation of potential neurotoxicity related to chemotherapy and radiotherapy.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Brain Neoplasms ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/therapy ; Glioma/diagnosis ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2018-06-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2018/3606970
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Article ; Online: Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: a Multicenter, Retrospective, Real-world Study (OPPORTUNITY).

Chisari, Clara G / Bianco, Assunta / Brescia Morra, Vincenzo / Calabrese, Massimiliano / Capone, Fioravante / Cavalla, Paola / Chiavazza, Carlotta / Comi, Cristoforo / Danni, Maura / Filippi, Massimo / Iaffaldano, Pietro / Lanzillo, Roberta / Lo Fermo, Salvatore / Lucisano, Alessandra / Lugaresi, Alessandra / Lus, Giacomo / Marfia, Gerolama Alessandra / Marinelli, Fabiana / Mirabella, Massimiliano /

Moiola, Lucia / Perin, Chiara / Realmuto, Sabrina / Toscano, Simona / Trojano, Maria / Vecchio, Domizia / Patti, Francesco

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2023 Volume 20, Issue 6, Page(s) 1696–1706

Abstract: Ocrelizumab is a recombinant humanized monoclonal antibody selectively targeting CD20-expressing B cells. The effect of ocrelizumab on primary progressive multiple sclerosis (PPMS) has been evaluated during phase 3 trials that enrolled patients under 55 ... ...

Abstract	Ocrelizumab is a recombinant humanized monoclonal antibody selectively targeting CD20-expressing B cells. The effect of ocrelizumab on primary progressive multiple sclerosis (PPMS) has been evaluated during phase 3 trials that enrolled patients under 55 years with a maximum Expanded Disability Status Scale (EDSS) of 6.5. However, little is known on older disabled patients with longer disease duration. We aimed to assess the clinical effectiveness of ocrelizumab in PPMS patients out of the ORATORIO eligibility criteria. This multicenter retrospective study collected data about the effectiveness of ocrelizumab in PPMS patients who received treatment between May 2017 and June 2022 in the Italian MS centers contributing to the Italian MS Registry who adhered to the Compassionate Use Program. The confirmed EDSS worsening (CEW) (defined as either a ≥ 1-point or ≥ 2-point increase in EDSS score from baseline that was confirmed at T12 and T24) was calculated. At the date of data extraction, out of 887 PPMS patients who had received ocrelizumab, 589 (mean age 49.7 ± 10.7 years, 242 (41.1%) females) were enrolled. The mean follow-up period was 41.3 ± 12.3 months. A total of 149 (25.3%) received ocrelizumab according to the ORATORIO criteria (ORATORIO group) and 440 (74.7%) outside the ORATORIO criteria (non-ORATORIO group). No differences in terms of cumulative probabilities of 12 and 24 months of CEW of ≤ 1 point were found between ORATORIO and non-ORATORIO groups. Cox regression analyses showed that age older than 65 years (HR 2.51, 25% CI 1.07-3.65; p = 0.01) was associated with higher risk of CEW at 24 months. Patients not responding to ORATORIO criteria for reimbursability may benefit from ocrelizumab treatment, as disease activity, disease duration, and EDSS seem to not impact the disability outcome. Our results may suggest to extend the possible use of this powerful agent in selected patients under the age of 65 years.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Aged ; Male ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Retrospective Studies ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Immunologic Factors/therapeutic use ; Immunologic Factors/pharmacology
Chemical Substances	ocrelizumab (A10SJL62JY) ; Antibodies, Monoclonal, Humanized ; Immunologic Factors
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-023-01415-y
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Article ; Online: Off-line and real-time monitoring of acetaminophen photodegradation by an electrochemical sensor.

Berto, Silvia / Carena, Luca / Chiavazza, Enrico / Marletti, Matteo / Fin, Andrea / Giacomino, Agnese / Malandrino, Mery / Barolo, Claudia / Prenesti, Enrico / Vione, Davide

Chemosphere

2018 Volume 204, Page(s) 556–562

Abstract: The photochemistry of N-acetyl-para-aminophenol (acetaminophen, APAP) is here investigated by using differential pulse voltammetry (DPV) analysis to monitor APAP photodegradation upon steady-state irradiation. The purpose of this work is to assess the ... ...

Abstract	The photochemistry of N-acetyl-para-aminophenol (acetaminophen, APAP) is here investigated by using differential pulse voltammetry (DPV) analysis to monitor APAP photodegradation upon steady-state irradiation. The purpose of this work is to assess the applicability of DPV to monitor the photochemical behaviour of xenobiotics, along with the development of an electrochemical set-up for the real-time monitoring of APAP photodegradation. We here investigated the APAP photoreactivity towards the main photogenerated reactive transients species occurring in sunlit surface waters (hydroxyl radical HO, carbonate radical CO
MeSH term(s)	Acetaminophen/metabolism ; Biosensing Techniques/methods ; Electrochemical Techniques ; Environmental Monitoring/methods ; Kinetics ; Photochemistry ; Photolysis
Chemical Substances	Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2018-08
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.03.069
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Article ; Online: Progranulin genetic polymorphisms influence progression of disability and relapse recovery in multiple sclerosis.

Vercellino, Marco / Fenoglio, Chiara / Galimberti, Daniela / Mattioda, Alessandra / Chiavazza, Carlotta / Binello, Eleonora / Pinessi, Lorenzo / Giobbe, Dario / Scarpini, Elio / Cavalla, Paola

Multiple sclerosis (Houndmills, Basingstoke, England)

2016 Volume 22, Issue 8, Page(s) 1007–1012

Abstract: Background: Progranulin (GRN) is a multifunctional protein involved in inflammation and repair, and also a neurotrophic factor critical for neuronal survival. Progranulin is strongly expressed in multiple sclerosis (MS) brains by macrophages and ... ...

Abstract	Background: Progranulin (GRN) is a multifunctional protein involved in inflammation and repair, and also a neurotrophic factor critical for neuronal survival. Progranulin is strongly expressed in multiple sclerosis (MS) brains by macrophages and microglia. Methods: In this study we evaluated GRN genetic variability in 400 MS patients, in correlation with clinical variables such as disease severity and relapse recovery. We also evaluated serum progranulin levels in the different groups of GRN variants carriers. Results: We found that incomplete recovery after a relapse is correlated with an increased frequency of the rs9897526 A allele (odds ratio (OR) 4.367, p = 0.005). A more severe disease course (Multiple Sclerosis Severity Score > 5) is correlated with an increased frequency of the rs9897526 A allele (OR 1.886, p = 0.002) and of the rs5848 T allele (OR 1.580, p = 0.019). Carriers of the variants associated with a more severe disease course (rs9897526 A, rs5848 T) have significantly lower levels of circulating progranulin (80.5 ± 9.1 ng/mL vs. 165.7 ng/mL, p = 0.01). Conclusion: GRN genetic polymorphisms likely influence disease course and relapse recovery in MS.
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458515610646
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Article ; Online: Reversible disconnection syndrome in a case of acute tumefactive demyelinating lesion: a PET study.

Chiavazza, Carlotta / Cistaro, Angelina / Fania, Piercarlo / Bertolotto, Antonio / Cavalla, Paola / Rudà, Roberta / Pinessi, Lorenzo / Soffietti, Riccardo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2016 Volume 37, Issue 12, Page(s) 2019–2023

MeSH term(s)	Adult ; Brain/diagnostic imaging ; Cognition Disorders/etiology ; Demyelinating Diseases/complications ; Demyelinating Diseases/diagnostic imaging ; Electroencephalography ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2016-12
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-016-2675-x
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Article ; Online: Charge-transfer complexes of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone with amino molecules in polar solvents.

Berto, Silvia / Chiavazza, Enrico / Ribotta, Valentina / Daniele, Pier Giuseppe / Barolo, Claudia / Giacomino, Agnese / Vione, Davide / Malandrino, Mery

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2015 Volume 149, Page(s) 75–82

Abstract: The charge-transfer complexes have scientific relevance because this type of molecular interaction is at the basis of the activity of pharmacological compounds and because the absorption bands of the complexes can be used for the quantification of ... ...

Abstract	The charge-transfer complexes have scientific relevance because this type of molecular interaction is at the basis of the activity of pharmacological compounds and because the absorption bands of the complexes can be used for the quantification of electron donor molecules. This work aims to assess the stability of the charge-transfer complexes between the electron acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and two drugs, procaine and atenolol, in acetonitrile and ethanol. The stability of DDQ in solution and the time required to obtain the maximum complex formation were evaluated. The stoichiometry and the stability of the complexes were determined, respectively, by Job's plot method and by the elaboration of UV-vis titrations data. The latter task was carried out by using the non-linear global analysis approach to determine the equilibrium constants. This approach to data elaboration allowed us to overcome the disadvantages of the classical linear-regression method, to obtain reliable values of the association constants and to calculate the entire spectra of the complexes. NMR spectra were recorded to identify the portion of the donor molecule that was involved in the interaction. The data support the participation of the aliphatic amino groups in complex formation and exclude the involvement of the aromatic amine present in the procaine molecule.
MeSH term(s)	Acetonitriles/chemistry ; Amines/chemistry ; Benzoquinones/chemistry ; Electrons ; Ethanol/chemistry ; Kinetics ; Proton Magnetic Resonance Spectroscopy ; Solvents/chemistry ; Spectrophotometry, Ultraviolet ; Time Factors
Chemical Substances	Acetonitriles ; Amines ; Benzoquinones ; Solvents ; dichlorodicyanobenzoquinone (1H5KD39UH7) ; Ethanol (3K9958V90M) ; acetonitrile (Z072SB282N)
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2015.04.044
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Article ; Online: Occurrence of ecchymotic angioedema-like cutaneous lesions as a possible side effect of fingolimod.

Masera, S / Chiavazza, C / Mattioda, A / Superti, G / Beggiato, E / Crosasso, P / Broganelli, P / Pinessi, L / Cavalla, P

Multiple sclerosis (Houndmills, Basingstoke, England)

2014 Volume 20, Issue 12, Page(s) 1666–1667

MeSH term(s)	Adult ; Angioedema/chemically induced ; Angioedema/diagnosis ; Angioedema/pathology ; Female ; Fingolimod Hydrochloride ; Humans ; Immunosuppressive Agents/adverse effects ; Knee/pathology ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/metabolism ; Propylene Glycols/adverse effects ; Receptors, Lysosphingolipid/antagonists & inhibitors ; Receptors, Lysosphingolipid/metabolism ; Skin/pathology ; Sphingosine/adverse effects ; Sphingosine/analogs & derivatives
Chemical Substances	Immunosuppressive Agents ; Propylene Glycols ; Receptors, Lysosphingolipid ; S1PR1 protein, human ; Fingolimod Hydrochloride (G926EC510T) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458514525872
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Article ; Online: Parity is associated with a longer time to reach irreversible disability milestones in women with multiple sclerosis.

Masera, S / Cavalla, P / Prosperini, L / Mattioda, A / Mancinelli, C R / Superti, G / Chiavazza, C / Vercellino, M / Pinessi, L / Pozzilli, C

Multiple sclerosis (Houndmills, Basingstoke, England)

2015 Volume 21, Issue 10, Page(s) 1291–1297

Abstract: Background: Multiple sclerosis (MS) frequently affects women of childbearing age. While short-term effects of pregnancy on MS course are well-known, whether pregnancy may influence long-term disability progression is debated.: Methods: A two-centre ... ...

Abstract	Background: Multiple sclerosis (MS) frequently affects women of childbearing age. While short-term effects of pregnancy on MS course are well-known, whether pregnancy may influence long-term disability progression is debated. Methods: A two-centre retrospective study to investigate long-term effect of pregnancy on disability was performed in a population of MS women. Survival analyses and multivariate Cox proportional regression models (including early predictors of MS severity and exposure to disease-modifying treatments) were performed to compare time to reach well-established disability milestones in nulliparous women and in those with pregnancies after MS onset ('parous'). Women with pregnancies before MS onset were excluded from analyses as they represent a heterogeneous group. Results: Data about 445 women (261 nulliparous, 184 'parous') were analysed. A longer time to reach Expanded Disability Status Scale (EDSS) 4.0 and 6.0 was observed in parous women; Cox regression models revealed a lower risk for 'parous' than nulliparous women in reaching EDSS 4.0 and 6.0 (HR = 0.552, p = 0.008 and HR = 0.422, p = 0.012 respectively). Conclusion: Our findings suggest that pregnancy after MS onset is associated with a slower long-term disability progression. Whether this represents a biological/immunological effect, or reflects a higher propensity toward childbearing in women with milder disease, it remains uncertain deserving further investigations.
MeSH term(s)	Adult ; Age of Onset ; Disability Evaluation ; Disabled Persons ; Disease Progression ; Female ; Humans ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/mortality ; Parity/physiology ; Pregnancy ; Retrospective Studies ; Risk ; Survival Analysis
Language	English
Publishing date	2015-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458514561907
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