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  1. Article: INTERDISZIPLINARITÄT gross geschrieben!

    Pestalozzi, Bernhard

    Schweizer Zeitschrift für Onkologie

    2017  Volume 15, Issue 4, Page(s) 1

    Language German
    Document type Article
    ZDB-ID 2140740-X
    ISSN 1660-4369
    Database Current Contents Medicine

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    Zs.A 5837: Show issues Location:
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  2. Article: Kongressberichte. St. Gallen 2013

    Pestalozzi, B.

    Schweizer Krebs-Bulletin

    2013  Volume 33, Issue 2, Page(s) 180

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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  3. Article: Kongressberichte. St. Gallen in Vienna 2015 - Convention Report

    Pestalozzi, B. C.

    Schweizer Krebs-Bulletin

    2015  Volume 35, Issue 2, Page(s) 204–210

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Identifying microbiota community patterns important for plant protection using synthetic communities and machine learning.

    Emmenegger, Barbara / Massoni, Julien / Pestalozzi, Christine M / Bortfeld-Miller, Miriam / Maier, Benjamin A / Vorholt, Julia A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7983

    Abstract: Plant-associated microbiomes contribute to important ecosystem functions such as host resistance to biotic and abiotic stresses. The factors that determine such community outcomes are inherently difficult to identify under complex environmental ... ...

    Abstract Plant-associated microbiomes contribute to important ecosystem functions such as host resistance to biotic and abiotic stresses. The factors that determine such community outcomes are inherently difficult to identify under complex environmental conditions. In this study, we present an experimental and analytical approach to explore microbiota properties relevant for a microbiota-conferred host phenotype, here plant protection, in a reductionist system. We screened 136 randomly assembled synthetic communities (SynComs) of five bacterial strains each, followed by classification and regression analyses as well as empirical validation to test potential explanatory factors of community structure and composition, including evenness, total commensal colonization, phylogenetic diversity, and strain identity. We find strain identity to be the most important predictor of pathogen reduction, with machine learning algorithms improving performances compared to random classifications (94-100% versus 32% recall) and non-modelled predictions (0.79-1.06 versus 1.5 RMSE). Further experimental validation confirms three strains as the main drivers of pathogen reduction and two additional strains that confer protection in combination. Beyond the specific application presented in our study, we provide a framework that can be adapted to help determine features relevant for microbiota function in other biological systems.
    MeSH term(s) Phylogeny ; Microbiota/genetics ; Bacteria/genetics ; Plants ; Symbiosis
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43793-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of theta burst stimulation over the dorsolateral prefrontal cortex on language switching - A behavioral and ERP study.

    Pestalozzi, Maria I / Annoni, Jean-Marie / Müri, René M / Jost, Lea B

    Brain and language

    2020  Volume 205, Page(s) 104775

    Abstract: This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either ... ...

    Abstract This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either excitatory or inhibitory TBS over the left DLPFC before conducting picture naming tasks in pure language blocks and a language switching block, as well as a nonverbal switching task. On the behavioral level, we found no effect of TBS. However, the ERP-analysis revealed an effect of Stimulation for the picture naming tasks, characterized by alterations in the left DLPFC at 20-72 ms, and in networks associated with conflict resolution and self-monitoring at 533-600 ms. As we did not find an interaction between Stimulation and Block (switching vs non-switching), prefrontal stimulation did not specifically modulate interlanguage control. The left DLPFC might rather be involved in enhancingmaintenance of task demands and self-monitoring during language production in both mono- and bilingual contexts.
    MeSH term(s) Adolescent ; Adult ; Electroencephalography/methods ; Evoked Potentials/physiology ; Female ; Humans ; Male ; Multilingualism ; Photic Stimulation/methods ; Prefrontal Cortex/physiology ; Psychomotor Performance/physiology ; Reaction Time/physiology ; Theta Rhythm/physiology ; Transcranial Magnetic Stimulation/methods ; Young Adult
    Language English
    Publishing date 2020-03-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 7448-2
    ISSN 1090-2155 ; 0093-934X
    ISSN (online) 1090-2155
    ISSN 0093-934X
    DOI 10.1016/j.bandl.2020.104775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1063: Show issues Location:
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  6. Article: A prospective study of risk-adapted therapy for large cell non-Hodgkin's lymphoma with VACOP-B followed by high-dose CBV and autologous progenitor cell transplantation for high-risk patients in remission.

    Stahel, R A / Jost, L M / Kroner, T / Dommann-Scherrer, C / Maurer, R / Glanzmann, C / Jacky, E / Pichert, G / Pestalozzi, B / Marincek, B / Sauter, C / Honegger, H

    British journal of haematology

    1999  Volume 104, Issue 4, Page(s) 763–769

    Abstract: ... therapy for patients with large cell lymphoma. Patients aged 60 years or less received 12 weeks of VACOP-B ...

    Abstract Several centres reported a favourable outcome after high-dose chemotherapy with autologous progenitor cell transplantation in selected patients with high-risk large cell non-Hodgkin's lymphoma in first remission. Based on these observations, we wanted to prospectively determine the outcome of a risk-adapted therapy for patients with large cell lymphoma. Patients aged 60 years or less received 12 weeks of VACOP-B chemotherapy. For high-risk patients in remission this was immediately followed by high-dose chemotherapy with cyclophosphamide, carmustine and etoposide and autologous progenitor cell transplantation. High-risk criteria were defined before the establishment of the International Index and included large cell lymphoma stage III or IV or mediastinal large lymphoma with sclerosis stage II or higher, and the presence of bulky tumours and/or an elevated LDH. 89 patients fulfilled the clinical selection criteria and were entered onto this multicentre study. 82 patients were evaluable after confirmation of large cell histology by pathology review. Of these, 51 were considered to be in the low-risk group and 31 in the high-risk group. The 3-year event-free survival for all patients was 68%. The 3-year event-free survival was 76% for the low-risk and 55% for the high-risk group (P = 0.061). Only 22/31 high-risk patients were able to receive the high-dose chemotherapy in first remission as intended. In conclusion, although our study demonstrated that a risk-adapted therapy for large cell lymphoma could be safely administered, the potential impact on outcome of the strategy chosen here is likely to be small.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/administration & dosage ; Cyclophosphamide/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/therapy ; Male ; Middle Aged ; Prednisone/administration & dosage ; Prospective Studies ; Risk Factors ; Vincristine/administration & dosage
    Chemical Substances Bleomycin (11056-06-7) ; Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 1999-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1046/j.1365-2141.1999.01263.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Primary breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.

    Pestalozzi, B

    Annals of oncology : official journal of the European Society for Medical Oncology

    2007  Volume 18 Suppl 2, Page(s) ii5–8

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Mastectomy ; Mastectomy, Segmental ; Neoplasm Staging ; Risk Assessment
    Language English
    Publishing date 2007-05-07
    Publishing country England
    Document type Journal Article ; Practice Guideline
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdm015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  8. Article ; Online: ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.

    Forster-Sack, Miriam / Zoche, Martin / Pestalozzi, Bernhard / Witzel, Isabell / Schwarz, Esther Irene / Herzig, Joel Julien / Fansa, Hisham / Tausch, Christoph / Ross, Jeff / Moch, Holger / Varga, Zsuzsanna

    The journal of pathology. Clinical research

    2024  Volume 10, Issue 2, Page(s) e12362

    Abstract: Most invasive lobular breast carcinomas (ILBCs) are luminal-type carcinomas with an HER2-negative phenotype (ERBB2 or HER2 un-amplified) and CDH1 mutations. Rare variants include ERBB2-amplified subtypes associated with an unfavorable prognosis and less ... ...

    Abstract Most invasive lobular breast carcinomas (ILBCs) are luminal-type carcinomas with an HER2-negative phenotype (ERBB2 or HER2 un-amplified) and CDH1 mutations. Rare variants include ERBB2-amplified subtypes associated with an unfavorable prognosis and less response to anti-HER2 targeted therapies. We analyzed the clinicopathological and molecular features of ERBB2-amplified ILBC and compared these characteristics with ERBB2-unamplified ILBC. A total of 253 patients with ILBC were analyzed. Paraffin-embedded formalin-fixed tumor samples from 250 of these patients were added to a tissue microarray. Protein expression of prognostic, stem cell and breast-specific markers was tested by immunohistochemistry (IHC). Hybrid capture-based comprehensive genomic profiling (CGP) was performed for 10 ILBCs that were either fluorescent in situ hybridization (FISH) or IHC positive for HER2 amplification/overexpression and 10 ILBCs that were either FISH or IHC negative. Results were compared with a CGP database of 44,293 invasive breast carcinomas. The CGP definition of ERBB2 amplification was five copies or greater. A total of 17 of 255 ILBC (5%) were ERBB2 amplified. ERBB2-amplified ILBC had higher tumor stage (p < 0.0001), more frequent positive nodal status (p = 0.00022), more distant metastases (p = 0.012), and higher histological grade (p < 0.0001), and were more often hormone receptor negative (p < 0.001) and more often SOX10 positive (p = 0.005). ERBB2 short variant sequence mutations were more often detected in ERBB2-unamplified tumors (6/10, p = 0.027), whereas CDH1 mutations/copy loss were frequently present in both subgroups (9/10 and 7/10, respectively). Amplification of pathogenic genes were more common in HER2-positive ILBC (p = 0.0009). CDK12 gene amplification (≥6 copies) was detected in 7 of 10 ERBB2-amplified ILBC (p = 0.018). There were no CDK12 gene amplifications reported in 44,293 invasive breast carcinomas in the FMI Insights CGP database. ERBB2-amplified ILBC is a distinct molecular subgroup with frequent coamplification of CDK12, whereas ERBB2 sequence mutations occur only in ERBB2-unamplified ILBC. CDK12/ERBB2 co-amplification may explain the poor prognosis and therapy resistance of ERBB2-amplified ILBC.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma, Lobular/genetics ; Carcinoma, Lobular/pathology ; Cyclin-Dependent Kinases/genetics ; In Situ Hybridization, Fluorescence ; Mutation ; Prognosis ; Receptor, ErbB-2/genetics
    Chemical Substances CDK12 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814357-7
    ISSN 2056-4538 ; 2056-4538
    ISSN (online) 2056-4538
    ISSN 2056-4538
    DOI 10.1002/2056-4538.12362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How to remembet the St. Gallen Consensus Conference 2011

    Pestalozzi, B.

    Schweizer Krebs-Bulletin

    2011  Volume 31, Issue 2, Page(s) 178–182

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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  10. Article: Französisch bitte!

    Pestalozzi, B.

    Schweizerisches Medizin-Forum

    2010  Volume 10, Issue 28/29, Page(s) 479

    Language German
    Document type Article
    ZDB-ID 2220114-2
    ISSN 1424-3784
    Database Current Contents Medicine

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