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  1. Article: Correction: Biswas, M.S. et al. Inactivation of Carbonyl-Detoxifying Enzymes by H

    Biswas, Md Sanaullah / Terada, Ryota / Mano, Jun'ichi

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 4

    Abstract: The author wishes to make the following correction to this paper [ ... ]. ...

    Abstract The author wishes to make the following correction to this paper [...].
    Language English
    Publishing date 2020-03-31
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9040289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Borderline indications for ovarian suppression: addressing uncertainties with patients.

    S Mano, Max

    Future oncology (London, England)

    2022  Volume 18, Issue 37, Page(s) 4111–4118

    Abstract: Ovarian function suppression (OFS) is a potentially life-saving treatment for young women diagnosed with high-risk hormonal-receptor (HR)+ early breast cancer (EBC), albeit one associated with significant side effects that may adversely affect quality of ...

    Abstract Ovarian function suppression (OFS) is a potentially life-saving treatment for young women diagnosed with high-risk hormonal-receptor (HR)+ early breast cancer (EBC), albeit one associated with significant side effects that may adversely affect quality of life. Of particular concern, this article raises a few borderline indications that were largely unaddressed in pivotal clinical trials but are still commonly encountered in daily practice. These, referred to here as 'borderline indications of OFS' remain a source of uncertainty for patients and physicians and are concisely addressed in this article.
    MeSH term(s) Humans ; Female ; Antineoplastic Agents, Hormonal/therapeutic use ; Quality of Life ; Uncertainty ; Chemotherapy, Adjuvant/adverse effects ; Ovary ; Breast Neoplasms/drug therapy ; Premenopause ; Tamoxifen/therapeutic use
    Chemical Substances Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45)
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-0478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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  3. Article ; Online: Does depression mediate the pain-frailty relationship? Latent variables approach.

    Tomás, José M / Sentandreu-Mañó, Trinidad / Martínez-Gregorio, Sara

    Geriatric nursing (New York, N.Y.)

    2023  Volume 51, Page(s) 388–393

    Abstract: Frailty is highly prevalent among older adults. This study aims to add evidence to the mediational role of depression in the pain-frailty relationship. Data came from a sample of 2578 Spanish older adults recruited from the Survey of Health, Aging, and ... ...

    Abstract Frailty is highly prevalent among older adults. This study aims to add evidence to the mediational role of depression in the pain-frailty relationship. Data came from a sample of 2578 Spanish older adults recruited from the Survey of Health, Aging, and Retirement in Europe (SHARE). A set of competing structural equation models were performed: (a) independent prediction, (b) full mediation, and (c) partial mediation. Results showed a better fit for the partial mediation model. This model was extended including covariates. The effects of pain and depression remained relevant in the final model, which explained 91% of the frailty variance. These findings support the relevance of the pain-depression dyad in frailty development. Although the pain shows a direct impact on frailty, this association is partially mediated by depression. The interplay of these conditions could be crucial for treatment effectiveness.
    MeSH term(s) Humans ; Aged ; Frailty ; Depression ; Frail Elderly ; Geriatric Assessment/methods ; Pain
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632559-2
    ISSN 1528-3984 ; 0197-4572
    ISSN (online) 1528-3984
    ISSN 0197-4572
    DOI 10.1016/j.gerinurse.2023.04.006
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  4. Article ; Online: Advances in Cell-Rich Inks for Biofabricating Living Architectures.

    Almeida-Pinto, José / Moura, Beatriz S / Gaspar, Vítor M / Mano, João F

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2313776

    Abstract: Advancing biofabrication toward manufacturing living constructs with well-defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation of tissue-like, ...

    Abstract Advancing biofabrication toward manufacturing living constructs with well-defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation of tissue-like, cell-dense inks for biofabrication remains, however, challenging at various levels of the bioprinting process. Promising advances have been made toward this goal, achieving relatively high cell densities that surpass those found in conventional platforms, pushing the current boundaries closer to achieving tissue-like cell densities. On this focus, herein the overarching challenges in the bioprocessing of cell-rich living inks into clinically grade engineered tissues are discussed, as well as the most recent advances in cell-rich living ink formulations and their processing technologies are highlighted. Additionally, an overview of the foreseen developments in the field is provided and critically discussed.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202313776
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  5. Article: Digital twins and the future of precision mental health.

    Spitzer, Michael / Dattner, Itai / Zilcha-Mano, Sigal

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1082598

    Abstract: Science faces challenges in developing much-needed precision mental health treatments to accurately identify and diagnose mental health problems and the optimal treatment for each individual. Digital twins (DTs) promise to revolutionize the field of ... ...

    Abstract Science faces challenges in developing much-needed precision mental health treatments to accurately identify and diagnose mental health problems and the optimal treatment for each individual. Digital twins (DTs) promise to revolutionize the field of mental health, as they are doing in other fields of science, including oncology and cardiology, where they have been successfully deployed. The use of DTs in mental health is yet to be explored. In this Perspective, we lay the conceptual foundations for mental health DTs (MHDT). An MHDT is a virtual representation of an individual's mental states and processes. It is continually updated from data collected over the lifespan of the individual, and guides mental health professionals in diagnosing and treating patients based on mechanistic models and statistical and machine learning tools. The merits of MHDT are demonstrated through the example of the working alliance between the therapist and the patient, which is one of the most consistent mechanisms predicting treatment outcome.
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1082598
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  6. Article ; Online: Cloning and Functional Verification of Endogenous

    Kanai, Masatake / Hikino, Kazumi / Mano, Shoji

    Genes

    2023  Volume 14, Issue 7

    Abstract: Castor ( ...

    Abstract Castor (
    MeSH term(s) Ricinus/genetics ; Ricinus/metabolism ; Gene Editing ; CRISPR-Cas Systems ; Seeds/genetics ; Ricin/genetics ; Ricin/metabolism ; Cloning, Molecular
    Chemical Substances Ricin (9009-86-3)
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14071327
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  7. Article ; Online: Mycosis Fungoides: successful re-treatment with Brentuximab Vedotin.

    James, Mariel / Nakamura, Mano / Whittaker, Sean / Morris, Stephen

    The British journal of dermatology

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae097
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    Ui VI Zs.23: Show issues Location:
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  8. Article: Members' goal orientation and working alliance in group therapy: A response surface analysis.

    Kivlighan, Martin / Bardhoshi, Gerta / Wang, Kun / Anders, Christopher / Zilcha-Mano, Sigal

    Journal of counseling psychology

    2024  Volume 71, Issue 3, Page(s) 179–189

    Abstract: Research suggests that a client's achievement goal orientation and alliance are important for positive treatment outcomes. However, it is currently unknown how a member's goal orientation and alliance in tandem relate to members' improvement in group ... ...

    Abstract Research suggests that a client's achievement goal orientation and alliance are important for positive treatment outcomes. However, it is currently unknown how a member's goal orientation and alliance in tandem relate to members' improvement in group therapy, despite conceptual wisdom regarding the additive effect of a high alliance and a mastery or approach goal orientation. Therefore, this study sought to examine the congruence between members' goal orientation and the member-group alliance on members' perceived improvement in group therapy. Data for this study came from 99 clients across 10 interpersonal process groups. Polynomial regression and response surface analysis were used to test the congruent and discrepant effects of members' goal orientation (i.e., approach-performance, avoidance-performance, and mastery orientation) and group alliance on their perceived improvement in group therapy. As hypothesized, members who reported congruent high group alliance and high mastery orientation or approach orientation compared to congruent low alliance and low mastery or approach orientation reported high levels of improvement in group therapy. Regarding discrepant effects, discrepant high alliance and low avoidance orientation compared to low alliance and high avoidance was positively related to improvement in group therapy, and discrepant high alliance and low approach orientation compared to low alliance and high approach was positively related to improvement in group therapy. Last, discrepant high alliance and low mastery and low alliance and high mastery were positively related to improvement in group therapy, suggesting a compensatory effect between mastery orientation and alliance on improvement. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    MeSH term(s) Humans ; Goals ; Psychotherapy, Group ; Motivation ; Treatment Outcome ; Achievement
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066555-6
    ISSN 1939-2168 ; 0022-0167
    ISSN (online) 1939-2168
    ISSN 0022-0167
    DOI 10.1037/cou0000722
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  9. Article ; Online: Neonatal Aromatase Inhibition Blocked Defeminization of AVPV Kiss1 Neurons and LH Surge-Generating System in Male Rats.

    Yamada, Koki / Mano, Tetsuya / Hazim, Safiullah / Takizawa, Marina / Inoue, Naoko / Uenoyama, Yoshihisa / Tsukamura, Hiroko

    Endocrinology

    2024  Volume 165, Issue 4

    Abstract: The neuroendocrine system that controls the preovulatory surge of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH), which triggers ovulation in female mammals, is sexually differentiated in rodents. A transient increase in circulating ... ...

    Abstract The neuroendocrine system that controls the preovulatory surge of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH), which triggers ovulation in female mammals, is sexually differentiated in rodents. A transient increase in circulating testosterone levels in male rats within a few hours of birth is primarily responsible for the defeminization of anteroventral periventricular nucleus (AVPV) kisspeptin neurons, which are critical regulators of the GnRH/LH surge. The present study aimed to determine whether neonatal estradiol-17β (E2) converted from testosterone by aromatase primarily causes the defeminization of AVPV kisspeptin neurons and the surge of GnRH/LH in male rodents. The results of the present study showed that the neonatal administration of letrozole (LET), a nonsteroidal aromatase inhibitor, within 2 hours of birth rescued AVPV Kiss1 expression and the LH surge in adult male rats, while the neonatal administration of testosterone propionate (TP) irreversibly attenuated AVPV Kiss1 expression and the LH surge in adult female rats. Furthermore, the neonatal LET-treated Kiss1-Cre-activated tdTomato reporter males exhibited a comparable number of AVPV Kiss1-Cre-activated tdTomato-expressing cells to that of vehicle-treated female rats, while neonatal TP-treated females showed fewer AVPV Kiss1-Cre-activated tdTomato-expressing cells than vehicle-treated females. Moreover, neonatal TP administration significantly decreased the number of arcuate Kiss1-expressing and Kiss1-Cre-activated tdTomato-positive cells and suppressed LH pulses in adult gonadectomized female rats; however, neonatal LET administration failed to affect them. These results suggest that E2 converted from neonatal testosterone is primarily responsible for the defeminization of AVPV kisspeptin neurons and the subsequent GnRH/LH surge generation in male rats.
    MeSH term(s) Animals ; Female ; Male ; Rats ; Aromatase/metabolism ; Estradiol/metabolism ; Gonadotropin-Releasing Hormone/metabolism ; Hypothalamus, Anterior/metabolism ; Kisspeptins/genetics ; Kisspeptins/metabolism ; Luteinizing Hormone/metabolism ; Mammals/metabolism ; Neurons/metabolism ; Red Fluorescent Protein ; Testosterone/metabolism
    Chemical Substances Aromatase (EC 1.14.14.1) ; Estradiol (4TI98Z838E) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Kiss1 protein, rat ; Kisspeptins ; Luteinizing Hormone (9002-67-9) ; Red Fluorescent Protein ; tdTomato ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqae028
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
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  10. Article ; Online: Oxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders.

    Zilcha-Mano, Sigal / Orbach, Meital / Malka, Michal / Lebowitz, Eli R

    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

    2023  , Page(s) 1–9

    Abstract: Objective: Two lines of research, on outcome moderators and on novel treatment targets, seek to improve the overall efficacy of child anxiety treatment, with mixed results. We propose that an integration of both lines of research can lead to improved ... ...

    Abstract Objective: Two lines of research, on outcome moderators and on novel treatment targets, seek to improve the overall efficacy of child anxiety treatment, with mixed results. We propose that an integration of both lines of research can lead to improved treatment efficacy. In a first proof of concept of this approach, we studied whether the interaction between baseline levels and targeted changes in peripheral oxytocin (OT) can predict differential responses to two childhood anxiety treatments.
    Method: A total of 124 mother-child dyads participated in the study. Children's salivary OT levels were measured at baseline and again, immediately after an experimental dyadic interaction in the lab. Dyads were subsequently randomized to receive one of two treatments, differing in their targets: SPACE (Supportive Parenting for Anxious Childhood Emotions) and CBT (cognitive-behavioral therapy). Treatment outcomes were assessed using the Childhood Anxiety Related Emotional Disorders scale, reported by both mother and child.
    Results: The findings suggest that in SPACE, where the mother is the main agent of change, higher baseline levels of child OT, coupled with increases in OT following a positive mother-child interaction, predicted greater treatment efficacy. By contrast, in CBT, where the child is the main agent of change, higher baseline levels of child OT, coupled with a decrease in OT following the interaction, predicted greater treatment efficacy.
    Conclusions: The findings highlight the importance of the integration between moderators and targets of treatments for progress toward improving treatment efficacy through precision medicine.
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073310-0
    ISSN 1537-4424 ; 1537-4416
    ISSN (online) 1537-4424
    ISSN 1537-4416
    DOI 10.1080/15374416.2023.2188557
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