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  1. Book ; Online ; E-Book: Nachhaltigkeit und Social Media

    Bush, Annika / Birke, Jonas

    Bildung Für eine Nachhaltige Entwicklung in der Digitalen Welt

    2022  

    Language German
    Size 1 online resource (285 pages)
    Publisher Springer Fachmedien Wiesbaden GmbH
    Publishing place Wiesbaden
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-658-35660-X ; 9783658356590 ; 978-3-658-35660-6 ; 3658356596
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Strip searching by the police: potential for abuse?

    Bush, Andy

    Archives of disease in childhood

    2024  Volume 109, Issue 2, Page(s) 77

    MeSH term(s) Humans ; Child ; Police ; Child Abuse ; Child Abuse, Sexual ; Child Welfare
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Editorial
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Learning from cystic fibrosis: How can we start to personalise treatment of Children's Interstitial Lung Disease (chILD)?

    Bush, Andrew

    Paediatric respiratory reviews

    2023  

    Abstract: Cystic fibrosis (CF) is a monogenic disorder cause by mutations in the CF Transmembrane Regulator (CFTR) gene. The prognosis of cystic fibrosis has been transformed by the discovery of highly effective modulator therapies (HEMT). Treatment has changed ... ...

    Abstract Cystic fibrosis (CF) is a monogenic disorder cause by mutations in the CF Transmembrane Regulator (CFTR) gene. The prognosis of cystic fibrosis has been transformed by the discovery of highly effective modulator therapies (HEMT). Treatment has changed from reactive therapy dealing with complications of the disease to pro-active correction of the underlying molecular functional abnormality. This has come about by discovering the detailed biology of the different CF molecular sub-endotypes; the development of biomarkers to assess response even in mild disease or young children; the performance of definitive large randomised controlled trials in patients with a common mutation and the development of in vitro testing systems to test efficacy in those patients with rare CFTR mutations. As a result, CF is now an umbrella term, rather than a specific diagnostic label; we have moved from clinical phenotypes to molecular subendotypes. Children's Interstitial Lung Diseases (chILDs) comprise more than 200 entities, and are a diverse group of diseases, for an increasing number of which an underlying gene mutation has been discovered. Many of these entities are umbrella terms, such as pulmonary alveolar proteinosis or hypersensitivity pneumonitis, for each of which there are multiple and very different endotypes. Even those chILDs for which a specific gene mutation has been discovered comprise, as with CF, different molecular subendotypes likely mandating different therapies. For most chILDs, current treatment is non-specific (corticosteroids, azithromycin, hydroxychloroquine). The variability of the different entities means that there is little evidence for the efficacy of any treatment. This review considers how some of the lessons of the success story of CF are being applied to chILD, thus opening the opportunities for truly personalised medicine in these conditions. Advances in knowledge in the molecular biology of surfactant protein C and Adenosine triphosphate binding cassette subfamily A member 3 (ABCA3), and the possibilities of discovering novel therapies by in vitro studies will especially be highlighted.
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Going Down, Dooby Doo Down, Down: Identifying Rapid Spirometry Decline.

    Bush, Andrew

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 10, Page(s) 1014–1015

    MeSH term(s) Humans ; Adult ; Spirometry ; Airway Obstruction ; Respiratory Physiological Phenomena ; Lung
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202307-1212ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Basic clinical management of preschool wheeze.

    Bush, Andrew

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 7, Page(s) e13988

    Abstract: Preschool wheeze is very common and often difficult to treat. Most children do not require any investigations; only a detailed history and physical examination to ensure an alternative diagnosis is not being missed; and the differential diagnosis, and ... ...

    Abstract Preschool wheeze is very common and often difficult to treat. Most children do not require any investigations; only a detailed history and physical examination to ensure an alternative diagnosis is not being missed; and the differential diagnosis, and hence investigation protocols for the child in whom a major illness is suspected, shows geographical variation. The pattern of symptoms may be divided into episodic viral and multiple trigger to guide treatment, but the pattern of symptoms must be re-assessed regularly. However, symptom patterns are a poor guide to underlying pathology. Attention to the proper use of spacers, and adverse environmental exposures such as tobacco smoke exposure, is essential. There are no disease-modifying therapies, so therapy is symptomatic. This paper reviews recent advances in treatment, including new data on the place of leukotriene receptor antagonists, prednisolone for acute attacks of wheeze, and antibiotics, based on new attempts to understand the underlying pathology in a way that is clinically practical.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Prednisolone ; Leukotriene Antagonists/therapeutic use ; Schools ; Respiratory Sounds/diagnosis ; Diagnosis, Differential
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; Leukotriene Antagonists
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Differing effects of mepolizumab across the life course.

    Bush, Andrew

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 2, Page(s) 123–125

    MeSH term(s) Humans ; Life Change Events ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Eosinophils
    Chemical Substances mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00004-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  7. Article: How to Choose the Correct Drug in Severe Pediatric Asthma.

    Bush, Andrew

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 902168

    Abstract: When a child with severe asthma (asthma defined clinically for the purposes of this review as wheeze, breathlessness, and chest tightness sometimes with cough) does not respond to treatment, it is important to be sure that an alternative or additional ... ...

    Abstract When a child with severe asthma (asthma defined clinically for the purposes of this review as wheeze, breathlessness, and chest tightness sometimes with cough) does not respond to treatment, it is important to be sure that an alternative or additional diagnosis is not being missed. In school age children, the next step is a detailed protocolized assessment to determine the nature of the problem, whether within the airway or related to co-morbidities or social/environmental factors, in order to personalize the treatment. For example, those with refractory difficult asthma due to persistent non-adherence may benefit from using budesonide and formoterol combined in a single inhaler [single maintenance and reliever treatment (SMART)] as both a reliever and preventer. For those with steroid-resistant Type 2 airway inflammation, the use of biologicals such as omalizumab and mepolizumab should be considered, but for mepolizumab at least, there is a paucity of pediatric data. Protocols are less well developed in preschool asthma, where steroid insensitive disease is much more common, but the use of two simple measurements, aeroallergen sensitization, and peripheral blood eosinophil count, allows the targeted use of inhaled corticosteroids (ICSs). There is also increasing evidence that chronic airway infection may be important in preschool wheeze, increasing the possibility that targeted antibiotics may be beneficial. Asthma in the first year of life is not driven by Type 2 inflammation, so beyond avoiding prescribing ICSs, no evidence based recommendations can be made. In the future, we urgently need to develop objective biomarkers, especially of risk, so that treatment can be targeted effectively; we need to address the scandal of the lack of data in children compared with adults, precluding making evidence-based therapeutic decisions and move from guiding treatment by phenotypes, which will change as the environment changes, to endotype based therapy.
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.902168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Too Little, Too Late: Adult Lung Disease Cannot Be Prevented by Interventions in Adult Life.

    Bush, Andrew

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 2, Page(s) 124–126

    MeSH term(s) Humans ; Child ; Adult ; Adolescent ; Tobacco Smoke Pollution ; Incidence ; Lung Neoplasms ; Lung ; Nicotiana
    Chemical Substances Tobacco Smoke Pollution
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202208-1537ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Giving a voice to the voiceless: end of life second opinions.

    Bush, Andy

    Archives of disease in childhood

    2022  Volume 108, Issue 4, Page(s) e3

    MeSH term(s) Humans ; Infant, Newborn ; Terminal Care ; Palliative Care ; Death ; Referral and Consultation ; Intensive Care Units, Neonatal
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2021-323103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A partnership between Māori healing and psychiatry in Aotearoa New Zealand.

    NiaNia, Wiremu / Bush, Allister

    BJPsych international

    2024  Volume 20, Issue 2, Page(s) 31–33

    Abstract: This paper describes an example of Māori healing and psychiatry working together in an Indigenous mental health context in Aotearoa (New Zealand). Each author outlines their perspectives on the context and the partnership. The case of a Māori teenager ... ...

    Abstract This paper describes an example of Māori healing and psychiatry working together in an Indigenous mental health context in Aotearoa (New Zealand). Each author outlines their perspectives on the context and the partnership. The case of a Māori teenager with pseudo-seizures and voice-hearing is described to illustrate the partnership in action.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2905058-3
    ISSN 2058-6264 ; 2056-4740
    ISSN (online) 2058-6264
    ISSN 2056-4740
    DOI 10.1192/bji.2022.25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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