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Article ; Online: Achieving Shoulder Balance Using Medial and Lateral Radiological Measures in Adolescent Idiopathic Scoliosis.

Gajaseni, Pawin / Labianca, Luca / Kalakoti, Piyush / Weinstein, Stuart

2022 Volume 42, Issue 1, Page(s) 47–51

Abstract: ... follow up was improved significantly at 95.8%. Preoperative (r=0.8; p<0.001) and post-operative ... measurements of RSH at 6-week (r=0.9; p<0.001) and last follow up (r=0.9; p<0.001) correlated strongly ...

Abstract	Background: Research has shown that postoperative shoulder imbalance is a common problem after spinal fusion in adolescent idiopathic scoliosis (AIS). The best radiographic predictor has not yet been determined and results are inconsistent. This study was to investigate whether using medial and lateral shoulder parameters can effectively achieve postoperative shoulder balance. Methods: A prospective database of AIS undergoing posterior spinal fusion were reviewed. Patient demographics and radiological parameters including radiographic shoulder height (RSH), clavicle angle, T1-tilt and first-rib angle at baseline, 6 weeks and last minimal follow up of 2 years were recorded. Correlations between radiological parameters were assessed using Pearson's correlation coefficients. Multivariable linear models identified predictors associated with increased RSH. Results: 219 patients (mean age:13.7 years; 81.7% female) were included. The mean follow-up time was 2.8 years (range:2.0-7.0). The mean RSH at baseline, 6 weeks and last follow up was improved significantly at 95.8%. Preoperative (r=0.8; p<0.001) and post-operative measurements of RSH at 6-week (r=0.9; p<0.001) and last follow up (r=0.9; p<0.001) correlated strongly with clavicle angle measured at respective time-points. In a multivariable linear model, we noted marginal increase in clavicle angle (+4.3°; p<0.001) to be associated with increased RSH. On the contrary, first rib angle and T1-tilt demonstrated moderate to weak correlation with RSH. Conclusion: Clavicle angle is strongly consistent with RSH. First rib angle and T1-tilt as demonstrate medial shoulder balance are moderate to weak correlation. Leveling T1 tilt and first rib angle do not guarantee the postoperative shoulder balance.
MeSH term(s)	Adolescent ; Female ; Humans ; Kyphosis ; Male ; Radiography ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Shoulder/diagnostic imaging ; Shoulder/surgery ; Thoracic Vertebrae/surgery
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1204065-4
ISSN	1555-1377 ; 1541-5457
ISSN (online)	1555-1377
ISSN	1541-5457
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Article ; Online: Curative treatments for colon cancer during the COVID-19 pandemic era.

Petrelli, Fausto / Labianca, Roberto / Zaniboni, Alberto

Tumori

2021 Volume 108, Issue 4, Page(s) 392–393

Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, to protect patients with cancer, reduction in hospital access, reduction in myelosuppression risk, and postponing/withholding unnecessary treatments were important in order to reduce risk of ... ...

Abstract	During the coronavirus disease 2019 (COVID-19) pandemic, to protect patients with cancer, reduction in hospital access, reduction in myelosuppression risk, and postponing/withholding unnecessary treatments were important in order to reduce risk of infection. Little is known about the risk burden for patients with resected colorectal cancer (CRC). Use of an oral chemotherapy regimen represents a convenient, safe, and manageable therapy for both fit and elderly patients. In the metastatic setting, treatment of solitary metastases may be performed, omitting postresection chemotherapy due to lack of literature data. In case of unresectable CRC, short induction chemotherapy, followed by a maintenance phase, may improve compliance and reduce toxicity. In the adjuvant setting, a shorter duration (3 months) may be discussed with patients except in very high-risk cases. Clinical judgment may reduce the risk of COVID-19 exposure in patients with CRC. Oral regimens, treatment delay, and chemotherapy holiday are ways to minimize the global risk for patients during the COVID-19 era.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; COVID-19 ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Humans ; Pandemics/prevention & control
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/03008916211049828
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Article ; Online: Dormant tie reactivation as an affiliative coping response to stressors during the COVID-19 crisis.

Yang, Seong Won / Soltis, Scott M / Ross, Jason R / Labianca, Giuseppe Joe

The Journal of applied psychology

2021 Volume 106, Issue 4, Page(s) 489–500

Abstract: This study takes an affiliative coping theory perspective to examine whether working adults reactivated dormant ties with individuals they had not contacted for at least 3 years to cope with stressors experienced due to the COVID-19 pandemic. Stressors ... ...

Abstract	This study takes an affiliative coping theory perspective to examine whether working adults reactivated dormant ties with individuals they had not contacted for at least 3 years to cope with stressors experienced due to the COVID-19 pandemic. Stressors originating in the workplace (job insecurity and remote work) and in the family (stressful familial social ties) were examined in a sample of 232 working adults in the southeastern United States. Individuals were more likely to reactivate their dormant ties when their job was insecure, and the magnitude of the reactivations was greater among individuals experiencing stressful social ties with family members than those not experiencing those stressors. We also found that there was a significant interaction between remote work and having a stressful tie within the household in dormant tie reactivation. Although previous theory has focused mostly on the benefits of frequent, active social relationships for coping, our results suggest that reactivating dormant ties might be a coping mechanism as well. Our study also suggests that workplace dormant tie research should broaden its focus beyond exchanged instrumental support to consider emotional support that might be transferred during reactivation. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
MeSH term(s)	Adaptation, Psychological ; Adult ; COVID-19/psychology ; Female ; Humans ; Interpersonal Relations ; Male ; Pandemics ; Physical Distancing ; SARS-CoV-2 ; Southeastern United States ; Stress, Psychological/psychology ; Teleworking ; Workplace/psychology
Language	English
Publishing date	2021-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	219157-x
ISSN	1939-1854 ; 0021-9010
ISSN (online)	1939-1854
ISSN	0021-9010
DOI	10.1037/apl0000909
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Article ; Online: Risk-Benefit Comparisons Between Shorter and Longer Durations of Adjuvant Chemotherapy in High-Risk Stage II Colorectal Cancer-Reply.

Zaniboni, Alberto / Petrelli, Fausto / Labianca, Roberto

JAMA oncology

2020 Volume 6, Issue 8, Page(s) 1302–1303

MeSH term(s)	Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy ; Humans
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Letter ; Comment
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2020.2262
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Article: Recycling of Contaminated Marine Sediment and Industrial By-Products through Combined Stabilization/Solidification and Granulation Treatment.

Todaro, Francesco / Colangelo, Francesco / De Gisi, Sabino / Farina, Ilenia / Ferone, Claudio / Labianca, Claudia / Petrella, Andrea / Cioffi, Raffaele / Notarnicola, Michele

Materials (Basel, Switzerland)

2023 Volume 16, Issue 6

Abstract: Stabilization/solidification (S/S) is becoming increasingly important, as it allows the remediation of contaminated sediments and their recovery into materials for civil engineering. This research proposes a cement-free cold granulation process for ... ...

Abstract	Stabilization/solidification (S/S) is becoming increasingly important, as it allows the remediation of contaminated sediments and their recovery into materials for civil engineering. This research proposes a cement-free cold granulation process for manufactured low-cost aggregates from marine sediments contaminated with organic compounds and metals. After the chemo-physical characterization of the study materials, two mix designs were prepared in a rotary plate granulator by adding two industrial by-products as geopolymer precursors, coal fly ash (CFA) and Blast Furnace Slag (BFS), but also alkaline activation solutions, water, and a fluidizer. The results indicated that sediments treated with mix 1 (i.e., with a higher percentage of water and fluidifier) represent the optimal solution in terms of metal leachability. The metal leachability was strictly influenced by aggregates' porosity, density, and microstructure. The technical performance (such as the aggregate impact value > 30%) suggested the use of granules as lightweight aggregates for pavement construction. The results indicated that cold granulation represents a sustainable solution to recycling contaminated marine sediments, CFA, and BFS into lightweight artificial aggregates.
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16062399
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Article ; Online: One-Day versus Three-Day Low-Residue Diet and Bowel Preparation Quality before Colonoscopy: A Multicenter, Randomized, Controlled Trial.

Scaglione, Giuseppe / Oliviero, Giovanni / Labianca, Orazio / Bianco, Maria Antonia / Granata, Rocco / Ruggiero, Luigi / Iovino, Paola

Digestive diseases (Basel, Switzerland)

2023 Volume 41, Issue 5, Page(s) 708–718

Abstract: Background: One-day low-residue diet (LRD) is recommended before colonoscopy, but only three single-center trials compared the 1-day versus 3-day LRD. The aim of this multicenter study was to compare the impact of a 3-day versus 1-day LRD on its ability ...

Abstract	Background: One-day low-residue diet (LRD) is recommended before colonoscopy, but only three single-center trials compared the 1-day versus 3-day LRD. The aim of this multicenter study was to compare the impact of a 3-day versus 1-day LRD on its ability to adequately and successfully prepare the bowel of outpatients that require a colonoscopy. The outpatients' tolerance and adherence to the LRD were also considered. Methods: Consecutive outpatients were randomized to 1-day versus 3-day LRD at three open-access endoscopy units. The primary endpoint consisted of the proportion of patients with a satisfactory degree of bowel cleanliness (Score 2-3 on the Boston Bowel Preparation Scale [BBPS] in each segment). Secondary endpoints were patients' tolerance and adherence to the prescribed diet evaluated by a standardized questionnaire. Results: 289 patients were included in the study (1-day LRD arm = 143, 3-day LRD arm = 146). BBPS ≥2 was not significantly different in the two dietary regimens in any of the three colonic segments (71% vs. 72%, p = 0.9). The percentage of patients with incomplete preparation was similar in the two arms (9% vs. 9%; p = 1.0). No significant differences were found among colonoscopy findings in terms of abnormalities (81% vs. 84%, p = 0.8). Both groups scored similarly in overall tolerance to LRD (48% vs. 49%, p = 1.0) and also in whether they would have adopted a different dietary regimen (p = 0.3). Conclusion: Our multicenter randomized study confirmed that optimal bowel cleansing is reached through a 1-day LRD.
MeSH term(s)	Humans ; Cathartics ; Colonoscopy ; Colon ; Diet ; Preoperative Care ; Polyethylene Glycols
Chemical Substances	Cathartics ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000529087
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Article: Time to Stable Dose of Psychostimulants in Pediatric Patients With ADHD.

Pasadyn, Selena R / Giuliano, Kimberly / LaBianca, Deanna / Manos, Michael

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2020 Volume 25, Issue 3, Page(s) 228–234

Abstract: Objectives: The prevalence of attention-deficit/hyperactivity disorder (ADHD) is increasing and psychostimulants are the pharmacological standard of care. Patients benefit most when there is efficient titration to a stable dose of medication as defined ... ...

Abstract	Objectives: The prevalence of attention-deficit/hyperactivity disorder (ADHD) is increasing and psychostimulants are the pharmacological standard of care. Patients benefit most when there is efficient titration to a stable dose of medication as defined by maintaining that same dose for 6 months. The aims of this study were to describe time to stable dose in a cohort of children with ADHD and examine the impact of demographic factors. Methods: A list of pediatric patients with a diagnosis of ADHD in the electronic health record was generated, and a retrospective chart review of stimulant use was conducted on 500 patients randomly selected from 2010 to 2015 who met inclusion criteria. Time to stable dosing and its association with demographic characteristics were assessed. Results: Patients were predominantly male (72%), white (81%), and privately insured (67%). Fifty-five percent of patients achieved a stable dose of medication on first attempt; therefore, the median time to stable dosing for the cohort was 0 days with the interquartile range being 0 to 133.8 days. There was significant increase in time to stable dose for patients younger than 10 years compared with those ≥10 years of age (p = 0.01). Time to stable dose was not significantly associated with race (p = 0.13), sex (p = 0.72), type of insurance (p = 0.56), or formulation being immediate or extended release (p = 0.56). Conclusions: Many patients had long titration periods when trying to reach a stable dose. Given that medication switching can be challenging for patients and families, more frequent contact with providers during titration may be necessary.
Language	English
Publishing date	2020-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-25.3.228
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Article ; Online: Development and clinical indications of cetuximab.

Labianca, R / La Verde, N / Garassino, M C

The International journal of biological markers

2017 Volume 22, Issue 4, Page(s) 40–46

Abstract: Cetuximab is a chimeric immunoglobulin G1 monoclonal antibody that targets the extracellular domain of the epidermal growth factor receptor (EGFR) with high specificity and affinity. It competitively inhibits endogenous ligand binding and thereby ... ...

Abstract	Cetuximab is a chimeric immunoglobulin G1 monoclonal antibody that targets the extracellular domain of the epidermal growth factor receptor (EGFR) with high specificity and affinity. It competitively inhibits endogenous ligand binding and thereby inhibits subsequent EGFR activation. The EGFR signaling pathways regulate cell differentiation, proliferation, migration, angiogenesis and apoptosis, all of which become deregulated in cancer cells. EGFR is an important target for cancer therapy and many studies have demonstrated that cetuximab is active in several types of cancer, particularly colorectal and head and neck cancer. Cetuximab enhances the effects of many standard cytotoxic agents, including irinotecan, and in combination with chemotherapy it can elicit antitumor responses in tumors that previously failed to respond to that chemotherapy. Cetuximab also enhances radiation-induced apoptosis. On the basis of a pivotal European randomized study (the BOND study) and of 2 clinical studies conducted in the USA, cetuximab has been approved in combination with irinotecan for patients affected by EGFR-expressing metastatic colon cancer after failure with irinotecan. There have only been a few small phase II trials on first-line treatment in metastatic colorectal cancer, but the results suggest promising activity of cetuximab together with irinotecan or oxaliplatin. There is some evidence that additive efficacy can be achieved using EGFR inhibitors in combination with vascular endothelial growth factor receptor inhibitors such as bevacizumab. A correlation between response and the main toxicity (acne-like skin reaction) has been observed but is unclear. EGFR status as a specific marker for EGFR inhibitors is controversial. At the moment, EGFR expression does not appear to be a predictive factor for response to EGFR inhibitors.
Language	English
Publishing date	2017-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	645113-5
ISSN	1724-6008 ; 0393-6155
ISSN (online)	1724-6008
ISSN	0393-6155
DOI	10.5301/JBM.2008.4051
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Article ; Online: Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).

Timoshevskaya, Nataliya / Voss, S Randal / Labianca, Caitlin N / High, Cassity R / Smith, Jeramiah J

Developmental dynamics : an official publication of the American Association of Anatomists

2020 Volume 250, Issue 6, Page(s) 822–837

Abstract: Background: Recent efforts to assemble and analyze the Ambystoma mexicanum genome have dramatically improved the potential to develop molecular tools and pursue genome-wide analyses of genetic variation.: Results: To better resolve the distribution ... ...

Abstract	Background: Recent efforts to assemble and analyze the Ambystoma mexicanum genome have dramatically improved the potential to develop molecular tools and pursue genome-wide analyses of genetic variation. Results: To better resolve the distribution and origins of genetic variation with A mexicanum, we compared DNA sequence data for two laboratory A mexicanum and one A tigrinum to identify 702 million high confidence polymorphisms distributed across the 32 Gb genome. While the wild-caught A tigrinum was generally more polymorphic in a genome-wide sense, several multi-megabase regions were identified from A mexicanum genomes that were actually more polymorphic than A tigrinum. Analysis of polymorphism and repeat content reveals that these regions likely originated from the intentional hybridization of A mexicanum and A tigrinum that was used to introduce the albino mutation into laboratory stocks. Conclusions: Our findings show that axolotl genomes are variable with respect to introgressed DNA from a highly polymorphic species. It seems likely that other divergent regions will be discovered with additional sequencing of A mexicanum. This has practical implications for designing molecular probes and suggests a need to study A mexicanum phenotypic variation and genome evolution across the tiger salamander clade.
MeSH term(s)	Ambystoma mexicanum/genetics ; Animals ; Biological Variation, Population ; Genome ; Mutation ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1102541-4
ISSN	1097-0177 ; 1058-8388
ISSN (online)	1097-0177
ISSN	1058-8388
DOI	10.1002/dvdy.257
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Ub I Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Tivantinib: critical review with a focus on hepatocellular carcinoma.

Rota Caremoli, Elena / Labianca, Roberto

Expert opinion on investigational drugs

2014 Volume 23, Issue 11, Page(s) 1563–1574

Abstract: Introduction: Sorafenib is the only approved agent for the treatment of advanced hepatocellular carcinoma (HCC). Sorafenib is an oral multikinase inhibitor that blocks several receptors involved in tumor cell proliferation and angiogenesis. The ... ...

Abstract	Introduction: Sorafenib is the only approved agent for the treatment of advanced hepatocellular carcinoma (HCC). Sorafenib is an oral multikinase inhibitor that blocks several receptors involved in tumor cell proliferation and angiogenesis. The hepatocyte-growth factor/mesenchymal-epithelial transition (MET) factor pathway represents another emerging target in HCC. Tivantinib (ARQ 197) is an oral, selective small MET tyrosine kinase inhibitor with antitumor activity, especially in MET-high patients. Recent clinical data exhibit promising activity in HCC. Areas covered: This article reviews the preclinical and clinical data of tivantinib (published and ongoing trials), focusing on development in advanced HCC. Comments regarding the failure of trials with nonspecific drugs reported in the past 2 years are also included. Expert opinion: A randomized Phase II trial in second-line HCC showed a significant improvement in time to progression with tivantinib treatment in MET-high patients. Tivantinib remains in clinical development and has not yet been approved for any indication. A Phase III study in MET-high HCC is ongoing in a second-line setting, after sorafenib failure. In case of a survival benefit, tivantinib might become the first treatment for selected patients, based on MET status as a predictor. Therefore, there is a need for identifying HCC molecular subclasses and for developing a trial design based on molecular biomarkers.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers/metabolism ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Pyrrolidinones/pharmacology ; Pyrrolidinones/therapeutic use ; Quinolines/pharmacology ; Quinolines/therapeutic use ; Research Design
Chemical Substances	ARQ 197 ; Antineoplastic Agents ; Biomarkers ; Protein Kinase Inhibitors ; Pyrrolidinones ; Quinolines ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2014-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1517/13543784.2014.949339
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