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Book ; Thesis: Die BCG-Infektion supprimiert die allergische Sensibilisierung und Atemwegshyperreaktivität in der BALB-c-Maus

Gerhold, Kerstin

2000

Author's details	von Kerstin Gerhold
Language	German
Size	80 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Berlin, Humboldt-Univ., Diss., 2000
HBZ-ID	HT012888982
Database	Catalogue ZB MED Medicine, Health

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2001 D 34	order for loan	Magazin

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Article ; Online: Health Care Utilization and Direct Costs Prior to Subspecialty Care in Children with Chronic Pain Compared with Other Chronic Childhood Diseases: A Cohort Study.

Gerhold, Kerstin / Al-Azazi, Saeed / El-Matary, Wael / Katz, Laurence Y / Lim, Lily S H / Marks, Seth D / Lix, Lisa M

The Journal of pediatrics

2024 Volume 271, Page(s) 114046

Abstract: Objectives: To understand the burden associated with pediatric chronic pain (CP) on the health care system compared with other costly chronic diseases prior to subspecialty care.: Study design: In this retrospective cohort study, we assessed all- ... ...

Abstract	Objectives: To understand the burden associated with pediatric chronic pain (CP) on the health care system compared with other costly chronic diseases prior to subspecialty care. Study design: In this retrospective cohort study, we assessed all-cause health care utilization and direct health care costs associated with pediatric CP (n = 91) compared with juvenile arthritis (n = 135), inflammatory bowel disease (n = 90), type 1 diabetes (n = 475) or type 2 diabetes (n = 289), anxiety (n = 7193), and controls (n = 273) 2 and 5 years prior to patients entering subspecialty care in Manitoba, Canada. Linked data from physician encounters, emergency department visits, hospitalizations, and prescriptions were extracted from administrative databases. Differences in health care utilization and direct health care costs associated with CP vs the other conditions were tested using negative binomial and zero-inflated negative binomial regression models, respectively. Results: After adjustment for age at diagnosis, sex, location of residence, and socioeconomic status, CP continued to be associated with the highest number of consulted physicians and subspecialists and the highest number of physician billings compared with all other conditions (P < .01, respectively). CP was significantly associated with higher physician costs than juvenile arthritis, inflammatory bowel disease, type 1 diabetes, type 2 diabetes, or controls (P < .01, respectively); anxiety was associated with the highest physician and prescription costs among all cohorts (P < .01, respectively). Conclusion: Compared with chronic inflammatory and endocrinologic conditions, pediatric CP and anxiety were associated with substantial burden on the health care system prior to subspecialty care, suggesting a need to assess gaps and resources in the management of CP and mental health conditions in the primary care setting.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2024.114046
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Article ; Online: Collaborating with a Youth Council to Improve Chronic Pain Resources.

Wittmeier, Kristy / Brown, Cara / Diaz, Francis / Pylypjuk, Heidi / Restall, Gayle / Anang, Polina / Gerhold, Kerstin

Canadian journal of pain = Revue canadienne de la douleur

2023 Volume 7, Issue 1, Page(s) 2254358

Abstract: Background: There is a recognized need to involve people with lived experience of chronic pain when developing chronic pain resources.: Aims: The aim of this study was to develop, implement, and evaluate a short-term youth council focused on ... ...

Abstract	Background: There is a recognized need to involve people with lived experience of chronic pain when developing chronic pain resources. Aims: The aim of this study was to develop, implement, and evaluate a short-term youth council focused on eliciting youths' recommendations for key features of chronic pain informational resources. Methods: In this mixed methods instrumental case study, demographic data were collected via Survey Monkey®. Select Patient-Reported Outcomes Measurement Information System® brief measures were used to provide context regarding pain impact within this group. Participants completed an initial interview, which informed youth council workshop delivery. Over two youth council workshops, participants reviewed select informational resources and identified key features of chronic pain resources. Participants evaluated their involvement experience during a second interview. Qualitative data were transcribed and analyzed using directed content analysis. Member-checking occurred during a third workshop, held virtually. Results: Seven youth self-identifying as girl/woman or demi-girl participated. The youth were satisfied with the youth council experience, highlighting the importance of meeting others, a relaxed environment, and participating in valuable work. A list of youth-identified key features for informational resources was created through the workshops, which includes considerations for audience groups, content, and presentation. Conclusion: Participants' input into youth council development and meeting others with lived experience contributed to a safe and supportive involvement experience. Youth council involvement supported the development of preliminary recommendations for chronic pain informational resources.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ISSN	2474-0527
ISSN (online)	2474-0527
DOI	10.1080/24740527.2023.2254358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chronic pain in children and adolescents in Manitoba: A retrospective chart review to inform the development of a provincial service for pediatric chronic pain.

Liu, Anna / Anang, Polina / Harling, Danielle / Wittmeier, Kristy / Gerhold, Kerstin

Canadian journal of pain = Revue canadienne de la douleur

2022 Volume 6, Issue 1, Page(s) 124–134

Abstract: Background: In the absence of an interdisciplinary service for pediatric chronic pain in Manitoba, pain management has been offered through a single provider outpatient setting with consultative services from physiotherapy, occupational therapy, and ... ...

Abstract	Background: In the absence of an interdisciplinary service for pediatric chronic pain in Manitoba, pain management has been offered through a single provider outpatient setting with consultative services from physiotherapy, occupational therapy, and psychiatry since October 2015. Aims: The aim of this study was to characterize the patient population of this clinic to understand needs and inform future service development for pediatric chronic pain. Methods: Demographics and disease characteristics of all patients seen in this clinic between October 1, 2015, and February 28, 2019, were analyzed retrospectively from electronic medical records. Results: A total of 157 patients, mean age 13.1 (sd ±3.0) years, 75.2% female, with a median duration of pain of 20.5 (interquartile range [IQR] = 10.0-45.8) months at their first visit were included in the study. At baseline, 74.0% of patients experienced insomnia, 76.6% fatigue, 86.5% symptoms of anxiety, and 58.69% symptoms of depression; 80.1% showed withdrawal from physical activity, 67.1% missed school, and 10.2% reported opioid usage. Throughout their care in clinic, 83.4% of patients received physiotherapy, 17.8% occupational therapy, 49.7% mental health support, and 51.6% care from multiple services. The clinic experienced a significant increase in median referrals from 1.0 to 5.0 (IQR = 2.0-9.0) per month and wait time from 35.0 to 97.0 (IQR = 88.0-251.0) days during the observation period. Conclusions: Developing an interdisciplinary service for pediatric chronic pain will provide an opportunity to improve access, coordination, and comprehensiveness of care and to employ culturally sensitive services to improve care for children and youth living with chronic pain in Manitoba and possibly other jurisdictions with similar demographics and needs.
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article
ISSN	2474-0527
ISSN (online)	2474-0527
DOI	10.1080/24740527.2022.2094228
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chronic pain in children and adolescents in Manitoba

Anna Liu / Polina Anang / Danielle Harling / Kristy Wittmeier / Kerstin Gerhold

Canadian Journal of Pain, Vol 6, Iss 1, Pp 124-

A retrospective chart review to inform the development of a provincial service for pediatric chronic pain

2022 Volume 134

Abstract: Background In the absence of an interdisciplinary service for pediatric chronic pain in Manitoba, pain management has been offered through a single provider outpatient setting with consultative services from physiotherapy, occupational therapy, and ... ...

Abstract	Background In the absence of an interdisciplinary service for pediatric chronic pain in Manitoba, pain management has been offered through a single provider outpatient setting with consultative services from physiotherapy, occupational therapy, and psychiatry since October 2015.Aims The aim of this study was to characterize the patient population of this clinic to understand needs and inform future service development for pediatric chronic pain.Methods Demographics and disease characteristics of all patients seen in this clinic between October 1, 2015, and February 28, 2019, were analyzed retrospectively from electronic medical records.Results A total of 157 patients, mean age 13.1 (sd ±3.0) years, 75.2% female, with a median duration of pain of 20.5 (interquartile range [IQR] = 10.0–45.8) months at their first visit were included in the study. At baseline, 74.0% of patients experienced insomnia, 76.6% fatigue, 86.5% symptoms of anxiety, and 58.69% symptoms of depression; 80.1% showed withdrawal from physical activity, 67.1% missed school, and 10.2% reported opioid usage. Throughout their care in clinic, 83.4% of patients received physiotherapy, 17.8% occupational therapy, 49.7% mental health support, and 51.6% care from multiple services. The clinic experienced a significant increase in median referrals from 1.0 to 5.0 (IQR = 2.0–9.0) per month and wait time from 35.0 to 97.0 (IQR = 88.0–251.0) days during the observation period.Conclusions Developing an interdisciplinary service for pediatric chronic pain will provide an opportunity to improve access, coordination, and comprehensiveness of care and to employ culturally sensitive services to improve care for children and youth living with chronic pain in Manitoba and possibly other jurisdictions with similar demographics and needs.
Keywords	pediatric chronic pain ; mental health ; pain center ; interdisciplinary health care team ; opioid use ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
Subject code	360
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Understand me: Youth with chronic pain on how knowledge gaps influence their pain experience.

Brown, Cara L / Restall, Gayle / Diaz, Francis Austin S / Anang, Polina / Gerhold, Kerstin / Pylypjuk, Heidi / Wittmeier, Kristy

Canadian journal of pain = Revue canadienne de la douleur

2023 Volume 7, Issue 1, Page(s) 2146489

Abstract: Background: There is a perceived lack of readily available resources to support self-management skills in youth living with chronic pain. The perspectives of youth regarding information gaps may improve the effectiveness of resources developed for them.! ...

Abstract	Background: There is a perceived lack of readily available resources to support self-management skills in youth living with chronic pain. The perspectives of youth regarding information gaps may improve the effectiveness of resources developed for them. Aim: The aim of this study was to explore the perspectives of youth living with chronic pain on the interactions among their pain experiences, chronic pain resources and research. Methods: Using an interpretive paradigm, we interviewed seven participants (age range 12-19 years) diagnosed with chronic pain. Two frameworks for meaningful engagement of citizens in research and policy informed the interview guide. Data were analyzed inductively using content analysis approaches to examine patterns and develop themes. Results: The participants' perceptions were captured by the overarching theme of "understand me." Four subthemes elaborate on the relationship between the participants' experiences and how their lives could be enhanced through research and knowledge mobilization. In the subtheme "my unique pain experience," the participants help us understand them by chronicling the variation in presentation of their chronic pain. The subtheme "people don't know it's a thing" emphasizes that there is general misunderstanding of chronic pain by the public and in the participants' support systems. The first two subthemes influence the third, which describes how the pain "kind of stops you from living." The fourth subtheme, "knowledge offers hope," offers a solution to dismantling misunderstanding of youth living with chronic pain. Conclusion: Future work needs to focus on embedding health literacy and knowledge mobilization into health and education structures to promote developmentally relevant self-management skills.
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2474-0527
ISSN (online)	2474-0527
DOI	10.1080/24740527.2022.2146489
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Do Patterns of Early Disease Severity Predict Grade 12 Academic Achievement in Youths With Childhood-Onset Chronic Rheumatic Diseases?

Lim, Lily S H / Ekuma, Okechukwu / Marrie, Ruth A / Brownell, Marni / Peschken, Christine A / Hitchon, Carol A / Gerhold, Kerstin / Lix, Lisa M

The Journal of rheumatology

2023 Volume 50, Issue 9, Page(s) 1165–1172

Abstract: Objective: To test the association of early disease severity with grade 12 standards test performance in individuals with childhood-onset chronic rheumatic diseases (ChildCRDs), including juvenile arthritis and systemic autoimmune rheumatic diseases.: ...

Abstract	Objective: To test the association of early disease severity with grade 12 standards test performance in individuals with childhood-onset chronic rheumatic diseases (ChildCRDs), including juvenile arthritis and systemic autoimmune rheumatic diseases. Methods: We used linked provincial administrative data to identify patients with ChildCRDs born between 1979 and 1998 in Manitoba, Canada. Primary outcomes were Language and Arts Achievement Index (LAI) scores and Math Achievement Index (MAI) scores from grade 12 standards test results as well as enrollment data. The secondary outcome was enrollment in grade 12 by 17 years of age. Latent class trajectory analysis identified disease severity groups using physician visits following diagnosis. Multivariable linear regression tested the association of disease severity groups with LAI and MAI scores, and logistic regression tested the association of disease severity with age-appropriate enrollment, after adjusting for sociodemographic factors and psychiatric morbidities. Results: The study cohort included 541 patients, 70.1% of whom were female. A 3-class trajectory model provided the best fit; it classified 9.7% of patients as having severe disease, 54.5% as having moderate disease, and 35.8% as having mild disease. After covariate adjustment, severe disease was associated with poorer LAI and MAI scores but not with age-appropriate enrollment. Conclusion: Among patients with ChildCRDs, those with severe disease performed more poorly on grade 12 standards tests, independent of sociodemographic and psychiatric risk factors. Clinicians should work with educators and policy makers to advocate for supports to improve educational outcomes of patients with ChildCRDs.
MeSH term(s)	Humans ; Child ; Female ; Adolescent ; Male ; Academic Success ; Rheumatic Diseases/epidemiology ; Morbidity ; Achievement ; Patient Acuity
Language	English
Publishing date	2023-02-01
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.220656
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Article: Segmental Myoclonus and Epilepsy in a Child with GAD 65 Antibodies.

Salman, Michael S / Xu, Qi / Bunge, Martin / Ilse, Werner / Gerhold, Kerstin / Udow, Sean J

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 49, Issue 1, Page(s) 136–139

MeSH term(s)	Child ; Epilepsy ; Family ; Glutamate Decarboxylase ; Humans ; Myoclonus/etiology
Chemical Substances	Glutamate Decarboxylase (EC 4.1.1.15)
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2021.21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understand Me

Cara L. Brown / Gayle Restall / Francis Austin S. Diaz / Polina Anang / Kerstin Gerhold / Heidi Pylypjuk / Kristy Wittmeier

Canadian Journal of Pain (2022)

Youth with Chronic Pain on How Knowledge Gaps Influence their Pain Experience

2022

Abstract: Background There is a perceived lack of readily available resources to support self-management skills in youth living with chronic pain. The perspectives of youth regarding information gaps may improve the effectiveness of resources developed for them ... ...

Abstract	Background There is a perceived lack of readily available resources to support self-management skills in youth living with chronic pain. The perspectives of youth regarding information gaps may improve the effectiveness of resources developed for them.Aim Explore the perspectives of youth living with chronic pain on the interactions among their pain experiences, chronic pain resources and research.Methods Using an interpretive paradigm, we interviewed seven participants (age range 12 – 19 years) diagnosed with chronic pain. Two frameworks for meaningful engagement of citizens in research and policy informed the interview guide. Data were analyzed inductively using content analysis approaches to examine patterns and develop themes.Results The participant’s perceptions were captured by the overarching theme of Understand Me. Four sub-themes elaborate on the relationship between the participants’ experiences and how their lives could be enhanced through research and knowledge mobilization. In the sub-theme My Unique Pain Experience, the participants help us understand them, by chronicling the variation in presentation of their chronic pain. The sub-theme People Don’t Know It’s a Thing emphasizes that there is general misunderstanding of chronic pain by the public and in the participants’ support systems. The first two sub-themes influence the third, which describes how the pain Kind of Stops You from Living. The fourth sub-theme, Knowledge Offers Hope, offers a solution to dismantling misunderstanding of youth living with chronic pain.Conclusion Future work needs to focus on embedding health literacy and knowledge mobilization into health and education structures to promote developmentally relevant self-management skills.
Keywords	Chronic pain ; youth ; qualitative ; resources ; patient engagement ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
Subject code	360
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Population-based Study of Grade 12 Academic Performance in Adolescents With Childhood-onset Chronic Rheumatic Diseases.

Lim, Lily S H / Ekuma, Okekchukwu / Marrie, Ruth Ann / Brownell, Marni / Peschken, Christine A / Hitchon, Carol A / Gerhold, Kerstin / Lix, Lisa Marie

The Journal of rheumatology

2021 Volume 49, Issue 3, Page(s) 299–306

Abstract: Objective: The aims of this study were (1) to compare grade 12 standardized test results of patients diagnosed with childhood-onset chronic rheumatic diseases (ChildCRD) and unaffected peers; and (2) to identify factors associated with test results of ... ...

Abstract	Objective: The aims of this study were (1) to compare grade 12 standardized test results of patients diagnosed with childhood-onset chronic rheumatic diseases (ChildCRD) and unaffected peers; and (2) to identify factors associated with test results of patients with ChildCRD and unaffected peers. Methods: This was a population-based retrospective cohort study. All patients with ChildCRD (juvenile arthritis and systemic autoimmune rheumatic diseases) from the only pediatric rheumatology center in Manitoba for birth cohorts January 1979 to December 1998 were linked to the provincial administrative databases containing records of healthcare use and education outcomes. Patients were matched by age, sex, and postal codes to their peers who did not have ChildCRD. The primary outcomes were the grade 12 Language Arts Achievement Index (LAI) and the Math Achievement Index (MAI) scores. ChildCRD, sociodemographic, and mental health factors were tested for their associations with LAI and MAI scores using multivariable linear regression. Results: Five hundred and forty-one patients with ChildCRD were matched to 2713 unaffected peers. Patients with ChildCRD had lower LAI and MAI scores compared to their peers. More patients with ChildCRD failed or did not take the language arts (51% vs 41%, Conclusion: This population-based study showed that patients with ChildCRD performed less well than their peers on grade 12 standardized testing, independent of sociodemographic and mental health comorbidities.
MeSH term(s)	Academic Performance ; Adolescent ; Child ; Cohort Studies ; Comorbidity ; Humans ; Retrospective Studies ; Rheumatic Diseases/epidemiology
Language	English
Publishing date	2021-11-01
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.201514
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