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  1. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease.

    Wan, Elizabeth R / Woolfson, Robin G / Greenwood, Richard / Walsh, Stephen B

    Kidney international reports

    2020  Volume 5, Issue 9, Page(s) 1610–1611

    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.06.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Home-based fecal calprotectin utilization in a general pediatric gastroenterology clinic.

    Schmidt, Melanie L / McCrady, Emma / Lee, Angus / Bowerbank, Terrence / Miller, Michael R / Watson, Melanie / Dhandapani, Ashok / Woolfson, Jessica P / Zizzo, Andréanne N / Bax, Kevin / Crowley, Eileen

    Journal of pediatric gastroenterology and nutrition

    2024  Volume 78, Issue 4, Page(s) 790–799

    Abstract: ... higher in children with IBD compared to non-IBD diagnosis (sFC 795 vs. 57 μg/g, hFC 595 vs. 47 μg/g, p ... < 0.001), and in ONI compared to functional GI disorders (sFC 85 vs. 54 μg/g, p = 0.003, hFC 57 vs. 40 ... μg/g, p < 0.001). No significant difference was observed between different ONI GI disorders or ...

    Abstract Objective: Remote investigation and monitoring have gained importance in ambulatory practice. A home-based fecal calprotectin (FC) test has been developed where the sample is processed and analyzed at home through a smartphone application. We aimed to assess the use of standard ELISA (sFC) versus home-based (hFC) FC testing in a general pediatric gastroenterology clinic.
    Methods: Ambulatory pediatric patients with hFC or sFC performed between August 2019 and November 2020 were included. Data regarding demographics, clinical characteristics, medication use, investigations, and final diagnosis, categorized as inflammatory bowel disease (IBD), functional gastrointestinal (GI) disorders, organic non-IBD (ONI) GI disorders, non-GI disorders, and undetermined after 6 months of investigation, were recorded.
    Results: A total of 453 FC tests from 453 unique patients were included. Of those, 249 (55%) were hFC. FC levels (median) were higher in children with IBD compared to non-IBD diagnosis (sFC 795 vs. 57 μg/g, hFC 595 vs. 47 μg/g, p < 0.001), and in ONI compared to functional GI disorders (sFC 85 vs. 54 μg/g, p = 0.003, hFC 57 vs. 40 μg/g, p < 0.001). No significant difference was observed between different ONI GI disorders or subtypes of functional disorders. Age did not significantly influence levels.
    Conclusions: Overall, hFC and sFC provide similar results in the general pediatric GI ambulatory setting. FC is a sensitive but not disease-specific marker to identify patients with IBD. Values appear to be higher in ONI GI disorders over functional disorders, although cut-off values have yet to be determined.
    MeSH term(s) Humans ; Child ; Leukocyte L1 Antigen Complex/analysis ; Gastroenterology ; Inflammatory Bowel Diseases/diagnosis ; Gastrointestinal Diseases/diagnosis ; Colonoscopy ; Feces/chemistry ; Biomarkers/analysis
    Chemical Substances Leukocyte L1 Antigen Complex ; Biomarkers
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12150
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    Zs.A 1728: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues.

    Rhys, Guto G / Dawson, William M / Beesley, Joseph L / Martin, Freddie J O / Brady, R Leo / Thomson, Andrew R / Woolfson, Derek N

    Biomacromolecules

    2021  Volume 22, Issue 5, Page(s) 2010–2019

    Abstract: Rational protein design requires understanding the contribution of each amino acid to a targeted protein fold. For a subset of protein structures, namely, α-helical coiled coils (CCs), knowledge is sufficiently advanced to allow the ... ...

    Abstract Rational protein design requires understanding the contribution of each amino acid to a targeted protein fold. For a subset of protein structures, namely, α-helical coiled coils (CCs), knowledge is sufficiently advanced to allow the rational
    MeSH term(s) Amino Acid Sequence ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Protein Folding ; Protein Structure, Secondary ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.1c00131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease

    Wan, Elizabeth R. / Woolfson, Robin G. / Greenwood, Richard / Walsh, Stephen B.

    Kidney International Reports

    2020  Volume 5, Issue 9, Page(s) 1610–1611

    Keywords Nephrology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2468-0249
    DOI 10.1016/j.ekir.2020.06.037
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Coiled coils 9-to-5: rational

    Dawson, William M / Martin, Freddie J O / Rhys, Guto G / Shelley, Kathryn L / Brady, R Leo / Woolfson, Derek N

    Chemical science

    2021  Volume 12, Issue 20, Page(s) 6923–6928

    Abstract: The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discriminate ...

    Abstract The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discriminate between states are weak. Nonetheless, for α-helical coiled-coil assemblies considerable progress has been made in rational
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc00460c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease

    Elizabeth R. Wan / Robin G. Woolfson / Richard Greenwood / Stephen B. Walsh

    Kidney International Reports, Vol 5, Iss 9, Pp 1610-

    2020  Volume 1611

    Keywords Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Differential sensing with arrays of de novo designed peptide assemblies.

    Dawson, William M / Shelley, Kathryn L / Fletcher, Jordan M / Scott, D Arne / Lombardi, Lucia / Rhys, Guto G / LaGambina, Tania J / Obst, Ulrike / Burton, Antony J / Cross, Jessica A / Davies, George / Martin, Freddie J O / Wiseman, Francis J / Brady, R Leo / Tew, David / Wood, Christopher W / Woolfson, Derek N

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 383

    Abstract: ... and complex mixtures. In place of hundreds of complex, membrane-bound G-protein coupled receptors ...

    Abstract Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place of hundreds of complex, membrane-bound G-protein coupled receptors, differential sensors employ arrays of small molecules. Here we show that arrays of computationally designed de novo peptides provide alternative synthetic receptors for differential sensing. We use self-assembling α-helical barrels (αHBs) with central channels that can be altered predictably to vary their sizes, shapes and chemistries. The channels accommodate environment-sensitive dyes that fluoresce upon binding. Challenging arrays of dye-loaded barrels with analytes causes differential fluorophore displacement. The resulting fluorimetric fingerprints are used to train machine-learning models that relate the patterns to the analytes. We show that this system discriminates between a range of biomolecules, drink, and diagnostically relevant biological samples. As αHBs are robust and chemically diverse, the system has potential to sense many analytes in various settings.
    MeSH term(s) Peptides/chemistry ; Protein Conformation, alpha-Helical ; Smell
    Chemical Substances Peptides
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36024-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Navigating the Structural Landscape of De Novo α-Helical Bundles.

    Rhys, Guto G / Wood, Christopher W / Beesley, Joseph L / Zaccai, Nathan R / Burton, Antony J / Brady, R Leo / Thomson, Andrew R / Woolfson, Derek N

    Journal of the American Chemical Society

    2019  Volume 141, Issue 22, Page(s) 8787–8797

    Abstract: The association of amphipathic α helices in water leads to α-helical-bundle protein structures. However, the driving force for this-the hydrophobic effect-is not specific and does not define the number or the orientation of helices in the associated ... ...

    Abstract The association of amphipathic α helices in water leads to α-helical-bundle protein structures. However, the driving force for this-the hydrophobic effect-is not specific and does not define the number or the orientation of helices in the associated state. Rather, this is achieved through deeper sequence-to-structure relationships, which are increasingly being discerned. For example, for one structurally extreme but nevertheless ubiquitous class of bundle-the α-helical coiled coils-relationships have been established that discriminate between all-parallel dimers, trimers, and tetramers. Association states above this are known, as are antiparallel and mixed arrangements of the helices. However, these alternative states are less well understood. Here, we describe a synthetic-peptide system that switches between parallel hexamers and various up-down-up-down tetramers in response to single-amino-acid changes and solution conditions. The main accessible states of each peptide variant are characterized fully in solution and, in most cases, to high resolution with X-ray crystal structures. Analysis and inspection of these structures helps rationalize the different states formed. This navigation of the structural landscape of α-helical coiled coils above the dimers and trimers that dominate in nature has allowed us to design rationally a well-defined and hyperstable antiparallel coiled-coil tetramer (apCC-Tet). This robust de novo protein provides another scaffold for further structural and functional designs in protein engineering and synthetic biology.
    MeSH term(s) Amino Acid Sequence ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Protein Conformation, alpha-Helical ; Protein Folding ; Proteins/chemistry ; Water/chemistry
    Chemical Substances Proteins ; Water (059QF0KO0R)
    Language English
    Publishing date 2019-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.8b13354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  10. Article ; Online: HLAMatchmaker is effective for selecting appropriate platelet units for alloimmunised thrombocytopaenic patients who are refractory to random donor platelets.

    O'Rafferty, C / Rooney, G / Hagan, R / Woolfson, M / O'Donghaile, D / Fitzgerald, J

    Transfusion medicine (Oxford, England)

    2017  Volume 27 Suppl 5, Page(s) 369–374

    Abstract: Background: HLAMatchmaker has been used in the Irish Blood Transfusion Service (IBTS) to select platelets for HLA-alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available since 2002, only three studies have been ... ...

    Abstract Background: HLAMatchmaker has been used in the Irish Blood Transfusion Service (IBTS) to select platelets for HLA-alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available since 2002, only three studies have been published supporting the programme's effectiveness for this indication.
    Objectives: We sought to examine increments to HLA-matched platelets (HMPs) at various matchmaker scores and to examine the impact of transfusing older platelets and ABO-mismatched platelets to this patient group.
    Methods/materials: A total of 20 consecutive HLA-alloimmunised thrombocytopaenic patients were retrospectively studied. Data collected included: pre- and post-transfusion platelet count, indication for transfusion, HLAMatchmaker score, age of unit and degree of ABO mismatch. Data were also collected on the last 3 U of (RDPs). The Mann-Whitney U-test was used to compare increments between transfusion episodes of random donor platelets (RDPs) vs HMPs with matchmaker scores <3, 4-7 or >8.
    Results: Increments at <2 h were available for 63 transfusion episodes. Increments at 2-24 h were available for 93 transfusion episodes. Increments were higher when transfusing HMPs than when transfusing RDPs. Increments for HMPs that were ABO mismatched were no different than for ABO-identical units, with the exception of late increments post-transfusing HMPs with a major ABO mismatch. Age of platelets did not influence increments.
    Conclusion: The use of HLAMatchmaker to select platelet units for thrombocytopaenic HLA-alloimmunised patients produced satisfactory platelet increments. When providing HLAMatchmaker-selected HMPs, ABO mismatch and the use of platelet units that are up to 7 days old should be permissible.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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