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Article ; Online: Use of Technologies at the Advanced Age.

Sy, Sarah / Sinclair, Alan / Munshi, Medha / Kahkoska, Anna R / Weinstock, Ruth / Cukierman-Yaffe, Tali

2024 Volume 26, Issue S1, Page(s) S172–S186

MeSH term(s)	Humans ; Technology
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2024.2511
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Zs.A 5269: Show issues

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Article ; Online: A survey of cost, access and outcomes for cannabinoid-based medicinal product use by Australians with endometriosis.

Proudfoot, Andrew / Duffy, Sarah / Sinclair, Justin / Abbott, Jason / Armour, Mike

The Australian & New Zealand journal of obstetrics & gynaecology

2024

Abstract: People with endometriosis use cannabis to manage their symptoms. This study aimed to identify costs, modes of administration, product composition, and self-reported effectiveness for those accessing medicinal cannabis in Australia. There were 192 survey ... ...

Abstract	People with endometriosis use cannabis to manage their symptoms. This study aimed to identify costs, modes of administration, product composition, and self-reported effectiveness for those accessing medicinal cannabis in Australia. There were 192 survey responses analysed. Most (63.5%) used a 'cannabis clinic' doctor, incurring an initial consultation cost of $100-$200+ (10.2% Medicare bulk-billed) and median cannabinoid medicine costs of $300AUD per month. Cost was a major barrier to access, necessitating reducing dosage (76.1%) and/or consuming illicit cannabis (42.9%), despite a prescription. Most (77%) medical consumers used two or more cannabis products, with delta-9-tetrahydrocannabinol predominant oil and flower products most frequently prescribed.
Language	English
Publishing date	2024-02-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	390815-x
ISSN	1479-828X ; 0004-8666
ISSN (online)	1479-828X
ISSN	0004-8666
DOI	10.1111/ajo.13804
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Zs.A 424: Show issues

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Article ; Online: Outcomes of Pediatric Proximal Phalanx Base Fractures.

Schutz, John / Korrell, Hannah / Look, Nicole / Lalka, Andy / Hild, Johanna / Cleary, Gabriela / Sinclair, Micah K / Sibbel, Sarah E

The Journal of the American Academy of Orthopaedic Surgeons

2024 Volume 32, Issue 9, Page(s) e434–e442

Abstract: Introduction: Extra-articular juxtaphyseal fractures of the proximal phalanx are among the most common finger fractures in children. Immobilization of the digit for 3 to 4 weeks after reduction of the fracture is the current standard of care. The ... ...

Abstract	Introduction: Extra-articular juxtaphyseal fractures of the proximal phalanx are among the most common finger fractures in children. Immobilization of the digit for 3 to 4 weeks after reduction of the fracture is the current standard of care. The purpose of this retrospective study was to evaluate outcomes after intervention among pediatric proximal phalanx base fractures and establish radiographic criteria to guide management. Methods: A multi-institutional retrospective review of skeletally immature patients treated for proximal phalanx juxtaphyseal fractures between 2002 and 2019 was conducted. Variables collected included Salter-Harris classification; initial, postreduction, early follow-up, and final angulation and displacement on the posterior-anterior and lateral radiographs; clinical rotational deformity at final follow-up; and method of treatment. Exclusion criteria included less than 3 weeks of follow-up; Salter-Harris III, IV, and V fractures; inadequate medical record details; and missing radiographs. Results: Six hundred thirty-four fractures meeting the inclusion criteria were categorized into no reduction, closed reduction (CR), and surgical (OP) groups. Only CR and OP groups saw large decreases in angulation by 11.8° CR (95% confidence interval, 10.1 to 13.6) and 19.0° OP (95% confidence interval, 8.7 to 29.3). Closed reduction patients had a mean coronal angulation value of 6.1° at post-reduction, which was maintained with immobilization to 5.8° at final follow-up. At final follow-up, scissoring was noted, three in the no reduction and three in the CR group for an overall 0.93% rotational malalignment rate. Discussion: Extra-articular proximal phalanx juxtaphyseal fractures rarely require surgical management and can typically be treated with or without CR, based on the degree of deformity, in the emergency department or clinical setting. Low rates of documented sequelae after nonsurgical management were seen in this cohort, allowing for establishment of treatment parameters that can result in clinically insignificant angular and rotational deformity. Level of evidence: Therapeutic IV.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Finger Phalanges/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Finger Injuries/therapy ; Fracture Fixation, Internal/methods ; Treatment Outcome
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-22-00940
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article ; Online: Working in value-discrepant environments inhibits clinicians' ability to provide compassion and reduces well-being: A cross-sectional study.

Pavlova, Alina / Paine, Sarah-Jane / Sinclair, Shane / O'Callaghan, Anne / Consedine, Nathan S

Journal of internal medicine

2023 Volume 293, Issue 6, Page(s) 704–723

Abstract: Background: The practice of compassion in healthcare leads to better patient and clinician outcomes. However, compassion in healthcare is increasingly lacking, and the rates of professional burnout are high. Most research to date has focused on ... ...

Abstract	Background: The practice of compassion in healthcare leads to better patient and clinician outcomes. However, compassion in healthcare is increasingly lacking, and the rates of professional burnout are high. Most research to date has focused on individual-level predictors of compassion and burnout. Little is known regarding how organizational factors might impact clinicians' ability to express compassion and well-being. The main study objective was to describe the association between personal and organizational value discrepancies and compassion ability, burnout, job satisfaction, absenteeism and consideration of early retirement among healthcare professionals. Methods: More than 1000 practising healthcare professionals (doctors, nurses and allied health professionals) were recruited in Aotearoa/New Zealand. The study was conducted via an online cross-sectional survey and was preregistered on AsPredicted (75407). The main outcome measures were compassionate ability and competence, burnout, job satisfaction and measures of absenteeism and consideration of early retirement. Results: Perceived discrepancies between personal and organizational values predicted lower compassion ability (B = -0.006, 95% CI [-0.01, -0.00], p < 0.001 and f Conclusions: Working in value-discrepant environments predicts a range of poorer outcomes among healthcare professionals, including hindering the ability to be compassionate. Scalable organizational and systems-level interventions that address operational processes and practices that lead to the experience of value discrepancies are recommended to improve clinician performance and well-being outcomes.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Empathy ; Burnout, Professional/prevention & control ; Health Personnel ; Physicians ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13615
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Ua VI Zs.44: Show issues

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Article ; Online: Establishing the Role of Inflammatory Markers in the Diagnosis and Treatment of Acute Hand Infections in the Pediatric Population.

Schutz, John / Lalka, Andy / Williams, Morgan A / Sibbel, Sarah E / Sinclair, Micah K

Journal of pediatric orthopedics

2023 Volume 43, Issue 10, Page(s) 649–653

Abstract: Introduction: Distinguishing the severity of the diagnosis and an appropriate treatment plan in pediatric hand infections can be complex due to the variable amount of information available at the presentation. Inflammatory blood markers, including white ...

Abstract	Introduction: Distinguishing the severity of the diagnosis and an appropriate treatment plan in pediatric hand infections can be complex due to the variable amount of information available at the presentation. Inflammatory blood markers, including white blood cell count, erythrocyte sedimentation rate, and C-reactive protein are reported to aid in determining the severity of infection and response to treatment in adult hand infections. The purpose of this study was to identify the relevance of inflammatory marker levels in pediatric patients with hand and wrist infections and to determine their utility in diagnosis and treatment. Methods: This multicenter, retrospective, cohort study included patients aged 0 to 18 who received treatment for an acute hand or wrist infection between 2009 and 2020. Data collected included demographics, time to presentation, diagnosis, inflammatory markers, culture results, antibiotic treatment, and surgical treatment. Infections were categorized as deep (osteomyelitis, tenosynovitis, abscess) and superficial (paronychia, felon, cellulitis). Exclusion criteria included: patients above 18 years of age, chronic infection, open fractures, and absence of any documented inflammatory markers. Statistically, t tests were used to compare mean differences in inflammatory markers between patients who did and did not receive pretreatment antibiotics and between patients who had superficial versus deep hand infections. Results: A total of 123 patients met the inclusion criteria. Pretreatment with antibiotics before definitive management was not significantly associated with differences in laboratory markers compared with patients not pretreated with antibiotics. Deep hand infections had inflammatory markers similar to superficial infections. Patients with deep hand infections required a bedside or operative procedure 78.9% of the time compared with superficial infections (21.2%) ( P <0.001). Patients with an isolated methicillin-resistant Staphylococcus aureus infection had inflammatory marker values that were not significantly different from patients infected with all other microbes. Conclusions: Inflammatory markers were not significantly different between patients who received pretreatment with antibiotics and those who did not. While deep infections were often treated with bedside or surgical procedures, the inflammatory marker values were similar to those of superficial infections. The same held true for patients infected with culture-positive, isolated methicillin-resistant Staphylococcus aureus bacteria. Consequently, inflammatory markers may be useful to identify the presence of infection and monitor the response to treatment, they did not aid in determining the specific type of infection or selection of a treatment plan. Level of evidence: Level III-retrospective comparative study.
MeSH term(s)	Adult ; Humans ; Child ; Methicillin-Resistant Staphylococcus aureus ; Retrospective Studies ; Cohort Studies ; Staphylococcal Infections/diagnosis ; Infections/drug therapy ; Abscess ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	604642-3
ISSN	1539-2570 ; 0271-6798
ISSN (online)	1539-2570
ISSN	0271-6798
DOI	10.1097/BPO.0000000000002508
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Zs.A 1681: Show issues

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Article ; Online: First diabetes survey in Surrey Downs Care Homes, 10 years after the UK National Diabetes Audit: What has changed?

Maltese, Giuseppe / Fountoulakis, Nikolaos / Jupp, Sarah / Cook, Susan / Floyd, Hilary / Malik, Imran / Sinclair, Alan J

Diabetic medicine : a journal of the British Diabetic Association

2023 Volume 41, Issue 3, Page(s) e15221

MeSH term(s)	Humans ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Nursing Homes ; Surveys and Questionnaires ; United Kingdom/epidemiology ; Medical Audit
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Letter
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.15221
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Zs.A 1954: Show issues

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Article ; Online: Using Primary Human Cells to Analyze Human Cytomegalovirus Biology.

Poole, Emma / Groves, Ian / Jackson, Sarah / Wills, Mark / Sinclair, John

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2244, Page(s) 51–81

Abstract: The extensive tropism of human cytomegalovirus (HCMV) results in the productive infection of multiple cell types within the human host. However, infection of other cell types, such as undifferentiated cells of the myeloid lineage, give rise to ... ...

Abstract	The extensive tropism of human cytomegalovirus (HCMV) results in the productive infection of multiple cell types within the human host. However, infection of other cell types, such as undifferentiated cells of the myeloid lineage, give rise to nonpermissive infections. This aspect has been used experimentally to model latent infection, which is known to be established in the pluripotent CD34+ hematopoietic progenitor cell population resident in the bone marrow in vivo. The absence of a tractable animal model for studies of HCMV has resulted in a number of laboratories employing experimental infection of cells in vitro to simulate both HCMV lytic and latent infection. Herein, we will focus on the techniques used in our laboratory for the isolation and use of primary cells to study aspects of HCMV latency, reactivation, and lytic infection.
MeSH term(s)	Antigens, CD34/metabolism ; Cell Differentiation ; Cytomegalovirus/metabolism ; Cytomegalovirus Infections/virology ; Hematopoietic Stem Cells/metabolism ; Monocytes/metabolism ; Primary Cell Culture/methods ; Signal Transduction ; Viral Tropism/genetics ; Viral Tropism/physiology ; Virus Activation ; Virus Latency
Chemical Substances	Antigens, CD34
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1111-1_4
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Article: Towards an Evidence-Based Classification System for Para Dressage: Associations between Impairment and Performance Measures.

Hobbs, Sarah Jane / Alexander, Jill / Wilkins, Celeste / St George, Lindsay / Nankervis, Kathryn / Sinclair, Jonathan / Penhorwood, Gemma / Williams, Jane / Clayton, Hilary M

Animals : an open access journal from MDPI

2023 Volume 13, Issue 17

Abstract: This study follows a previously defined framework to investigate the impact of impairment on performance in Para dressage athletes. Twenty-one elite Para dressage athletes (grades I to V) and eleven non-disabled dressage athletes (competing at Prix St. ... ...

Abstract	This study follows a previously defined framework to investigate the impact of impairment on performance in Para dressage athletes. Twenty-one elite Para dressage athletes (grades I to V) and eleven non-disabled dressage athletes (competing at Prix St. Georges or Grand Prix) participated. Data were collected in two phases: performing a two minute custom dressage test on a riding simulator while kinematic data were synchronously collected using inertial measurement units (2000 Hz) and optical motion capture (100 Hz), and clinically assessed using a battery of impairment assessment tools administered by qualified therapists. Impairment and performance measures were compared between Para and non-disabled athletes. Significant differences between athlete groups were found for all impairment measures and two performance measures: simulator trunk harmonics (
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13172785
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Article: Electromyographic and Kinematic Comparison of the Leading and Trailing Fore- and Hindlimbs of Horses during Canter.

St George, Lindsay B / Clayton, Hilary M / Sinclair, Jonathan K / Richards, Jim / Roy, Serge H / Hobbs, Sarah Jane

Animals : an open access journal from MDPI

2023 Volume 13, Issue 11

Abstract: This study compared muscle activity and movement between the leading (Ld) and trailing (Tr) fore- (F) and hindlimbs (H) of horses cantering overground. Three-dimensional kinematic and surface electromyography (sEMG) data were collected from right triceps ...

Abstract	This study compared muscle activity and movement between the leading (Ld) and trailing (Tr) fore- (F) and hindlimbs (H) of horses cantering overground. Three-dimensional kinematic and surface electromyography (sEMG) data were collected from right triceps brachii, biceps femoris, middle gluteal, and splenius from 10 ridden horses during straight left- and right-lead canter. Statistical parametric mapping evaluated between-limb (LdF vs. TrF, LdH vs. TrH) differences in time- and amplitude-normalized sEMG and joint angle-time waveforms over the stride. Linear mixed models evaluated between-limb differences in discrete sEMG activation timings, average rectified values (ARV), and spatio-temporal kinematics. Significantly greater gluteal ARV and activity duration facilitated greater limb retraction, hip extension, and stifle flexion (
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13111755
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Article: Characteristics of the Flight Arc in Horses Jumping Three Different Types of Fences in Olympic Competition.

Clayton, Hilary M / St George, Lindsay / Sinclair, Jonathan / Hobbs, Sarah Jane

Journal of equine veterinary science

2021 Volume 104, Page(s) 103698

Abstract: Show jumping horses must execute fences of varying height and width, but the effect of this on jumping kinematics during the airborne phase have not been described. The aim of this study was to describe differences within- and between-horses in CM ... ...

Abstract	Show jumping horses must execute fences of varying height and width, but the effect of this on jumping kinematics during the airborne phase have not been described. The aim of this study was to describe differences within- and between-horses in CM trajectory, trunk orientation and average trunk angular velocity in a group of elite horses executing three fences: vertical fence (1.60 m), spread fence (1.50 × 1.80 m), water jump (4.5 m) during an Olympic competition. Two-dimensional kinematic data (60 Hz) were collected from video cameras set perpendicular to each fence. After manual digitization, linear and angular variables related to the position and rotation of the CM and trunk were calculated. Linear fixed effects models evaluated within-group differences between fences and kinematic variables. Repeated measures correlation (rmcorr) evaluated within-horse associations between kinematic variables and fence type. Compared with the water jump, CM vertical velocity, CM peak height, and average trunk angular velocity were significantly higher (P < .05) and CM horizontal velocity was significantly lower (P < .05) for the vertical and spread fences. Peak CM height coincided approximately with the middle of the spread fence, toward the take-off for the water jump and landing for the vertical fence. The trunk was significantly more inclined at take-off for the vertical fence and significantly less inclined for the water jump at landing. Rmcorr analysis revealed that individual horses generally employ similar jumping techniques for each fence type. Findings provide original insight into the mechanical requirements for elite horses jumping different fence types.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Horses ; Sports ; Torso
Language	English
Publishing date	2021-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2021.103698
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