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  1. Article ; Online: Role of orthopedia homebox protein in subclassification of pulmonary carcinoid tumors: Retrospective analysis of 110 cases.

    Çetin, Mehmet / Fındık, Göktürk / Demirağ, Funda / Türk, İlteriş / Aydoğdu, Koray

    Indian journal of pathology & microbiology

    2023  Volume 66, Issue 4, Page(s) 786–789

    Abstract: Background: Orthopedia homeobox protein (OTP), highlighted as a sensitive and specific marker for pulmonary carcinoids, may provide a more objective criterion for subclassification.: Materials and methods: A total of 110 patients who underwent ... ...

    Abstract Background: Orthopedia homeobox protein (OTP), highlighted as a sensitive and specific marker for pulmonary carcinoids, may provide a more objective criterion for subclassification.
    Materials and methods: A total of 110 patients who underwent surgery for pulmonary carcinoids (2009-2019) were included. Gender, age, application complaint, tumor diameter and location, typical and atypical tumor type, lymph node involvement, stage, recurrence, and survival data were evaluated retrospectively with OTP nuclear staining.
    Results: The sensitivity of OTP was 66.4%. OTP in subclassifying pulmonary carcinoids was not significant. There was no significant relationship between OTP and lymph node involvement, recurrence, and survival.
    Conclusion: OTP does not provide significant results in the subclassification of typical and atypical carcinoid tumors and the evaluation of recurrence and survival of carcinoid tumor cases.
    MeSH term(s) Humans ; Retrospective Studies ; Homeodomain Proteins/metabolism ; Biomarkers, Tumor/analysis ; Nerve Tissue Proteins/analysis ; Nerve Tissue Proteins/metabolism ; Carcinoid Tumor/diagnosis ; Carcinoid Tumor/surgery ; Lung Neoplasms/diagnosis ; Carcinoma, Neuroendocrine/pathology ; Adenoma
    Chemical Substances Homeodomain Proteins ; Biomarkers, Tumor ; Nerve Tissue Proteins
    Language English
    Publishing date 2023-12-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_210_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Are precautions actually a risk factor in the development of bronchopleural fistula after pneumonectomy? A retrospective analysis of 299 cases.

    Solak, Necati / Çetin, Mehmet / Can, Mehmet Ali / Gürçay, Nesrin / Gülhan, Selim Şakir Erkmen / Aydoğdu, Koray / Fındık, Göktürk / Bıçakçıoğlu, Pınar

    Updates in surgery

    2024  

    Abstract: Purpose: Bronchopleural fistula most commonly occurs after pneumonectomies, with high morbidity and mortality. A preventive approach is essential. Risk factors can be classified depending on the patient, anatomy, surgical technique, and other causes.: ...

    Abstract Purpose: Bronchopleural fistula most commonly occurs after pneumonectomies, with high morbidity and mortality. A preventive approach is essential. Risk factors can be classified depending on the patient, anatomy, surgical technique, and other causes.
    Methods: Patients (n = 370) who underwent pneumonectomy between 2010 and 2020 were evaluated. The digital media and archive files of the patients (n = 299) were reviewed retrospectively.
    Results: While 271 patients (90.6%) were male, 28 (9.4%) were female. The mean age was 56.63 years. The bronchopleural fistula rate was 14.7% (44/299). Serum protein deficiency, right pneumonectomy, completion pneumonectomy, bronchial manual suturing, advanced stage, prolongation of time after neoadjuvant therapy, length of drain and hospital stay, tissue support for the stump, and short bronchial stump were significant for bronchopleural fistula. Smoking in patients operated on for malignancy and low serum albumin value in benign and chronic infectious diseases were significant in terms of fistula. In patients who developed bronchopleural fistula, the 5-year survival rate was 18.4%.
    Conclusion: The most important risk factors in bronchopleural fistula depend on the surgical technique and so are completely preventable. Contrary to the literature, short stump and tissue support to the stump were found to be risk factors for fistula. In addition, the effect of the time between neoadjuvant therapy and operation should be examined in further studies.
    Language English
    Publishing date 2024-03-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01772-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Foreign Body Aspiration Involved with Bronchial Carcinoma

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 6, Iss 150, Pp 216-

    Two Cases

    2016  Volume 218

    Abstract: Foreign body aspirations are rare in adults. As they can be asymptomatic for a long time, they can mimic many pathologic situations. We presented two cases with endobronchial lesions occurred as a result of foreign body aspiration that mimicking ... ...

    Abstract Foreign body aspirations are rare in adults. As they can be asymptomatic for a long time, they can mimic many pathologic situations. We presented two cases with endobronchial lesions occurred as a result of foreign body aspiration that mimicking bronchial carcinoma.
    Keywords foreign body ; aspiration ; lung cancer ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Foreign Body Aspiration Involved with Bronchial Carcinoma

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 6, Iss 150, Pp 216-

    Two Cases

    2016  Volume 218

    Abstract: Foreign body aspirations are rare in adults. As they can be asymptomatic for a long time, they can mimic many pathologic situations. We presented two cases with endobronchial lesions occurred as a result of foreign body aspiration that mimicking ... ...

    Abstract Foreign body aspirations are rare in adults. As they can be asymptomatic for a long time, they can mimic many pathologic situations. We presented two cases with endobronchial lesions occurred as a result of foreign body aspiration that mimicking bronchial carcinoma.
    Keywords foreign body ; aspiration ; lung cancer ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
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  5. Article ; Online: Importance of Histopathological Grading for Treatment Selection in Malignant Mesothelioma.

    Türk, İlteriş / Findik, Gokturk / Çetin, Mehmet / Bicakcioglu, Pinar / Gülhan, Selim Şakir Erkmen / Aydoğdu, Koray / Yılmaz, Ülkü / Demirağ, Funda

    The Thoracic and cardiovascular surgeon

    2023  Volume 71, Issue 6, Page(s) 497–503

    Abstract: Background: Complexities in TNM staging in epithelioid malignant pleural mesothelioma (MPM) may lead to errors in treatment selection, leading to major surgical interventions in patients with low survival expectations.: Methods: Sixty-nine stage I ... ...

    Abstract Background: Complexities in TNM staging in epithelioid malignant pleural mesothelioma (MPM) may lead to errors in treatment selection, leading to major surgical interventions in patients with low survival expectations.
    Methods: Sixty-nine stage I epithelioid MPM patients, including 27 patients treated with pleurectomy/decortication (P/D) and multimodal therapy (MMT) (the P/D [MMT] group), and 42 patients treated with chemotherapy or chemoradiotherapy (the CRT group), were included in the study. After an initial evaluation of overall survival, all patients were grouped in terms of histopathological parameters and treatment types, and then, a secondary survival evaluation was performed for the groups.
    Results: Forty-one patients were male, the mean age was 61.8 years. The median survival time was 26 months in the P/D (MMT) group, and 19.6 months in the CRT group, but the difference was not statistically significant. After grouping according to pathological criteria, a median survival time of 32.4 ± 2.9 months in the P/D (MMT) group and 21.9 ± 3.2 months in the CRT group was obtained among patients with histopathological low-grade tumors. Among patients with high-grade tumors, the median survival time was 18.3 ± 2.6 months in the P/D (MMT) group and 17 ± 4.4 months in the CRT group. Among patients with low-grade tumors, the P/D (MMT) group had longer survival. Median survival times were similar among patients with high-grade tumors.
    Conclusion: In epithelioid MPM, histopathological grading by video-assisted thoracic surgery pleural biopsy can prove accurate in selecting patients for P/D and MMT.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Mesothelioma, Malignant ; Mesothelioma/pathology ; Mesothelioma/therapy ; Patient Selection ; Pleural Neoplasms ; Lung Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-02-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0043-1761209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.186: Show issues Location:
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  6. Article ; Online: Atraumatic First Rib Fracture

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 7, Iss 113, Pp 396-

    2014  Volume 398

    Abstract: Rib fractures are usually seen after a trauma, while atraumatic spontaneous rib fractures are quite rare. A first rib fracture identified in our 17 years old female patient who had not a history of trauma except lifting a heavy weight was examined in ... ...

    Abstract Rib fractures are usually seen after a trauma, while atraumatic spontaneous rib fractures are quite rare. A first rib fracture identified in our 17 years old female patient who had not a history of trauma except lifting a heavy weight was examined in details in terms of the potential complications and followed-up for a long time. We presented our experience on this case with atraumatic first rib fracture that has different views for the etiology in light of the literature.
    Keywords Pain ; Atraumatic ; First Rib Fracture ; Medicine ; R
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Atraumatic First Rib Fracture

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 7, Iss 113, Pp 396-

    2014  Volume 398

    Abstract: Rib fractures are usually seen after a trauma, while atraumatic spontaneous rib fractures are quite rare. A first rib fracture identified in our 17 years old female patient who had not a history of trauma except lifting a heavy weight was examined in ... ...

    Abstract Rib fractures are usually seen after a trauma, while atraumatic spontaneous rib fractures are quite rare. A first rib fracture identified in our 17 years old female patient who had not a history of trauma except lifting a heavy weight was examined in details in terms of the potential complications and followed-up for a long time. We presented our experience on this case with atraumatic first rib fracture that has different views for the etiology in light of the literature.
    Keywords Pain ; Atraumatic ; First Rib Fracture ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Diagnosis and Management of True Thymic Hyperplasia; Description with Cases in Two Sisters

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 4, Iss 140, Pp 503-

    2013  Volume 505

    Abstract: Thymic Hyperplasia is an extremely rare neoplasm of thymus which is localized in the anterior mediastinum. Generally it occurs secondary to the different diseases. Some of them occurs idiopathicly. Until today there are more than 50 cases reported and ... ...

    Abstract Thymic Hyperplasia is an extremely rare neoplasm of thymus which is localized in the anterior mediastinum. Generally it occurs secondary to the different diseases. Some of them occurs idiopathicly. Until today there are more than 50 cases reported and most of them are children between the ages of 1 and 17. A few cases are adults. But until today there is no reported case with the same brothers and sisters. Therefore we want to point on whether thymic hyperplasia can be hereditary or not.
    Keywords Thymus ; .Mediastinal tumor ; Genetics ; Medicine ; R
    Language English
    Publishing date 2013-10-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Inflammatory Myofibroblastic Tumor Causing Endobronchial Lesion

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 4, Iss 138, Pp 275-

    Case Report

    2013  Volume 277

    Abstract: Inflammatory myofibroblastic tumor (IMT) is a benign neoplasm rarely presented with malignant features such as local invasiveness, recurrence, distant metastasis, or malignant transformation whose etiology is unknown certainly. The incidence rate of IMT ... ...

    Abstract Inflammatory myofibroblastic tumor (IMT) is a benign neoplasm rarely presented with malignant features such as local invasiveness, recurrence, distant metastasis, or malignant transformation whose etiology is unknown certainly. The incidence rate of IMT among all pulmonary tumor is 0.7-1 %. Most patients are detected under 40 years of age and usually patients are asymptomatic. IMT is observed such as solitary pulmonary nodules or mass. It is usually considered as endobronchial mesenchymal lesion. We aimed to present 20-year-old female patient because of the endobronchial IMT is detected is a rare and IMT’s surgical treatment.
    Keywords Mesenchymal tumour ; myofibroblastic tumor ; surgery ; Medicine ; R
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
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  10. Article ; Online: A Giant Intrathoracic Ectopic Thymoma Presenting with Hemopthysis

    Koray Aydogdu

    Journal of Clinical and Analytical Medicine , Vol 4, Iss 138, Pp 284-

    Case Report

    2013  Volume 286

    Abstract: Thymoma is the most common malignancy of the anterior mediastinum and originates within the epithelial cells of the thymus. Over 90% of thymomas occur in the thymic tissue in the anterosuperior mediastinum. Approximately one half of the patients are ... ...

    Abstract Thymoma is the most common malignancy of the anterior mediastinum and originates within the epithelial cells of the thymus. Over 90% of thymomas occur in the thymic tissue in the anterosuperior mediastinum. Approximately one half of the patients are asymptomatic. A 34-year-old male patient submitted with hemoptysis. Positron Emission Tomography Computed Tomography (PET-CT) showed a 9x6,5x10 cm lession with a SUV max value of 4,16 placed in the paracardiac area. A transthoracic fine needle aspiation biopsy was performed and find neoplasia with lenfoepithelial component. Here we aimed to represent a case of intrathoracic ectopic localized huge thymoma submitted with hemoptysis which is quite rare.
    Keywords Thymoma ; hemoptysis ; surgery ; Medicine ; R
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
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