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Article ; Online: A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque.

Jenkins, Tiffany / Wang, Rongzhang / Harder, Olivia / Xue, Miaoge / Chen, Phylip / Corry, Jacqueline / Walker, Christopher / Teng, Michael / Mejias, Asuncion / Ramilo, Octavio / Niewiesk, Stefan / Li, Jianrong / Peeples, Mark E

Journal of virology

2021 Volume 95, Issue 3

Abstract: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in children of <5 years of age worldwide, infecting the majority of infants in their first year of life. Despite the widespread impact of this virus, no ... ...

Abstract	Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in children of <5 years of age worldwide, infecting the majority of infants in their first year of life. Despite the widespread impact of this virus, no vaccine is currently available. For more than 50 years, live attenuated vaccines (LAVs) have been shown to protect against other childhood viral infections, offering the advantage of presenting all viral proteins to the immune system for stimulation of both B and T cell responses and memory. The RSV LAV candidate described here, rgRSV-L(G1857A)-G(L208A), contains two modifications: an attenuating mutation in the
MeSH term(s)	Animals ; Binding Sites ; Female ; Humans ; Macaca mulatta ; Male ; Mutation ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus, Human/drug effects ; Respiratory Syncytial Virus, Human/immunology ; S-Adenosylmethionine/metabolism ; Sigmodontinae ; Vaccination ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
Chemical Substances	Respiratory Syncytial Virus Vaccines ; Viral Envelope Proteins ; Viral Proteins ; attachment protein G ; S-Adenosylmethionine (7LP2MPO46S)
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01568-20
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Article: re: Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA (2004) Beta cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 47:31-39.

Jenkins, A B / Furler, S M / Campbell, L V

Diabetologia

2004 Volume 47, Issue 9, Page(s) 1642–3; author reply 1643–4

MeSH term(s)	Glucose Intolerance/physiopathology ; Glucose Tolerance Test ; Humans ; Islets of Langerhans/physiopathology ; Islets of Langerhans/secretion
Language	English
Publishing date	2004-09
Publishing country	Germany
Document type	Comment ; Letter
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-004-1478-4
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Article ; Online: Prime time for handheld echocardiography in COVID-19 pandemic.

Jenkins, Sam / Garg, Pankaj

Clinical medicine (London, England)

2020 Volume 20, Issue 4, Page(s) e132

MeSH term(s)	COVID-19 ; Cardiovascular Diseases/diagnostic imaging ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Echocardiography/instrumentation ; Humans ; Occupational Diseases/prevention & control ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission
Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Letter
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.Let.20.4.3
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Article ; Online: Portable ultrasound assessment of jugular venous pressure is an accurate method for estimating volaemic status in patients with cardiac disease.

Jenkins, Sam / Knowles, Patrick / Briffa, Norman

Journal of ultrasound

2022 Volume 25, Issue 4, Page(s) 939–947

Abstract: Purpose: The objective of this study was to determine whether ultrasound-measured jugular venous pressure (U-JVP) could accurately estimate central venous pressure (CVP).: Methods: This prospective, diagnostic, single-centre study was performed at ... ...

Abstract	Purpose: The objective of this study was to determine whether ultrasound-measured jugular venous pressure (U-JVP) could accurately estimate central venous pressure (CVP). Methods: This prospective, diagnostic, single-centre study was performed at the Cardiac Intensive Care Unit of the Northern General Hospital, Sheffield, UK. Post-cardiac surgery patients were recruited from January to May 2019. The investigators were blinded to the central venous pressure when measuring the jugular venous pressure. U-JVP and direct CVP were measured simultaneously. Measurements were taken whilst the patient was ventilated and then repeated when the patient was extubated, providing non-ventilated readings. Results: One-hundred and fourteen consecutive participants with a male predominance of 71% and mean age of 65 ± 12 years were included in the analysis. Bland-Altman plots revealed that U-JVP marginally overestimated CVP by 0.91 mmHg (95% limits of agreement were -2.936 to 4.754) in ventilated patients and by 0.11 mmHg (95% limits of agreement between -2.481 and 2.695) in non-ventilated patients. Reasonable sensitivity and specificity of ultrasound-measured jugular venous pressure was achieved for low and high central venous pressure in both ventilated and non-ventilated patients. Conclusion: U-JVP accurately estimates cardiac filling pressure and fluid status in patients after cardiac surgery, irrespective of their ventilatory status. Jugular venous pressure measurement by insonation is a reliable technique that can be taught to medical students and other health professionals to non-invasively estimate central venous pressure and may be useful for assessment of volaemic status in patients with heart failure. Trial registration: ClinicalTrials.gov public (identifier NCT03815188).
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Female ; Jugular Veins/diagnostic imaging ; Prospective Studies ; Central Venous Pressure ; Ultrasonography ; Heart Diseases/diagnostic imaging
Language	English
Publishing date	2022-03-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-022-00654-7
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Article ; Online: Negative pressure wound therapy in patients with diabetes undergoing left internal thoracic artery harvest: A randomized control trial.

Jenkins, Sam / Komber, Mohamed / Mattam, Kavitha / Briffa, Norman

The Journal of thoracic and cardiovascular surgery

2022 Volume 167, Issue 1, Page(s) 256–268

Abstract: Background: Patients with diabetes undergoing CABG are at risk of wound infection. Incisional negative pressure wound therapy has been shown to be effective in decreasing incidence of infection in high-risk wounds. Near infrared spectroscopy (NIRS) can ... ...

Abstract	Background: Patients with diabetes undergoing CABG are at risk of wound infection. Incisional negative pressure wound therapy has been shown to be effective in decreasing incidence of infection in high-risk wounds. Near infrared spectroscopy (NIRS) can be used to assess wound oxygenation and low values can predict infection. Objectives: To evaluate utility of NIRS to assess wound oxygenation, to assess effect of sternotomy, left internal thoracic artery harvest, and wound dressing type on wound edge oxygenation. Methods: In this blinded randomized control trial, patients with diabetes undergoing isolated coronary artery bypass grafting with a left internal thoracic artery were randomized to receive either incisional negative pressure wound therapy dressing or a standard dressing. NIRS measurements were made on the left upper arm (control), and left and right parasternal regions on day -1 (preoperative), day 5, and week 6 after surgery. Results were analyzed using repeated measures parametric methods. Results: Eighty patients with diabetes were recruited, 40 to the incisional negative pressure wound therapy group and 40 to the standard dressing group. Adjusted NIRS readings dropped significantly in all patients by day 5 and partially recovered by week 6. In both groups, there was no difference between readings on the left and right. At all time points and on both sides, there was no difference in readings between patients in the 2 groups. Conclusions: NIRS can be used to assess oxygenation adjacent to a sternotomy wound. Adjusted tissue oxygen levels change with time after sternotomy and left internal thoracic artery harvest in patients with diabetes. Wound dressing type does not influence day 5 wound edge oxygenation.
MeSH term(s)	Humans ; Negative-Pressure Wound Therapy/adverse effects ; Mammary Arteries/transplantation ; Surgical Wound Infection/epidemiology ; Diabetes Mellitus ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods
Language	English
Publishing date	2022-04-09
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2022.01.060
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Book ; Online: Understanding the Role and Design Space of Demand Sinks in Low-carbon Power Systems

van der Jagt, Sam / Patankar, Neha / Jenkins, Jesse

2023

Abstract: As the availability of weather-dependent, zero marginal cost resources such as wind and solar power increases, a variety of flexible electricity loads, or `demand sinks', could be deployed to use intermittently available low-cost electricity to produce ... ...

Abstract	As the availability of weather-dependent, zero marginal cost resources such as wind and solar power increases, a variety of flexible electricity loads, or `demand sinks', could be deployed to use intermittently available low-cost electricity to produce valuable outputs. This study provides a general framework to evaluate any potential demand sink technology and understand its viability to be deployed cost-effectively in low-carbon power systems. We use an electricity system optimization model to assess 98 discrete combinations of capital costs and output values that collectively span the range of feasible characteristics of potential demand sink technologies. We find that candidates like hydrogen electrolysis, direct air capture, and flexible electric heating can all achieve significant installed capacity (>10% of system peak load) if lower capital costs are reached in the future. Demand sink technologies significantly increase installed wind and solar capacity while not significantly affecting battery storage, firm generating capacity, or the average cost of electricity.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	690
Publishing date	2023-11-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cost-effectiveness of rimegepant oral lyophilisate compared to best supportive care for the acute treatment of migraine in the UK.

Johnston, Karissa / Powell, Lauren C / Popoff, Evan / L'Italien, Gil J / Pawinski, Robert / Ahern, Aideen / Large, Sam / Tran, Thang / Jenkins, Aaron

Journal of medical economics

2024 Volume 27, Issue 1, Page(s) 627–643

Abstract: Aims: Migraine is the most common disabling headache disorder and is characterized by recurrent throbbing head pain and symptoms of photophobia, phonophobia, nausea, and vomiting. Rimegepant 75 mg, an oral lyophilisate calcitonin gene-related peptide ... ...

Abstract	Aims: Migraine is the most common disabling headache disorder and is characterized by recurrent throbbing head pain and symptoms of photophobia, phonophobia, nausea, and vomiting. Rimegepant 75 mg, an oral lyophilisate calcitonin gene-related peptide antagonist, is the first treatment approved for both the acute and preventative treatment of migraine, and the first acute therapy approved in over 20-years. The objective was to assess the cost-utility of rimegepant compared with best supportive care (BSC) in the UK, for the acute treatment of migraine in the adults with inadequate symptom relief after taking at least 2 triptans, or for whom triptans are contraindicated or not tolerated. Materials and methods: A Results: Rimegepant resulted in an incremental cost-utility ratio (ICUR) of £10,309 per QALY gained vs BSC, which is cost-effectiveness at a willingness to pay threshold of £30,000/QALY. Rimegepant generated +0.44 incremental QALYs and higher incremental lifetime costs (£4,492). Improved QALYs for rimegepant were a result of less time spent with severe and moderate headache pain. Conclusion: This study highlights the economic value of rimegepant which was found to be cost-effective for the acute treatment of migraine in adults unsuitable for triptans.
MeSH term(s)	Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/economics ; Cost-Benefit Analysis ; Quality-Adjusted Life Years ; Piperidines/therapeutic use ; Piperidines/economics ; Piperidines/administration & dosage ; Pyridines/therapeutic use ; Pyridines/economics ; United Kingdom ; Adult ; Male ; Female ; Markov Chains ; Administration, Oral ; Middle Aged
Chemical Substances	Piperidines ; Pyridines ; rimegepant sulfate (1383NM3Q0H)
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2270945-9
ISSN	1941-837X ; 1369-6998
ISSN (online)	1941-837X
ISSN	1369-6998
DOI	10.1080/13696998.2024.2340932
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Article: Prime time for handheld echocardiography in COVID-19 pandemic

Jenkins, Sam / Garg, Pankaj

Clin Med (Lond)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #647425
Database	COVID19

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Article ; Online: Shedding and exclusion from childcare in children with Shiga toxin-producing

Vusirikala, Amoolya / Rowell, Sam / Dabke, Girija / Fox, Georgina / Bell, Jade / Manuel, Rohini / Jenkins, Claire / Love, Nicola / McCarthy, Noel / Sumilo, Dana / Balasegaram, Sooria

Epidemiology and infection

2024 Volume 152, Page(s) e42

Abstract: Excluding children with Shiga toxin- ... ...

Abstract	Excluding children with Shiga toxin-producing
MeSH term(s)	Child ; Humans ; Shiga-Toxigenic Escherichia coli ; Escherichia coli Infections/microbiology ; Child Care ; Diarrhea/epidemiology ; Diarrhea/microbiology ; Escherichia coli Proteins
Chemical Substances	Escherichia coli Proteins
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S095026882400027X
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Article ; Online: Opening the Pathway: An Example of Universal Design for Learning as a Guide to Inclusive Teaching Practices.

Orndorf, Hayley C / Waterman, Margaret / Lange, Donna / Kavin, Denise / Johnston, Sam Catherine / Jenkins, Kristin P

CBE life sciences education

2022 Volume 21, Issue 2, Page(s) ar28

Abstract: Universal Design for Learning (UDL) provides a flexible framework for supporting a wide variety of learners. We report here on a conference that presented the UDL framework as a way to increase success of deaf and hard-of-hearing (deaf/hh) students in ... ...

Abstract	Universal Design for Learning (UDL) provides a flexible framework for supporting a wide variety of learners. We report here on a conference that presented the UDL framework as a way to increase success of deaf and hard-of-hearing (deaf/hh) students in introductory biology courses. The Opening the Pathway conference was an NSF Advanced Technological Education project focusing on raising awareness about careers in biotechnology and student success in introductory biology, a key gateway course for careers in biotechnology. The participants were professionals who work with deaf/hh students at pivotal points in students' educational pathways for raising awareness of biotechnology career options, including community college faculty, high school faculty at schools for the deaf, and American Sign Language (ASL) interpreters. The conference goal was to provide an effective, meaningful professional development experience in biology instruction. The conference explicitly addressed the role of a UDL approach in building accessible, inclusive, productive learning environments, particularly for deaf/hh students, and demonstrated how to make effective pedagogical practices, specifically case-based learning, inclusive and UDL-aligned in an introductory biology context. We describe the conference, conference outcomes for participants, and in particular the application of the UDL framework to create an inclusive experience.
MeSH term(s)	Humans ; Learning ; Schools ; Students ; Universal Design ; Universities
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2465176-X
ISSN	1931-7913 ; 1931-7913
ISSN (online)	1931-7913
ISSN	1931-7913
DOI	10.1187/cbe.21-09-0239
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