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  1. Article: Lawrence Saunders.

    Loeb, R F

    The New England journal of medicine

    1968  Volume 279, Issue 17, Page(s) 950

    MeSH term(s) Books/history ; Education, Medical/economics ; Education, Medical/history ; History, 20th Century ; Publishing/history ; United States
    Language English
    Publishing date 1968-10-24
    Publishing country United States
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM196810242791721
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  2. Article ; Online: Richmond T. Prehn: In Memoriam (1922-2016).

    Loeb, Lawrence A

    Cancer research

    2017  Volume 77, Issue 3, Page(s) 593–594

    MeSH term(s) Biomedical Research ; History, 20th Century ; History, 21st Century ; Medical Oncology/history
    Language English
    Publishing date 2017--01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-3328
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  3. Article ; Online: Rare Mutations in Cancer Drug Resistance and Implications for Therapy.

    Beckman, Robert A / Loeb, Lawrence A

    Clinical pharmacology and therapeutics

    2020  Volume 108, Issue 3, Page(s) 437–439

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/genetics ; Drug Resistance, Neoplasm/genetics ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Risk Factors
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1938
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  4. Article ; Online: Tobacco Causes Human Cancers--A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide.

    Loeb, Lawrence A

    Cancer research

    2016  Volume 76, Issue 4, Page(s) 765–766

    Abstract: The recognition that tobacco smoke is carcinogenic led to the most significant and successful effort at reducing cancer incidence in human history. A major milestone of this effort was the publication in Cancer Research by Wynder and colleagues, which ... ...

    Abstract The recognition that tobacco smoke is carcinogenic led to the most significant and successful effort at reducing cancer incidence in human history. A major milestone of this effort was the publication in Cancer Research by Wynder and colleagues, which demonstrated the ability of tobacco tars to produce tumors in mice. This study provided a powerful link between the epidemiology of cancer and mechanisms of carcinogenesis. This commentary asserts that we have a moral obligation to translate our success in reducing lung cancer in the United States to the 1.25 billion smokers throughout the rest of the world. See related article by Wynder et al., Cancer Res 1953;13:855-64.
    MeSH term(s) Humans ; Neoplasms/epidemiology ; Neoplasms/etiology ; Nicotiana/adverse effects
    Language English
    Publishing date 2016-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-0149
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  5. Article ; Online: Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.

    Loeb, Lawrence A

    Cancer research

    2016  Volume 76, Issue 8, Page(s) 2057–2059

    Abstract: ... become resistant to therapy. Cancer Res; 76(8); 2057-9. ©2016 AACRSee related article by Loeb et al. Cancer Res ...

    Abstract The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for the striking heterogeneity of malignant cells within a tumor and for the rapidity by which cancers become resistant to therapy. Cancer Res; 76(8); 2057-9. ©2016 AACRSee related article by Loeb et al. Cancer Res. 1974;34:2311-21.
    MeSH term(s) Disease Progression ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Phenotype
    Language English
    Publishing date 2016--15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-0794
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  6. Article ; Online: Multiple sclerosis and hypogonadism: is there a relationship?

    Hammad, Muhammed A M / Rush, Adriana / Loeb, Charles A / Banton, Jasmin / Abou Chawareb, Elia / Khanmammadova, Narmina / Gevorkyan, Rafael R / Barham, David W / Yafi, Faysal A / Jenkins, Lawrence C

    Sexual medicine reviews

    2024  Volume 12, Issue 2, Page(s) 178–182

    Abstract: Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system and is widely recognized as a disease primarily affecting women. The relationship between MS and hypogonadism is complex and not fully ... ...

    Abstract Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system and is widely recognized as a disease primarily affecting women. The relationship between MS and hypogonadism is complex and not fully understood, with recent evidence showing that hypogonadism may have a significant impact on the quality of life and disease progression of patients with MS.
    Objectives: This review aims to provide an overview of the current knowledge regarding the relationship between MS and hypogonadism, including the mechanisms underlying this relationship; the effects of hypogonadism on patients with MS; and the potential benefits and drawbacks of testosterone replacement therapy for patients with MS and hypogonadism.
    Methods: This scientific review analyzed 19 articles that investigated the potential relationship among MS, testosterone levels, and hypogonadism. The articles were published between November 2008 and March 2022 and were identified through a comprehensive search of the PubMed database. The search terms used included "multiple sclerosis," "testosterone," "hypogonadism," and "MS and testosterone levels."
    Results: Of the 19 articles reviewed, 11 described a positive correlation between low testosterone levels and dysfunction within the hypothalamic-pituitary-gonadal axis in individuals with MS. These findings suggest that low testosterone levels may contribute to dysfunction within the hypothalamus-pituitary-gonadal axis, which plays a crucial role in regulating testosterone production. The results also showed a relationship between sexual dysfunction and low testosterone levels, as well as a positive correlative relationship between these factors.
    Conclusion: The reviewed articles indicate a complex relationship among MS, testosterone levels, and the hypothalamic-pituitary-gonadal axis, with low testosterone levels potentially contributing to dysfunction in this axis and to sexual dysfunction. Further research is needed to better understand the effects of testosterone therapy on MS and sexual dysfunction in patients with MS.
    MeSH term(s) Humans ; Female ; Quality of Life ; Multiple Sclerosis/complications ; Hypogonadism/complications ; Hypogonadism/drug therapy ; Testosterone/therapeutic use ; Sexual Dysfunction, Physiological/etiology
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-01-07
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2722257-3
    ISSN 2050-0521 ; 2050-0513
    ISSN (online) 2050-0521
    ISSN 2050-0513
    DOI 10.1093/sxmrev/qead050
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  7. Article ; Online: Evolutionary dynamics and significance of multiple subclonal mutations in cancer.

    Beckman, Robert A / Loeb, Lawrence A

    DNA repair

    2017  Volume 56, Page(s) 7–15

    Abstract: For the last 40 years the authors have collaborated on trying to understand the complexities of human cancer by formulating testable mathematical models that are based on mutation accumulation in human malignancies. We summarize the concepts encompassed ... ...

    Abstract For the last 40 years the authors have collaborated on trying to understand the complexities of human cancer by formulating testable mathematical models that are based on mutation accumulation in human malignancies. We summarize the concepts encompassed by multiple mutations in human cancers in the context of source, accumulation during carcinogenesis and tumor progression, and therapeutic consequences. We conclude that the efficacious treatment of human cancer by targeted therapy will involve individualized, uniquely directed specific agents singly and in simultaneous combinations, and take into account the importance of targeting resistant subclonal mutations, particularly those subclones with alterations in DNA repair genes, DNA polymerase, and other genes required to maintain genetic stability.
    MeSH term(s) Carcinogenesis ; DNA Repair ; DNA Replication ; DNA, Neoplasm/metabolism ; Humans ; Models, Biological ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology
    Chemical Substances DNA, Neoplasm
    Language English
    Publishing date 2017-06-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2017.06.002
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  8. Article ; Online: Contemporary cost-analysis comparison of direct-to-consumer vs. traditional prescriptions of phosphodiesterase-5 inhibitors.

    Schneider, Douglas / Loeb, Charles A / Brevik, Andrew / El-Khatib, Farouk / Jenkins, Lawrence C / Yafi, Faysal A

    International journal of impotence research

    2022  Volume 35, Issue 5, Page(s) 460–464

    Abstract: After a focused telehealth visit, patients can now access phosphodiesterase-5 inhibitor (PDE5 inhibitor) prescriptions through online direct-to-consumer (DTC) healthcare companies. This study seeks to quantify the cost of DTC PDE5 inhibitor treatment ... ...

    Abstract After a focused telehealth visit, patients can now access phosphodiesterase-5 inhibitor (PDE5 inhibitor) prescriptions through online direct-to-consumer (DTC) healthcare companies. This study seeks to quantify the cost of DTC PDE5 inhibitor treatment compared to a traditional physician visit and local pharmacy prescription. Two DTC companies, two compounding pharmacies with national reach, three online Canadian pharmacies, and sixteen American pharmacy chains were queried for prices of 90-day regimens of common PDE5 inhibitors. Prices for chains were determined using their publicly available price on GoodRx
    MeSH term(s) United States ; Humans ; Aged ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Sildenafil Citrate/therapeutic use ; Tadalafil/therapeutic use ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Canada ; National Health Programs ; Prescriptions
    Chemical Substances Phosphodiesterase 5 Inhibitors ; Sildenafil Citrate (BW9B0ZE037) ; Tadalafil (742SXX0ICT) ; Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35)
    Language English
    Publishing date 2022-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-022-00567-3
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  9. Article ; Online: Accurate detection of subclonal variants in paired diagnosis-relapse acute myeloid leukemia samples by next generation Duplex Sequencing.

    Kamath-Loeb, Ashwini S / Shen, Jiang-Cheng / Schmitt, Michael W / Kohrn, Brendan F / Loeb, Keith R / Estey, Elihu H / Dai, Jin / Chien, Sylvia / Loeb, Lawrence A / Becker, Pamela S

    Leukemia research

    2022  Volume 115, Page(s) 106822

    Abstract: Mutations characterize diverse human cancers; there is a positive correlation between elevated mutation frequency and tumor progression. One exception is acute myeloid leukemia (AML), which has few clonal single nucleotide mutations. We used highly ... ...

    Abstract Mutations characterize diverse human cancers; there is a positive correlation between elevated mutation frequency and tumor progression. One exception is acute myeloid leukemia (AML), which has few clonal single nucleotide mutations. We used highly sensitive and accurate Duplex Sequencing (DS) to show now that AML, in addition, has an extensive repertoire of variants with low allele frequencies, < 1%, which is below the accurate detection limit of most other sequencing methodologies. The subclonal variants are unique to each individual and change in composition, frequency, and sequence context from diagnosis to relapse. Their functional significance is apparent by the observation that many are known variants and cluster within functionally important protein domains. Subclones provide a reservoir of variants that could expand and contribute to the development of drug resistance and relapse. In accord, we accurately identified subclonal variants in AML driver genes NRAS and RUNX1 at allele frequencies between 0.1% and 0.3% at diagnosis, which expanded to comprise a major fraction (14-53%) of the blast population at relapse. Early and accurate detection of subclonal variants with low allele frequency thus offers the opportunity for early intervention, prior to detection of clinical relapse, to improve disease outcome and enhance patient survival.
    MeSH term(s) Alleles ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Mutation ; Recurrence
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2022.106822
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  10. Article ; Online: Human cancers express mutator phenotypes: origin, consequences and targeting.

    Loeb, Lawrence A

    Nature reviews. Cancer

    2011  Volume 11, Issue 6, Page(s) 450–457

    Abstract: Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator ...

    Abstract Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
    MeSH term(s) Animals ; Base Sequence ; DNA Damage ; DNA Repair ; Disease Progression ; Humans ; Mice ; Mutation ; Neoplasm Metastasis/genetics ; Neoplasms/genetics ; Phenotype ; Sequence Analysis, DNA
    Language English
    Publishing date 2011-05-19
    Publishing country England
    Document type Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/nrc3063
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