Article: The role of interleukin 6 in the pathogenesis and therapy of Castleman disease - an immunologist's perspective.
2023 Volume 162, Issue 2-3, Page(s) 106–111
Abstract: Castleman disease (CD) is a heterogeneous group of diseases characterized by lymphadenopathy and systemic inflammatory manifestations. CD can be divided into uni- (UCD) and multicentric form (MCD) according to the disease extent. MCD is usually ... ...
Title translation | Úloha interleukinu 6 v patogenezi a léčbě Castlemanovy choroby – pohled imunologa. |
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Abstract | Castleman disease (CD) is a heterogeneous group of diseases characterized by lymphadenopathy and systemic inflammatory manifestations. CD can be divided into uni- (UCD) and multicentric form (MCD) according to the disease extent. MCD is usually accompanied by the features of a systemic inflammatory response including fever, weight loss, hepatosplenomegaly, ascites, and edema. In these patients, we can also observe elevation of inflammatory parameters and anemia within the laboratory assessment. Based on etiological nature, the CD can be further divided into human herpesvirus-8-associated (HHV8-associated) and idiopathic form. Interleukin 6 (IL-6) plays a central role in the disease pathogenesis. Inhibition of IL-6 has been shown to be an effective treatment modality. Currently, siltuximab, a chimeric monoclonal antibody targeting IL-6, is the only approved treatment for MCD. Its short-term and long-term efficacy and safety have been demonstrated in a few clinical studies. |
MeSH term(s) | Humans ; Castleman Disease/drug therapy ; Castleman Disease/pathology ; Interleukin-6/therapeutic use ; Treatment Outcome |
Chemical Substances | Interleukin-6 ; IL6 protein, human |
Language | English |
Publishing date | 2023-07-18 |
Publishing country | Czech Republic |
Document type | Journal Article |
ZDB-ID | 413441-2 |
ISSN | 1805-4420 ; 0008-7335 |
ISSN (online) | 1805-4420 |
ISSN | 0008-7335 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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