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  1. Article ; Online: The Evolving Management of Desmoid Fibromatosis.

    Prendergast, Katherine / Kryeziu, Sara / Crago, Aimee M

    The Surgical clinics of North America

    2022  Volume 102, Issue 4, Page(s) 667–677

    Abstract: Desmoid fibromatosis is a rare disease caused by genetic alterations that activate β-catenin. The tumors were previously treated with aggressive surgeries but do not metastasize and may regress spontaneously. For these reasons, in the absence of symptoms ...

    Abstract Desmoid fibromatosis is a rare disease caused by genetic alterations that activate β-catenin. The tumors were previously treated with aggressive surgeries but do not metastasize and may regress spontaneously. For these reasons, in the absence of symptoms and when growth would not induce significant complications, active observation is considered first-line therapy. When intervention is required, surgery can be considered based on anatomy and risk of postoperative recurrence, but increasingly nonoperative therapies such as liposomal doxorubicin or sorafenib are prescribed. Cryoablation, chemoembolization, and high-intensity focused ultrasound can also be used to obtain local control in selected patients.
    MeSH term(s) Fibromatosis, Aggressive/diagnosis ; Fibromatosis, Aggressive/therapy ; Humans ; Mutation
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2022.05.005
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  2. Article ; Online: Extended surgical resection and histology in retroperitoneal sarcoma.

    Crago, Aimee M

    Annals of surgical oncology

    2015  Volume 22, Issue 5, Page(s) 1401–1403

    MeSH term(s) Humans ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/surgery ; Sarcoma/pathology ; Sarcoma/surgery
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-014-4135-2
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  3. Article ; Online: Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.

    Crago, Aimee M / Cardona, Kenneth / Koseła-Paterczyk, Hanna / Rutkowski, Piotr

    Surgical oncology clinics of North America

    2022  Volume 31, Issue 3, Page(s) 419–430

    Abstract: Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genomically complex tumors commonly diagnosed in the extremities or trunk of elderly patients. They likely represent a spectrum of disease differentiated by myxoid stroma and ... ...

    Abstract Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genomically complex tumors commonly diagnosed in the extremities or trunk of elderly patients. They likely represent a spectrum of disease differentiated by myxoid stroma and curvilinear vessels observed in MFS but not in UPS. Limb-sparing surgery is the standard of care although the infiltrative nature of MFS mandates wider resection margins than are necessary for UPS. UPS are conversely associated with high risks of distal recurrence, often prompting recommendations for adjuvant chemotherapy. In both histologies, anthracycline-based therapies or gemcitabine and docetaxel are used to manage advanced disease; immunotherapy may be of benefit in a subset of patients.
    MeSH term(s) Adult ; Aged ; Extremities/pathology ; Fibrosarcoma/surgery ; Histiocytoma, Malignant Fibrous/pathology ; Humans ; Sarcoma/drug therapy ; Sarcoma/pathology ; Soft Tissue Neoplasms/pathology
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2022.03.006
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  4. Article ; Online: Transarterial Chemoembolization with Doxorubicin Eluting Beads for Extra-Abdominal Desmoid Tumors: Initial Experience.

    Kim, Daehee / Keohan, Mary Louise / Gounder, Mrinal M / Crago, Aimee M / Erinjeri, Joseph P

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 8, Page(s) 1141–1151

    Abstract: ... 161.8 ml (range: 28.3-420.0 ml). The mean doxorubicin dose was 13.3 mg/m: Conclusion: DEB-TACE ...

    Abstract Purpose: To evaluate the feasibility, efficacy, and safety of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) as an alternative local treatment for extra-abdominal desmoid tumors (DTs).
    Methods: Eleven adult female patients (mean age = 40.1 years) with symptomatic, progressively enlarging extra-abdominal DTs were determined ineligible for cryoablation after failing observation or systemic therapy and treated with a single session doxorubicin DEB-TACE. Six rectus sheath, one chest wall, three axilla, and one upper extremity DTs were included. The median follow-up was 155.0 ± 52.3 days. Treatment response was assessed by MRIs and maximum visual analog scale (VAS).
    Results: All procedures were technically successful without immediate complications. The average size of treated DT was 161.8 ml (range: 28.3-420.0 ml). The mean doxorubicin dose was 13.3 mg/m
    Conclusion: DEB-TACE may be a safe and effective local treatment alternative in DT patients.
    MeSH term(s) Adult ; Antibiotics, Antineoplastic ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/methods ; Doxorubicin ; Female ; Fibromatosis, Aggressive/diagnostic imaging ; Fibromatosis, Aggressive/therapy ; Humans ; Liver Neoplasms/therapy ; Treatment Outcome
    Chemical Substances Antibiotics, Antineoplastic ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03149-4
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    Zs.A 1378: Show issues Location:
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  5. Article ; Online: Pseudoaneurysm within a desmoid tumor in an extremity: report of 2 cases.

    Long, Niamh M / Gounder, Mrinal M / Crago, Aimee M / Chou, Alexander J / Panicek, David M

    Skeletal radiology

    2021  Volume 50, Issue 10, Page(s) 2107–2115

    Abstract: Desmoid tumor is considered a benign neoplasm, yet substantial morbidity can result from local invasion of structures adjacent to the tumor or from complications related to its treatment. We report two patients with extremity desmoid tumor who were each ... ...

    Abstract Desmoid tumor is considered a benign neoplasm, yet substantial morbidity can result from local invasion of structures adjacent to the tumor or from complications related to its treatment. We report two patients with extremity desmoid tumor who were each found at MRI to have an unsuspected pseudoaneurysm within their tumor after prior treatments (surgery and systemic therapy in one, surgery alone in the other). Such a pseudoaneurysm probably results from weakening of an arterial wall by adjacent desmoid tumor, as well as from local trauma. Due to the potential risk for life-threatening rupture of a pseudoaneurysm, one patient underwent surgical repair and the other, coil embolization. To our knowledge the presence of pseudoaneurysm has been reported within a few cases of abdominal desmoid tumor but not within an extremity desmoid tumor. This diagnosis has not been reported to have been made at MRI, either.
    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/surgery ; Extremities ; Fibromatosis, Aggressive/diagnostic imaging ; Fibromatosis, Aggressive/surgery ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2021-03-16
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-021-03748-1
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    Zs.A 1304: Show issues Location:
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  6. Article ; Online: Liposarcoma: Multimodality Management and Future Targeted Therapies.

    Crago, Aimee M / Dickson, Mark A

    Surgical oncology clinics of North America

    2016  Volume 25, Issue 4, Page(s) 761–773

    Abstract: ... is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local ...

    Abstract There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2016.05.007
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  7. Article ; Online: Multimodality Management of Soft Tissue Tumors in the Extremity.

    Crago, Aimee M / Lee, Ann Y

    The Surgical clinics of North America

    2016  Volume 96, Issue 5, Page(s) 977–992

    Abstract: Most extremity soft tissue sarcomas present as a painless mass. Work-up should generally involve cross-sectional imaging with MRI and a core biopsy for pathologic diagnosis. Limb-sparing surgery is the standard of care, and may be supplemented with ... ...

    Abstract Most extremity soft tissue sarcomas present as a painless mass. Work-up should generally involve cross-sectional imaging with MRI and a core biopsy for pathologic diagnosis. Limb-sparing surgery is the standard of care, and may be supplemented with radiation for histologic subtypes at higher risk for local recurrence and chemotherapy for those at higher risk for distant metastases. This article reviews the work-up and surgical approach to extremity soft tissue sarcomas, and the role for radiation and chemotherapy, with particular attention given to the distinguishing characteristics of some of the most common subtypes.
    MeSH term(s) Combined Modality Therapy ; Disease Management ; Extremities ; Humans ; Soft Tissue Neoplasms/therapy
    Language English
    Publishing date 2016-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2016.05.001
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  8. Article ; Online: The importance of surgical margins in retroperitoneal sarcoma.

    Kirane, Amanda / Crago, Aimee M

    Journal of surgical oncology

    2016  Volume 113, Issue 3, Page(s) 270–276

    Abstract: Surgery is the "gold-standard" treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease-related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of ... ...

    Abstract Surgery is the "gold-standard" treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease-related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of adjacent organs to improve margins or prescription of neoadjuvant radiation leads to better outcomes. This review summarizes data addressing prognostic value of margin, extent of surgery necessary to optimize treatment of retroperitoneal sarcomas, and role of histology in optimizing therapy.
    MeSH term(s) Chemotherapy, Adjuvant ; Humans ; Leiomyosarcoma/prevention & control ; Leiomyosarcoma/surgery ; Liposarcoma/prevention & control ; Liposarcoma/surgery ; Neoadjuvant Therapy/methods ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm, Residual/prevention & control ; Prognosis ; Radiotherapy, Adjuvant ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/prevention & control ; Retroperitoneal Neoplasms/surgery ; Sarcoma/pathology ; Sarcoma/prevention & control ; Sarcoma/surgery ; Surgical Procedures, Operative/methods ; Surgical Procedures, Operative/standards ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.24135
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  9. Article ; Online: Principles in Management of Soft Tissue Sarcoma.

    Crago, Aimee M / Brennan, Murray F

    Advances in surgery

    2015  Volume 49, Page(s) 107–122

    MeSH term(s) Combined Modality Therapy/standards ; Disease Management ; Humans ; Practice Guidelines as Topic ; Retroperitoneal Neoplasms/therapy ; Sarcoma/therapy
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 411889-3
    ISSN 1878-0555 ; 0065-3411
    ISSN (online) 1878-0555
    ISSN 0065-3411
    DOI 10.1016/j.yasu.2015.04.002
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    Zs.A 92: Show issues Location:
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  10. Article ; Online: The Landmark Series: Desmoid.

    Fiore, Marco / Crago, Aimee / Gladdy, Rebecca / Kasper, Bernd

    Annals of surgical oncology

    2021  Volume 28, Issue 3, Page(s) 1682–1689

    Abstract: Desmoid-type fibromatosis represents a challenge in the landscape of surgical oncology, for several reasons. The tumors can be infiltrative and locally aggressive, surgery may be morbid, and patients are usually young, and thus treatment sequelae must be ...

    Abstract Desmoid-type fibromatosis represents a challenge in the landscape of surgical oncology, for several reasons. The tumors can be infiltrative and locally aggressive, surgery may be morbid, and patients are usually young, and thus treatment sequelae must be managed for decades. Desmoids do not have metastatic potential, therefore management strategies for desmoids have evolved to employ frontline treatments that are largely non-operative. In fact, with unpredictable and benign behavior, we now recognize that desmoids can also stabilize and regress, making active observation an option for many patients. Moreover, many medical therapies are active in the disease. We reviewed landmark studies describing contemporary issues that affect treatment recommendations for desmoid patients: prognostic factors, indication to active surveillance, role of surgical margins, postoperative radiotherapy, and the most recent expert consensus papers.
    MeSH term(s) Disease Progression ; Fibromatosis, Aggressive/therapy ; Humans
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09395-5
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