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Article ; Online: Surprising regulation of cell cycle entry.

Sherr, Charles J

2019 Volume 366, Issue 6471, Page(s) 1315–1316

MeSH term(s)	Cell Cycle ; Cell Division ; Cyclin-Dependent Kinase 4 ; Piperazines ; Pyridines
Chemical Substances	Piperazines ; Pyridines ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; palbociclib (G9ZF61LE7G)
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaz4043
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Zs.MG 77: Show issues

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Article ; Online: Acquired palbociclib resistance in KRAS-mutant lung cancer.

Sherr, Charles J

Oncotarget

2018 Volume 9, Issue 67, Page(s) 32734–32735

Language	English
Publishing date	2018-08-28
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.26027
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Article ; Online: A New Cell-Cycle Target in Cancer - Inhibiting Cyclin D-Dependent Kinases 4 and 6.

Sherr, Charles J

The New England journal of medicine

2016 Volume 375, Issue 20, Page(s) 1920–1923

MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Cell Cycle/drug effects ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Female ; Humans ; Mice ; Neoplasms/drug therapy ; Neoplasms/physiopathology ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyridines/pharmacology ; Pyridines/therapeutic use
Chemical Substances	Piperazines ; Protein Kinase Inhibitors ; Pyridines ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22) ; palbociclib (G9ZF61LE7G)
Language	English
Publishing date	2016-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMp1612343
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Article ; Online: How politics trumped peer review at Texas cancer institute.

Sherr, Charles J

BMJ (Clinical research ed.)

2012 Volume 345, Page(s) e7334

MeSH term(s)	Academies and Institutes ; Humans ; Peer Review ; Politics ; Texas
Language	English
Publishing date	2012-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.e7334
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Article ; Online: Sexually dimorphic tumor suppression by small mitochondrial

van Oosterwijk, Jolieke G / Tillman, Heather / Sherr, Charles J

Oncotarget

2019 Volume 10, Issue 12, Page(s) 1235–1237

Abstract: Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not ... ...

Abstract	Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity.
Language	English
Publishing date	2019-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.26651
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Article ; Online: Ink4-Arf locus in cancer and aging.

Sherr, Charles J

Wiley interdisciplinary reviews. Developmental biology

2012 Volume 1, Issue 5, Page(s) 731–741

Abstract: Three tumor suppressor genes at the small (<50 kb) INK4-ARF (CDKN2A/B) locus on human chromosome 9p21 coordinate a signaling network that depends on the activities of the retinoblastoma (RB) protein and the p53 transcription factor. Disruption of this ... ...

Abstract	Three tumor suppressor genes at the small (<50 kb) INK4-ARF (CDKN2A/B) locus on human chromosome 9p21 coordinate a signaling network that depends on the activities of the retinoblastoma (RB) protein and the p53 transcription factor. Disruption of this circuitry, frequently by codeletion of INK4-ARF, is a hallmark of cancer, begging the question of why the intimate genetic linkage of these tumor suppressor genes has been maintained in mammals despite the risk of their coinactivation. The INK4-ARF locus is not highly expressed under normal physiologic conditions in young mammals, but its induction becomes more pronounced as animals age. Notably, INK4-ARF is actively silenced en bloc in embryonic, fetal, and adult stem cells but becomes poised to respond to oncogenic stress signals as stem cells lose their self-renewal capacity and differentiate, thereby providing a potent barrier to tumor formation. Epigenetic remodeling of the locus as a whole provides a mechanism for coordinating the activities of RB and p53. A hypothesis is that the INK4-ARF locus may have evolved to physiologically restrict the self-renewal capacities and numbers of stem and progenitor cells with the attendant consequence of limiting tissue regenerative capacity, particularly as animals age. Deletion of INK4-ARF contributes to the aberrant self-renewal capacity of tumor cells and occurs frequently in many forms of human cancer.
MeSH term(s)	Aging/genetics ; Aging/pathology ; Animals ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Epigenesis, Genetic/genetics ; Gene Deletion ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Retinoblastoma Protein ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p16 ; Retinoblastoma Protein ; Tumor Suppressor Protein p53
Language	English
Publishing date	2012-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1759-7692
ISSN (online)	1759-7692
DOI	10.1002/wdev.40
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Article: Exploring the cognitive development of children born to adolescent mothers in South Africa.

Steventon Roberts, Kathryn J / Smith, Colette / Toska, Elona / Cluver, Lucie / Wittesaele, Camille / Langwenya, Nontokozo / Shenderovich, Yulia / Saal, Wylene / Jochim, Janina / Chen-Charles, Jenny / Marlow, Marguerite / Sherr, Lorraine

Infant and child development

2023 Volume 32, Issue 3, Page(s) e2408

Abstract: This study explores the cognitive development of children born to adolescent mothers within South Africa compared to existing reference data, and explores development by child age bands to examine relative levels of development. Cross-sectional analyses ... ...

Abstract	This study explores the cognitive development of children born to adolescent mothers within South Africa compared to existing reference data, and explores development by child age bands to examine relative levels of development. Cross-sectional analyses present data from 954 adolescents (10-19 years) and their first-born children (0-68 months). All adolescents completed questionnaires relating to themselves and their children, and standardized child cognitive assessments (Mullen Scales of Early Learning) were undertaken. Cognitive development scores of the sample were lower than USA reference population scores and relative performance compared to the reference population was found to decline with increasing child age. When compared to children born to adult mothers in the sub-Saharan African region, children born to adolescent mothers (human immunodeficiency virus [HIV] unexposed; Highlights: An exploration of the cognitive development of children born to adolescent mothers within South Africa utilizing the Mullen Scales of Early Learning.Cognitive development scores of children born to adolescent mothers within South Africa were lower compared to USA norm reference data and declined with child age.Previous studies utilizing the Mullen Scales of Early Learning within sub-Saharan Africa were summarized, and comparisons were made with the current sample.Findings highlight a potential risk of developmental delay among children born to adolescent mothers compared to children of adult mothers in the sub-Saharan African region.
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1479433-0
ISSN	1522-7219 ; 1522-7227
ISSN (online)	1522-7219
ISSN	1522-7227
DOI	10.1002/icd.2408
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Zs.A 3719: Show issues

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Article ; Online: Forging a signature of in vivo senescence.

Sharpless, Norman E / Sherr, Charles J

Nature reviews. Cancer

2015 Volume 15, Issue 7, Page(s) 397–408

Abstract: Cellular senescence', a term originally defining the characteristics of cultured cells that exceed their replicative limit, has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. Proposed relationships ...

Abstract	'Cellular senescence', a term originally defining the characteristics of cultured cells that exceed their replicative limit, has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. Proposed relationships between cellular senescence, tumour suppression, loss of tissue regenerative capacity and ageing suffer from lack of uniform definition and consistently applied criteria. Here, we highlight caveats in interpreting the importance of suboptimal senescence-associated biomarkers, expressed either alone or in combination. We advocate that more-specific descriptors be substituted for the now broadly applied umbrella term 'senescence' in defining the suite of diverse physiological responses to cellular stress.
MeSH term(s)	Animals ; Biomarkers ; Cell Cycle ; Cellular Senescence ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p21/physiology ; DNA Damage ; Genes, p16 ; Humans ; Telomere Shortening ; Tumor Suppressor Protein p53/physiology
Chemical Substances	Biomarkers ; CDKN1A protein, human ; Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p21 ; Tumor Suppressor Protein p53
Language	English
Publishing date	2015-06-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2062767-1
ISSN	1474-1768 ; 1474-175X
ISSN (online)	1474-1768
ISSN	1474-175X
DOI	10.1038/nrc3960
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Zs.A 5563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 24: Show issues

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Article ; Online: The development of children born to young mothers with no, first- or second-generation HIV acquisition in the Eastern Cape province, South Africa: a cross-sectional study.

Sherr, Lorraine / Haag, Katharina / Steventon Roberts, Kathryn J / Cluver, Lucie Dale / Wittesaele, Camille / Saliwe, Bongiwe / Tolmay, Janke / Langwenya, Nontokozo / Jochim, Janina / Saal, Wylene / Zhou, Siyanai / Marlow, Marguerite / Chen-Charles, Jenny J / Toska, Elona

BMJ open

2022 Volume 12, Issue 10, Page(s) e058340

Abstract: Background: The intergenerational effects of HIV require long-term investigation. We compared developmental outcomes of different generations impacted by HIV-children of mothers not living with HIV, the 'second generation' (ie, with recently infected ... ...

Abstract	Background: The intergenerational effects of HIV require long-term investigation. We compared developmental outcomes of different generations impacted by HIV-children of mothers not living with HIV, the 'second generation' (ie, with recently infected mothers) and the 'third generation' (ie, children of perinatally infected mothers). Methods: A cross-sectional community sample of N=1015 young mothers (12-25 years) and their first children (2-68 months, 48.2% female), from South Africa's Eastern Cape Province. 71.3% (n=724) of children were born to mothers not living with HIV; 2.7% (n=27; 1 living with HIV) were third-generation and 26.0% (n=264; 11 living with HIV) second-generation children. Child scores on the Mullen Scales of Early Learning (MSEL), the WHO Ten Questions Screen for Disability and maternal demographics were compared between groups using χ Results: Second-generation children performed poorer on gross (M=47.0, SD=13.1) and fine motor functioning (M=41.4, SD=15.2) and the MSEL composite score (M=90.6, SD=23.0) than children with non-infected mothers (gross motor: M=50.4, SD=12.3; fine motor: M=44.4, SD=14.1; composite score: M=94.1, SD=20.7). The third generation performed at similar levels to non-exposed children (gross motor: M=52.4, SD=16.1; fine motor: M=44.3, SD=16.1, composite score: M=94.7, SD=22.2), though analyses were underpowered for definite conclusions. Hierarchical regression analyses suggest marginal predictive effects of being second-generation child compared with having a mother not living with HIV (B=-3.3, 95% CI=-6.8 to 0 .1) on MSEL total scores, and non-significant predictive effects of being a third-generation child (B=1.1, 5% CI=-7.5 to 9.7) when controlling for covariates. No group differences were found for disability rates (26.9% third generation, 27.7% second generation, 26.2% non-exposed; χ Conclusion: Recently infected mothers and their children may struggle due to the disruptiveness of new HIV diagnoses and incomplete access to care/support during pregnancy and early motherhood. Long-standing familial HIV infection may facilitate care pathways and coping, explaining similar cognitive development among not exposed and third-generation children. Targeted intervention and fast-tracking into services may improve maternal mental health and socioeconomic support.
MeSH term(s)	Cross-Sectional Studies ; Female ; HIV Infections/epidemiology ; Humans ; Male ; Mental Health ; Mothers ; Pregnancy ; South Africa/epidemiology
Language	English
Publishing date	2022-10-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-058340
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Article ; Online: Achieving the health and well-being Sustainable Development Goals among adolescent mothers and their children in South Africa: Cross-sectional analyses of a community-based mixed HIV-status cohort.

Toska, Elona / Saal, Wylene / Chen Charles, Jenny / Wittesaele, Camille / Langwenya, Nontokozo / Jochim, Janina / Steventon Roberts, Kathryn J / Anquandah, Jason / Banougnin, Boladé Hamed / Laurenzi, Christina / Sherr, Lorraine / Cluver, Lucie

PloS one

2022 Volume 17, Issue 12, Page(s) e0278163

Abstract: The Sustainable Development Goals (SDGs) are a visionary and multi-sectoral agenda for human development. With less than a decade left to reach these targets, it is important to identify those at greatest risk of not meeting these ambitious targets. ... ...

Abstract	The Sustainable Development Goals (SDGs) are a visionary and multi-sectoral agenda for human development. With less than a decade left to reach these targets, it is important to identify those at greatest risk of not meeting these ambitious targets. Adolescent mothers and their children are a highly vulnerable group. We mapped 35 SGD-related targets among 1,046 adolescent mothers and their oldest child (n = 1046). Questionnaires using validated scales were completed by 10- to 24-year-old adolescent girls and young women who had their first child before age 20 in an HIV-endemic district in the Eastern Cape province of South Africa. Maternal outcomes included 26 SDG-aligned indicators, while child-related outcomes included 9 indicators. Data was collected by trained researchers, following informed voluntary consent by the adolescent mothers and their caregivers. Frequencies and chi-square tests were conducted to compare progress along SDG-aligned indicators among adolescent mothers by HIV status. Overall, adolescent mothers reported low attainment of SDG-aligned indicators. While four in five adolescent mothers lived in poor households, nearly 93% accessed at least one social cash transfer and 80% accessed a child support grant for their children. Food security rates among adolescent mothers (71%) were lower than among their children (91%). Only two-thirds of adolescent mothers returned to school after childbirth, and only one-fifth were either studying or employed. Over half of adolescent mothers had experienced at least one type of violence (domestic, sexual or community). HIV-positive status was associated with higher rates of hunger and substance use, poorer school attendance, and higher rates of exposure to violence. Understanding progress and gaps in meeting the SDGs among highly vulnerable groups is critical, particularly for adolescent mothers and their children. These complex vulnerabilities suggest that programming for adolescent mothers must address their unique needs.
MeSH term(s)	Humans ; Female ; Adolescent ; Young Adult ; Adult ; Child ; Cross-Sectional Studies ; Sustainable Development ; Adolescent Mothers ; South Africa/epidemiology ; HIV Infections/epidemiology ; HIV Infections/prevention & control
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278163
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