Article: Approaches to prophylaxis and therapy.
2003 Volume 66, Page(s) 281–292
Abstract: Despite important progress in experimental treatment of neurodegenerative diseases, no therapeutic strategy has today proven its capability to cure or even to stabilise human TSEs. Pathogenesis experiments performed in rodent TSE models have shown that ... ...
| Abstract | Despite important progress in experimental treatment of neurodegenerative diseases, no therapeutic strategy has today proven its capability to cure or even to stabilise human TSEs. Pathogenesis experiments performed in rodent TSE models have shown that central nervous system damages are detectable long before the appearance of the clinical symptoms. At the time of disease onset, PrP(Sc) accumulation has almost reached its highest level, and the neuropathological lesions (spongiosis, gliosis) are as intense as they are at the time of death. Therefore, the neurodegeneration that is present at the onset of the disease is beyond therapy, and, in theory, only a preclinical diagnosis of TSEs would permit the prevention (or delay) of neurodegeneration. Unfortunately, there are no diagnostic tests that can be used to show TSE agent infection during the preclinical phase of the disease. Nevertheless, since the appearance of variant Creutzfeldt-Jakob disease (vCJD), those in the scientific community working on experimental therapy have increased their efforts. Tens of drugs have been tested in several experimental models, and there are some high-output screening platforms being used in Europe and in the US. Any rational therapeutic strategy needs to be based on pathogenesis data and/or knowledge on the nature of the causative agent. Therefore, progress in therapy is tightly linked to a better understanding of the basic science of TSE. |
|---|---|
| MeSH term(s) | Animals ; Brain/metabolism ; Brain Chemistry ; Drug Evaluation, Preclinical ; Humans ; Immune Sera/administration & dosage ; Immune System/pathology ; Immunization ; Mass Screening ; Models, Animal ; Nervous System/pathology ; PrPSc Proteins/analysis ; PrPSc Proteins/metabolism ; Prion Diseases/pathology ; Prion Diseases/prevention & control ; Prion Diseases/therapy ; Prions/immunology ; Research Design |
| Chemical Substances | Immune Sera ; PrPSc Proteins ; Prions |
| Language | English |
| Publishing date | 2003-07-11 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 213294-1 |
| ISSN | 1471-8391 ; 0007-1420 |
| ISSN (online) | 1471-8391 |
| ISSN | 0007-1420 |
| DOI | 10.1093/bmb/66.1.281 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ua VI Zs.277: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.